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Studies Found: 1104

EYE - DRY EYE

Randomized, crossover clinical efficacy trial in humans and mice on tear secretion promotion and ...

Year Published: 2021

The incidence of dry eye disease is increasing worldwide because of the aging population and increasing use of information technology. Dry eye disease manifests as tear-layer instability and inflammation caused by osmotic hypersensitization in tear fluids; however, to our knowledge, no agent that treats both pathologies simultaneously is available. Molecular hydrogen (H2) is known to be effective ...
BRAIN - BRAIN INJURY

Hydrogen gas post-conditioning attenuates early neuronal pyroptosis in a rat model of subarachnoid ...

Year Published: 2021

Neuronal pyroptosis serves an important role in the progress of neurologic dysfunction following subarachnoid hemorrhage (SAH), which is predominantly caused by a ruptured aneurysm. Hydrogen gas has been previously reported to be an effective anti-inflammatory agent against ischemia-associated diseases by regulating mitochondrial function. The objective of the present study was to investigate the ...
PANCREAS - PANCREATITIS

Pre-inhalation of hydrogen-rich gases protect against caerulein-induced mouse acute pancreatitis ...

Year Published: 2021

Background: Acute pancreatitis (AP) lacks targeted prevention and treatment measures. Some key points in the pathogenesis of AP remain unclear, such as early activation of pancreatic enzymes. Several recent reports have shown the protective effect of hydrogen on several AP animal models, and the mechanism is related to antioxidant activity. Heat shock protein 60 (Hsp60) is known to accompany ...
EAR - HEARING LOSS

Inhalation of Molecular Hydrogen, a Rescue Treatment for Noise-Induced Hearing Loss

Year Published: 2021

Noise exposure is the most important external factor causing acquired hearing loss in humans, and it is strongly associated with the production of reactive oxygen species (ROS) in the cochlea. Several studies reported that the administration of various compounds with antioxidant effects can treat oxidative stress-induced hearing loss. However, traditional systemic drug administration to the human ...
LUNG - LUNG INJURY

Hydrogen Attenuates Endotoxin-Induced Lung Injury by Activating Thioredoxin 1 and Decreasing Tissue ...

Year Published: 2021

Endotoxin-induced lung injury is one of the major causes of death induced by endotoxemia, however, few effective therapeutic options exist. Hydrogen inhalation has recently been shown to be an effective treatment for inflammatory lung injury, but the underlying mechanism is unknown. In the current study we aim to investigate how hydrogen attenuates endotoxin-induced lung injury and provide ...
BRAIN - ADDICTION

Hydrogen enriched saline alleviates morphine tolerance via inhibiting neuroinflammation, GLT-1, GS ...

Year Published: 2021

The development and maintenance of morphine tolerance showed association with neuroinflammation and dysfunction of central glutamatergic system (such as nitration of glutamate transporter). Recent evidence indicated that hydrogen could reduce the levels of neuroinflammation and oxidative stress, but its role in morphine tolerance has not been studied. The rats were intrathecally administered with ...
LIVER - NON-ALCOHOLIC STEATOHEPATITIS (NASH)

Hydrogen-rich water protects liver injury in nonalcoholic steatohepatitis though HO-1 enhancement ...

Year Published: 2021

Nonalcoholic steatohepatitis (NASH) could progress to hepatic fibrosis when absence of effective control. The purpose of our experiment was to investigate the protective effect of drinking water with high concentration of hydrogen in our study named hydrogen rich water (HRW) on mice with non-alcoholic fatty liver disease to elucidate the mechanism underlying the molecular hydrogen therapeutic ...
WHOLE BODY - CANCER

Drinking Hydrogen-Rich Water Alleviates Chemotherapy-Induced Neuropathic Pain Through the Regulation ...

Year Published: 2021

Introduction: Chemotherapy-induced neuropathic pain (CINP) is one of the most common complications of chemotherapeutic drugs which limits the dose and duration of potentially life-saving anticancer treatment and compromises the quality of life of patients. Our previous studies have reported that molecular hydrogen (H2) can be used to prevent and treat various diseases. But the underlying mechanism ...
BONE - OSTEOARTHRITIS (OA)

Hydrogen (H 2) Alleviates Osteoarthritis by Inhibiting Apoptosis and Inflammation via the JNK ...

Year Published: 2021

Background: Osteoarthritis (OA) is a very common condition and leads to joint pain, disability, and price tag all over the world. Pathogenesis of OA is closely related to numerous inflammatory and apoptosis cytokines. Hydrogen (H2) reportedly exhibits a diversity of effects such as anti-apoptotic, anti-inflammatory, and anti-oxidative properties via the JNK pathway. However, it is unknown whether ...
HEART - METABOLIC SYNDROME

Drinking Molecular Hydrogen Water Is Beneficial to Cardiovascular Function in Diet-Induced Obesity ...

Year Published: 2021

Molecular hydrogen (MH) reportedly exerts therapeutic effects against inflammatory diseases as a suppressor of free radical chain reactions. Here, the cardiovascular protective effects of the intake of molecular hydrogen water (MHW) were investigated using high-fat diet-induced obesity (DIO) mice. MHW was prepared using supplier sticks and degassed water as control. MHW intake for 2 weeks did not ...
WHOLE BODY - SEPSIS

Hydrogen Gas Therapy Attenuates Inflammatory Pathway Signaling in Septic Mice

Year Published: 2021

Background: Molecular hydrogen (H2) has been used in clinical cases. However, there are few studies of H2 therapy to treat sepsis, and anti-inflammatory mechanisms of H2 are mostly unknown. We aimed to confirm effects of H2 therapy on sepsis and reveal its therapeutic mechanism via RNA sequencing in multiple organs in septic mice. Methods: Nine-week-old C57BL/6 male mice underwent cecal ligation ...
HEART - SURGERY/TRANSPLANTATION

Hydrogen gas inhalation alleviates myocardial ischemia-reperfusion injury by the inhibition of ...

Year Published: 2021

Aims: Reperfusion therapy is the most common and effective treatment against ischemic heart disease (IHD), but the process inflicts massive ischemia/reperfusion (I/R) injury for which no treatment exists. Notably, reperfusion after ischemia causes ischemia/reperfusion injury (IR injury) and the 'no-reflow' phenomenon seriously affecting the therapeutic effects in clinical practice. The principle ...
KIDNEY - SURGERY/TRANSPLANTATION

Prevention of Chronic Rejection of Marginal Kidney Graft by Using a Hydrogen Gas-Containing ...

Year Published: 2021

In clinical kidney transplantation, the marginal kidney donors are known to develop chronic allograft rejection more frequently than living kidney donors. In our previous study, we have reported that the hydrogen gas-containing organ preservation solution prevented the development of acute injuries in the kidney of the donor after cardiac death by using preclinical miniature pig model. In the ...
KIDNEY - CHRONIC KIDNEY DISEASE

Hydrogen-rich water reduced oxidative stress and renal fibrosis in rats with unilateral ureteral ...

Year Published: 2021

Background: Congenital obstructive nephropathy (CKD) is commonly implicated in the pathophysiology of chronic kidney disease occurring in the pediatric and adolescent age groups and the release of reactive oxygen species contribute to the worsening of renal fibrosis. Molecular hydrogen (H2) protects against tissue injury by reducing oxidative stress. We evaluated the efficacy of oral H2-rich water ...
KIDNEY - KIDNEY FAILURE

THE USE OF MOLECULAR HYDROGEN IN CORRECTION OF NO-REFLOW SYNDROME IN THE POLYURIC STAGE OF SUBLIMATE ...

Year Published: 2021

Objective - to find out the possibility of using molecular hydrogen in the correction of no-reflow syndrome in the polyuric stage of acute kidney injury 72 hours after the administration of mercuric chloride in rats on a hyposodium diet. The experiments were performed on 60 male white non-linear sexually mature rats weighing 0.16-0.18 kg to study the effect of water loading with saturation with ...
BRAIN - PARKINSON'S DISEASE

Randomized double-blind placebo-controlled trial of hydrogen inhalation for Parkinson's disease: a ...

Year Published: 2021

Background: Oxidative stress is involved in the progression of Parkinson's disease (PD). Recent studies have confirmed that molecular hydrogen (H2) functions as a highly effective antioxidant in animal models of PD. A placebo-controlled, randomized, double-blind, parallel-group clinical pilot study was conducted to assess the efficacy of hydrogen gas inhalation in Japanese patients with PD on ...
PERITONIUM - SEPSIS

Peritoneal lavage with hydrogen-rich saline can be an effective and practical procedure for acute ...

Year Published: 2021

Purpose: Acute peritonitis has remained a fatal disease despite of recent advances in care and treatment, including antibiotic and anticoagulant treatments. The cause of death is mostly sepsis-induced multiple organ failure. Oxidative stress can play an important role in this situation, but antioxidant therapy to capture any excessive reactive oxygen species has not yet been fully established. ...
WHOLE BODY - ENVIRONMENTAL POLLUTION

Hydrogen-Rich Medium Regulates Cr(VI)-Induced ER Stress and Autophagy Signaling in DF-1 Cells

Year Published: 2021

Related studies have shown that chromium (Cr) is toxic to cells, and hydrogen can protect cells by regulating endoplasmic reticulum (ER) stress and autophagy. However, there are few reports on the protective effects of hydrogen on heavy metal-induced cell damage. The objective of this study was to investigate the protection of hydrogen-rich medium (HRM) on Cr(VI)-induced ER stress and autophagy in ...
WHOLE BODY - CANCER

Combined treatment with dissolved hydrogen molecule and platinum nanocolloid exerts ...

Year Published: 2021

Many studies have shown that redox regulation is an effective therapeutic strategy for different types of cancer. We have previously demonstrated that combined treatment with dissolved hydrogen molecule (H2) and platinum nanocolloid (Pt-nc) has carcinostatic effects and that increased intracellular reactive oxygen species (ROS) levels were closely associated with carcinostatic effects in Ehrlich ...
WHOLE BODY - CANCER

A PdMo bimetallene with precise wavelength adjustment and catalysis for synergistic photothermal ...

Year Published: 2021

By delivering the idea of green and safe hydrogen energy and novel photothermal therapy to the biomedical field, engineering of therapeutic nanomaterials for treatment of major diseases (such as cancer) holds great significance. In this work, a novel PdMo bimetallene was synthesized by a solvothermal reduction method, and it was explored and applied in the field of anti-tumor therapy for the first ...
HEART - ATHEROSCLEROSIS

Effects of hydrogen as adjuvant treatment for unstable angina

Year Published: 2021

Oxidative stress and inflammation are closely related to atherosclerotic cardiovascular disease. It is established that hydrogen has significant protective effects on many diseases as a potential antioxidative and anti-inflammatory agent. The purpose of this study is to evaluate the effect of hydrogen on unstable angina in vitro and in vivo. An atherosclerosis model in vitro was constructed by ...
INTESTINE - INFLAMMATORY BOWEL DISEASE (IBD)

Molecular hydrogen is comparable to sulfasalazine as a treatment for DSS-induced colitis in mice

Year Published: 2021

Colitis is an inflammatory condition of the bowels associated with abdominal pain, diarrhea, fatigue, and fever. Its etiology is multifactorial but related to the overproduction of inflammatory and oxidative mediators. There is currently no cure for this disease, and drugs used to manage it often have deleterious side effects. H2 is recognized as having anti-inflammatory and antioxidant effects, ...
MOUTH - CANCER

Acid-electrolyzed functional water-induces Interleukin-1α release from Intracellular Storage Sites ...

Year Published: 2021

The aim of this study was to examine the acid-electrolyzed functional water (FW)-mediated cytokine release in an oral squamous cell carcinoma-derived cell line (OSCC) following treatment with FW. FW is generated by the electrolysis of a sodium chloride solution and accelerate the burn wound healing. To elucidate the underlying mechanisms, the cytokine/chemokine secretion profile of HSC3 cells was ...
WHOLE BODY - ROS-SCAVENGING

Packaging with hydrogen gas modified atmosphere can extend chicken egg storage

Year Published: 2021

Background: Although hydrogen gas (H2 ) has been widely used in industry and gradually used in medicine, it is less applied to agriculture, especially in modified atmosphere packing (MAP). Results: During chicken egg storage, H2 MAP not only slowed down or delayed the reduction in antioxidant capacities, but also alleviated the deterioration of egg quality. The extent of micro-cracks in the ...
BRAIN - STROKE

Intravenous Hydrogen Therapy With Intracisternal Magnesium Sulfate Infusion in Severe Aneurysmal ...

Year Published: 2021

Background and purpose: Poor-grade subarachnoid hemorrhage still has a poor prognosis. This randomized controlled clinical trial evaluated intracisternal magnesium sulfate infusion combined with intravenous hydrogen therapy in patients with poor-grade subarachnoid hemorrhage. Methods: Thirty-seven patients with poor-grade subarachnoid hemorrhage were randomized to Mg+H2, Mg, and control groups. Mg ...