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Studies Found: 14

UTERUS - CANCER

RNA sequencing analysis reveals apoptosis induction by hydrogen treatment in endometrial cancer via ...

Year Published: 2020

Background: To evaluate the activity of hydrogen in endometrial cancer and elucidate its underlying molecular mechanisms. Methods: Ishikawa, HEC1A and AN3CA cells were incubated in DMEM medium with or without hydrogen. RNA sequencing was used to explore the association of hydrogen treatment with signaling pathways and functional genes in endometrial cancer cells. The apoptotic rates of the three ...
BREAST - CANCER

Magnesium-based micromotors for enhanced active and synergistic hydrogen chemotherapy

Year Published: 2020

Hydrogen therapy has recently emerged as an attractive approach for combating major diseases including cancer, diabetes, stroke and Parkinson's disease. Herein, we ingeniously fabricated a fully biodegradable Magnesium (Mg) based micromotor for the active hydrogen and chemotherapeutics delivery, and firstly proposed the concept of a self-propelled micromotor platform used for cancer active ...
BLADDER - CANCER

A Photo-Activated H2 Nanogenerator for Enhanced Chemotherapy of Bladder Cancer

Year Published: 2020

Hydrogen gas can mitigate oxidative stress in many diseases that is regarded to be safe and free of side effect. Inspired by a metalloenzyme in a variety of microorganisms, here we propose a photo-activated H2 nanogenerator that comprises a fluorinated chitosan (FCS), a chemotherapeutic drug (Gemcitabine, GEM), and a catalyst of H2 production ([FeFe]TPP) that can form self-assembled ...
BREAST - CANCER

NIR-Driven Water Splitting H2 Production Nanoplatform for H2-Mediated Cascade-Amplifying Synergetic ...

Year Published: 2020

As a newly emerging treatment strategy for many diseases, hydrogen therapy has attracted a lot of attention because of its excellent biosafety. However, high diffusivity and low solubility make it difficult to accumulate in the local lesions. Herein, we develop H2 self-generation nano-platform by in situ water splitting driven by near infrared (NIR) laser. In this work, core-shell nanoparticles ...
UTERUS - CANCER

Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic ...

Year Published: 2020

Background: Pyroptosis belongs to a novel inflammatory programmed cell death pathway, with the possible prognosis of endometrial cancer related to the terminal protein GSDMD. Hydrogen exerts a biphasic effect on cancer by promoting tumor cell death and protecting normal cells, which might initiate GSDMD pathway-mediated pyroptosis. Methods: We performed immunohistochemical staining and western ...
INTESTINE - CANCER

Hydrogen attenuates radiation-induced intestinal damage by reducing oxidative stress and ...

Year Published: 2020

The small intestine is known to be particularly sensitive to radiation, and the major limiting factor of radiotherapy is the gastrointestinal syndrome that subsequently develops after its administration. The detrimental effects of radiation are mostly mediated via the overproduction of reactive oxygen species (ROS), especially the hydroxyl radical (·OH). Because hydrogen is a selective ·OH ...
OVARIES - CANCER

Biodegradable Mg Implants Suppress the Growth of Ovarian Tumor

Year Published: 2020

The common treatment of epithelial ovarian cancer is aggressive surgery followed by platinum-based cytotoxic chemotherapy. However, residual tumor cells are resistant to chemotherapeutic drugs during postoperative recurrence. The treatment of ovarian cancer requires new breakthroughs and advances. In recent years, magnesium alloy has been widely developed as a new biodegradable material because of ...
LUNG - CANCER

Hydrogen gas represses the progression of lung cancer via downregulating CD47

Year Published: 2020

Hydrogen gas (H2) has been identified to play an anti-tumor role in several kinds of cancers, but the molecular mechanisms remains largely unknown. In our previous study, our project group found that H2 could decreased the expression of CD47 in lung cancer A549 cells via using the next generation sequencing, indicating that CD47 might be involved in H2-mediated lung cancer repression. Therefore, ...
LUNG - CANCER

Suppression of autophagy facilitates hydrogen gas-mediated lung cancer cell apoptosis

Year Published: 2020

Our previous study found that hydrogen gas (H2) could efficiently inhibit lung cancer progression; however, the underlying mechanisms still remains to be elucidated. The present study aimed to explore the roles of H2 in lung cancer cell autophagy, and reveal the effects of autophagy on H2-mediated lung cancer cell apoptosis and the underlying mechanisms. The expression levels of proteins ...
LUNG - CANCER

Hydrogen therapy can be used to control tumor progression and alleviate the adverse events of ...

Year Published: 2020

Chemotherapy, targeted therapy, and immunotherapy are used against advanced non-small cell lung cancer. A clinically efficacious method for relieving the adverse events associated of such therapies is lacking. Fifty-eight adult patients were enrolled in our trial to relieve pulmonary symptoms or the adverse events of drugs. Twenty patients who refused drug treatment were assigned equally and ...
MOUTH - CANCER

Hydrogen-bubbled platinum-colloid suppresses human esophagus- or tongue-carcinoma cells with ...

Year Published: 2020

Carcinostatic effects of combined use of hydrogen nano-bubbles (nano-H) and platinum–povidone (PVP-–Pt) were examined. Hydrogen-dissolved medium was prepared by hydrogen-gas bubbling with a microporous gas-emittance-terminal into a medium in the absence or presence of PVP–Pt (nano-H, nano-H/PVP–Pt). Human esophagus-derived carcinoma cells KYSE70 were repressed for cell proliferation with ...
LUNG - CANCER

Two weeks of hydrogen inhalation can significantly reverse adaptive and innate immune system ...

Year Published: 2020

Following standard treatments, the traditional model for enhancing anti-tumor immunity involves performing immune reconstitution (e.g., adoptive immune cell therapies or immunoenhancing drugs) to prevent recurrence. For patients with advanced non-small cell lung cancer, we report here on two objectives, the immunosenescence for advanced non-small cell lung cancer and hydrogen gas inhalation for ...
STOMACH - CANCER

Effects of alkaline water intake on gastritis and miRNA expression (miR-7, miR-155, miR-135b and ...

Year Published: 2020

It is known that abnormal expression of miRNAs in the gastric cancer (GC) contributes to its carcinogenesis. Therefore, ingestion of commercial (usual) water on a daily basis may be a contributing factor for the occurrence of alterations in the gastric mucosal. In this study, it was evaluated the expression of the miRNAs miR-29c, miR-7, miR-155, and miR-135b in the gastric tissue of patients with ...
LUNG - CANCER

Hydrogen gas activates coenzyme Q10 to restore exhausted CD8 + T cells, especially PD-1 + Tim3 + ...

Year Published: 2020

As previously reported, hydrogen gas improves the prognosis of patients with cancer by restoring exhausted CD8+ T cells into active CD8+ T cells, possibly by activating mitochondria. As mitochondrial activators exhibit synergistic effects with nivolumab, the current study investigated whether hydrogen gas also affects the clinical outcomes of nivolumab. A total of 42 of 56 patients with lung ...