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Studies Found: 1183

BRAIN - ALZHEIMER'S DISEASE (AD)

Hydrogen-rich water ameliorates neuropathological impairments in a mouse model of Alzheimer's ...

Year Published: 2022

Hydrogen exhibits the potential to treat Alzheimer's disease. Stereotactic injection has been previously used as an invasive method of administering active hydrogen, but this method has limitations in clinical practice. In this study, triple transgenic (3×Tg) Alzheimer's disease mice were treated with hydrogen-rich water for 7 months. The results showed that hydrogen-rich water prevented synaptic ...
INTESTINE - INFLAMMATORY BOWEL DISEASE (IBD)

Microbial hydrogen economy alleviates colitis by reprogramming colonocyte metabolism and reinforcing ...

Year Published: 2022

With the rapid development and high therapeutic efficiency and biosafety of gas-involving theranostics, hydrogen medicine has been particularly outstanding because hydrogen gas (H2), a microbial-derived gas, has potent anti-oxidative, anti-apoptotic, and anti-inflammatory activities in many disease models. Studies have suggested that H2-enriched saline/water alleviates colitis in murine models; ...
BRAIN - STROKE

Gender-based differences in neuroprotective effects of hydrogen gas against intracerebral ...

Year Published: 2022

Background: Post-stroke depression (PSD) severely affects recovery in patients with intracerebral hemorrhage (ICH). Although hydrogen gas (H2) exerts excellent neuroprotective effects in patients with ICH, there are sex-based differences in H2 efficacy in several diseases. Herein, we determined whether estrogen increases susceptibility to the neuroprotective effects of H2 in males with ICH-induced ...
BRAIN - TRAUMATIC BRAIN INJURY

Hydrogen-rich saline alleviates early brain injury through inhibition of necroptosis and ...

Year Published: 2022

Traumatic brain injury (TBI) has been recognized as a serious public health issue and a key contributor to disability and death, with a huge economic burden worldwide. Hydrogen, which is a slight and specific cytotoxic oxygen radical scavenger, has been demonstrated to ameliorate early brain injury (EBI) through reactive oxygen species (ROS), oxidative stress injury, apoptosis and necroptosis. ...
INTESTINE - CANCER

Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer ...

Year Published: 2022

Background: Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in the world. Tumor removal remains the preferred frontline treatment; however, effective non-surgical interventions remain a high priority. 5-fluorouracil (5-FU) is a widely used chemotherapy agent, and molecular hydrogen (H2) has been recognized for its antioxidant and anti-inflammatory effects, with research ...
LUNG - SEPSIS

Hydrogen-rich and hyperoxygenate saline inhibits lipopolysaccharide-induced lung injury through ...

Year Published: 2022

Background: Background: Acute lung injury (ALI) is one kind of frequently occurred emergency in Intensive Care Unite with a high mortality. The underlying causes are uncontrolled inflammatory reactions and intractable hypoxemia, which are difficult to control and improve. In the past 10 years, gas medical studies have found that both hydrogen molecules and oxygen molecules have protective effects ...
WHOLE BODY - CANCER

Molecular Hydrogen Enhances Proliferation of Cancer Cells That Exhibit Potent Mitochondrial Unfolded ...

Year Published: 2022

Molecular hydrogen ameliorates pathological states in a variety of human diseases, animal models, and cell models, but the effects of hydrogen on cancer have been rarely reported. In addition, the molecular mechanisms underlying the effects of hydrogen remain mostly unelucidated. We found that hydrogen enhances proliferation of four out of seven human cancer cell lines (the responders). The ...
WHOLE BODY - EXCERCISE

Molecular Hydrogen Mitigates Performance Decrement during Repeated Sprints in Professional Soccer ...

Year Published: 2022

Hydrogen-rich water (HRW) supplementation has been shown to have an antifatigue effect across different modes of exercise. However, its effect on repeated sprint performance is unknown. The aim of this study was to assess the effect of pre-exercise HRW consumption on repeated sprint performance, lactate, and perceptual responses using a repeated sprint protocol. This randomized, double blinded, ...
WHOLE BODY - HYPERTENSION

Effects of hydrogen-rich water and ascorbic acid treatment on spontaneously hypertensive rats

Year Published: 2022

Hydrogen-rich water (HW) has been suggested to possess antioxidant properties of value in treatments of lifestyle diseases and for prevention of latent pathologies. To date, the potential benefits of HW against the deleterious effects of excessive salt intake and hypertension have not been investigated. Here, we first examined the effects of HW or HW supplemented with 0.1% ascorbic acid (HWA) on ...
WHOLE BODY - SARS/COVID

Hydrogen-oxygen therapy alleviates clinical symptoms in twelve patients hospitalized with COVID-19: ...

Year Published: 2022

A global public health crisis caused by the 2019 novel coronavirus disease (COVID-19) leads to considerable morbidity and mortality, which bring great challenge to respiratory medicine. Hydrogen-oxygen therapy contributes to treat severe respiratory diseases and improve lung functions, yet there is no information to support the clinical use of this therapy in the COVID-19 pneumonia.A retrospective ...
WHOLE BODY - VIRAL INFECTION

Nano-bubble hydrogen water: An effective therapeutic agent against inflammation related disease ...

Year Published: 2022

Since the anti-inflammatory effect of hydrogen has been widely known, it was supposed that hydrogen could suppress tissue damage by inhibiting virus-related inflammatory reactions. However, hydrogen is slightly soluble in water, which leads to poor effect of oral hydrogen-rich water therapy. In this study, the nano-bubble hydrogen water (nano-HW) (about 0.7 ​ppm) was prepared and its therapeutic ...
BRAIN - COMA

Hydrogen inhalation promotes recovery of a patient in persistent vegetative state from intracerebral ...

Year Published: 2022

Background: Persistent vegetative state (PVS) is a devastating and long-lasting clinical condition with high morbidity and mortality; currently, there are no available effective interventions. Case summary: We report the case of an 11-year-old boy with PVS caused by severe intracerebral bleeding in the left hemisphere following anticoagulation treatment. The patient's PVS severity showed no ...
LUNG - SARS/COVID

Molecular Hydrogen Positively Affects Physical and Respiratory Function in Acute Post-COVID-19 ...

Year Published: 2022

Molecular hydrogen (H2) is potentially a novel therapeutic gas for acute post-coronavirus disease 2019 (COVID-19) patients because it has antioxidative, anti-inflammatory, anti-apoptosis, and antifatigue properties. The aim of this study was to determine the effect of 14 days of H2 inhalation on the respiratory and physical fitness status of acute post-COVID-19 patients. This randomized, ...
WHOLE BODY - SEPSIS

H2 Inhibits the Formation of Neutrophil Extracellular Traps

Year Published: 2022

Neutrophil extracellular traps (NETs) contribute to inflammatory pathogenesis in numerous conditions, including infectious and cardiovascular diseases, and have attracted attention as potential therapeutic targets. H2 acts as an antioxidant and has been clinically and experimentally proven to ameliorate inflammation. This study was performed to investigate whether H2 could inhibit NET formation ...
LIVER - IMMUNE REGULATION

Long-term and daily use of molecular hydrogen induces reprogramming of liver metabolism in rats by ...

Year Published: 2022

Molecular hydrogen (H2) has emerged as a new therapeutic option in several diseases and is widely adopted by healthy people. However, molecular data to support therapeutic functions attributed to the biological activities of H2 remain elusive. Here, using transcriptomic and metabolomic approaches coupled with biochemistry and micro-CT technics, we evaluated the effect of long-term (6 months) and ...
SKIN - SURGERY/TRANSPLANTATION

Hydrogen-generating Si-based agent protects against skin flap ischemia-reperfusion injury in rats

Year Published: 2022

Hydrogen is effective against ischemia-reperfusion (I/R) injury in skin flaps. However, the difficulty of continuously administering a sufficient amount of hydrogen using conventional methods has been an issue in the clinical application of hydrogen-based therapy. An Si-based agent administered orally was previously shown to continuously generate a large amount of hydrogen in the intestinal ...
WHOLE BODY - DIABETES

The improvement of insulin level after hydrogen-rich water therapy in streptozotocin-induced ...

Year Published: 2022

Background and aim: Water plays a pivotal role in the body. Alteration of the fluid balance promotes metabolic disorder, thus leading to the development of various diseases, such as diabetes mellitus (DM). Hydrogen-rich water (HW) is recognized as a novel antioxidant. This study aimed to investigate the role of HW on insulin, insulin receptor (IRs), and superoxide dismutase (SOD) levels in ...
HEART - CARDIAC HYPERTROPHY

Hydrogen Attenuates Thyroid Hormone-Induced Cardiac Hypertrophy in Rats by regulating angiotensin II ...

Year Published: 2022

Cardiac hypertrophy occurs as a result of high levels of thyroid hormone, which may contribute to heart failure and is closely related to oxidative stress. Hydrogen is a good antioxidant. In this study, we found that intragastric levothyroxine administration for two weeks caused obvious cardiac hypertrophy without reduced systolic function. Additionally, hydrogen inhalation ameliorated the ...
BRAIN - SEPSIS

PPARα contributes to the therapeutic effect of hydrogen gas against sepsis-associated ...

Year Published: 2022

Sepsis-associated encephalopathy (SAE), a fatal complication of sepsis, contributes to cognitive impairment, high morbidity, and mortality. The molecular mechanism of hydrogen (H2) administration, as a promising strategy for the treatment of SAE, is still unclear. Peroxisome proliferator-activated receptor α (PPARα) is essential for alleviating symptoms and complications of SAE. However, little ...
INTESTINE - SURGERY/TRANSPLANTATION

Protective Effects of Hydrogen-Rich Saline on Experimental Intestinal Volvulus in Rats

Year Published: 2022

Background: Intestinal volvulus can cause morbidity and mortality. Surgical reduction, on the other hand, could result in ischemia-reperfusion (I/R) injury. Hydrogen rich saline solution (HRSS neutralizes free radicals in the body. This study aimed to investigate the effects of HRSS in I/R injury in experimental intestinal volvulus in rats. Methods: Thirty rats were randomly allocated into 5 ...
BRAIN - CARDIAC ARREST

FDG-PET/CT Assessment of the Cerebral Protective Effects of Hydrogen in Rabbits with Cardiac Arrest

Year Published: 2022

Background: Anatomical imaging methods and histological examinations have limited clinical value for early monitoring of brain function damage after cardiac arrest (CA) in vivo. Objective: We aimed to assess the cerebral protective effects of hydrogen in rabbits with CA by using fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT). Methods: Male rabbits were divided ...
SKIN - WOUND HEALING

Local Treatment of Hydrogen-Rich Saline Promotes Wound Healing In Vivo by Inhibiting Oxidative ...

Year Published: 2022

Wound healing is a complex dynamic process involving a large number of biological events. Excessive oxidative stress is a key factor delaying wound healing. Hydrogen is an antioxidant, anti-inflammatory, and antiapoptotic medical gas with safety, effectiveness, and penetrability. However, the effects of local treatment of hydrogen on wound healing and its potential mechanisms remain unclear. In ...
HEART - DIABETES

Co-administration of hydrogen and metformin exerts cardioprotective effects by inhibiting pyroptosis ...

Year Published: 2022

Hydrogen is a novel medical gas with several properties, including anti-oxidative, anti-inflammatory, anti-apoptotic, anti-allergic, and energy metabolism stimulating properties. Hydrogen therapy has been proven effective in the treatment of myocardial ischemia, myocardial infarction, and ischemia-reperfusion injury. Diabetic cardiomyopathy (DCM) is a serious cardiovascular complication of ...
KIDNEY - ACUTE KIDNEY INJURY

Development of a novel porcine ischemia/reperfusion model inducing different ischemia times in ...

Year Published: 2022

Background: Acute kidney injury and its central pathology, renal ischemia reperfusion injury (IRI), have been studied in many animal models. Although renal IRI has been induced in pig models in many ways, simultaneous bilateral ischemia or unilateral ischemia along with contralateral nephrectomy models only provide data on the renal response to a single ischemia time. Moreover, it has been ...
WHOLE BODY - EXCERCISE

Short-Term Consumption of Hydrogen-Rich Water Enhances Power Performance and Heart Rate Recovery in ...

Year Published: 2022

(1) Background: Exercise that exceeds the body's accustomed load can lead to oxidative stress and increased fatigue during intense training or competition, resulting in decreased athletic performance and an increased risk of injury, and the new medicinal H2 may be beneficial as an antioxidant. Therefore, we explored the effect of short-term supplementation of hydrogen-rich water (HRW) on the work ...