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Studies Found: 446

LUNG - SURGERY/TRANSPLANTATION

Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway

Year Published: 2013

Hyperoxic lung injury is a major concern in critically ill patients who receive high concentrations of oxygen to treat lung diseases. Successful abrogation of hyperoxic lung injury would have a huge impact on respiratory and critical care medicine. Hydrogen can be administered as a therapeutic medical gas. We recently demonstrated that inhaled hydrogen reduced transplant-induced lung injury and ...
HEART - DIABETES

Hydrogen-rich medium suppresses the generation of reactive oxygen species, elevates the Bcl-2/Bax ...

Year Published: 2013

The purpose of the present study was to determine whether using hydrogen-rich medium (HRM) to increase hydrogen levels in endothelial cells (ECs) protects ECs from apoptosis induced by advanced glycation end products (AGEs). The thoracic aorta was removed from 2-3-year-old Sprague-Dawley rats, and ECs were isolated and cultured. After culturing ECs in the presence of AGEs and/or with HRM for 24 h, ...
SKIN - RADIOPROTECTION

The balneotherapy effect of hydrogen reduced water on UVB-mediated skin injury in hairless mice

Year Published: 2013

Exposure to UVB radiation induced skin damage that results to increase risk of skin cancer. Despite the clinical importance of skin-induced damage, antioxidants imposed limited therapeutic success. Hydrogen molecule (H2) has been known as a safe antioxidant in the prevention and therapeutic approach towards several diseases. Drinking hydrogen reduced water (HRW), inhalation of hydrogen gas, and ...
HEART - HIGH BLOOD PRESSURE

Protection of oral hydrogen water as an antioxidant on pulmonary hypertension

Year Published: 2013

This study aimed to explore the protective effect of hydrogen as an antioxidant on monocrotaline (MCT)-induced pulmonary hypertension (PH). Forty-eight SD rats were equally randomized into four groups: SHAM group, MCT group, MCT+Oral-H2 group and MCT+Inj-H2 group. The results showed that the mean pulmonary arterial pressure, right ventricle weight and right ventricular hypertrophy index in MCT ...
INTESTINE - INFLAMMATORY BOWEL DISEASE

Protective effects of hydrogen-rich saline on ulcerative colitis rat model

Year Published: 2013

Background: Ulcerative colitis (UC) is associated with enhanced production of reactive oxygen species and altered angiogenesis. Molecular hydrogen has been documented as a novel antioxidant to treat various reactive oxygen species-related diseases. The present study aimed to investigate the effects of hydrogen on UC using a rat model. Materials and methods: UC in rats was induced with ...
HEART - SURGERY/TRANSPLANTATION

Hydrogen-rich saline attenuates vascular smooth muscle cell proliferation and neointimal hyperplasia ...

Year Published: 2013

Hydrogen-rich saline has been reported to prevent neointimal hyperplasia induced by carotid balloon injury. The purpose of the present study was to further investigate the molecular mechanisms underlying this phenomenon. Daily injection of a hydrogen-rich saline solution (HRSS) in rats was employed to study the effect of hydrogen on balloon injury-induced neointimal hyperplasia and the ...
INTESTINE - INFLAMMATORY BOWEL DISEASE

Lactulose mediates suppression of dextran sodium sulfate-induced colon inflammation by increasing ...

Year Published: 2013

Background: Molecular hydrogen (H2) is a potent antioxidant and able to protect organs from oxidative stress injuries. Orally administered lactulose, a potent H2 inducer, is digested by colon microflora and significantly increases H2 production, indicating its potential anti-inflammatory action. Objective: To evaluate the anti-inflammatory effects of lactulose on dextran sodium sulfate ...
BONE - OSTEOPOROSIS

Treatment with hydrogen molecule alleviates TNFα-induced cell injury in osteoblast

Year Published: 2013

Tumor necrosis factor-alpha (TNFα) plays a crucial role in inflammatory diseases such as rheumatoid arthritis and postmenopausal osteoporosis. Recently, it has been demonstrated that hydrogen gas, known as a novel antioxidant, can exert therapeutic anti-inflammatory effect in many diseases. In this study, we investigated the effect of treatment with hydrogen molecule (H2) on TNFα-induced cell ...
SPLEEN - RADIOPROTECTION

Protective effect of hydrogen-rich saline against radiation-induced immune dysfunction

Year Published: 2014

Recent studies showed that hydrogen can be used as an effective radioprotective agent through scavenging free radicals. This study was undertaken to evaluate the radioprotective effects of hydrogen on immune system in mice. H2 was dissolved in physiological saline using an apparatus produced by our department. Spleen index and histological analysis were used to evaluate the splenic structural ...
KIDNEY - HIGH BLOOD PRESSURE

Consumption of hydrogen-rich water alleviates renal injury in spontaneous hypertensive rats

Year Published: 2014

In hypertensive animals and patients, oxidative stress represents the primary risk factor for progression of renal disease. Recently, it has been demonstrated that hydrogen, as a novel antioxidant, can selectively reduce hydroxyl radicals and peroxynitrite anion to exert therapeutic antioxidant activity. Herein, we investigated the protective effect of hydrogen-rich water (HW) against renal injury ...
HEART - HEART ATTACK

Hydrogen gas protects against serum and glucose deprivation-induced myocardial injury in H9c2 cells ...

Year Published: 2014

Ischemia or hypoxia‑induced myocardial injury is closely associated with oxidative stress. Scavenging free radicals and/or enhancing endogenous antioxidative defense systems may be beneficial for the impediment of myocardial ischemic injury. Hydrogen (H2) gas, as a water‑ and lipid‑soluble small molecule, is not only able to selectively eliminate hydroxyl (·OH) free radicals, but also to ...
EYE - RETINAL INJURY

Hydrogen-rich saline promotes survival of retinal ganglion cells in a rat model of optic nerve crush

Year Published: 2014

Objective: To investigate the effect of molecular hydrogen (H2) in a rat model subjected to optic nerve crush (ONC). Methods: We tested the hypothesis that after optic nerve crush (ONC), retinal ganglion cell (RGC) could be protected by H₂. Rats in different groups received saline or hydrogen-rich saline every day for 14 days after ONC. Retinas from animals in each group underwent measurements ...
HEART - ATHEROSCLEROSIS

Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial ...

Year Published: 2014

Background: The redox imbalance between nitric oxide and superoxide generated in the endothelium is thought to play a pivotal role in the development of endothelial dysfunction. A third reactive oxygen species (ROS), H2O2, is known to have both beneficial and detrimental effects on the vasculature. Nonetheless, the influence of the hydroxyl radical, a byproduct of H2O2 decay, is unclear, and there ...
LIVER - ROS-SCAVENGING

Hepatic oxidoreduction-related genes are upregulated by administration of hydrogen-saturated ...

Year Published: 2014

The effects of the administration of molecular hydrogen-saturated drinking water (hydrogen water) on hepatic gene expression were investigated in rats. Using DNA microarrays, 548 upregulated and 695 downregulated genes were detected in the liver after 4 weeks of administration of hydrogen water. Gene Ontology analysis revealed that genes for oxidoreduction-related proteins, including ...
EAR - HEARING LOSS

Inhaled hydrogen gas therapy for prevention of noise-induced hearing loss through reducing reactive ...

Year Published: 2014

Reactive oxygen species (ROS) that form in the inner ear play an important role in noise-induced hearing loss (NIHL). Recent studies have revealed that molecular hydrogen (H2) has great potential for reducing ROS. In this study, we examined the potential of hydrogen gas to protect against NIHL. We tested this hypothesis in guinea pigs with 0.5%, 1.0% and 1.5% H2 inhalation in air for 5h a day ...
EAR - CANCER

Hydrogen protects auditory hair cells from cisplatin-induced free radicals

Year Published: 2014

Cisplatin is a widely used chemotherapeutic agent for the treatment of various malignancies. However, its maximum dose is often limited by severe ototoxicity. Cisplatin ototoxicity may require the production of reactive oxygen species (ROS) in the inner ear by activating enzymes specific to the cochlea. Molecular hydrogen was recently established as an antioxidant that selectively reduces ROS, and ...
BRAIN - BRAIN INJURY

Neuroprotective Effect of Hydrogen-Rich Saline against Neurologic Damage and Apoptosis in Early ...

Year Published: 2014

Backgrounds: Early brain injury (EBI) plays a key role in the pathogenesis of subarachnoid hemorrhage (SAH). Neuronal apoptosis is involved in the pathological process of EBI. Hydrogen can inhibit neuronal apoptosis and attenuate EBI following SAH. However, the molecular mechanism underlying hydrogen-mediated anti-apoptotic effects in SAH has not been elucidated. In the present study, we aimed to ...
LUNG - SEPSIS

Saturated hydrogen saline attenuates lps-induced lung disfuction

Year Published: 2015

Acute lung injury induced by lipopolysaccharides (LPSs) is caused by pulmonary inflammation and pulmonary vascular permeability. Activation of p38 mitogen-activated protein kinase causes inflammation, and proinflammatory cytokines and oxidative stress induce autophagy, a catabolic mechanism responsible for protein degradation and recycling of damaged proteins and cytoplasmic organelles. If not ...
LUNG - SEPSIS

Hydrogen-rich saline ameliorates lung injury associated with cecal ligation and puncture-induced ...

Year Published: 2015

Aims: Although hydrogen has been proved to be a novel therapeutic medical gas in several lung injury animal models, to our knowledge, it has not been tested yet in acute lung injury (ALI) induced by cecal ligation and puncture (CLP). This study was to investigate the hypothesis that hydrogen could ameliorate CLP-induced lung injury in rats. Methods and results: Our experiments exhibited that gas ...
ENDOTHELIUM - SEPSIS

Protective effects of hydrogen-rich medium on lipopolysaccharide-induced monocytic adhesion and ...

Year Published: 2015

We observed the effect of hydrogen-rich medium on lipopolysaccharide (LPS)-induced human umbilical vein endothelial cells (HUVECs), hyaline leukocyte conglutination, and permeability of the endothelium. Endotheliocytes were inoculated on 6-well plates and randomly divided into 4 groups: control, H2, LPS, LPS+H2, H2, and LPS+H2 in saturated hydrogen-rich medium. We applied Wright's stain-ing to ...
BRAIN - DIABETES

Protective effect of hydrogen‑rich medium against high glucose‑induced apoptosis of Schwann ...

Year Published: 2015

Diabetic peripheral neuropathy (DPN) is considered to be one of the most prevalent and life threatening microvascular diabetic complications. DPN affects up to 50% of patients with diabetes mellitus and there are currently no efficacious therapeutic strategies available for its treatment. Previous studies have reported that oxidative stress and poly(ADP‑ribose) polymerase‑1 (PARP‑1) may be ...
ENDOTHELIUM - SEPSIS

Hydrogen-Rich Medium Attenuated Lipopolysaccharide-Induced Monocyte-Endothelial Cell Adhesion and ...

Year Published: 2015

Sepsis is the leading cause of death in critically ill patients. In recent years, molecular hydrogen, as an effective free radical scavenger, has been shown a selective antioxidant and anti-inflammatory effect, and it is beneficial in the treatment of sepsis. Rho-associated coiled-coil protein kinase (ROCK) participates in junction between normal cells, and regulates vascular endothelial ...
HEART - DIABETES

Treatment with hydrogen molecule attenuates cardiac dysfunction in streptozotocin-induced diabetic ...

Year Published: 2015

Introduction: Diabetic cardiomyopathy, a disorder of the heart muscle in diabetic patients, is one of the major causes of heart failure. The aim of present study was to investigate the therapeutic effect of hydrogen molecule on streptozotocin-induced diabetic cardiomyopathy in mice. Methods: Diabetes was induced in adult male mice by consecutive peritoneal injection of streptozotocin (50 ...
SPINE - SPINAL CORD INJURY

Hydrogen-rich saline injection into the subarachnoid cavity within 2 weeks promotes recovery after ...

Year Published: 2015

Hydrogen can relieve tissue-damaging oxidative stress, inflammation and apoptosis. Injection of hydrogen-rich saline is an effective method for transporting molecular hydrogen. We hypothesized that hydrogen-rich saline would promote the repair of spinal cord injury induced by Allen's method in rats. At 0.5, 1, 2, 4, 8, 12 and 24 hours after injury, then once daily for 2 weeks, 0.25 mL/kg ...
KIDNEY - HAEMODIALYSIS

Dialysate With High Dissolved Hydrogen Facilitates Dissociation of Indoxyl Sulfate From Albumin

Year Published: 2015

Protein-bound toxins such as indoxyl sulfate (IS) are not efficiently removed by conventional hemodialysis (HD). To improve the removal of IS, we performed an in vitro study to evaluate the effects of high dissolved hydrogen on the dissociation of IS from albumin using simulated HD. Wasted dialysate from peritoneal dialysis was concentrated a hundred times using extracorporeal ultrafiltration ...