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Studies Found: 54

WHOLE BODY - EXCERCISE

Effects of an H2-infused, Nitric Oxide-Producing Functional Beverage on Exercise and Cognitive ...

Year Published: 2021

Background. Exercise performance and recovery are impaired by excessive levels of oxidative stress and inflammation. However, both reactive oxygen species (ROS) and inflammation improve exercise performance including mitochondrial ATP production and force of muscle contraction. They also are essential mediators in providing the benefits and training adaptations that occur from exercise. Nitric ...
WHOLE BODY - HYDROGEN BIOLOGY

Safety of Prolonged Inhalation of Hydrogen Gas in Air in Healthy Adults

Year Published: 2021

Ischemia-reperfusion injury is common in critically ill patients, and directed therapies are lacking. Inhaled hydrogen gas diminishes ischemia-reperfusion injury in models of shock, stroke, and cardiac arrest. The purpose of this study was to investigate the safety of inhaled hydrogen gas at doses required for a clinical efficacy study. Design: Prospective, single-arm study. Setting: Tertiary care ...
BRAIN - TRAUMATIC BRAIN INJURY

An H2-infused, nitric oxide-producing functional beverage as a neuroprotective agent for TBIs and ...

Year Published: 2021

Traumatic brain injuries (TBIs) are a leading cause of death and disability. Sports-related TBIs are estimated to be more than several million per year. The pathophysiology of TBIs involves high levels of inflammation, oxidative stress, dysregulation of ion homeostasis, mitochondrial dysfunction, and apoptosis. There is also a reduction in cerebral blood flow, leading to hypoxia and reduced ...
BRAIN - STROKE

Longitudinal multiparametric MRI study of hydrogen-enriched water with minocycline combination ...

Year Published: 2020

Free radicals are downstream mediators of several cytotoxic cascades contributing to ischemic brain injury. Molecular hydrogen (H2) is an antioxidant potentially useful in the treatment of stroke. Hydrogen is easy to deliver, biologically non-toxic and diffuses freely through all biological structures including the blood-brain barrier and cellular membranes. This study evaluated the efficacy of ...
WHOLE BODY - METABOLIC SYNDROME

The Effects of 24-Week, High-Concentration Hydrogen-Rich Water on Body Composition, Blood Lipid ...

Year Published: 2020

Purpose: Metabolic syndrome is associated with several medical risk factors including dyslipidemia, hyperglycemia, and obesity, which has become a worldwide pandemic. The sequelae of this condition increase the risk of cardiovascular and neurological disease and increased mortality. Its pathophysiology is associated with redox dysregulation, excessive inflammation, and perturbation of cellular ...
SKIN - WOUND HEALING

Hydrogen generating patch improves skin cell viability, migration activity, and collagen expression

Year Published: 2020

Molecular hydrogen recently attracted lots of attention in biomedical community because of its abilities to modulate signal transduction, protein phosphorylation, and gene expression that enable its anti-inflammatory, anti-allergy, and anti-apoptotic activities. However, controllable and local delivery of hydrogen molecules to tissues still remains challenging. Here, we propose a new method of ...
BRAIN - BRAIN INJURY

Hydrogen gas therapy improves survival rate and neurological deficits in subarachnoid hemorrhage ...

Year Published: 2019

The high morbidity, high mortality, and significant shortage of effective therapies for subarachnoid hemorrhage (SAH) have created an urgency to discover novel therapies. Human studies in Asia have established the safety of hydrogen gas in the treatment of hepatic, renal, pulmonary, and cardiac diseases. Mechanistically, hydrogen gas has been shown to affect oxidative stress, inflammation, and ...
BRAIN - SURGERY/TRANSPLANTATION

Perioperatively Inhaled Hydrogen Gas Diminishes Neurologic Injury Following Experimental Circulatory ...

Year Published: 2019

Highlights • Inhaled hydrogen gas has been shown to temper the sequelae of ischemic insults. Its application in cardiopulmonary bypass has not been investigated. • Neonatal swine were cannulated to cardiopulmonary bypass and exposed to prolonged circulatory arrest (75 min at 25°C). Swine were randomized to treatment with or without inhaled 2.4% hydrogen gas mixtures for 24 h during and ...
WHOLE BODY - HYDROGEN BIOLOGY

Safety of inhaled hydrogen gas in healthy mice

Year Published: 2019

The purpose of this work was to determine the safety of inhaled hydrogen gas in healthy animals. Female mice were exposed to medical air with or without hydrogen gas (concentration 2.4%) for 72 hours (n = 25 mice/group). Mice underwent a standardized and validated neurobehavioral examination, SmithKline Beecham, Harwell, Imperial College, Royal London Hospital, Phenotype Assessment (SHIRPA) ...
BRAIN - CARDIOPULMONARY RESUSCITATION (CPR)

Inhalation of high-concentration hydrogen gas attenuates cognitive deficits in a rat model of ...

Year Published: 2019

Cognitive deficits are a devastating neurological outcome seen in survivors of cardiac arrest. We previously reported water electrolysis derived 67% hydrogen gas inhalation has some beneficial effects on short-term outcomes in a rat model of global brain hypoxia-ischemia induced by asphyxia cardiac arrest. In the present study, we further investigated its protective effects in long-term spatial ...
WHOLE BODY - AGING

Supplementation with hydrogen-producing composition confers beneficial effects on physiology and ...

Year Published: 2019

Recently, molecular hydrogen (H 2 )has become known as a new class of antioxidants and redox-modulating interventions. Effects of H 2 have been documented for many acute and chronic pathological conditions. The present study was aimed at determining the effect of hydrogen on the physiology and longevity of Drosophila. The flies were given a patented food supplement consisting of a mixture of inert ...
WHOLE BODY - EXCERCISE

Acute Supplementation with Molecular Hydrogen Benefits Submaximal Exercise Indices. Randomized, ...

Year Published: 2019

Background: Clinical studies have reported hydrogen-rich water (HRW) to have therapeutic and ergogenic effects. The aim of this study was to determine the effect of acute supplementation with HRW on exercise performance as measured by VO2, respiratory exchange ratio (RER), heart rate (HR), and respiratory rate (RR). Methods: Baseline levels of all exercise indices were determined in nineteen (4 ...
BRAIN - CARDIOPULMONARY RESUSCITATION (CPR)

Inhalation of high concentration hydrogen gas improves short-term outcomes in a rat model of ...

Year Published: 2018

Cardiogenic global brain hypoxia-ischemia is a devastating medical problem that is associated with unfavorable neurologic outcomes. Low dose hydrogen gas (up to 2.9%) has been shown to be neuroprotective in a variety of brain diseases. In the present study, we investigated the protective effect of water by electrolysis-derived high concentration hydrogen gas (60%) in a rat model of asphyxia ...
BONE - SURGERY/TRANSPLANTATION

In vivo quantification of hydrogen gas concentration in bone marrow surrounding magnesium fracture ...

Year Published: 2018

Statement of significance: An electrochemical H2 sensor was used to monitor the degradation of a Mg fracture fixation system in a lapine ulna fracture model. Interestingly, the H2 concentration in the bone marrow is 82% higher than H2 saturated water solution. This suggests H2 generated in situ is trapped in the bone marrow and bone is less permeable than the surrounding tissues. The detectable H2 ...
BRAIN - NEUROPROTECTION

Hydrogenized Water Effects on Protection of Brain Cells from Oxidative Stress and Glutamate Toxicity

Year Published: 2018

Hydrogenized water is known to have protective effects on cells and tissues, mainly through its antioxidant activities. Here we examined the protective effects of a commercial source of hydrogenized water on cultured human brain cells. Hydrogenized water was able to protect brain cells from oxidative stress and glutamate toxicity. At H 2 concentrations above 0.01 mM the glutathione levels ...
LUNG - SEPSIS

Protection by Inhaled Hydrogen Therapy in a Rat Model of Acute Lung Injury Can be Tracked in vivo ...

Year Published: 2017

Inhaled hydrogen gas (H2) provides protection in rat models of human acute lung injury (ALI). We previously reported that biomarker imaging can detect oxidative stress and endothelial cell death in vivo in a rat model of ALI. Our objective was to evaluate the ability of Tc-hexamethylpropyleneamineoxime (HMPAO) and Tc-duramycin to track the effectiveness of H2 therapy in vivo in the hyperoxia rat ...
STOMACH - GASTROENTERITIS

Efficacy of Neutral Electrolyzed Water for Inactivation of Human Norovirus

Year Published: 2017

Human norovirus (NoV) is the leading cause of acute gastroenteritis worldwide. Persistence on surfaces and resistance to many conventional disinfectants contribute to widespread transmission of norovirus. We examined the efficacy of neutral electrolyzed water (NEW; pH 7) for inactivation of human NoV GII.4 Sydney in suspension (ASTM method 1052-11) and on stainless steel surfaces (ASTM method ...
WHOLE BODY - AGING

Effects of Hydrogenized Water on Intracellular Biomarkers for Antioxidants, Glucose Uptake, Insulin ...

Year Published: 2016

Hydrogen has been shown in several clinical trials to be completely safe without adverse events and there are no warnings in the literature of its toxicity or adverse effects during long-term exposure. Molecular hydrogen has proven useful and convenient as a novel antioxidant and modifier of gene expression in many conditions where oxidative stress and changes in gene expression result in cellular ...
BLOOD - EXCERCISE

Effect of electrolyzed high-pH alkaline water on blood viscosity in healthy adults

Year Published: 2016

Background: Previous research has shown fluid replacement beverages ingested after exercise can affect hydration biomarkers. No specific hydration marker is universally accepted as an ideal rehydration parameter following strenuous exercise. Currently, changes in body mass are used as a parameter during post-exercise hydration. Additional parameters are needed to fully appreciate and better ...
BRAIN - TRAUMATIC BRAIN INJURY

Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic ...

Year Published: 2014

Traumatic brain injury (TBI) in its various forms has emerged as a major problem for modern society. Acute TBI can transform into a chronic condition and be a risk factor for neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, probably through induction of oxidative stress and neuroinflammation. Here, we examined the ability of the antioxidant molecular hydrogen given in ...
SKIN - CANCER

Hydration During Breast Radiotherapy May Lower Skin Toxicity

Year Published: 2014

No abstract available
LUNG - SURGERY/TRANSPLANTATION

Hydrogen Preconditioning During Ex Vivo Lung Perfusion Improves the Quality of Lung Grafts in Rats

Year Published: 2014

Background: Although the benefits of ex vivo lung perfusion (EVLP) have been globally advocated, the potentially deleterious effects of applying EVLP, in particular activation of proinflammatory cascades and alteration of metabolic profiles, are rarely discussed. This study examined proinflammatory events and metabolic profiles in lung grafts on EVLP and tested whether preconditioning lung grafts ...
LUNG - SURGERY/TRANSPLANTATION

Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway

Year Published: 2013

Hyperoxic lung injury is a major concern in critically ill patients who receive high concentrations of oxygen to treat lung diseases. Successful abrogation of hyperoxic lung injury would have a huge impact on respiratory and critical care medicine. Hydrogen can be administered as a therapeutic medical gas. We recently demonstrated that inhaled hydrogen reduced transplant-induced lung injury and ...
BRAIN - STROKE

Hydrogen Inhalation Ameliorated Mast Cell–Mediated Brain Injury After Intracerebral Hemorrhage in ...

Year Published: 2013

Objective: Hydrogen inhalation was neuroprotective in several brain injury models. Its mechanisms are believed to be related to antioxidative stress. We investigated the potential neurovascular protective effect of hydrogen inhalation especially effect on mast cell activation in a mouse model of intracerebral hemorrhage. Design: Controlled in vivo laboratory study. Setting: Animal research ...
HEART - SURGERY/TRANSPLANTATION

A novel method of preserving cardiac grafts using a hydrogen-rich water bath

Year Published: 2013

Background: Exogenously administered hydrogen exerts cytoprotective effects through anti-oxidant, anti-inflammatory, and anti-apoptotic mechanisms in various disease settings, including organ transplantation. Our objective in this study was to evaluate the efficacy of a novel cold storage device equipped with a hydrogen-rich water bath. Methods: The study used an established rat heterotopic ...