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Studies Found: 446

BRAIN - BRAIN INJURY

Hydrogen-Rich Saline Attenuated Subarachnoid Hemorrhage-Induced Early Brain Injury in Rats by ...

Year Published: 2015

Early brain injury (EBI), highlighted with inflammation and apoptosis, occurring within 72 h after subarachnoid hemorrhage (SAH), is associated with the prognosis of SAH. Recent studies have revealed that hydrogen-rich saline (HS) exerted multiple neuroprotective properties in many neurological diseases including SAH, involved to anti-oxidative and anti-apoptotic effect. We have previously ...
EYE - RADIOPROTECTION

Sirtuin Type 1 Mediates the Retinal Protective Effect of Hydrogen-Rich Saline Against Light-Induced ...

Year Published: 2015

Purpose: Molecular hydrogen has been used as an antioxidant to treat many diseases in clinical and animal studies. However, the therapeutic mechanism of molecular hydrogen remains unclear. We previously reported mitigation of light-induced damage in the rat retina by intraperitoneal injection of hydrogen-rich saline (HRS). In the present study, we investigated whether Sirtuin Type 1 (Sirt1), a ...
EYE - RETINAL INJURY

Hydrogen-rich saline reduces cell death through inhibition of DNA oxidative stress and ...

Year Published: 2015

Overactivation of poly (ADP-ribose) polymerase 1 (PARP-1), as a result of sustained DNA oxidation in ischemia‑reperfusion injury, triggers programmed cell necrosis and apoptosis. The present study was conducted to demonstrate whether hydrogen‑rich saline (HRS) has a neuroprotective effect on retinal ischemia reperfusion (RIR) injury through inhibition of PARP‑1 activation. RIR was induced by ...
BRAIN - ALZHEIMER'S DISEASE

Hydrogen-rich water attenuates amyloid β-induced cytotoxicity through upregulation of Sirt1-FoxO3a ...

Year Published: 2015

Amyloid β (Aβ) peptides are identified in cause of neurodegenerative diseases such as Alzheimer's disease (AD). Previous evidence suggests Aβ-induced neurotoxicity is linked to the stimulation of reactive oxygen species (ROS) production. The accumulation of Aβ-induced ROS leads to increased mitochondrial dysfunction and triggers apoptotic cell death. This suggests antioxidant therapies may be ...
HEART - HIGH BLOOD PRESSURE

Hydrogen ameliorates pulmonary hypertension in rats by anti-inflammatory and anti-oxidant effects

Year Published: 2015

Objective: The pathogenesis of pulmonary arterial hypertension (PAH) involves reactive oxygen species and inflammation. Beneficial effects of molecular hydrogen, which exerts both anti-inflammatory and antioxidative effects, have been reported for various pathologic conditions. We therefore hypothesized that molecular hydrogen would improve monocrotaline (MCT)-induced PAH in rats. Methods: ...
WHOLE BODY - ROS-SCAVENGING

Antioxidant activities of nano-bubble hydrogen-dissolved water assessed by ESR and 2,2′-bipyridyl ...

Year Published: 2015

We prepared nano-bubble hydrogen-dissolved water (nano-H water) which contained hydrogen nano-bubbles of <717-nm diameter for 54% of total bubbles. In the DMPO-spin trap electron spin resonance (ESR) method, the DMPO-OH:MnO ratio, being attributed to amounts of hydroxyl radicals (OH), was 2.78 for pure water (dissolved hydrogen [DH]≤0.01ppm, oxidation-reduction potential [ORP]=+324mV), 2.73 for ...
WHOLE BODY - ROS-SCAVENGING

The Evaluation and Quantitation of Dihydrogen Metabolism Using Deuterium Isotope in Rats

Year Published: 2015

Purpose: Despite the significant interest in molecular hydrogen as an antioxidant in the last eight years, its quantitative metabolic parameters in vivo are still lacking, as is an appropriate method for determination of hydrogen effectivity in the mammalian organism under various conditions. Basic procedures: Intraperitoneally-applied deuterium gas was used as a metabolic tracer and deuterium ...
PANCREAS - PANCREATITIS

Protective Effects of Hydrogen Gas on Experimental Acute Pancreatitis

Year Published: 2016

Acute pancreatitis (AP) is an inflammatory disease mediated by damage to acinar cells and pancreatic inflammation. In patients with AP, subsequent systemic inflammatory responses and multiple organs dysfunction commonly occur. Interactions between cytokines and oxidative stress greatly contribute to the amplification of uncontrolled inflammatory responses. Molecular hydrogen (H2) is a potent free ...
BRAIN - MULTIPLE SCLEROSIS

Hydrogen-rich water improves neurological functional recovery in experimental autoimmune ...

Year Published: 2016

Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease of the central nervous system (CNS). The high costs, inconvenient administration, and side effects of current Food and Drug Administration (FDA)-approved drugs often lead to poor adherence to the long-term treatment of MS. Molecular hydrogen (H2) has been reported to exhibit anti-oxidant, anti-apoptotic, anti-inflammatory, ...
EYE - RETINAL INJURY

Hydrogen-rich Saline is ineffective in oxygen-induced retinopathy

Year Published: 2016

Aims: Hydrogen-rich saline (HRS) is a novel protection against various oxidative disorders and almost all types of inflammation. Moreover, its toxicity and side effects are rarely reported. We sought to clarify the protective effect of HRS against the oxygen-induced retinopathy (OIR) in C57BL/6 J model. Main methods: The OIR in the HRS treated mice and the untreated controls were systematically ...
HEART - HIGH BLOOD PRESSURE

Inhibitory Effects of Hydrogen on Proliferation and Migration of Vascular Smooth Muscle Cells via ...

Year Published: 2016

Molecular hydrogen (H₂) has recently attracted considerable attention for the prevention of oxidative stress-related vascular diseases. The purpose of this study is to evaluate the effects of hydrogen on proliferation and migration of vascular smooth muscle cells (VSMCs) stimulated by angiotensin II (Ang II) in vitro, and on vascular hypertrophy induced by abdominal aortic coarctation (AAC) in ...
MOUTH - WOUND HEALING

Hydrogen-Rich Water Intake Accelerates Oral Palatal Wound Healing via Activation of the ...

Year Published: 2016

The wound healing process attempts to restore the integrity and function of the injured tissue. Additionally, proinflammatory cytokines, growth factors, and oxidative stress play important roles in wound healing. The aim of this study was to determine whether hydrogen-rich water intake induces the activation of the Nrf2/antioxidant defense pathway in rat palatal tissue, thereby reducing systemic ...
WHOLE BODY - AGING

Effects of Hydrogenized Water on Intracellular Biomarkers for Antioxidants, Glucose Uptake, Insulin ...

Year Published: 2016

Hydrogen has been shown in several clinical trials to be completely safe without adverse events and there are no warnings in the literature of its toxicity or adverse effects during long-term exposure. Molecular hydrogen has proven useful and convenient as a novel antioxidant and modifier of gene expression in many conditions where oxidative stress and changes in gene expression result in cellular ...
LIVER - LIVER INJURY

Hydrogen-Rich Saline Attenuates Acute Hepatic Injury in Acute Necrotizing Pancreatitis by Inhibiting ...

Year Published: 2016

Objectives: The objective of this study was to study the role of hydrogen-rich saline (HRS) on acute hepatic injury (AHI) in acute necrotizing pancreatitis (ANP). Methods: Rats were used for this study and an ANP model was induced by injecting 5% sodium taurocholate into the biliary-pancreatic duct. Experiments were performed in 3 groups: sham, ANP, and ANP + HRS (HRS). Animals were killed at 3, ...
BONE MARROW - SURGERY/TRANSPLANTATION

Successful treatment with hydrogen rich water in a case of chronic graft-versus-host-disease

Year Published: 2016

The incidence of chronic graft-versus-host-disease is rising year by year, which has become the leading cause of non-transplantation related death and has become the most difficult complication of allogeneic hematopoietic stem cell transplantation to deal with. Inflammation and fibrosis play dominant roles in the pathogenesis of chronic graft-versus-host-disease. Studies have shown that molecular ...
BLADDER - BLADDER OUTLET OBSTRUCTION

Preventive Effect of Hydrogen Water on the Development of Detrusor Overactivity in a Rat Model of ...

Year Published: 2016

Purpose: Bladder ischemia and oxidative stress contribute to the pathogenesis of bladder dysfunction caused by bladder outlet obstruction (BOO). Molecular hydrogen (H2) reportedly acts as an effective antioxidant. We investigated whether oral ingestion of hydrogen water (H2-water) has a beneficial effect on bladder function in a rat model of BOO. Materials and methods: H2-water was made by ...
LUNG - SEPSIS

Protective effect and mechanism of hydrogen treatment on lung epithelial barrier dysfunction in rats ...

Year Published: 2016

This study aimed to explore the protective effect of hydrogen and to investigate the underlying mechanism of its preliminary effect on the alveolar epithelial barrier function in septic rats. Forty-five male Sprague-Dawley rats were divided randomly into three groups (N = 15): control [saline injection (intraperitoneal, ip), air drawing; SA], acute lung injury group [lipopolysaccharide (LPS) ...
LIVER - OBSTRUCTIVE JAUNDICE

Hydrogen-rich saline protects against mitochondrial dysfunction and apoptosis in mice with ...

Year Published: 2016

Previous studies have demonstrated that hydrogen-rich saline (HS) protects against bile duct ligation (BDL)-induced liver injury by suppressing oxidative stress and inflammation. Mitochondria, which are targets of excessive reactive oxygen species and central mediators of apoptosis, have a pivotal role in hepatic injury during obstructive jaundice (OJ); however, the implications of HS in the ...
BRAIN - STROKE

Neuroprotective Effect of Hydrogen-Rich Saline in Global Cerebral Ischemia/Reperfusion Rats: ...

Year Published: 2016

Recently, it has been suggested that molecular hydrogen (H2) can selectively reduce the levels of hydroxyl radicals (.OH), and ameliorate oxidative and inflammatory injuries to organs in global cerebral ischemia reperfusion models. Global cerebral ischemia/reperfusion (I/R) can induce a sudden activation of inflammatory cytokines and later influence the systemic immunoreactivity which may ...
MUSCLE - EXCERCISE

Effects of hydrogen bathing on exercise-induced oxidative stress and delayed-onset muscle soreness

Year Published: 2016

Several studies have reported that molecular hydrogen (H2) acts as a therapeutic medical gas owing to scavenging reactive oxygen species (ROS). However, little is known about effects of H2 on exercise-induced oxidative stress. The purpose of this study was to investigate the effects of weekly hydrogen bathing on exercise-induced oxidative stress and delayed-onset muscle soreness (DOMS). Nine ...
PREGNANCY - HIGH BLOOD PRESSURE

Hydrogen inhibits cytotrophoblast cells apoptosis in hypertensive disorders complicating pregnancy

Year Published: 2016

Hypertensive disorders complicating pregnancy (HDCP) is one of the most serious medical disorders during pregnancy. Hydrogen is a therapeutic antioxidant and used to treat HDCP effectively. However, the molecular mechanism about the effect of hydrogen on HDCP still remains unclear. In this study, we found ROS content in HDCP group was significantly higher than that in the control and was reduced ...
WHOLE BODY - CANCER

Protective Effects of Hydrogen against Low-Dose Long-Term Radiation-Induced Damage to the Behavioral ...

Year Published: 2016

Molecular hydrogen (H2) has been previously reported playing an important role in ameliorating damage caused by acute radiation. In this study, we investigated the effects of H2 on the alterations induced by low-dose long-term radiation (LDLTR). All the mice in hydrogen-treated or radiation-only groups received 0.1 Gy, 0.5 Gy, 1.0 Gy, and 2.0 Gy whole-body gamma radiation, respectively. After the ...
HEART - HEART ATTACK

Hydrogen inhibits isoproterenol‑induced autophagy in cardiomyocytes in vitro and in vivo

Year Published: 2017

A previous study from our group has demonstrated that hydrogen administration can attenuate cardiovascular hypertrophy in vivo by targeting reactive oxygen species‑dependent mitogen‑activated protein kinase signaling. The aim of the present study is to determine the effect of hydrogen on cardiomyocyte autophagy during β‑adrenoceptor activation in vivo and in vitro. We prepared ...
LIVER - FATTY LIVER DISEASE (NONALCOHOLIC)

Hydrogen-rich saline improves non‑alcoholic fatty liver disease by alleviating oxidative stress ...

Year Published: 2017

Non-alcoholic fatty liver disease (NAFLD) comprises a range of liver diseases, between steatosis and non‑alcoholic steatohepatitis and liver cirrhosis, which are closely associated with diabetes mellitus. Previous studies have indicated that oxidative stress is a key factor in the development of NAFLD. Molecular hydrogen (H2) may ameliorate oxidative stress injuries by selectively neutralizing ...
LIVER - CANCER

Protective effect of hydrogen‑rich water on liver function of colorectal cancer patients treated ...

Year Published: 2017

The present study was conducted to investigate the protective effect of hydrogen-rich water on the liver function of colorectal cancer (CRC) patients treated with mFOLFOX6 chemotherapy. A controlled, randomized, single-blind clinical trial was designed. A total of 152 patients with CRC were recruited by the Department of Oncology of Taishan Hospital (Taian, China) between June 2010 and February ...