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Studies Found: 1183

WHOLE BODY - HYDROGEN BIOLOGY

Response of Escherichia coli to hydrogen nanobubbles: an in vitro evaluation using synchrotron ...

Year Published: 2021

Hydrogen (H2)-rich water, an apparent source of molecular H2, is an emerging functional drink with many purported benefits for human health (Yang et al., 2020; Ostojic, 2021). The preventive and therapeutic effects of H2 on various pathological processes have been intensively investigated in numerous clinical trials; it is commonly believed that the beneficial effects are mainly attributed to its ...
LIVER - LIVER INJURY

A Preliminary Study on the Effect of Hydrogen Gas on Alleviating Early CCl 4-Induced Chronic Liver ...

Year Published: 2021

As a small-molecule reductant substance, hydrogen gas has an obvious antioxidant function. It can selectively neutralize hydroxyl radicals (•OH) and peroxynitrite (ONOO•) in cells, reducing oxidative stress damage. The purpose of this study was to investigate the effect of hydrogen gas (3%) on early chronic liver injury (CLI) induced by CCl4 and to preliminarily explore the protective ...
BRAIN - ENVIRONMENTAL POLLUTION

Therapeutic Effects of Hydrogen Gas Inhalation on Trimethyltin-Induced Neurotoxicity and Cognitive ...

Year Published: 2021

Oxidative stress (OS) is one of the causative factors in the pathogenesis of various neurodegenerative diseases, including Alzheimer's disease (AD) and cognitive dysfunction. In the present study, we investigated the effects of hydrogen (H2) gas inhalation in trimethyltin (TMT)-induced neurotoxicity and cognitive dysfunction in the C57BL/6 mice. First, mice were divided into the following groups: ...
BRAIN - BRAIN INJURY

Hydrogen Attenuated Inflammation Response and Oxidative in Hypoxic Ischemic Encephalopathy via Nrf2 ...

Year Published: 2021

Hypoxia and ischemia cause neonatal encephalopathy and brain injury and can further result in cerebral palsy, cognitive impairment, growth restriction, and epilepsy. Induction of neuroprotection is a crucial therapeutic strategy for the treatment of perinatal hypoxic-ischaemic encephalopathy (HIE). Hydrogen has neuroprotective effects against brain-related diseases. Inflammation and oxidative ...
WHOLE BODY - DIABETES (TYPE II)

Electrolyzed hydrogen-rich water for oxidative stress suppression and improvement of insulin ...

Year Published: 2021

Introduction: Electrolyzed hydrogen-rich water (EHW) is known to have suppressive effects on oxidative stress (OS). However, its benefit in type 2 diabetes mellitus (T2DM) remains unclear. This study aimed to investigate the effect of EHW on T2DM. Methods: This was a multicenter, prospective, double-blind, randomized controlled trial of 50 patients with T2DM who were assigned to the EHW or ...
STOMACH - GASTRIC MUCOSAL INJURY

Metal-Organic Framework Based Hydrogen Release Platform for Multi-Effective Helicobacter Pylori ...

Year Published: 2021

Helicobacter pylori (H. pylori) infection is the leading cause of chronic gastritis, peptic ulcer and gastric cancer. Antibiotics, as traditional method for eliminating H. pylori, have no targeting effect, which cause serious bacterial resistance and gut dysbacteriosis. Moreover, antibiotics can hardly address hyperactive inflammatory response or damaged gastric mucosal barrier caused by H. pylori ...
WHOLE BODY - ROS-SCAVENGING

Photosynthesis-inspired H2 generation using a chlorophyll-loaded liposomal nanoplatform to detect ...

Year Published: 2020

A disturbance of reactive oxygen species (ROS) homeostasis may cause the pathogenesis of many diseases. Inspired by natural photosynthesis, this work proposes a photo-driven H2-evolving liposomal nanoplatform (Lip NP) that comprises an upconversion nanoparticle (UCNP) that is conjugated with gold nanoparticles (AuNPs) via a ROS-responsive linker, which is encapsulated inside the liposomal system ...
BREAST - CANCER

NIR-Driven Water Splitting H2 Production Nanoplatform for H2-Mediated Cascade-Amplifying Synergetic ...

Year Published: 2020

As a newly emerging treatment strategy for many diseases, hydrogen therapy has attracted a lot of attention because of its excellent biosafety. However, high diffusivity and low solubility make it difficult to accumulate in the local lesions. Herein, we develop H2 self-generation nano-platform by in situ water splitting driven by near infrared (NIR) laser. In this work, core-shell nanoparticles ...
WHOLE BODY - SURGERY/TRANSPLANTATION

In Vivo Evaluation of Bioabsorbable Fe-35Mn-1Ag: First Reports on In Vivo Hydrogen Gas Evolution in ...

Year Published: 2020

This work investigates the influence of Ag (1 wt%) on the mechanical properties, in vitro and in vivo corrosion, and biocompatibility of Fe-35Mn. The microstructure of Fe-35Mn-1Ag possesses a uniform dispersion of discrete silver particles. Slight improvements in compressive properties are attributed to enhanced density and low porosity volume. Fe-35Mn-1Ag exhibits good in vitro and in vivo ...
WHOLE BODY - HYDROGEN BIOLOGY

Low-Flow Nasal Cannula Hydrogen Therapy

Year Published: 2020

Background: Molecular hydrogen (H2) is a biologically active gas that is widely used in the healthcare sector. In recent years, on-site H2 gas generators, which produce high-purity H2 by water electrolysis, have begun to be introduced in hospitals, clinics, beauty salons, and fitness clubs because of their ease of use. In general, these generators produce H2 at a low-flow rate, so physicians are ...
WHOLE BODY - HYDROGEN BIOLOGY

Pharmacokinetics of a single inhalation of hydrogen gas in pigs

Year Published: 2020

The benefits of inhaling hydrogen gas (H2) have been widely reported but its pharmacokinetics have not yet been sufficiently analyzed. We developed a new experimental system in pigs to closely evaluate the process by which H2 is absorbed in the lungs, enters the bloodstream, and is distributed, metabolized, and excreted. We inserted and secured catheters into the carotid artery (CA), portal vein ...
LUNG - CANCER

Hydrogen gas activates coenzyme Q10 to restore exhausted CD8 + T cells, especially PD-1 + Tim3 + ...

Year Published: 2020

As previously reported, hydrogen gas improves the prognosis of patients with cancer by restoring exhausted CD8+ T cells into active CD8+ T cells, possibly by activating mitochondria. As mitochondrial activators exhibit synergistic effects with nivolumab, the current study investigated whether hydrogen gas also affects the clinical outcomes of nivolumab. A total of 42 of 56 patients with lung ...
BONE - SURGERY/TRANSPLANTATION

Comparative Assessment of In Vitro and In Vivo Biodegradation of Mg-1Ca Magnesium Alloys for ...

Year Published: 2020

Use of magnesium implants is a new trend in orthopedic research because it has several important properties that recommend it as an excellent resorbable biomaterial for implants. In this study, the corrosion rate and behavior of magnesium alloys during the biodegradation process were determined by in vitro assays, evolution of hydrogen release, and weight loss, and further by in vivo assays ...
EYE - CORNEAL INJURY

Hydrogen promotes the activation of Cu, Zn superoxide dismutase in a rat corneal alkali-burn model

Year Published: 2020

Aim: To investigate the effects of hydrogen (H2) on Cu, Zn superoxide dismutase (SOD1) activation in a rat model of corneal alkali burn. Methods: In each rat, one cornea was subjected to alkali exposure. Physiological saline (saline group) or H2-dissolved saline (H2 group) was instilled continuously on the cornea for 5min before and after alkali exposure. Inflammatory cells, neovascularization, ...
WHOLE BODY - DIABETES

Effects of hydrogen-rich water prepared by alternating-current-electrolysis on antioxidant activity, ...

Year Published: 2020

Hydrogen-rich water is conventionally prepared by direct current-electrolysis, but has been not or scarcely prepared by alternating current (AC)-electrolysis. The AC preparations from tap water for 20-30 minutes exhibit a dissolved hydrogen concentration of 1.55 mg/L, which was close to the theoretical maximum value of 1.6 mg/L. These preparations also displayed an oxidation-reduction potential of ...
WHOLE BODY - INFLAMMATION

Molecular hydrogen protects against oxidative stress-induced RAW 264.7 macrophage cells through the ...

Year Published: 2020

Background Oxidative stress is involved in the development of many inflammatory, metabolic and aging diseases.Objective In this study we investigated, the protective effects of H2 on RAW 264.7 macrophage cell against LPS-and H2O2-induced oxidative stress by the inhibition of MAPK pathway and also activate the Nrf2 pathway.ResultsOur results showed H2 increased the macrophage cell proliferation and ...
WHOLE BODY - EXCERCISE

Hydrogen-Rich Water Supplementation and Up-Hill Running Performance: Effect of Athlete Performance ...

Year Published: 2020

Purpose: Hydrogen-rich water (HRW) has been shown to have an antifatigue effect. This study assessed up-hill running performance, as well as physiological and perceptual responses after supplementation with 1680 mL HRW between 24 h and 40 min before running, in athletes of heterogeneous running ability. Methods: Sixteen males (mean [SD] age 31.6 [8.6] y, VO2max 57.2 [8.9] mL·kg-1·min-1, body fat ...
EYE - CORNEAL INJURY

Retracted: An Immunohistochemical Study of the Increase in Antioxidant Capacity of Corneal ...

Year Published: 2020

Corneal alkali burns are potentially blinding injuries. Alkali induces oxidative stress in corneas followed by excessive corneal inflammation, neovascularization, and untransparent scar formation. Molecular hydrogen (H2), a potent reactive oxygen species (ROS) scavenger, suppresses oxidative stress and enables corneal healing when applied on the corneal surface. The purpose of this study was to ...
BREAST - CANCER

Magnesium-based micromotors for enhanced active and synergistic hydrogen chemotherapy

Year Published: 2020

Hydrogen therapy has recently emerged as an attractive approach for combating major diseases including cancer, diabetes, stroke and Parkinson's disease. Herein, we ingeniously fabricated a fully biodegradable Magnesium (Mg) based micromotor for the active hydrogen and chemotherapeutics delivery, and firstly proposed the concept of a self-propelled micromotor platform used for cancer active ...
STOMACH - CANCER

Effects of alkaline water intake on gastritis and miRNA expression (miR-7, miR-155, miR-135b and ...

Year Published: 2020

It is known that abnormal expression of miRNAs in the gastric cancer (GC) contributes to its carcinogenesis. Therefore, ingestion of commercial (usual) water on a daily basis may be a contributing factor for the occurrence of alterations in the gastric mucosal. In this study, it was evaluated the expression of the miRNAs miR-29c, miR-7, miR-155, and miR-135b in the gastric tissue of patients with ...
BLADDER - CANCER

A Photo-Activated H2 Nanogenerator for Enhanced Chemotherapy of Bladder Cancer

Year Published: 2020

Hydrogen gas can mitigate oxidative stress in many diseases that is regarded to be safe and free of side effect. Inspired by a metalloenzyme in a variety of microorganisms, here we propose a photo-activated H2 nanogenerator that comprises a fluorinated chitosan (FCS), a chemotherapeutic drug (Gemcitabine, GEM), and a catalyst of H2 production ([FeFe]TPP) that can form self-assembled ...
LUNG - CANCER

Two weeks of hydrogen inhalation can significantly reverse adaptive and innate immune system ...

Year Published: 2020

Following standard treatments, the traditional model for enhancing anti-tumor immunity involves performing immune reconstitution (e.g., adoptive immune cell therapies or immunoenhancing drugs) to prevent recurrence. For patients with advanced non-small cell lung cancer, we report here on two objectives, the immunosenescence for advanced non-small cell lung cancer and hydrogen gas inhalation for ...
BONE - OSTEONECROSIS

A study on the protective effect of molecular hydrogen on osteoradionecrosis of the jaw in rats

Year Published: 2020

The aim of this study was to investigate the protective effect of hydrogen in a rat model of osteoradionecrosis of the jaw (ORNJ). The rats and bone marrow-derived mesenchymal stem cells (BMSCs) were pre-treated with hydrogen before receiving irradiation (7Gy per fraction, five fractions in total once a day for rats, 4Gy for BMSCs). Reactive oxygen species (ROS) and cell differentiation were ...
STOMACH - PROTEIN DIGESTION

Hydrogen molecules can modulate enzymatic activity and structural properties of pepsin in vitro

Year Published: 2020

Hydrogen gas therapy has been recognized as the promising application merit. However, the underlying mechanism on the biological effects remains far from being understood. In this work, pepsin used as a research model, the effects of hydrogen-rich water on the protein activities and structural properties were investigated by enzymatic assay, atomic force microscopy-based peakforce quantitative ...
BONE - OSTEOARTHRITIS (OA)

Protective Effects of Hydrogen-Rich Water Against Cartilage Damage in a Rat Model of Osteoarthritis ...

Year Published: 2020

BACKGROUND The aim of this study was to investigate the mechanisms underlying the potential effects of hydrogen-rich water (HW) on articular cartilage in a rat osteoarthritis (OA) model. MATERIAL AND METHODS A rat model of OA was established using the modified Hulth method, and rats were forced to exercise for 30 min every day 1 week after surgery for 7 weeks. Mankin's method was used to score the ...