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Studies Found: 446

BRAIN - SEIZURE

Hydrogen Alleviates Necroptosis and Cognitive Deficits in Lithium–Pilocarpine Model of Status ...

Year Published: 2019

Status epilepticus without prompt seizure control always leads to neuronal death and long-term cognitive deficits, but effective intervention is still absent. Here, we found that hydrogen could alleviate the hippocampus-dependent spatial learning and memory deficit in lithium–pilocarpine model of status epilepticus in rats, as evidenced by the results in Morris water maze test. Hydrogen ...
BRAIN - TRAUMATIC BRAIN INJURY

Case Report: Buccal administration of hydrogen-producing blend after a mild traumatic brain injury ...

Year Published: 2019

Background: Sport-related mild traumatic brain injury (TBI) is a serious trauma that could impair brain function of an injured athlete. Treatment solutions for mild TBI typically concentrate on complete rest, while non-traditional therapeutic options remain largely ineffective. Molecular hydrogen (H 2 ) is an innovative neuroprotective agent that can easily reach the brain, yet no data are ...
BRAIN - BRAIN INJURY

Hydrogen ventilation combined with mild hypothermia improves short-term neurological outcomes in a ...

Year Published: 2019

Despite its poor outcomes, therapeutic hypothermia (TH) is the current standard treatment for neonatal hypoxic-ischaemic encephalopathy (HIE). In this study, due to its antioxidant, anti-inflammatory, and antiapoptotic properties, the effectiveness of molecular hydrogen (H2) combined with TH was evaluated by means of neurological and histological assessments. Piglets were divided into three ...
BONE MARROW - CANCER

Hydrogen Gas Inhalation Alleviates Radiation-Induced Bone Marrow Damage in Cancer Patients

Year Published: 2019

Abstract: Background: Radiotherapy for cancer patients is one of the useful methods; however, it not only impairs the targeted tumor tissues but also damage the normal surrounding tissues. Intensity modulated radiation therapy (IMRT) for cancer patients has been recently performed to alleviate the adverse effects, but reducing bone marrow damage is limited in the patients with multiple tumor ...
WHOLE BODY - SLEEP APNEA

Hydrogen gas reduces chronic intermittent hypoxia-induced hypertension by inhibiting sympathetic ...

Year Published: 2019

Molecular hydrogen is reported to be used medically to ameliorate various systemic pathological conditions. This study aimed to investigate the effect of hydrogen (H2 ) gas on hypertension induced by intermittent hypoxia in rats. The adult rats were exposed to chronic intermittent hypoxia (CIH) 8 hours/day for 5 weeks and/or H 2 gas 2 hours/day. We found that the systolic and diastolic blood ...
KIDNEY - SLEEP APNEA

Hydrogen protects against chronic intermittent hypoxia induced renal dysfunction by promoting ...

Year Published: 2019

Aims Hydrogen gas (H2) has a diversity of effects such as anti-apoptotic, anti-inflammatory and anti-oxidative properties. However, molecular mechanism underlying the potential effect of H2 on chronic intermittent hypoxia (CIH) induced renal injury remains obscure. Materials and methods In the present study, adult male Sprague-Dawley rats were randomly allocated into four groups: control (CON) ...
LUNG - ENVIRONMENTAL POLLUTION

Hydrogen ameliorates lung injury in a rat model of subacute exposure to concentrated ambient PM2.5 ...

Year Published: 2019

Background: Ambient fine particulate matter (PM2.5) could induce lung injury. Aryl hydrocarbon receptor (AhR) is involved in the molecular mechanisms of prooxidative and pro-inflammatory effect of PM2.5. Molecular hydrogen has antioxidant properties. The protective effect and mechanism of hydrogen on PM2.5-induced lung injury remain unclear. Objectives: This study aimed to determine whether ...
WHOLE BODY - SEPSIS

Hydrogen alleviates mitochondrial dysfunction and organ damage via autophagy‑mediated NLRP3 ...

Year Published: 2019

Sepsis is a highly heterogeneous syndrome that is caused by a dysregulated host response to infection. The disproportionate inflammatory response to invasive infection is a triggering event inducing sepsis. The activation of inflammasomes in sepsis can amplify inflammatory responses. It has been reported that damaged mitochondria contribute to NACHT, LRR and PYD domains‑containing protein 3 ...
WHOLE BODY - FASTING

Hydrogen Water on Survival Rate after Fasting in Drosophila Model

Year Published: 2019

In this study, we use a Drosophila model to examine the effect of drinking hydrogen water on survival rate after fasting. The cells produce free radicals to help to absorb nutritious substances due to metabolism, which is a unique phenomenon for biological organisms. But if over the tension of free radicals can seriously affect the physiological functions, and even lead to death. Recently, ...
BRAIN - ENVIRONMENTAL POLLUTION

Hydrogen rich water ameliorate Trimethyltin induced spatial learning and memory impairment by ...

Year Published: 2020

Background: As an important member of organic tin compounds, Trimethyltin (TMT) exists widely in industrial and agricultural productions. TMT can induce significant neurodegeneration in the limbic system, particular in hippocampus. However, the molecular mechanisms in TMT-induced learning and memory impairment are not fully clear. Thus, this research was to explore the role of Synaptophysin (SYP) ...
BRAIN - TRAUMATIC BRAIN INJURY

Hydrogen inhalation inhibits microglia activation and neuroinflammation in a rat model of traumatic ...

Year Published: 2020

Traumatic brain injury (TBI) is a major cause of mortality and disability worldwide. To date, therapies to treat any forms of TBI are still limited. Recent studies have demonstrated the potential neuroprotective effects of molecular hydrogen on TBI. Although it has been demonstrated that hydrogen inhalation (HI) for about 5 hrs immediately after TBI has a beneficial effect on brain injury, the ...
BRAIN - SEPSIS

Hydrogen gas alleviates blood-brain barrier impairment and cognitive dysfunction of septic mice in ...

Year Published: 2020

Sepsis-associated encephalopathy (SAE) is a cognitive impairment caused by sepsis and is related to increased morbidity and mortality. Damage to the blood-brain barrier (BBB) has been proved to be one of the important causes of SAE. Molecular hydrogen (H2) is a promising method for the treatment of SAE, yet the underlying mechanism is not clear. This study was designed to demonstrate whether H2 ...
BRAIN - SLEEP DEPRIVATION

Hydrogen vs. Caffeine for Improved Alertness in Sleep-Deprived Humans

Year Published: 2020

Molecular hydrogen (H2) has been suggested as an agent capable of exerting neuromodulating effects; yet, its potential to affect brain circuits linked to alertness remains poorly examined. In this randomized controlled cross-over pilot trial, we compared acute effects of single-dose hydrogen-rich water (HRW) and caffeine on estimates by the Visual Analog Scale (VAS) for alertness and on Attention ...
WHOLE BODY - BLOOD COMPOSITION

Effects of long-term hydrogen intervention on the physiological function of rats

Year Published: 2020

The potential therapeutic effects of molecular hydrogen (H2) have now been confirmed in various human and animal-disease models. However, the effects of H2 on the physiological function in a normal state have been largely neglected. Hydrogen-rich water (HRW) intake and hydrogen inhalation (HI) are the most common used methods for hydrogen administration, the difference in the effects between HRW ...
BRAIN - SEPSIS

Hydrogen Gas Alleviates Sepsis-Induced Brain Injury by Improving Mitochondrial Biogenesis Through ...

Year Published: 2020

Sepsis-associated encephalopathy (SAE) affects approximately one-third of septic patients, and there is a lack of effective therapeutics for SAE. Hydrogen gas is a new medical gas that exerts anti-inflammation, antioxidation, and anti-apoptotic effects and can effectively protect septic mice. Mitochondrial dysfunction, which can be improved by mitochondrial biogenesis, is a type of molecular ...
BRAIN - BRAIN INJURY

Hydrogen Gas Attenuates Hypoxic-Ischemic Brain Injury via Regulation of the MAPK/HO-1/PGC-1a Pathway ...

Year Published: 2020

Neonatal hypoxic-ischemic encephalopathy (HIE) is a leading cause of death in neonates with no effective treatments. Recent advancements in hydrogen (H2) gas offer a promising therapeutic approach for ischemia reperfusion injury; however, the impact of this approach for HIE remains a subject of debate. We assessed the therapeutic effects of H2 gas on HIE and the underlying molecular mechanisms in ...
ENDOTHELIUM - SHOCK

Hydrogen Gas Inhalation Attenuates Endothelial Glycocalyx Damage and Stabilizes Hemodynamics in a ...

Year Published: 2020

Background: Hydrogen gas (H2) inhalation during hemorrhage stabilizes post-resuscitation hemodynamics, improving short-term survival in a rat hemorrhagic shock and resuscitation (HS/R) model. However, the underlying molecular mechanism of H2 in HS/R is unclear. Endothelial glycocalyx (EG) damage causes hemodynamic failure associated with HS/R. In this study, we tested the hypothesis that H2 ...
HEART - CARDIAC ARREST

Hydrogen gas inhalation alleviates oxidative stress in patients with post-cardiac arrest syndrome

Year Published: 2020

Oxidative stress plays a key role in the pathophysiology of post-cardiac arrest syndrome. Molecular hydrogen reduces oxidative stress and exerts anti-inflammatory effects in an animal model of cardiac arrest. However, its effect on human post-cardiac arrest syndrome is unclear. We consecutively enrolled five comatose post-cardiac arrest patients (three males; mean age, 65 ± 15 years; four ...
BLOOD - BLOOD COMPOSITION

Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells ...

Year Published: 2020

The evidence for the beneficial effects of drinking hydrogen-water (HW) is rare. We aimed to investigate the effects of HW consumption on oxidative stress and immune functions in healthy adults using systemic approaches of biochemical, cellular, and molecular nutrition. In a randomized, double-blind, placebo-controlled study, healthy adults (20-59 y) consumed either 1.5 L/d of HW (n = 20) or plain ...
SKIN - WOUND HEALING

Hydrogen generating patch improves skin cell viability, migration activity, and collagen expression

Year Published: 2020

Molecular hydrogen recently attracted lots of attention in biomedical community because of its abilities to modulate signal transduction, protein phosphorylation, and gene expression that enable its anti-inflammatory, anti-allergy, and anti-apoptotic activities. However, controllable and local delivery of hydrogen molecules to tissues still remains challenging. Here, we propose a new method of ...
LUNG - SURGERY/TRANSPLANTATION

Hydrogen water alleviates obliterative airway disease in mice

Year Published: 2020

Objective: Bronchiolitis obliterans syndrome arising from chronic airway inflammation is a leading cause of death following lung transplantation. Several studies have suggested that inhaled hydrogen can protect lung grafts from ischemia-reperfusion injury via anti-inflammatory and -oxidative mechanisms. We investigated whether molecular hydrogen-saturated water can preserve lung allograft function ...
LUNG - ASTHMA

Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch

Year Published: 2020

Mechanisms mediating the protective effects of molecular hydrogen (H2) are not well understood. This study explored the possibility that H2 exerts its anti-inflammatory effect by modulating energy metabolic pathway switch. Activities of glycolytic and mitochondrial oxidative phosphorylation systems were assessed in asthmatic patients and in mouse model of allergic airway inflammation. The effects ...
LUNG - CANCER

Hydrogen gas represses the progression of lung cancer via downregulating CD47

Year Published: 2020

Hydrogen gas (H2) has been identified to play an anti-tumor role in several kinds of cancers, but the molecular mechanisms remains largely unknown. In our previous study, our project group found that H2 could decreased the expression of CD47 in lung cancer A549 cells via using the next generation sequencing, indicating that CD47 might be involved in H2-mediated lung cancer repression. Therefore, ...
KIDNEY - SURGERY/TRANSPLANTATION

Hydrogen-rich water alleviates cyclosporine A-induced nephrotoxicity via the Keap1/Nrf2 signaling ...

Year Published: 2020

Oxidative stress induced by long-term cyclosporine A (CsA) administration is a major cause of chronic nephrotoxicity, which is characterized by tubular atrophy, tubular cell apoptosis, and interstitial fibrosis in the progression of organ transplantation. Although hydrogen-rich water (HRW) has been used to prevent various oxidative stress-related diseases, its underlying mechanisms remain unclear. ...
LIVER - LIVER DISEASE

Hydrogen inhalation alleviates nonalcoholic fatty liver disease in metabolic syndrome rats

Year Published: 2020

Hydrogen exhibits therapeutic and preventive effects against various diseases. The present study investigated the potential protective effect and dose‑dependent manner of hydrogen inhalation on high fat and fructose diet (HFFD)‑induced nonalcoholic fatty liver disease (NAFLD) in Sprague‑Dawley rats. Rats were randomly divided into four groups: i) Control group, regular diet/air inhalation; ...