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Studies Found: 54

WHOLE BODY - SURGERY/TRANSPLANTATION

Fast escape of hydrogen from gas cavities around corroding magnesium implants

Year Published: 2013

Magnesium materials are of increasing interest in the development of biodegradable implants as they exhibit properties that make them promising candidates. However, the formation of gas cavities after implantation of magnesium alloys has been widely reported in the literature. The composition of the gas and the concentration of its components in these cavities are not known as only a few studies ...
HEART - SURGERY/TRANSPLANTATION

Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated ...

Year Published: 2012

Recent evidence suggests that molecular hydrogen has therapeutic value for disease states that involve inflammation. We hypothesized that drinking hydrogen-rich water (HW) daily would protect cardiac and aortic allograft recipients from inflammation-associated deterioration. Heterotopic heart transplantation with short-course tacrolimus immunosuppression and orthotopic aortic transplantation were ...
HEART - SURGERY/TRANSPLANTATION

Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein grafts in rats

Year Published: 2012

Aims: Arterialized vein grafts often fail due to intimal hyperplasia. Hydrogen potently protects organs and cells from many insults via its anti-inflammatory and antioxidant properties. We investigated the efficacy of oral administration of hydrogen-rich water (HW) for prevention of intimal hyperplasia. Methods and results: The inferior vena cava was excised, stored in cold Ringer solution for 2 ...
LUNG - SURGERY/TRANSPLANTATION

Profiling molecular changes induced by hydrogen treatment of lung allografts prior to procurement

Year Published: 2012

We previously demonstrated that donor treatment with inhaled hydrogen protects lung grafts from cold ischemia/reperfusion (I/R) injury during lung transplantation. To elucidate the mechanisms underlying hydrogen's protective effects, we conducted a gene array analysis to identify changes in gene expression associated with hydrogen treatment. Donor rats were exposed to mechanical ventilation with ...
INTESTINE - SURGERY/TRANSPLANTATION

Hydrogen-Enriched Preservation Protects the Isogeneic Intestinal Graft and Amends Recipient Gastric ...

Year Published: 2011

Inhaled hydrogen gas exerts antioxidant and anti-inflammatory effects in rat intestinal transplantation. Here, we investigated whether ex vivo donor organ treatment with dissolved hydrogen would prevent intestinal graft injury. Isogeneic intestinal transplantation was performed in Lewis rats with vascular flush, luminal preservation, and cold graft storage in nitrogen-bubbled (SITxN2) or ...
BRAIN - STROKE

Hydrogen Gas Reduced Acute Hyperglycemia-Enhanced Hemorrhagic Transformation In A Focal Ischemia Rat ...

Year Published: 2011

Hyperglycemia is one of the major factors for hemorrhagic transformation after ischemic stroke. In this study, we tested the effect of hydrogen gas on hemorrhagic transformation in a rat focal cerebral ischemia model. Sprague-Dawley rats (n=72) were divided into the following groups: sham; sham treated with hydrogen gas (H(2)); Middle Cerebral Artery Occlusion (MCAO); and MCAO treated with H(2) ...
BRAIN - SURGERY/TRANSPLANTATION

Hydrogen is neuroprotective against surgically induced brain injury

Year Published: 2011

Neurosurgical operations cause unavoidable damage to healthy brain tissues. Direct surgical injury as well as surgically induced oxidative stress contributes to the subsequent formation of brain edema. Therefore, we tested the neuroprotective effects of hydrogen (H2) in an established surgical brain injury (SBI) model in rats. Adult male Sprague - Dawley rats (weight 300-350g) were divided into ...
LUNG - SURGERY/TRANSPLANTATION

Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism ...

Year Published: 2011

We recently demonstrated the inhalation of hydrogen gas, a novel medical therapeutic gas, ameliorates ventilator-induced lung injury (VILI); however, the molecular mechanisms by which hydrogen ameliorates VILI remain unclear. Therefore, we investigated whether inhaled hydrogen gas modulates the nuclear factor-kappa B (NFκB) signaling pathway. VILI was generated in male C57BL6 mice by performing a ...
LUNG - SURGERY/TRANSPLANTATION

The effect of donor treatment with hydrogen on lung allograft function in rats

Year Published: 2011

Because inhaled hydrogen provides potent anti-inflammatory and antiapoptotic effects against acute lung injury, we hypothesized that treatment of organ donors with inhaled hydrogen during mechanical ventilation would decrease graft injury after lung transplantation. Orthotopic left lung transplants were performed using a fully allogeneic Lewis to Brown Norway rat model. The donors were exposed to ...
BRAIN - BRAIN INJURY

Protective Effect of Hydrogen Gas Therapy After Germinal Matrix Hemorrhage in Neonatal Rats

Year Published: 2011

Germinal matrix hemorrhage (GMH) is a neurological disease of very low birth weight premature infants leading to post-hemorrhagic hydrocephalus, cerebral palsy, and mental retardation. Hydrogen (H2) is a potent antioxidant shown to selectively reverse cytotoxic oxygen-radical injury in the brain. This study investigated the therapeutic effect of hydrogen gas after neonatal GMH injury. Neonatal ...
BRAIN - STROKE

Hydrogen Inhalation is Neuroprotective and Improves Functional Outcomes in Mice After Intracerebral ...

Year Published: 2011

Oxidative stress contributes significantly to the development of secondary brain injury after intracerebral hemorrhage (ICH). It has been previously demonstrated that hydrogen gas can decrease oxidative stress by scavenging reactive oxygen species. We hypothesized that hydrogen therapy will reduce brain oxidative stress in mice after ICH and thereby will lead to reduced brain edema and improved ...
LUNG - SURGERY/TRANSPLANTATION

Abstract B95: Hydrogen Gas Inhalation Attenuates Ventilator-Induced Lung Injury In Mice

Year Published: 2010

No abstract available
KIDNEY - SURGERY/TRANSPLANTATION

Oral hydrogen water prevents chronic allograft nephropathy in rats

Year Published: 2010

Reactive oxygen species (ROS) contribute to the development of interstitial fibrosis and tubular atrophy seen in chronic allograft nephropathy (CAN). As molecular hydrogen gas can act as a scavenger of ROS, we tested the effect of treatment with hydrogen water (HW) in a model of kidney transplantation, in which allografts from Lewis rats were orthotopically transplanted into Brown Norway ...
LUNG - SURGERY/TRANSPLANTATION

Hydrogen inhalation ameliorates ventilator-induced lung injury

Year Published: 2010

Mechanical ventilation (MV) can provoke oxidative stress and an inflammatory response, and subsequently cause ventilator-induced lung injury (VILI), a major cause of mortality and morbidity of patients in the intensive care unit. Inhaled hydrogen can act as an antioxidant and may be useful as a novel therapeutic gas. We hypothesized that, owing to its antioxidant and anti-inflammatory properties, ...
LUNG - SURGERY/TRANSPLANTATION

Inhaled Hydrogen Gas Therapy for Prevention of Lung Transplant-Induced Ischemia/Reperfusion Injury ...

Year Published: 2010

Successful abrogation of ischemia/reperfusion (I/R) injury of lung grafts could significantly improve short- and long-term outcomes for lung transplant (LTx) recipients. Hydrogen gas has potent antioxidant and antiapoptotic properties and has been recently used in number of experimental and clinical studies. The purpose of this research was to investigate whether inhaled hydrogen gas could reduce ...
BONE MARROW - SURGERY/TRANSPLANTATION

Hydrogen gas treatment prolongs replicative lifespan of bone marrow multipotential stromal cells in ...

Year Published: 2010

Cell therapy with bone marrow multipotential stromal cells/mesenchymal stem cells (MSCs) represents a promising approach in the field of regenerative medicine. Low frequency of MSCs in adult bone marrow necessitates ex vivo expansion of MSCs after harvest; however, such a manipulation causes cellular senescence with loss of differentiation, proliferative, and therapeutic potentials of MSCs. ...
HEART - SURGERY/TRANSPLANTATION

Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon ...

Year Published: 2010

Recent advances in novel medical gases, including hydrogen and carbon monoxide (CO), have demonstrated significant opportunities for therapeutic use. This study was designed to evaluate the effects of inhaled hydrogen or CO, or both, on cold ischemia/reperfusion (I/R) injury of the myocardium. Syngeneic heterotopic heart transplantation was performed in rats after 6 or 18 hours of cold ischemia in ...
WHOLE BODY - METABOLIC SYNDROME

Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic ...

Year Published: 2010

Metabolic syndrome is characterized by cardiometabolic risk factors that include obesity, insulin resistance, hypertension and dyslipidemia. Oxidative stress is known to play a major role in the pathogenesis of metabolic syndrome. The objective of this study was to examine the effectiveness of hydrogen rich water (1.5-2 L/day) in an open label, 8-week study on 20 subjects with potential metabolic ...
INTESTINE - INFLAMMATORY BOWEL DISEASE (IBD)

Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate

Year Published: 2009

By its antioxidant effect, molecular hydrogen gas (H2) was reported to protect organs from tissue damage induced by ischemia reperfusion. To evaluate its anti-inflammatory effects, we established a mouse model of human inflammatory bowel disease (IBD) by supplying mice with water containing (1) dextran sodium sulfate (DSS) (5%), (2) DSS (5%) and H2, or (3) H2 only ad libitum up to 7 days. At ...
LIVER - HEPATITIS, AUTOIMMUNE

Hydrogen from intestinal bacteria is protective for Concanavalin A-induced hepatitis

Year Published: 2009

It is well known that some intestinal bacteria, such as Escherichia coli, can produce a remarkable amount of molecular hydrogen (H(2)). Although the antioxidant effects of H(2) are well documented, the present study examined whether H(2) released from intestinally colonized bacteria could affect Concanavalin A (ConA)-induced mouse hepatitis. Systemic antibiotics significantly decreased the level ...
BRAIN - BRAIN INJURY

Hydrogen gas is ineffective in moderate and severe neonatal hypoxia-ischemia rat models

Year Published: 2009

Hydrogen gas (H(2)) has been shown to ameliorate brain injury in experimental adult rat focal ischemia and in a mild neonatal hypoxia-ischemia (HI, 90 min hypoxia) rat model. In this study we tested H(2) in moderate (120 min hypoxia) and severe (150 min hypoxia) neonatal HI rat models. We hypothesized that H(2) would improve outcomes after neonatal HI by scavenging free radicals. Two hundred (200) ...
INTESTINE - SURGERY/TRANSPLANTATION

Hydrogen Inhalation Ameliorates Oxidative Stress in Transplantation Induced Intestinal Graft Injury

Year Published: 2008

Ischemia/reperfusion (I/R) injury during small intestinal transplantation (SITx) frequently causes complications including dysmotility, inflammation and organ failure. Recent evidence indicates hydrogen inhalation eliminates toxic hydroxyl radicals. Syngeneic, orthotopic SITx was performed in Lewis rats with 3 h of cold ischemic time. Both donor and recipient received perioperative air or 2% ...
SKIN - COSMETIC ISSUES

The Efficacy and Tolerability of Electrolyzed Oxidized Water in Treating Mild to Moderate Acne

Year Published: 2004

The purpose of this study was to determine the efficacy and the tolerability of the Charme™ system, a hand-held device that electrolyzes a water-based sodium chloride solution and delivers electrolyzed oxidized water (EOW) to the skin, in the treatment of mild to moderate acne. A total of 31 patients with mild to moderate acne vulgaris were enrolled in this 8-week, open-label, split-face pilot ...
WHOLE BODY - AGING

Effect of electrolyzed water intake on lifespan of autoimmune disease prone mice

Year Published: 1998

Recent studies on electrolyzed water indicate that anode or acidic water is most effective as disinfectants; whereas, reduced or alkaline water processed through cathode is used as safe drinking water. The present drinking water study was undertaken in two strains of autoimmune disease prone mice to establish the spontaneous disease process and longevity. Weanling MRL/lpr and NZBxNZW [B/W] F1 ...
WHOLE BODY - DIVING

Decompression comparison of helium and hydrogen in rats

Year Published: 1997

The hypothesis that there are differences in decompression risk between He and H2 was examined in 1,607 unanesthetized male albino rats subjected to dives on 2% O2-balance He or 2% O2-balance H2 (depths < or = 50 ATA, bottom times < or = 60 min). The animals were decompressed to 10.8 ATA with profiles varying from rapid to slow, with up to four decompression stops of up to 60 min each. Maximum ...