search - Hydrogen Studies

Molecular hydrogen attenuates gefitinib-induced exacerbation of naphthalene-evoked acute lung injury ...

Year Published: 2019

Although inhibition of epidermal growth factor receptor (EGFR)-mediated cell signaling by the EGFR tyrosine kinase inhibitor gefitinib is highly effective against advanced non-small cell lung cancer, this drug might promote severe acute interstitial pneumonia. We previously reported that molecular hydrogen (H2) acts as a therapeutic and preventive anti-oxidant. Here, we show that treatment with H2 ...

MOUTH - DENTURE CARE

Efficacy of newly developed denture cleaning device on physical properties of denture material and ...

Year Published: 2019

Background/purpose: Electrolyzed water has antimicrobial activity against oral microbes. The purpose of this study was to investigate the effects of a denture cleaning device that uses electrolyzed water on Candida biofilm on denture base-material and the physical properties of the denture material. Materials and methods: Denture base-resin disks were prepared with Polymethyl methacrylate. After ...

HEART - SEPSIS

H2 Protects Against Lipopolysaccharide-Induced Cardiac Dysfunction via Blocking TLR4-Mediated ...

Year Published: 2019

Background and Purpose: Septic cardiomyopathy, which is one of the features of multi-organ dysfunction in sepsis, is characterized by ventricular dilatation, reduced ventricular contractility, and reduction in ejection fraction and, if severe, can lead to death. To date, there is no specific therapy that exists, and its treatment represents a large unmet clinical need. Herein, we investigated the ...

BRAIN - ENVIRONMENTAL POLLUTION

Hydrogen gas protects against delayed encephalopathy after acute carbon monoxide poisoning in a rat ...

Year Published: 2019

Objective: The protective effects of 2%-4% hydrogen gas in delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) have been previously reported. This study aimed to assess the neuroprotective effects of high concentration hydrogen (HCH) on DEACMP. Methods: A total of 36 male Sprague-Dawley rats were divided into 3 groups. In the DEACMP group, rats were exposed to CO to induce CO ...

WHOLE BODY - SEPSIS

Molecular hydrogen potentiates hypothermia and prevents hypotension and fever in LPS-induced ...

Year Published: 2019

Molecular hydrogen (H2) exerts anti-oxidative, anti-apoptotic, and anti-inflammatory effects. Here we tested the hypothesis that H2 modulates cardiovascular, inflammatory, and thermoregulatory changes in systemic inflammation (SI) induced by lipopolysaccharide (LPS) at different doses (0.1 or 1.5 mg/kg, intravenously, to induce mild or severe SI) in male Wistar rats (250-300 g). LPS or saline was ...

INTESTINE - EXCERCISE

Effects of the long-term consumption of hydrogen-rich water on the antioxidant activity and the gut ...

Year Published: 2019

Expending a considerable amount of physical energy inevitably leads to fatigue during both training and competition in football. An increasing number of experimental findings have confirmed the relationship between the generation and clearance of free radicals, fatigue, and exercise injury. Recently, hydrogen was identified as a new selective antioxidant with potential beneficial applications in ...

WHOLE BODY - CANCER

A green, efficient and precise hydrogen therapy of cancer based on in-vivo electrochemistry

Year Published: 2019

By combined use of traditional Chinese acupuncture Fe needle electrode and in-vivo electrochemistry, we achieve in-vivo H2 generation in tumors in a controllable manner and exploited it for effective and green therapy of tumor for the first time. The cathodic acupuncture electrodes working under the applied voltage of ~ 3 volt (with minimal damage to the living body) undergo effectively ...

LUNG - SURGERY/TRANSPLANTATION

Protective effects of a hydrogen-rich solution during cold ischemia in rat lung transplantation

Year Published: 2019

Background: Molecular hydrogen can reduce the oxidative stress of ischemia-reperfusion injury in various organs for transplantation and potentially improve survival rates in recipients. This study aimed to evaluate the protective effects of a hydrogen-rich preservation solution against ischemia-reperfusion injury after cold ischemia in rat lung transplantation. Methods: Lewis rats were divided ...

LUNG - ASTHMA

The combination of alkaline water provision and asthma-induced gymnastics towards peak expiratory ...

Year Published: 2019

Background: Asthma is an abnormality in the form of chronic airway inflammation which can be reduced by providing asthma-induced gymnastics and healthy lifestyle such as consuming alkaline water.Aims: The objective of this study is to examine a combination of alkaline water provision and asthma-induced gymnastics towards peak expiratory flow rate of asthma patients at Surakarta Lung Clinic, ...

EAR - HEARING LOSS

An LCMS-based untargeted metabolomics protocol for cochlear perilymph: highlighting metabolic ...

Year Published: 2019

Introduction Noise-induced hearing loss (NIHL) is an increasing problem in society and accounts for a third of all cases of acquired hearing loss. NIHL is caused by formation of reactive oxygen species (ROS) in the cochlea causing oxidative stress. Hydrogen gas (H2) can alleviate the damage caused by oxidative stress and can be easily administered through inhalation. Objectives To present a ...

MOUTH - FUNGAL INFECTION

Antifungal effects of hydrogen water on the growth of Candida albicans

Year Published: 2019

Objectives: This study assessed the antifungal effects of neutral electrolysis hydrogen water, an agent known for its oral anti-bacterial effects on the growth of C. albicans in vitro. Methods: Hydrogen water, denture cleansing agent, and Listerine® were compared to a tap water control. We serially cultured C. albicans KCTC 27239 in SD media to analyze the inhibitory effect of each treatment on ...

BONE - SURGERY/TRANSPLANTATION

Bone regeneration is enhanced by the combined use of acid‐electrolyzed functional water with ...

Year Published: 2019

Hydroxyapatite/collagen (HAP/Col) composite has a nanostructure and composition similar to that of natural bone. Herein, we have evaluated the beneficial effects of acid‐electrolyzed functional water (FW) in combination with HAP/Col composite as an irrigation material in a rat calvarium defect model. The rats were divided into four groups: control, PBS irrigation; FW, FW irrigation; HAP/Col, ...

LUNG - SHOCK

Hydrogen gas inhalation ameliorates lung injury after hemorrhagic shock and resuscitation

Year Published: 2019

Background: Hemorrhagic shock and resuscitation (HSR) is known to cause inflammatory reactions in the lung parenchyma and acute lung injury, increasing the risk of complications that can lead to death. Hydrogen gas has shown to inhibit the formation and eliminate reactive oxygen species (ROS), which are known to cause reperfusion injury. Hence, the purpose of this study was to investigate the ...

WHOLE BODY - SURGERY/TRANSPLANTATION

Slightly acidic electrolyzed water disrupts biofilms and effectively disinfects Pseudomonas ...

Year Published: 2019

Introduction: Biofilm formation is an important issue in the healthcare industry, but conventional disinfectants are not effective for biofilms formed in the hospital environment and on medical instruments. In this study, aim at determine the effectiveness of slightly acidic electrolyzed water (SAEW) on biofilm removal and the disinfection of biofilm-forming Pseudomonas aeruginosa. Methods: Mucoid ...

WHOLE BODY - STROKE

Hydrogen-rich saline protects rat from oxygen glucose deprivation and reperusion-induced apoptosis ...

Year Published: 2019

Background: Hydrogen is received as an inert gas that thought to be non-functional in vivo previously. Recently, emerging evidences showed that in ischemia/reperfusion (IR) condition, hydrogen reduced cellular reactive oxygen species (ROS) production and ameliorated cell apoptosis. However, the underlying mechanism of hydrogen on IR-induced apoptosis remains elusive. Here we tried to unravel the ...

LUNG - SHOCK

Hyperoxygenated Hydrogen-Rich Solution Suppresses Lung Injury Induced by Hemorrhagic Shock in Rats

Year Published: 2019

Background: Hemorrhagic shock could induce acute lung injury (ALI), which is associated with cell hypoxia, lung tissue inflammation, free radical damage, and excessive cell apoptosis. Our previous studies demonstrated that hyperoxygenated solution could alleviate cell hypoxia. Furthermore, hydrogen-rich solution (HS) could relieve lung tissue inflammation, free radical damage and excessive cell ...

WHOLE BODY - EXCERCISE

Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, ...

Year Published: 2019

Acute physical exercise increases reactive oxygen species in skeletal muscle, leading to tissue damage and fatigue. Molecular hydrogen (H2) acts as a therapeutic antioxidant directly or indirectly by inducing antioxidative enzymes. Here, we examined the effects of drinking H2 water (H2-infused water) on psychometric fatigue and endurance capacity in a randomized, double-blind, placebo-controlled ...

BRAIN - NEUROPROTECTION

Protective effect of hydrogen-rich water on oxidative stress cell model and the impact of the ...

Year Published: 2019

Objective: To explore the protective effect of hydrogen-rich water on the oxidative stress injury of astrocytes in mice and its effect on phosphatidylinositol 3 kinase/protein kinase B (PI3K/Akt) signal pathway. Methods: In vitro, mice astrocytes were cultured and the logarithmic growth period cells were taken for experiment. (1) Experiment one: some cells were acted by 1.25, 2.50, 5.00, 10.00 ...

LIVER - SURGERY/TRANSPLANTATION

Inhalation of molecular hydrogen prevents ischemia-reperfusion liver damage during major liver ...

Year Published: 2019

Background: Liver resection is a surgical procedure associated with a high risk of hepatic failure that can be fatal. One of the key mechanisms involves ischemia-reperfusion damage. Building on the well-known positive effects of hydrogen at mitigating this damage, the goal of this work was to demonstrate the antioxidant, anti-inflammatory, and anti-apoptotic effects of inhaled hydrogen in domestic ...

EYE - RETINAL INJURY

Protective effects of hydrogen gas in a rat model of branch retinal vein occlusion via decreasing ...

Year Published: 2019

Background: Oxidative stress (OS) is an essential factor in the pathogenesis of branch retinal vein occlusion (BRVO). Studies have demonstrated the role of hydrogen gas in the regulation of OS. This study was designed to evaluate the efficacy of hydrogen gas on the BRVO rat model. Methods: Twenty-four BRVO rats were randomly divided into two groups: the hydrogen gas (H) group (42% H2, 21% O2, 37% ...

HEART - HEART ATTACK

Attenuation of Cardiac Ischaemia-reperfusion Injury by Treatment with Hydrogen-rich Water

Year Published: 2019

Background: Hydrogen has been shown to exert a bioactive effect on the myocardium. This study examined the signalling pathways for hydrogen attenuating ischaemia-reperfusion injury. Methods: In total, 20 male Wistar rats were evaluated for the effects of hydrogen-rich water on ischaemia-reperfusion in hearts. Left ventricular tissue was taken for screening and analysis of active protein factors by ...

BRAIN - CANCER

Molecular hydrogen suppresses glioblastoma growth via inducing the glioma stem-like cell ...

Year Published: 2019

Background: Glioblastoma (GBM) is the most common type of primary malignant brain tumor. Molecular hydrogen has been considered a preventive and therapeutic medical gas in many diseases including cancer. In our study, we sought to assess the potential role of molecular hydrogen on GBM. Methods: The in vivo studies were performed using a rat orthotopic glioma model and a mouse subcutaneous ...

BRAIN - CANCER

Effect of Hydrogen-Rich Water on Radiation-Induced Cognitive Dysfunction in Rats

Year Published: 2019

The goal of this work was to determine whether hydrogen-rich water (HRW) could attenuate radiation-induced cognitive dysfunction in rats and to explore the underlying mechanisms. Rats received 30 Gy whole-brain irradiation using a 6-MeV electron beam. Either purified water or HRW (0.8-0.9 ppm) was administrated at 10 min prior to irradiation, as well as a daily HRW treatment after irradiation for ...

HEART - HEART ATTACK

Effect of hydrogen-rich water on the Nrf2/ARE signaling pathway in rats with myocardial ...

Year Published: 2019

The effects of hydrogen-rich water on oxidative stress via the Nrf2/ARE signaling pathway were studied in rats with myocardial ischemia-reperfusion injury (MIRI). Sixty rats were randomly divided into a hydrogen-rich water group and a control group, with 30 rats in each group. The two groups were randomly divided into three groups: pre-ischemic period, ischemic period and reperfusion period. After ...

HEART - HEART ATTACK

Protein chip and bioinformatic analyses of differentially expressed proteins involved in the effect ...

Year Published: 2019

Background: The differentially expressed proteins (DEPs) involved in the effect of hydrogen-rich water on myocardial ischemia reperfusion injury (MIRI) and their biological processes and signaling pathway were analyzed. Methods: 20 Wistar rats were randomly and equally divided into a control and a hydrogen-rich group. Hearts were removed and fixed in a Langendorff device. The control group was ...