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Studies Found: 446

INTESTINE - SURGERY/TRANSPLANTATION

Hydrogen-Enriched Preservation Protects the Isogeneic Intestinal Graft and Amends Recipient Gastric ...

Year Published: 2011

Inhaled hydrogen gas exerts antioxidant and anti-inflammatory effects in rat intestinal transplantation. Here, we investigated whether ex vivo donor organ treatment with dissolved hydrogen would prevent intestinal graft injury. Isogeneic intestinal transplantation was performed in Lewis rats with vascular flush, luminal preservation, and cold graft storage in nitrogen-bubbled (SITxN2) or ...
HEART - HIGH BLOOD PRESSURE

Chronic hydrogen-rich saline treatment reduces oxidative stress and attenuates left ventricular ...

Year Published: 2012

In hypertensive animals and patients, oxidative stress represents the primary risk factor for progression of left ventricular hypertrophy. Recently, it has been demonstrated that hydrogen, as a novel antioxidant, can selectively reduce hydroxyl radicals and peroxynitrite anion to exert therapeutic antioxidant activity. In the current study, we explored the effect of chronic treatment with ...
WHOLE BODY - CANCER

Hydrogen-rich saline protects immunocytes from radiation-induced apoptosis

Year Published: 2012

Background: Radiation often causes depletion of immunocytes in tissues and blood, which results in immunosuppression. Molecular hydrogen (H2) has been shown in recent studies to have potential as a safe and effective radioprotective agent through scavenging free radicals. This study was designed to test the hypothesis that H2 could protect immunocytes from ionizing radiation (IR). ...
EYE - RETINAL INJURY

Hydrogen-rich saline protects retina against glutamate-induced excitotoxic injury in guinea pig

Year Published: 2012

Molecular hydrogen (H(2)) is an efficient antioxidant that can selectively reduce hydroxyl radicals and inhibit oxidative stress-induced injuries. We investigated the protective effects and mechanism of hydrogen-rich saline in a glutamate-induced retinal injury model. Retinal excitotoxicity was induced in healthy guinea pigs by injecting glutamate into the vitreous cavity. After 30 min, ...
WHOLE BODY - DIABETES

Therapeutic effects of hydrogen saturated saline on rat diabetic model and insulin resistant model ...

Year Published: 2012

Background: Molecular hydrogen, as a novel antioxidant, has been proven effective in treating many diseases. This study aimed to evaluate the therapeutic effects of hydrogen saturated saline in treatment of a rat model of diabetes mellitus and a rat model of insulin resistant. Methods: A rat diabetes mellitus model was established by feeding a high fat/high carbohydrate diet followed by injection ...
HEART - ATHEROSCLEROSIS

Hydrogen decreases athero-susceptibility in apolipoprotein B-containing lipoproteins and aorta of ...

Year Published: 2012

It is to characterize the underlying molecular mechanisms of the anti-atherosclerotic effects of hydrogen (dihydrogen; H(2)), a novel antioxidant. In particular, to examine the effects of hydrogen on athero-susceptibility in lipoproteins and aorta of apolipoprotein E knockout (apoE-/-) mice. Plasma analysis by enzymatic method and spectrophotometric measurement showed that eight weeks ...
HEART - SURGERY/TRANSPLANTATION

Hydrogen-rich saline prevents neointima formation after carotid balloon injury by suppressing ROS ...

Year Published: 2012

Background: Reactive oxygen species (ROS) play a pivotal role in neointima hyperplasia after balloon injury. Molecular hydrogen has emerged as a novel antioxidant and has been proven effective in treating many diseases. Objectives: We aimed to determine the mechanism by which hydrogen affects neointima formation. Methods: We assessed the influence of a hydrogen-rich saline solution (HRSS) by daily ...
EAR - HEARING LOSS

Inhalation of hydrogen gas attenuates ouabain-induced auditory neuropathy in gerbils

Year Published: 2012

Aim: Auditory neuropathy (AN) is a hearing disorder characterized by abnormal auditory nerve function with preservation of normal cochlear hair cells. This study was designed to investigate whether treatment with molecular hydrogen (H(2)), which can remedy damage in various organs via reducing oxidative stress, inflammation and apoptosis, is beneficial to ouabain-induced AN in gerbils. Methods: AN ...
HEART - SURGERY/TRANSPLANTATION

Hydrogen-supplemented drinking water protects cardiac allografts from inflammation-associated ...

Year Published: 2012

Recent evidence suggests that molecular hydrogen has therapeutic value for disease states that involve inflammation. We hypothesized that drinking hydrogen-rich water (HW) daily would protect cardiac and aortic allograft recipients from inflammation-associated deterioration. Heterotopic heart transplantation with short-course tacrolimus immunosuppression and orthotopic aortic transplantation were ...
LUNG - SEPSIS

Effect of hydrogen inhalation on p38 MAPK activation in rats with lipopolysaccharide- induced acute ...

Year Published: 2012

Objective: To investigate the effect of hydrogen inhalation on lipopolysaccharide (LPS)-induced acute lung injury (ALI) and the underlying molecular mechanisms. Methods: Thirty-two male SD rats were randomly divided into 4 groups (n=8), namely the normal saline group (SA), saline with 2% hydrogen gas inhalation group (SH group), ALI group, and ALI with hydrogen inhalation group (LH group). In the ...
BRAIN - STROKE

Protective effects of hydrogen-rich saline in a rat model of permanent focal cerebral ischemia via ...

Year Published: 2012

Hydrogen gas (H(2)) as a new medical gas exerts organ-protective effects through regulating oxidative stress, inflammation and apoptosis. In contrast to H(2), hydrogen-rich saline (HS) may be more suitable for clinical application. The present study was designed to investigate whether HS can offer a neuroprotective effect in a rat model of permanent focal cerebral ischemia and what mechanism(s) ...
LIVER - NON-ALCOHOLIC STEATOHEPATITIS

Hydrogen-rich water prevents progression of nonalcoholic steatohepatitis and accompanying ...

Year Published: 2012

Oxidative stress is a strong contributor to the progression from simple fatty liver to nonalcoholic steatohepatitis (NASH). Molecular hydrogen is an effective antioxidant that reduces cytotoxic reactive oxygen species. In this study, we investigated the effects of hydrogen-rich water and the drug pioglitazone on the progression of NASH in mouse models. A methionine-choline-deficient (MCD) diet ...
BLOOD - BLOOD COMPOSITION

Colloidal platinum in hydrogen-rich water exhibits radical-scavenging activity and improves blood ...

Year Published: 2012

The 'colloidal platinum' stabilized with polyvinylpyrrolidone (Pt/PVP-colloid) was dispersed in hydrogen-rich water (HW; hydrogen concentration, 0.82 ppm; oxidation-reduction potential, -583 mV) or regular water (RW; <0.01 ppm, +218 mV). And we evaluated the antioxidant activity of Pt/PVP-colloid in HW or RW on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and improvement of blood ...
BRAIN - TRAUMATIC BRAIN INJURY

Protective effects of hydrogen-rich saline in a rat model of traumatic brain injury via reducing ...

Year Published: 2012

Background: Hydrogen gas (H(2)) has been considered as a novel antioxidant to selectively reduce the toxic reactive oxygen species (ROS) such as hydroxyl radical (•OH) without affecting the other signal ROS. Our recent study shows that H(2) inhalation is beneficial to traumatic brain injury (TBI) via reducing oxidative stress. In contrast to H(2), hydrogen-rich saline (HS) may be more suitable ...
BRAIN - BRAIN INJURY

Beneficial effect of hydrogen-rich saline on cerebral vasospasm after experimental subarachnoid ...

Year Published: 2012

Cerebral vasospasm (CV) remains a common and devastating complication in patients with subarachnoid hemorrhage (SAH). Despite its clinical significance and extensive research, the underlying pathogenesis and therapeutic perspectives of CV remain incompletely understood. Recently, it has been suggested that molecular hydrogen (H(2)) can selectively reduce levels of hydroxyl radicals (·OH) and ...
TESTES - RADIOPROTECTION

Hydrogen-rich saline protects spermatogenesis and hematopoiesis in irradiated BALB/c mice

Year Published: 2012

Background: Recent studies show that molecular hydrogen (dihydrogen, H2) has potential as an effective and safe radioprotective agent through reducing oxidative stress. The aim of this study was to investigate whether H2 is able to protect spermatogenesis and hematopoiesis from radiation-induced injuries. Material/methods: H2 was dissolved in physiological saline using an apparatus produced by our ...
BRAIN - STROKE

Lactulose ameliorates cerebral ischemia-reperfusion injury in rats by inducing hydrogen by ...

Year Published: 2013

Molecular hydrogen has been proved effective in ameliorating cerebral ischemia/reperfusion (I/R) injury by selectively neutralizing reactive oxygen species. Lactulose can produce considerable amount of hydrogen through fermentation by the bacteria in the gastrointestinal tract. To determine the neuroprotective effects of lactulose against cerebral I/R injury in rats and explore the probable ...
BRAIN - NEUROPROTECTION

Coadministration of hydrogen gas as part of the carrier gas mixture suppresses neuronal apoptosis ...

Year Published: 2013

Background: In animal models, several anesthetics induce widespread increases in neuronal apoptosis in the developing brain with subsequent neurologic deficits. Although the mechanisms are largely unknown, the neurotoxicity may, at least in part, be due to elevated oxidative stress caused by mitochondrial dysfunction. In an investigation of potential therapies that could protect against this type ...
EYE - CORNEAL INJURY

Hydrogen saline prevents selenite-induced cataract in rats

Year Published: 2013

The aim of this study was to investigate the potential antioxidative effect and mechanism for the protective effects of hydrogen saline on selenite-induced cataract in rats. Sprague-Dawley rat pups were divided into the following groups: control (Group A), selenite induced (Group B), and selenite plus hydrogen saline treated (Group C). Rat pups in Groups B and C received a single subcutaneous ...
PERITONIUM - PERITONEAL DIALYSIS

Transperitoneal administration of dissolved hydrogen for peritoneal dialysis patients: a novel ...

Year Published: 2013

Background: Oxidative stress (OS) related to glucose degradation products such as methylglyoxal is reportedly associated with peritoneal deterioration in patients treated with peritoneal dialysis (PD). However, the use of general antioxidant agents is limited due to their harmful effects. This study aimed to clarify the influence of the novel antioxidant molecular hydrogen (H2) on peritoneal OS ...
BONE - SPACEFLIGHT

Treatment of hydrogen molecule abates oxidative stress and alleviates bone loss induced by modeled ...

Year Published: 2013

Treatment with molecular hydrogen alleviates microgravity-induced bone loss through abating oxidative stress, restoring osteoblastic differentiation, and suppressing osteoclast differentiation and osteoclastogenesis. Introduction: Recently, it has been suggested that hydrogen gas exerts a therapeutic antioxidant activity by selectively reducing cytotoxic reactive oxygen species (ROS). The aim of ...
SKIN - CANCER

Hydrogen Protects Mice From Dermatitis Caused by Local Radiation

Year Published: 2013

Abstract Background: Radiation therapy produced unwanted side effect on normal tissues, such as radiodermatitis. Hydrogen was previously shown capable of radiation protective in both animals and cell cultures. The effect of hydrogen was now to be investigated on radiation-induced cutaneous. Objective: Development of dermatitis is a frequent side effect of radiotherapy of patients with ...
BRAIN - BRAIN INJURY

The effect of hydrogen gas on a mouse bilateral common carotid artery occlusion

Year Published: 2013

In recent studies, molecular hydrogen selectively reduced the levels of hydroxyl radicals in vitro and exerted a therapeutic anti-oxidant activity in a rat middle cerebral artery occlusion model. The aim of this study was to investigate the effect of hydrogen gas on a mouse bilateral common carotid artery occlusion (BCCAO) model. Male C57BL/6J mice were subjected to transient BCCAO with a ...
BRAIN - PARKINSON'S DISEASE

Oral ‘hydrogen water’ induces neuroprotective ghrelin secretion in mice

Year Published: 2013

The therapeutic potential of molecular hydrogen (H₂) is emerging in a number of human diseases and in their animal models, including in particular Parkinson's disease (PD). H₂ supplementation of drinking water has been shown to exert disease-modifying effects in PD patients and neuroprotective effects in experimental PD model mice. However, H₂ supplementation does not result in detectable ...
BONE - SURGERY/TRANSPLANTATION

Treatment with hydrogen molecules prevents RANKL-induced osteoclast differentiation associated with ...

Year Published: 2013

The bone protective effects of the hydrogen molecule (H2) have been demonstrated in several osteoporosis models while the underlying molecular mechanism has remained unclear. Osteoclast differentiation is an important factor related to the pathogenesis of bone-loss related diseases. In this work, we evaluated the effects of incubation with H2 on receptor activator of NFκB ligand (RANKL)-induced ...