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Studies Found: 1138

KIDNEY - CANCER

Molecular hydrogen alleviates nephrotoxicity induced by anti-cancer drug cisplatin without ...

Year Published: 2009

Cisplatin is a widely used anti-cancer drug in the treatment of a wide range of tumors; however, its application is limited by nephrotoxicity, which is affected by oxidative stress. We have reported that molecular hydrogen (H(2)) acts as an efficient antioxidant (Ohsawa et al. in Nat Med 13:688-694, 2007). Here we show that hydrogen efficiently mitigates the side effects of cisplatin by reducing ...
KIDNEY - HAEMODIALYSIS

Biological Effects of Electrolyzed Water in Hemodialysis

Year Published: 2009

Background: Chronic inflammation in haemodialysis (HD) patients indicates a poor prognosis. However, therapeutic approaches are limited. Hydrogen gas (H(2)) ameliorates oxidative and inflammatory injuries to organs in animal models. We developed an HD system using a dialysis solution with high levels of dissolved H(2) and examined the clinical effects. Methods: Dialysis solution with H(2) (average ...
WHOLE BODY - ALCOHOLIC HANGOVER

Electrolyzed-reduced water inhibits acute ethanol-induced hangovers in Sprague-Dawley rats

Year Published: 2009

Ethanol consumption disturbs the balance between the pro- and anti-oxidant systems of the organism, leading to oxidative stress. Electrolyzed-reduced water (ERW) is widely used by people in East Asia for drinking purposes because of its therapeutic properties including scavenging effect of reactive oxygen species. This study was performed to investigate the effect of ERW on acute ethanol-induced ...
MOUTH - CANCER

Platinum nanocolloid-supplemented hydrogen-dissolved water inhibits growth of human tongue carcinoma ...

Year Published: 2009

Hydrogen-dissolved water (HD-water) or platinum nanocolloid (Pt-nc) has been individually expected as a new therapeutic agent for oxidative stress-related diseases, whereas little is known about their combined effects on cancer, which were elucidated in the present study. HD-water was prepared by microporous gas bubbling, and supplemented with Pt-nc consisting of 0.003-1 ppm Pt and PVP polymers. ...
HEART - HEART ATTACK (MYOCARDIAL INFARCTION)

Hydrogen-rich saline protects myocardium against ischemia/reperfusion injury in rats

Year Published: 2009

Protective effect of hydrogen (H(2)) gas on cardiac ischemia-reperfusion (I/R) injury has been demonstrated previously. This study was designed to test the hypothesis that hydrogen-rich saline (saline saturated with molecular hydrogen), which is easy to use, induces cardioprotection against ischemia (30 min) and reperfusion (24 h) injury in rats. Adult male Sprague-Dawley rats underwent 30-min ...
BLOOD - CANCER

Enhanced induction of mitochondrial damage and apoptosis in human leukemia HL-60 cells due to ...

Year Published: 2009

Electrolzyed-reduced water (ERW) is a higher pH and lower oxidation-reduction potential water. In the present study, we examined the enhanced effect of ERW in the apoptosis of leukemia cells (HL-60) induced by glutathione (GSH). An enhanced inhibitory effect on the viability of the HL-60 cells was observed after treatment with a combination of ERW with various concentrations of GSH, whereas no ...
LIVER - LIVER DISEASE

Hepatoprotective effect of electrolyzed reduced water against carbon tetrachloride-induced liver ...

Year Published: 2009

The study investigated the protective effect of electrolyzed reduced water (ERW) against carbon tetrachloride (CCl(4))-induced liver damage. Male ICR mice were randomly divided into control, CCl(4), CCl(4)+silymarin, and CCl(4)+ERW groups. CCl(4)-induced liver lesions include leukocytes infiltration, hepatocyte necrosis, ballooning degeneration, mitosis, calcification, fibrosis and an increase of ...
INTESTINE - INTESTINAL INJURY

Hydrogen-rich saline protects against intestinal ischemia/reperfusion injury in rats

Year Published: 2009

Hydrogen gas was reported to reduce reactive oxygen species and alleviate cerebral, myocardial and hepatic ischemia/reperfusion (I/R) injuries. This paper studied the effect of hydrogen-rich saline, which was easier for clinical application, on the intestinal I/R injury. Model of intestinal I/R injury was induced in male Sprague-Dawley rats. Physiological saline, hydrogen-rich saline or ...
INTESTINE - SURGERY/TRANSPLANTATION

Hydrogen Inhalation Ameliorates Oxidative Stress in Transplantation Induced Intestinal Graft Injury

Year Published: 2008

Ischemia/reperfusion (I/R) injury during small intestinal transplantation (SITx) frequently causes complications including dysmotility, inflammation and organ failure. Recent evidence indicates hydrogen inhalation eliminates toxic hydroxyl radicals. Syngeneic, orthotopic SITx was performed in Lewis rats with 3 h of cold ischemic time. Both donor and recipient received perioperative air or 2% ...
BRAIN - BRAIN INJURY

Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model

Year Published: 2008

Hypoxia-ischemia (HI) brain injury is a major cause of neuronal cell death especially apoptosis in the perinatal period. This study was designated to examine the effect of hydrogen therapy on apoptosis in an established neonatal HI rat pup model. Seven-day-old rat pups were subjected to left common carotid artery ligation and then 90 min hypoxia (8% oxygen at 37 C). Immediately after HI insult, ...
BRAIN - BRAIN INJURY

Neuroprotective Effects of Hydrogen Saline in Neonatal Hypoxia-ischemia Rat Model

Year Published: 2008

Cerebral hypoxia-ischemia (HI) represents a major cause of brain damage in the term newborn. This study aimed to examine the short and long-term neuroprotective effect of hydrogen saline (H(2) saline) using an established neonatal HI rat pup model. Seven-day-old rat pups were subjected to left common carotid artery ligation and then 90 min hypoxia (8% oxygen at 37 degrees C). H(2) saturated saline ...
WHOLE BODY - DIABETES (TYPE II)

“Nordenau Phenomenon” – Application of Natural Reduced Water to Therapy

Year Published: 2008

This prospective observation study examines changes in the relevant tests parameters of 411 diabetes patients drinking natural reduced water from the “Nordenau Spring”, as well as a correlation of these changes with the fluctuation of the reactive oxygen species in their blood. The average age of the test persons is 71.5 years and the daily consumption of reduced water is as much as two ...
HEART - HEART ATTACK (MYOCARDIAL INFARCTION)

Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion ...

Year Published: 2008

Inhalation of hydrogen (H(2)) gas has been demonstrated to limit the infarct volume of brain and liver by reducing ischemia-reperfusion injury in rodents. When translated into clinical practice, this therapy must be most frequently applied in the treatment of patients with acute myocardial infarction, since angioplastic recanalization of infarct-related occluded coronary artery is routinely ...
BLOOD - HYDROGEN BIOLOGY

The Effects of Electrolyzed Reduced Water on Blood and Organ Tissues of Mice

Year Published: 2008

The main purpose of this study is to investigate the effects of electrolyzed reduced water (ERW) on blood components and electrolytes, as well as elected tissues on mice. The mice were supplied either tap water (control group) and ERW (experimental group) for two months. There were no significant different between two groups anatomically and physiologically. In the blood electrolyte study, the ...
WHOLE BODY - DIABETES (TYPE II)

Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 ...

Year Published: 2008

Oxidative stress is recognized widely as being associated with various disorders including diabetes, hypertension, and atherosclerosis. It is well established that hydrogen has a reducing action. We therefore investigated the effects of hydrogen-rich water intake on lipid and glucose metabolism in patients with either type 2 diabetes mellitus (T2DM) or impaired glucose tolerance (IGT). We ...
INTESTINE - PARASITE INFECTION

Effects of Electrolyzed Alkaline Reduced Water on Echinostoma hortense Infection and Immune Response ...

Year Published: 2008

To examine the effect of the electrolyzed alkaline reduced water (ERW) on animal immunity, by employing Echinostoma hortense that is a parasite in the small intestine, the immune response of C57BL/6 was examined. To C57BL/6 mice, Echinostoma hortense metacercaria 15 per animal was in oculate dorsally, the worm was collected after 2 weeks, and the change of goblet cells and mast cells in the mucosa ...
HEART - ATHEROSCLEROSIS

Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice

Year Published: 2008

Oxidative stress is implicated in atherogenesis; however most clinical trials with dietary antioxidants failed to show marked success in preventing atherosclerotic diseases. We have found that hydrogen (dihydrogen; H(2)) acts as an effective antioxidant to reduce oxidative stress [I. Ohsawa, M. Ishikawa, K. Takahashi, M. Watanabe, K. Nishimaki, K. Yamagata, K. Katsura, Y. Katayama, S, Asoh, S. ...
MOUTH - CANCER

Neutral pH Hydrogen-Enriched Electrolyzed Water Achieves Tumor-Preferential Clonal Growth Inhibition ...

Year Published: 2008

The properties and effects of neutral pH hydrogen-enriched electrolyzed water (NHE water) on tumor cells were examined. NHE water diminished hydroxyl radicals as demonstrated by ESR in a cell-free system. Human tongue carcinoma cells HSC-4 were inhibited for either colony formation efficiencies or colony sizes by NHE water without significant inhibition to normal human tongue epithelial-like cells ...
BRAIN - ROS-SCAVENGING

Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted ...

Year Published: 2008

Hydrogen is an established anti-oxidant that prevents acute oxidative stress. To clarify the mechanism of hydrogen's effect in the brain, we administered hydrogen-rich pure water (H(2)) to senescence marker protein-30 (SMP30)/gluconolactonase (GNL) knockout (KO) mice, which cannot synthesize vitamin C (VC), also a well-known anti-oxidant. These KO mice were divided into three groups; recipients of ...
WHOLE BODY - CANCER

Inhibitory effect of electrolyzed reduced water on tumor angiogenesis

Year Published: 2008

Vascular endothelial growth factor (VEGF) is a key mediator of tumor angiogenesis. Tumor cells are exposed to higher oxidative stress compared to normal cells. Numerous reports have demonstrated that the intracellular redox (oxidation/reduction) state is closely associated with the pattern of VEGF expression. Electrolyzed reduced water (ERW) produced near the cathode during the electrolysis of ...
LIVER - SURGERY/TRANSPLANTATION

Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing ...

Year Published: 2007

We have recently showed that molecular hydrogen has great potential for selectively reducing cytotoxic reactive oxygen species, such as hydroxyl radicals, and that inhalation of hydrogen gas decreases cerebral infarction volume by reducing oxidative stress [I. Ohsawa, M. Ishikawa, K. Takahashi, M. Watanabe, K. Nishimaki, K. Yamagata, K.-I. Katsura, Y. Katayama, S. Asoh, S. Ohta, Hydrogen acts as a ...
PANCREAS - DIABETES (TYPE II)

Preservative effect of electrolyzed reduced water on pancreatic beta-cell mass in diabetic db/db ...

Year Published: 2007

Oxidative stress is produced under diabetic conditions and involved in progression of pancreatic beta-cell dysfunction. Both an increase in reactive oxygen free radical species (ROS) and a decrease in the antioxidant defense mechanism lead to the increase in oxidative stress in diabetes. Electrolyzed reduced water (ERW) with ROS scavenging ability may have a potential effect on diabetic animals, a ...
KIDNEY - HAEMODIALYSIS

Less-oxidative hemodialysis solution rendered by cathode-side application of electrolyzed water

Year Published: 2007

Electrolyzed water (EW) generated on the cathode side reportedly displays anti-oxidative properties, and application of EW to hemodialysis (HD) systems supposedly suppresses oxidative markers in patients on HD. However, most of the chemical properties and biological effects of such solutions remain unclear. This study aimed to examine those issues to clarify the scientific background for the ...
WHOLE BODY - ROS-SCAVENGING

Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals

Year Published: 2007

Acute oxidative stress induced by ischemia-reperfusion or inflammation causes serious damage to tissues, and persistent oxidative stress is accepted as one of the causes of many common diseases including cancer. We show here that hydrogen (H(2)) has potential as an antioxidant in preventive and therapeutic applications. We induced acute oxidative stress in cultured cells by three independent ...
WHOLE BODY - DIABETES (TYPE II)

Redox Regulation by Reduced Waters as Active Hydrogen Donors and Intracellular ROS Scavengers for ...

Year Published: 2007

The analysis using the DBNBS reduction method and the DCFH-DA intracellular reactive oxygen species (ROS) determination method revealed that ERW and diseases-improvable natural waters such as Nordenau water in Germany and Hita water in Japan were all reduced waters (RWs) which could function as active hydrogen donors and intracellular ROS scavengers. RWs suppressed the activity of protein tyrosine ...