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Studies Found: 1335

LIVER - SURGERY/TRANSPLANTATION

Protective effect of intraportal infusion of hypothermic hydrogen-rich saline solution on hepatic ...

Year Published: 2017

The aim of the present study was to investigate the effects of intraportal administration of hypothermic hydrogen-rich saline solution (HRSS) on hepatic ischemia/reperfusion (I/R) injury. Thirty rats were divided equally into six groups; 1) sham, no I/R or transfusion, 2) I/R injury (60 minutes ischemia + 120 minutes reperfusion, 3) I/R injury + normal saline 24°C, 4) I/R injury + normal saline ...
HEART - HEART ATTACK

Hydrogen Gas Attenuates Myocardial Ischemia Reperfusion Injury Independent of Postconditioning in ...

Year Published: 2017

Background/aims: To study the effect of inhaling hydrogen gas on myocardial ischemic/reperfusion(I/R) injury in rats. Methods: Seventy male Wistar albino rats were divided into five groups at random as the sham group (Sham). The I/R group (I/R), The ischemic postconditioning group (IPo), The I/R plus hydrogen group (IH2) and the ischemic postconditioning plus hydrogen group (IPoH2). The Sham group ...

Hydrogen-rich saline attenuates spinal cord hemisection-induced testicular injury in rats

Year Published: 2017

To study how hydrogen-rich saline (HS) promotes the recovery of testicular biological function in a hemi-sectioned spinal cord injury (hSCI) rat model, a right hemisection was performed at the T11-T12 of the spinal cord in Wistar rats. Animals were divided into four groups: normal group; vehicle group: sham-operated rats administered saline; hSCI group: subjected to hSCI and administered saline; ...
BRAIN - STRESS RESILIENCE

Molecular hydrogen increases resilience to stress in mice

Year Published: 2017

The inability to successfully adapt to stress produces pathological changes that can lead to depression. Molecular hydrogen has anti-oxidative and anti-inflammatory activities and neuroprotective effects. However, the potential role of molecular hydrogen in stress-related disorders is still poorly understood. The present study aims to investigate the effects of hydrogen gas on resilience to stress ...
BRAIN - CARDIOPULMONARY RESUSCITATION (CPR)

Hydrogen-rich saline attenuates hippocampus endoplasmic reticulum stress after cardiac arrest in ...

Year Published: 2017

Background: Hydrogen-rich saline can selectively scavenge reactive oxygen species (ROS) and protect brain against ischemia reperfusion (I/R) injury. Endoplasmic reticulum stress (ERS) has been implicated in the pathological process of cerebral ischemia. However, very little is known about the role of hydrogen-rich saline in mediating pathophysiological reactions to ERS after I/R injury caused by ...

Protective Effects of Hydrogen-Rich Saline Against Lipopolysaccharide-Induced Alveolar ...

Year Published: 2017

Background Fibrotic change is one of the important reasons for the poor prognosis of patients with acute respiratory distress syndrome (ARDS). The present study investigated the effects of hydrogen-rich saline, a selective hydroxyl radical scavenger, on lipopolysaccharide (LPS)-induced pulmonary fibrosis. Material/Methods Male ICR mice were divided randomly into 5 groups: Control, LPS-treated plus ...
EAR - CANCER

Hydrogen Inhalation Protects against Ototoxicity Induced by Intravenous Cisplatin in the Guinea Pig

Year Published: 2017

Introduction: Permanent hearing loss and tinnitus as side-effects from treatment with the anticancer drug cisplatin is a clinical problem. Ototoxicity may be reduced by co-administration of an otoprotective agent, but the results in humans have so far been modest. Aim: The present preclinical in vivo study aimed to explore the protective efficacy of hydrogen (H2) inhalation on ototoxicity induced ...
HEART - HEART ATTACK

High-concentration hydrogen protects mouse heart against ischemia/reperfusion injury through ...

Year Published: 2017

The study investigated the role of Akt1 through the cardioprotection of high-concentration hydrogen (HCH). C57BL/6 mice were randomly divided into the following groups: sham, I/R, I/R + HCH, I/R + HCH + LY294002 (PI3K inhibitor), I/R + HCH + wortmannin (PI3K inhibitor), I/R + LY294002, and I/R + wortmannin. After 45 min of ischemia, HCH (67% H2 and 33% O2) was administered to mice during a 90-min ...
LIVER - SHOCK

Hyperoxygenated hydrogen-rich solution suppresses shock- and resuscitation-induced liver injury

Year Published: 2017

Background: It is not known whether simultaneous delivery of hydrogen and oxygen can reduce injury caused by hemorrhagic shock and resuscitation (HSR). This study investigated the therapeutic potential of hyperoxygenated hydrogen-rich solution (HHOS), a combined hydrogen/oxygen carrier, in a rat model of HSR-induced liver injury. Materials and methods: Rats (n = 60) were randomly divided into 5 ...
LIVER - SURGERY/TRANSPLANTATION

Hydrogen protects against liver injury during CO2 pneumoperitoneum in rats

Year Published: 2017

The aim of the current study was to identify the protective effect of hydrogen gas against liver injury during CO2 pneumoperitoneum. Rats were randomly divided into three groups: control group (C group), pneumoperitoneum group (P15 group) and hydrogen group (H2 group). Rats in the C group were subjected to anesthesia for 90 min. Rats in the P15 group received an abdominal insufflation of CO2 for ...

Molecular mechanisms underlying the protective effects of hydrogen-saturated saline on noise-induced ...

Year Published: 2017

Objectives: This study aimed to explore the molecular mechanism of the protective effects of hydrogen-saturated saline on NIHL. Methods: Guinea pigs were divided into three groups: hydrogen-saturated saline; normal saline; and control. For saline administration, the guinea pigs were given daily abdominal injections 3 d before and 1 h before noise exposure. ABR were tested to examine cochlear ...
PANCREAS - PANCREATITIS

Hydrogen Treatment Protects Mice Against Chronic Pancreatitis by Restoring Regulatory T Cells Loss

Year Published: 2017

Background/aims: Chronic pancreatitis is an inflammatory disease of the pancreas characterized by progressive tissue destruction and fibrogenesis. The development of chronic pancreatitis is associated with immune cell dysregulation. Currently, the specific and effective treatment of chronic pancreatitis remains absent. Methods: By using an L-arginine induced chronic pancreatitis mouse model, we ...

Hydrogen-Rich Saline Alleviates Kidney Fibrosis Following AKI and Retains Klotho Expression

Year Published: 2017

Purpose: Acute kidney injury (AKI) is a prominent risk factor for the development of chronic kidney disease (CKD). To date, the related mechanism and effective therapy have not been rigorously explored. The present study aims to investigate the reno-protection of hydrogen-rich saline (HRS) against ischemia/reperfusion (IR)-induced AKI. Methods: Adult male C57 mice were randomly allocated into ...
BRAIN - SURGERY/TRANSPLANTATION

Hydrogen-Rich Saline Attenuates Brain Injury Induced by Cardiopulmonary Bypass and Inhibits ...

Year Published: 2017

Background/aims: Cardiopulmonary bypass (CPB) is prone to inducing brain injury during open heart surgery. A hydrogen-rich solution (HRS) can prevent oxidation and apoptosis, and inhibit inflammation. This study investigated effects of HRS on brain injury induced by CPB and regulatory mechanisms of the PI3K/Akt/GSK3β signaling pathway. Methods: A rat CPB model and an in vitro cell hypoxia model ...

Retracted: Molecular Hydrogen Effectively Heals Alkali-Injured Cornea via Suppression of Oxidative ...

Year Published: 2017

The aim of this study was to examine the effect of molecular hydrogen (H2) on the healing of alkali-injured cornea. The effects of the solution of H2 in phosphate buffered saline (PBS) or PBS alone topically applied on the alkali-injured rabbit cornea with 0.25 M NaOH were investigated using immunohistochemical and biochemical methods. Central corneal thickness taken as an index of corneal ...
EYE - RADIOPROTECTION

Retracted: Therapeutic effect of molecular hydrogen in corneal UVB-induced oxidative stress and ...

Year Published: 2017

The aim of this study is to examine whether molecular hydrogen (H2) is able to reduce oxidative stress after corneal damage induced by UVB irradiation. We previously found that UVB irradiation of the cornea caused the imbalance between the antioxidant and prooxidant enzymes in the corneal epithelium, followed by the imbalance between metalloproteinases and their physiological inhibitors ...
BRAIN - CARDIOPULMONARY RESUSCITATION (CPR)

Hydrogen Inhalation is Superior to Mild Hypothermia for Improving Neurological Outcome and Survival ...

Year Published: 2017

Background: Postcardiac arrest syndrome is the consequence of whole-body ischemia-reperfusion events that lead to multiple organ failure and eventually to death. Recent animal studies demonstrated that inhalation of hydrogen greatly mitigates postresuscitation myocardial dysfunction and brain injury. However, the influence of underlying heart disease on the efficacy of hydrogen is still unknown. ...
WHOLE BODY - EXCERCISE

Potential Therapeutic and Preventive Effect of Drinking Hydrogen-rich Water on Acute Fatigue

Year Published: 2017

Acute fatigue is a condition defined as a sudden onset of physical and mental exhaustion particularly after a short but strenuous period of physical exercise due to effect of waste product of muscle contraction within muscle fiber and accumulation of metabolites within the muscle fiber. Until recently, it's believed that lactic acid build-up and reactive oxygen species (ROS) resulting oxidative ...
LUNG - SEPSIS

Protection by Inhaled Hydrogen Therapy in a Rat Model of Acute Lung Injury Can be Tracked in vivo ...

Year Published: 2017

Inhaled hydrogen gas (H2) provides protection in rat models of human acute lung injury (ALI). We previously reported that biomarker imaging can detect oxidative stress and endothelial cell death in vivo in a rat model of ALI. Our objective was to evaluate the ability of Tc-hexamethylpropyleneamineoxime (HMPAO) and Tc-duramycin to track the effectiveness of H2 therapy in vivo in the hyperoxia rat ...
SKIN - PSORIASIS

Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis en plaques

Year Published: 2018

Psoriasis and parapsoriasis en plaques are chronic inflammatory skin diseases, both representing therapeutic challenge in daily practice and adversely affecting the quality of life. Reactive oxygen species (ROS) has been evidenced to be involved in the pathogenesis of the chronic inflammatory diseases. We now report that hydrogen water, an effective ROS scavenger, has significant and rapid ...
LUNG - SURGERY/TRANSPLANTATION

Hydrogen-Rich Saline Attenuates Acute Lung Injury Induced by Limb Ischemia/Reperfusion via ...

Year Published: 2018

Limb ischemia/reperfusion (LI/R) injury is associated with high morbidity and mortality. The hypothesis of this study is that hydrogen-rich solution could attenuateacute lung injury and improve mortality via chemerin and NLRP3 after LI/R in rats. A rat model of LI/R was performed by clamping the bilateral femoral arteries for 3 h followed by reperfusion. HRS was administered intraperitoneally (10 ...

Protective effects of hydrogen-rich medium on lipopolysaccharides-induced injury in human ...

Year Published: 2018

Objective: In this study, lipopolysaccharides (LPS) was used to damage human periodontal ligament cells (hPDLCs) and consequently investigate the protective effects of hydrogen on reducing oxidative stress and cell apoptosis rate. Methods: hPDLCs were isolated, and then cultured with normal medium+1 μg·mL⁻¹ LPS or with hydrogen-rich medium+ 1 μg·mL⁻¹ LPS. Cell proliferation activity was ...

Breathing Hydrogen-Oxygen Mixture Decreases Inspiratory Effort in Patients with Tracheal Stenosis

Year Published: 2018

Background: Hydrogen-oxygen mixture (H2-O2) may reduce airway resistance in patients with acute severe tracheal stenosis, yet data supporting the clinical use of H2-O2 are insufficient. Objectives: To evaluate the efficacy and safety of breathing H2-O2 in acute severe tracheal stenosis. Methods: Thirty-five consecutive patients with severe acute tracheal stenosis were recruited in this prospective ...
BONE MARROW - AGING

Hydrogen alleviates cellular senescence via regulation of ROS/p53/p21 pathway in bone marrow-derived ...

Year Published: 2018

Senescence has become a hot point issue in recent decades and requires urgent attention. As a novel and effective antioxidant, hydrogen has been proved to alleviate cellular senescence in endothelial cells in vitro. However, the effects and mechanisms of hydrogen on senescence in vivo are still unclear. In the present study, 12-month-old Sprague Dawley (SD) rats were intraperitoneal administration ...
INTESTINE - FOOD POISONING

Intestinal Microbiota Ecological Response to Oral Administrations of Hydrogen-Rich Water and ...

Year Published: 2018

The objective of the current experiment was to explore the intestinal microbiota ecological response to oral administrations of hydrogen-rich water (HRW) and lactulose (LAC) in female piglets fed a Fusarium mycotoxin-contaminated diet. A total of 24 individually-housed female piglets (Landrace × large × white; initial average body weight, 7.25 ± 1.02 kg) were randomly assigned to ...