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Studies Found: 1104

LUNG - CANCER

Suppression of autophagy facilitates hydrogen gas-mediated lung cancer cell apoptosis

Year Published: 2020

Our previous study found that hydrogen gas (H2) could efficiently inhibit lung cancer progression; however, the underlying mechanisms still remains to be elucidated. The present study aimed to explore the roles of H2 in lung cancer cell autophagy, and reveal the effects of autophagy on H2-mediated lung cancer cell apoptosis and the underlying mechanisms. The expression levels of proteins ...
BONE - SURGERY/TRANSPLANTATION

Hydrogen inhibits the osteoclastogenesis of mouse bone marrow mononuclear cells

Year Published: 2020

Hydrogen (H2) is one of the major biodegradation products of magnesium (Mg) alloys implanted for bony fracture healing and reconstruction; H2 thus plays a significant role in the regulation of local microenvironment and the biology of resident cells. The interactions between the H2 and the local cells are of great interest, and a full understanding of the effect of H2 on bone marrow mononuclear ...
WHOLE BODY - AGING

In vivo antiaging effects of alkaline water supplementation

Year Published: 2020

Telomeres length and telomerase activity are currently considered aging molecular stigmata. Water is a major requirement for our body and water should be alkaline. Recent reports have shown that aging is related to a reduced water intake. We wanted to investigate the effect of the daily intake of alkaline water on the molecular hallmark of aging and the anti-oxidant response. We watered a mouse ...
PERITONIUM - PERITONEAL DIALYSIS

Molecular hydrogen regulates PTEN-AKT-mTOR signaling via ROS to alleviate peritoneal ...

Year Published: 2020

As a convenient, effective and economical kidney replacement therapy for end-stage renal disease (ESRD), peritoneal dialysis is available in approximately 11% of ESRD patients worldwide. However, long-term peritoneal dialysis treatment causes peritoneal fibrosis. In recent years, the application potential of molecular hydrogen in the biomedicine has been well recognized. Molecular hydrogen ...
KIDNEY - SURGERY/TRANSPLANTATION

Hydrogen-rich water alleviates cyclosporine A-induced nephrotoxicity via the Keap1/Nrf2 signaling ...

Year Published: 2020

Oxidative stress induced by long-term cyclosporine A (CsA) administration is a major cause of chronic nephrotoxicity, which is characterized by tubular atrophy, tubular cell apoptosis, and interstitial fibrosis in the progression of organ transplantation. Although hydrogen-rich water (HRW) has been used to prevent various oxidative stress-related diseases, its underlying mechanisms remain unclear. ...
LUNG - CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

Effect of hydrogen inhalation on IL-40 and SIgA in a Rat Model of Pulmonary Mucosal Immunity

Year Published: 2020

Background Recently, some researchers have reported that PIgR expression is down-regulated in Chronic Obstructive Pulmonary Disease (COPD) and SIgA deficiency correlates with severity of airflow obstruction. What’ s more, some studies have demonstrated that 2 percent of hydrogen or hydrogen water is effective in treating and preventing various diseases. Objectives The aim of this study was to ...
LUNG - CANCER

Hydrogen gas represses the progression of lung cancer via downregulating CD47

Year Published: 2020

Hydrogen gas (H2) has been identified to play an anti-tumor role in several kinds of cancers, but the molecular mechanisms remains largely unknown. In our previous study, our project group found that H2 could decreased the expression of CD47 in lung cancer A549 cells via using the next generation sequencing, indicating that CD47 might be involved in H2-mediated lung cancer repression. Therefore, ...
WHOLE BODY - DIABETES (TYPE II)

Molecular hydrogen improves type 2 diabetes through inhibiting oxidative stress

Year Published: 2020

The aim of the present study was to investigate the potential therapeutic effects of molecular hydrogen on type 2 diabetes mellitus (T2DM) in rats. Following maintenance on a high-fat diet for 4 weeks, a T2DM model was established using an injection of 30 mg/kg streptozotocin via the caudal vein into Sprague-Dawley rats. On day 0 and Day 80, the blood samples were obtained from each rat for the ...
WHOLE BODY - EXCERCISE

The role of drinking hydrogen-rich water produced by alkaline stick on resistance exercise in ...

Year Published: 2020

In the double-blind study, the effect of drinking Hydrogen-Rich Water (HRW) producing by alkaline stick and tap water (placebo) on 9 male athletes in resistance training during 24 h were studied, and Lactate Dehydrogenase (LDH), Creatine Kinase (CPK) and Lactic Acid (LAC) levels in their blood samples were tested. The decrease of LAC and LDH values in the HRW group compared with the placebo were ...
LUNG - ASTHMA

Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch

Year Published: 2020

Mechanisms mediating the protective effects of molecular hydrogen (H2) are not well understood. This study explored the possibility that H2 exerts its anti-inflammatory effect by modulating energy metabolic pathway switch. Activities of glycolytic and mitochondrial oxidative phosphorylation systems were assessed in asthmatic patients and in mouse model of allergic airway inflammation. The effects ...
MUSCLE - EXCERCISE

Molecular hydrogen downregulates acute exhaustive exercise-induced skeletal muscle damage

Year Published: 2020

Physical exercise-induced skeletal muscle damage may be characterized by increased oxidative stress, inflammation, and apoptosis which may be beneficial when exercise is regular, but it is rather harmful when exercise is exhaustive and performed acutely by unaccustomed individuals. Molecular hydrogen (H2) has emerged as a potent antioxidant, anti-inflammatory, and anti-apoptotic agent, but its ...
WHOLE BODY - EXCERCISE

Inhaled molecular hydrogen attenuates intense acute exercise-induced hippocampal inflammation in ...

Year Published: 2020

Physical exercise-induced inflammation may be beneficial when exercise is regular but it may be harmful when exercise is intense and performed by unaccustomed individuals/rats. Molecular hydrogen (H2) has recently emerged as a powerful anti-inflammatory, antioxidant and anti-apoptotic molecule in a number of pathological conditions, but little is known about its putative role under physiological ...
WHOLE BODY - EXCERCISE

Acute ingestion of hydrogen-rich water does not improve incremental treadmill running performance in ...

Year Published: 2020

There is emerging evidence that hydrogen-rich water (H2-water) has beneficial effects on the physiological responses to exercise. However, few studies investigate its ergogenic potential. This randomized controlled trial examined the effects of H2-water ingestion on physiological responses and exercise performance during incremental treadmill running. In a double-blind crossover design, 14 ...
LUNG - SURGERY/TRANSPLANTATION

Hydrogen water alleviates obliterative airway disease in mice

Year Published: 2020

Objective: Bronchiolitis obliterans syndrome arising from chronic airway inflammation is a leading cause of death following lung transplantation. Several studies have suggested that inhaled hydrogen can protect lung grafts from ischemia-reperfusion injury via anti-inflammatory and -oxidative mechanisms. We investigated whether molecular hydrogen-saturated water can preserve lung allograft function ...
BONE MARROW - SURGERY/TRANSPLANTATION

Hydrogen in Patients With Corticosteroid-Refractory/Dependent Chronic Graft-Versus-Host-Disease: A ...

Year Published: 2020

Chronic graft-versus-host-disease (cGVHD) is the leading cause of late non-relapse mortality after allogeneic hematopoietic stem cell transplantation(HSCT). There is no standard therapy for patients refractory or dependent to corticosteroid treatment. We hypothesized that hydrogen may exert therapeutic effects on cGVHD patients with few side effects. A prospective open-label phase 2 study of ...
OVARIES - CANCER

Biodegradable Mg Implants Suppress the Growth of Ovarian Tumor

Year Published: 2020

The common treatment of epithelial ovarian cancer is aggressive surgery followed by platinum-based cytotoxic chemotherapy. However, residual tumor cells are resistant to chemotherapeutic drugs during postoperative recurrence. The treatment of ovarian cancer requires new breakthroughs and advances. In recent years, magnesium alloy has been widely developed as a new biodegradable material because of ...
INTESTINE - OBESITY

Saturated hydrogen improves lipid metabolism disorders and dysbacteriosis induced by a high-fat diet

Year Published: 2020

Studies have shown that metabolic diseases, such as obesity, are significantly associated with intestinal flora imbalance. The amplification of opportunistic pathogens induced by the glyoxylic acid cycle contributes to intestinal flora imbalance. Promising, though, is that saturated hydrogen can effectively improve the occurrence and development of metabolic diseases, such as obesity. However, the ...
LUNG - ASTHMA

Effects of high-fat diet on the epithelial-mesenchymal transition of respiratory tract through the ...

Year Published: 2020

Background High fat diet is extensively studied to be associated with trending metabolic diseases. In addition to type 2 diabetes and hypertension, high fat diet is strongly associated with asthma and other respiratory diseases among children however, the pathogenicity regarding these pulmonary diseases begs for extensive research. This study investigated the mechanism of the ...
INTESTINE - CANCER

Hydrogen attenuates radiation-induced intestinal damage by reducing oxidative stress and ...

Year Published: 2020

The small intestine is known to be particularly sensitive to radiation, and the major limiting factor of radiotherapy is the gastrointestinal syndrome that subsequently develops after its administration. The detrimental effects of radiation are mostly mediated via the overproduction of reactive oxygen species (ROS), especially the hydroxyl radical (·OH). Because hydrogen is a selective ·OH ...
WHOLE BODY - PARASITE INFECTION

Electrolyzed Oxidizing Water Modulates the Immune Response in BALB/c Mice Experimentally Infected ...

Year Published: 2020

Chagas disease is a major public health problem in Latin America. The mixed Th1/Th2 immune response is required against Trypanosoma cruzi. Electrolyzed oxidizing water (EOW) has been shown to have germicidal efficacy. The objective of this study was to evaluate the EOW effectiveness in T. cruzi-infected BALB/c mice clinically, immunologically, and histologically. The severity of the infection was ...
SKIN - WOUND HEALING

Hydrogen generating patch improves skin cell viability, migration activity, and collagen expression

Year Published: 2020

Molecular hydrogen recently attracted lots of attention in biomedical community because of its abilities to modulate signal transduction, protein phosphorylation, and gene expression that enable its anti-inflammatory, anti-allergy, and anti-apoptotic activities. However, controllable and local delivery of hydrogen molecules to tissues still remains challenging. Here, we propose a new method of ...
SKIN - SURGERY/TRANSPLANTATION

Hydrogen-rich saline reduces tissue injury and improves skin flap survival on a rat hindlimb ...

Year Published: 2020

Background: Degloving injuries represent a challenge in plastic surgery. The aim of this study is to acknowledge the protective effects of hydrogen-rich saline (HRS) solution on a rat hindlimb degloved skin flap. Methods: Twenty-one Sprague-Dawley rats were divided into three groups (control, saline and HRS). Degloving injury model was established, and flaps were sutured back following 5 min of ...
ENDOTHELIUM - SHOCK

1.2% Hydrogen gas inhalation protects the endothelial glycocalyx during hemorrhagic shock: a ...

Year Published: 2020

Purpose Hydrogen gas (H2) inhalation improved the survival rate of hemorrhagic shock. However, its mechanisms are unknown. We hypothesized that H2 protected the endothelial glycocalyx during hemorrhagic shock and prolonged survival time. Methods 83 Sprague–Dawley rats were anesthetized with isoflurane. The animals were randomly assigned to 5 groups: room air with no shock, 1.2% H2 with no shock, ...
BLOOD - BLOOD COMPOSITION

Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells ...

Year Published: 2020

The evidence for the beneficial effects of drinking hydrogen-water (HW) is rare. We aimed to investigate the effects of HW consumption on oxidative stress and immune functions in healthy adults using systemic approaches of biochemical, cellular, and molecular nutrition. In a randomized, double-blind, placebo-controlled study, healthy adults (20-59 y) consumed either 1.5 L/d of HW (n = 20) or plain ...
PREGNANCY - OFFSPRING DEVELOPMENT

Effect of ionised (electrolysed) water on the rat embryo development

Year Published: 2020

The aim of this study was to investigate the effects ionised water has on embryonic development using Wistar rat animal model. For that purpose, alkaline and acidic water was prepared with a domestic water ioniser. It was found that the concentrations of Cl–, SO42– ions increased in acidic water, while in alkaline water, Ca2+ concentration decreased and halogenated hydrocarbon concentrations ...