Search

Studies Found: 446

BRAIN - PARKINSON'S DISEASE

Randomized double-blind placebo-controlled trial of hydrogen inhalation for Parkinson’s ...

Year Published: 2021

Background: Oxidative stress is involved in the progression of Parkinson's disease (PD). Recent studies have confirmed that molecular hydrogen (H2) functions as a highly effective antioxidant in animal models of PD. A placebo-controlled, randomized, double-blind, parallel-group clinical pilot study was conducted to assess the efficacy of hydrogen gas inhalation in Japanese patients with PD on ...
KIDNEY - CHRONIC KIDNEY DISEASE

Hydrogen-rich water reduced oxidative stress and renal fibrosis in rats with unilateral ureteral ...

Year Published: 2021

Background: Congenital obstructive nephropathy (CKD) is commonly implicated in the pathophysiology of chronic kidney disease occurring in the pediatric and adolescent age groups and the release of reactive oxygen species contribute to the worsening of renal fibrosis. Molecular hydrogen (H2) protects against tissue injury by reducing oxidative stress. We evaluated the efficacy of oral H2-rich water ...
LIVER - LIVER DISEASE

Electrolyzed Hydrogen Water Protects against Ethanol-Induced Cytotoxicity by Regulating Aldehyde ...

Year Published: 2021

Excessive alcohol consumption can cause multi-systemic diseases. Among them, alcoholic liver disease is the most frequent and serious disease. Electrolytic hydrogen water (EHW) is produced at the cathode during electrolysis of water and contains a large amount of molecular hydrogen and a low content of platinum nanoparticles with alkaline properties. In this study, we found that EHW inhibits ...
LUNG - LUNG INJURY

Hydrogen alleviates acute lung injury induced by limb ischaemia/reperfusion in mice

Year Published: 2021

Aims: Limb ischaemia/reperfusion (LIR) occurs in various clinical conditions including critical limb ischaemia, abdominal aortic aneurysm, and traumatic arterial injury. Reperfusion of the acutely ischemic limb can lead to a systemic inflammation response and multiple organ dysfunction syndrome, further resulting in significant morbidity and mortality. Molecular hydrogen exhibits therapeutic ...
WHOLE BODY - ROS-SCAVENGING

Studies on the Properties and Real Existence of Aqueous Solution Systems that are Assumed to Have ...

Year Published: 2004

We evaluated the properties and real existence of an electrolyzed-reduced water, which we prepared, and three commercially purchased water goods, that are advertised to have antioxidant activities by the action of 'active hydrogen,' on the basis of the results of examinations for inhibitory effects on the oxidative reactions of biomolecules, quantitative analyses of the minerals, and the ESR ...
LIVER - SURGERY/TRANSPLANTATION

Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing ...

Year Published: 2007

We have recently showed that molecular hydrogen has great potential for selectively reducing cytotoxic reactive oxygen species, such as hydroxyl radicals, and that inhalation of hydrogen gas decreases cerebral infarction volume by reducing oxidative stress [I. Ohsawa, M. Ishikawa, K. Takahashi, M. Watanabe, K. Nishimaki, K. Yamagata, K.-I. Katsura, Y. Katayama, S. Asoh, S. Ohta, Hydrogen acts as a ...
HEART - HEART ATTACK

Hydrogen-rich saline protects myocardium against ischemia/reperfusion injury in rats

Year Published: 2009

Protective effect of hydrogen (H(2)) gas on cardiac ischemia-reperfusion (I/R) injury has been demonstrated previously. This study was designed to test the hypothesis that hydrogen-rich saline (saline saturated with molecular hydrogen), which is easy to use, induces cardioprotection against ischemia (30 min) and reperfusion (24 h) injury in rats. Adult male Sprague-Dawley rats underwent 30-min ...
INTESTINE - INFLAMMATORY BOWEL DISEASE

Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate

Year Published: 2009

By its antioxidant effect, molecular hydrogen gas (H2) was reported to protect organs from tissue damage induced by ischemia reperfusion. To evaluate its anti-inflammatory effects, we established a mouse model of human inflammatory bowel disease (IBD) by supplying mice with water containing (1) dextran sodium sulfate (DSS) (5%), (2) DSS (5%) and H2, or (3) H2 only ad libitum up to 7 days. At ...
LIVER - AUTOIMMUNE

Hydrogen from intestinal bacteria is protective for Concanavalin A-induced hepatitis

Year Published: 2009

It is well known that some intestinal bacteria, such as Escherichia coli, can produce a remarkable amount of molecular hydrogen (H(2)). Although the antioxidant effects of H(2) are well documented, the present study examined whether H(2) released from intestinally colonized bacteria could affect Concanavalin A (ConA)-induced mouse hepatitis. Systemic antibiotics significantly decreased the level ...
BRAIN - PARKINSON'S DISEASE

Hydrogen in drinking water reduces dopaminergic neuronal loss in the ...

Year Published: 2009

It has been shown that molecular hydrogen (H(2)) acts as a therapeutic antioxidant and suppresses brain injury by buffering the effects of oxidative stress. Chronic oxidative stress causes neurodegenerative diseases such as Parkinson's disease (PD). Here, we show that drinking H(2)-containing water significantly reduced the loss of dopaminergic neurons in PD model mice using both acute and chronic ...
LUNG - DIVING

Saturated hydrogen saline protects the lung against oxygen toxicity

Year Published: 2010

Exposure to high oxygen concentrations leads to acute lung injury, including lung tissue and alveolar edema formation, congestion, intra-alveolar hemorrhage, as well as endothelial and epithelial cell apoptosis or necrosis. Several studies have reported that molecular hydrogen is an efficient antioxidant by gaseous rapid diffusion into tissues and cells. Moreover, consumption of water with ...
WHOLE BODY - SEPSIS

Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and ...

Year Published: 2010

Despite recent advances in antibiotic therapy and intensive care, sepsis is still considered to be the most common cause of death in intensive care units. Excessive production of reactive oxygen species plays an important role in the pathogenesis of sepsis. Recently, it has been suggested that molecular hydrogen (H2) exerts a therapeutic antioxidant activity by selectively reducing hydroxyl ...
HEART - RADIOPROTECTION

The potential cardioprotective effects of hydrogen in irradiated mice

Year Published: 2010

Most ionizing radiation-induced damage is caused by hydroxyl radicals, and the selective reduction of hydroxyl by hydrogen in vitro has been demonstrated previously. Irradiation of the heart can cause chronic cardiac disease. This study was designed to test the hypothesis that hydrogen-rich water (pure water saturated with molecular hydrogen), which is easy to use, induces cardioprotection against ...
EYE - RETINAL INJURY

Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops ...

Year Published: 2010

Purpose: Retinal ischemia-reperfusion (I/R) injury by transient elevation of intraocular pressure (IOP) is known to induce neuronal damage through the generation of reactive oxygen species. Study results have indicated that molecular hydrogen (H(2)) is an efficient antioxidant gas that selectively reduces the hydroxyl radical (*OH) and suppresses oxidative stress-induced injury in several organs. ...
WHOLE BODY - CANCER

Growth Suppression of HL60 and L6 Cells by Atomic Hydrogen

Year Published: 2010

We previously reported electrolyzed reduced water (ERW) which produced near the cathode by electrolysis has a reductive activity. We also revealed that ERW contains both molecular hydrogen and platinum nanoparticles (Pt nps) derived from platinum-coated titanium electrodes. Pt nps have catalysis activity converting molecular hydrogen to atomic hydrogen. Thus, we regard a solution containing both ...
LUNG - SURGERY/TRANSPLANTATION

Inhaled Hydrogen Gas Therapy for Prevention of Lung Transplant-Induced Ischemia/Reperfusion Injury ...

Year Published: 2010

Successful abrogation of ischemia/reperfusion (I/R) injury of lung grafts could significantly improve short- and long-term outcomes for lung transplant (LTx) recipients. Hydrogen gas has potent antioxidant and antiapoptotic properties and has been recently used in number of experimental and clinical studies. The purpose of this research was to investigate whether inhaled hydrogen gas could reduce ...
PANCREAS - PANCREATITIS

Hydrogen-rich saline ameliorates the severity of l-arginine-induced acute pancreatitis in rats

Year Published: 2010

Molecular hydrogen, which reacts with the hydroxyl radical, has been considered as a novel antioxidant. Here, we evaluated the protective effects of hydrogen-rich saline on the l-arginine (l-Arg)-induced acute pancreatitis (AP). AP was induced in Sprague-Dawley rats by giving two intraperitoneal injections of l-Arg, each at concentrations of 250mg/100g body weight, with an interval of 1h. ...
KIDNEY - SURGERY/TRANSPLANTATION

Oral hydrogen water prevents chronic allograft nephropathy in rats

Year Published: 2010

Reactive oxygen species (ROS) contribute to the development of interstitial fibrosis and tubular atrophy seen in chronic allograft nephropathy (CAN). As molecular hydrogen gas can act as a scavenger of ROS, we tested the effect of treatment with hydrogen water (HW) in a model of kidney transplantation, in which allografts from Lewis rats were orthotopically transplanted into Brown Norway ...
LUNG - CANCER

Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress

Year Published: 2011

Molecular hydrogen (H(2)) is an efficient antioxidant that diffuses rapidly across cell membranes, reduces reactive oxygen species (ROS), such as hydroxyl radicals and peroxynitrite, and suppresses oxidative stress-induced injury in several organs. ROS have been implicated in radiation-induced damage to lungs. Because prompt elimination of irradiation-induced ROS should protect lung tissue from ...
WHOLE BODY - DIVING

Protective effect of hydrogen-rich saline on decompression sickness in rats

Year Published: 2011

Introduction: Hydrogen (H2) has been reported to be effective in the treatment of oxidative injury, which plays an important role in the process of decompression sickness (DCS). This study was designed to test whether H2-rich saline (saline saturated with molecular hydrogen) protected rats against DCS. Methods: Models of DCS were induced in male Sprague-Dawley rats weighing 300-310 g. H2-rich ...
LUNG - ENVIRONMENTAL POLLUTION

Consumption of hydrogen water reduces paraquat-induced acute lung injury in rats

Year Published: 2011

Exposure to paraquat leads to acute lung injury and oxidative stress is widely accepted as a contributor to paraquat-induced acute lung injury. Recent studies have reported that consumption of water with dissolved molecular hydrogen to a saturated level (hydrogen water) prevents oxidative stress-induced diseases. Here, we investigated whether consumption of saturated hydrogen saline protects rats ...
EAR - HEARING LOSS

Hydrogen in drinking water attenuates noise-induced hearing loss in guinea pigs

Year Published: 2011

It has been shown that molecular hydrogen acts as a therapeutic and preventive antioxidant by selectively reducing the hydroxyl radical, the most cytotoxic of the reactive oxygen species. In the present study, we tested the hypothesis that acoustic damage in guinea pigs can be attenuated by the consumption of molecular hydrogen. Guinea pigs received normal water or hydrogen-rich water for 14 days ...
MOUTH - PERIODONTITIS

Hydrogen-rich water attenuates experimental periodontitis in a rat model

Year Published: 2011

Reactive oxygen species (ROS) contribute to the development of periodontitis. As molecular hydrogen can act as a scavenger of ROS, we examined the effects of treatment with hydrogen-rich water on a rat model of periodontitis. A ligature was placed around the maxillary molars for 4 weeks to induce periodontitis, and the animals were given drinking water with or without hydrogen-rich water. The rats ...
MUSCLE - MUSCULAR DYSTROPHY

Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of ...

Year Published: 2011

Background: Molecular hydrogen has prominent effects on more than 30 animal models especially of oxidative stress-mediated diseases and inflammatory diseases. In addition, hydrogen effects on humans have been reported in diabetes mellitus type 2, hemodialysis, metabolic syndrome, radiotherapy for liver cancer, and brain stem infarction. Hydrogen effects are ascribed to specific radical-scavenging ...
LUNG - SURGERY/TRANSPLANTATION

Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism ...

Year Published: 2011

We recently demonstrated the inhalation of hydrogen gas, a novel medical therapeutic gas, ameliorates ventilator-induced lung injury (VILI); however, the molecular mechanisms by which hydrogen ameliorates VILI remain unclear. Therefore, we investigated whether inhaled hydrogen gas modulates the nuclear factor-kappa B (NFκB) signaling pathway. VILI was generated in male C57BL6 mice by performing a ...