search - Hydrogen Studies

Involvement of Neutrophil Dynamics and Function in Exercise-Induced Muscle Damage and Delayed-Onset ...

Year Published: 2018

The purpose of this study was to investigate the involvement of neutrophil dynamics and function in exercise-induced muscle damage (EIMD) and delayed-onset muscle soreness (DOMS), and the effect of molecular hydrogen (H₂) intake on these parameters. Nine healthy and active young men performed H₂ and placebo bath trial in a crossover design. They carried out downhill running (-8% slope) for 30 ...

LUNG - CANCER

Therapeutic efficacy of hydrogen‑rich saline alone and in combination with PI3K inhibitor in ...

Year Published: 2018

The aim of the present study was to investigate the effects of combination therapy of LY294002, a specific inhibitor of phosphatidylinositol 3‑kinase (PI3K), with hydrogen‑rich saline on the proliferation and apoptosis of the non‑small cell lung cancer (NSCLC) A549 cell line and the mechanisms underpinning this. Excessive production of reactive oxygen species (ROS) may induce DNA mutations, ...

LIVER - METABOLIC SYNDROME

Effects of alkaline-electrolyzed and hydrogen-rich water, in a high-fat-diet nonalcoholic fatty ...

Year Published: 2018

AIM To identify the effect of hydrogen-rich water (HRW) and electrolyzed-alkaline water (EAW) on high-fat-induced non-alcoholic fatty acid disease in mice. METHODS Mice were divided into four groups: (1) Regular diet (RD)/regular water (RW); (2) high-fat diet (HFD)/RW; (3) RD/EAW; and (4) HFD/EAW. Weight and body composition were measured. After twelve weeks, animals were sacrificed, and livers ...

INTESTINE - SEPSIS

Hydrogen-Rich Saline Regulates Intestinal Barrier Dysfunction, Dysbiosis, and Bacterial ...

Year Published: 2018

Bacterial translocation is a major cause of multiple organ dysfunction syndrome in critical illness, and its management is an important therapeutic strategy. In this study, we focused on the key factors responsible for bacterial translocation including the intestinal microbiome and investigated the impact of molecular hydrogen therapy as a countermeasure against bacterial translocation in a murine ...

HEART - ATHEROSCLEROSIS

Administration of hydrogen-rich water prevents vascular aging of the aorta in LDL receptor-deficient ...

Year Published: 2018

The main cause of arteriosclerosis is atherosclerosis in the aorta. Atherosclerosis is recognized as a chronic inflammatory condition that begins with the dysfunction or activation of arterial endothelium. Low-density lipoprotein (LDL) and especially its oxidized form play a key role in endothelial dysfunction and atherogenesis. Recent studies showed that senescent cells are involved in the ...

BRAIN - ALZHEIMER'S DISEASE

Hydrogen-rich water improves cognitive impairment gender-dependently in APP/PS1 mice without ...

Year Published: 2018

Alzheimer's disease (AD) is characterised as a provoked inflammatory response and oxidative stress along with amyloid β peptide (Aβ) deposition and neurofibrillary tangles in the brain, and effective treatment is greatly needed. Molecular hydrogen, which has been proposed to be an antioxidant that selectively reduces reactive oxygen species, was found to exert beneficial effects in Aβ ...

WHOLE BODY - HIGH BLOOD PRESSURE

Hydrogen gas reduces chronic intermittent hypoxia‐induced hypertension by inhibiting sympathetic ...

Year Published: 2018

Molecular hydrogen is reported to be used medically to ameliorate various systemic pathological conditions. This study aimed to investigate the effect of hydrogen (H2) gas on hypertension induced by intermittent hypoxia in rats. The adult rats were exposed to chronic intermittent hypoxia (CIH) 8 hours/day for 5 weeks and/or H 2 gas 2 hours/day. We found that the systolic and diastolic blood ...

BRAIN - AUTISM SPECTRUM DISORDER

Hydrogen-Rich Water Ameliorates Autistic-Like Behavioral Abnormalities in Valproic Acid-Treated ...

Year Published: 2018

Due to its anti-inflammatory and anti-oxidative effects, recent research has demonstrated that molecular hydrogen can serve as a new medical approach for depression, anxiety and traumatic brain injury. However, its potential effects on neurodevelopmental diseases, such as autism are still elusive. The present study aims to investigate the potential effects of hydrogen-rich water (HRW) ...

MUSCLE - ATHEROSCLEROSIS

Hydrogen molecules (H2) improve perfusion recovery via antioxidant effects in experimental ...

Year Published: 2018

Reactive oxygen species (ROS) impair neovascularization and perfusion recovery following limb ischemia in patients with peripheral arterial disease (PAD). Hydrogen molecules (H2) comprise an antioxidant gas that has been reported to neutralize cytotoxic ROS. The present study investigated whether H2 may serve as a novel therapeutic strategy for PAD. H2‑saturated water or dehydrogenized water was ...

NOSE - RHINITIS

Beneficial effects of hydrogen gas inhalation on a murine model of allergic rhinitis

Year Published: 2018

Allergic rhinitis (AR) is a common chronic inflammatory condition. It has been previously indicated that oxidative stress may contribute to allergic inflammation, including AR. Although molecular hydrogen (H2), an antioxidative agent, has been effective in treatment of numerous oxidative stress-associated diseases, the effect of inhalation of a high concentration of H2 on AR remains unknown. In ...

SKIN - WOUND HEALING

Hydrogen gas inhalation protects against cutaneous ischaemia/reperfusion injury in a mouse model of ...

Year Published: 2018

Pressure ulcer formation depends on various factors among which repetitive ischaemia/reperfusion(I/R) injury plays a vital role. Molecular hydrogen (H2 ) was reported to have protective effects on I/R injuries of various internal organs. In this study, we investigated the effects of H2 inhalation on pressure ulcer and the underlying mechanisms. H2 inhalation significantly reduced wound area, ...

HEART - HIGH BLOOD PRESSURE

Protective effect of hydrogen-rich saline on pressure overload-induced cardiac hypertrophyin rats: ...

Year Published: 2018

Background: Molecular hydrogen has been shown to have antioxidant effect and have been used to prevent oxidative stress-related diseases. The goal of this study was to explore if hydrogen-rich saline (HRS) plays a cardioprotective effect on abdominal aortic constriction (AAC) induced cardiac hypertrophy in rats. 60adult Sprague-Dawley rats received surgically the AAC for 6-week. After the surgery, ...

HEART - HEART FAILURE

Inhalation of Hydrogen Attenuates Progression of Chronic Heart Failure via Suppression of Oxidative ...

Year Published: 2018

Background: Continuous damage from oxidative stress and apoptosis are the important mechanisms that facilitate chronic heart failure (CHF). Molecular hydrogen (H2) has potentiality in the aspects of anti-oxidation. The objectives of this study were to investigate the possible mechanism of H2 inhalation in delaying the progress of CHF. Methods and Results: A total of 60 Sprague-Dawley (SD) rats ...

EAR - ENVIRONMENTAL POLLUTION

The Effect of Hydrogen Inhalation on Temporary Threshold Shift Following Simultaneous Exposure to ...

Year Published: 2018

Background: People might simultaneously be exposed to noise and carbon monoxide in occupational settings. The previous studies revealed that the inhalation of molecular hydrogen (H2) exerts some healing effects on multiple diseases including hearing loss. Objectives: The levels of free radicals have been shown to increase due to the exposure to noise plus carbon monoxide. This study examined the ...

WHOLE BODY - METABOLIC SYNDROME

L-Arabinose Elicits Gut-Derived Hydrogen Production and Ameliorates Metabolic Syndrome in C57BL/6J ...

Year Published: 2019

Obesity and metabolic syndrome (MS) associated with excess calorie intake has become a great public health concern worldwide. L-arabinose, a naturally occurring plant pentose, has a promising future as a novel food ingredient with benefits in MS; yet the mechanisms remain to be further elucidated. Gut microbiota is recently recognized to play key roles in MS. Molecular hydrogen, an emerging ...

LUNG - SEPSIS

Hydrogen gas reduces HMGB1 release in lung tissues of septic mice in an Nrf2/HO-1-dependent pathway

Year Published: 2019

Background: Lung injury is a vital contributor of mortality in septic patients. Our previous studies have found that molecular hydrogen (H2), which has anti-oxidant, anti-inflammatory, and anti-apoptosis effects, had a therapeutic effect on a septic animal model through increasing expression of nuclear factor-erythroid 2-related factor 2 (Nrf2). The aim of this research was to investigate the ...

HEART - HEART ATTACK

Hydrogen-rich saline alleviates inflammation and apoptosis in myocardial I/R injury via ...

Year Published: 2019

Ischemia/reperfusion (I/R)‑induced inflammatory reaction is one of the most important elements in myocardial I/R injury. In addition, autophagy serves an important role in normal cardiac homeostasis, and obstructions to the autophagy process lead to severe consequences for the heart. Hydrogen exerts an effective therapeutic role in numerous diseases associated with I/R injury via its ...

LIVER - SURGERY/TRANSPLANTATION

Hydrogen-rich solution attenuates cold ischemia-reperfusion injury in rat liver transplantation

Year Published: 2019

Background: Liver transplantation (LT) is considered the standard treatment for end-stage liver disease, but ideal donors remain in limited supply, resulting in an unavoidable increase in the need to use grafts from marginal donors. The attenuation of ischemia-reperfusion injury (IRI) in such marginal donors is therefore crucial for reducing the possibility of the primary non-function of grafts ...

LUNG - SURGERY/TRANSPLANTATION

Protective effects of a hydrogen-rich solution during cold ischemia in rat lung transplantation

Year Published: 2019

Background: Molecular hydrogen can reduce the oxidative stress of ischemia-reperfusion injury in various organs for transplantation and potentially improve survival rates in recipients. This study aimed to evaluate the protective effects of a hydrogen-rich preservation solution against ischemia-reperfusion injury after cold ischemia in rat lung transplantation. Methods: Lewis rats were divided ...

WHOLE BODY - EXCERCISE

Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, ...

Year Published: 2019

Acute physical exercise increases reactive oxygen species in skeletal muscle, leading to tissue damage and fatigue. Molecular hydrogen (H2) acts as a therapeutic antioxidant directly or indirectly by inducing antioxidative enzymes. Here, we examined the effects of drinking H2 water (H2-infused water) on psychometric fatigue and endurance capacity in a randomized, double-blind, placebo-controlled ...

HEART - HEART ATTACK

Attenuation of Cardiac Ischaemia-reperfusion Injury by Treatment with Hydrogen-rich Water

Year Published: 2019

Background: Hydrogen has been shown to exert a bioactive effect on the myocardium. This study examined the signalling pathways for hydrogen attenuating ischaemia-reperfusion injury. Methods: In total, 20 male Wistar rats were evaluated for the effects of hydrogen-rich water on ischaemia-reperfusion in hearts. Left ventricular tissue was taken for screening and analysis of active protein factors by ...

WHOLE BODY - AGING

Supplementation with hydrogen-producing composition confers beneficial effects on physiology and ...

Year Published: 2019

Recently, molecular hydrogen (H 2 )has become known as a new class of antioxidants and redox-modulating interventions. Effects of H 2 have been documented for many acute and chronic pathological conditions. The present study was aimed at determining the effect of hydrogen on the physiology and longevity of Drosophila. The flies were given a patented food supplement consisting of a mixture of inert ...

LIVER - FATTY LIVER DISEASE (NONALCOHOLIC)

Hydrogen-rich water reduces liver fat accumulation and improves liver enzyme profiles in patients ...

Year Published: 2019

Background and aims: While non-alcoholic fatty liver disease (NAFLD) is rapidly becoming the most common liver disease worldwide, its treatment remains elusive. Since metabolic impairment plays a major role in NAFLD pathogenesis, any pharmaceuticals, such as molecular hydrogen (H2), that advance lipid and glucose metabolism could be appropriate to tackle this complex condition. The aim of this ...

BRAIN - DEMENTIA

FoxO1-mediated autophagy plays an important role in the neuroprotective effects of hydrogen in a rat ...

Year Published: 2019

Vascular dementia (VD) is a heterogeneous group of brain disorders in which cognitive impairment is attributed to cerebrovascular pathologies. Autophagy, a self-cannibalization mechanism, has been demonstrated to be involved in VD progression. Molecular hydrogen is known for its powerful anti-oxidative, anti-apoptotic, and anti-inflammatory activities, and it is also involved in autophagy. ...

LIVER - EXCERCISE

Hydrogen water intake may suppress liver glycogen utilization without affecting redox biomarkers ...

Year Published: 2019

BACKGROUND: Studies have revealed that molecular hydrogen (H2) exhibits therapeutic effects against various diseases through biological activities such as antioxidation. However, little is known about the effects of H2 on redox biomarkers and related indicators during exercise. Therefore, we examined whether 2 weeks of H2 water intake could affect the redox biomarkers, energy metabolism, and ...