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Studies Found: 446

BONE - RHEUMATOID ARTHRITIS

Molecular hydrogen inhibits lipopolysaccharide/interferon γ-induced nitric oxide production through ...

Year Published: 2011

Molecular hydrogen has been reported to be effective for a variety of disorders and its effects have been ascribed to the reduction of oxidative stress. However, we have recently demonstrated that hydrogen inhibits type I allergy through modulating intracellular signal transduction. In the present study, we examined the hydrogen effects on lipopolysaccharide/interferon γ LPS/IFNγ-induced nitric ...
MUSCLE - DISUSE ATROPHY

Effect of Molecular Hydrogen Saturated Alkaline Electrolyzed Water on Disuse Muscle Atrophy in ...

Year Published: 2011

The objectives of this paper were to determine the level of oxidative stress in atrophied gastrocnemius, and to verify the effect of molecular hydrogen (H2) saturated alkaline electrolyzed water (HSW) on gastrocnemius atrophy by modifying the redox status, indicated by 8-hydroxy-2'-deoxyguanosine (8-OHdG), malondialdehyde (MDA), and superoxide dismutase (SOD)-like activity. Female Wistar rats were ...
BONE - ROS-SCAVENGING

Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene ...

Year Published: 2011

Background: Molecular hydrogen (H2) functions as an extensive protector against oxidative stress, inflammation and allergic reaction in various biological models and clinical tests; however, its essential mechanisms remain unknown. H2 directly reacts with the strong reactive nitrogen species peroxynitrite (ONOO-) as well as hydroxyl radicals (•OH), but not with nitric oxide radical (NO•). We ...
WHOLE BODY - SEPSIS

Combination therapy with molecular hydrogen and hyperoxia in a murine model of polymicrobial sepsis

Year Published: 2012

Sepsis is the most common cause of death in intensive care units. Some studies have found that hyperoxia may be beneficial to sepsis. However, the clinical use of hyperoxia is hindered by concerns that it could exacerbate organ injury by increasing free radical formation. Recently, it has been suggested that molecular hydrogen (H2) at low concentration can exert a therapeutic antioxidant activity ...
LUNG - SEPSIS

Molecular hydrogen ameliorates lipopolysaccharide-induced acute lung injury in mice through reducing ...

Year Published: 2012

Acute lung injury (ALI) is still a leading cause of morbidity and mortality in critically ill patients. Recently, our and other studies have found that hydrogen gas (H₂) treatment can ameliorate the lung injury induced by sepsis, ventilator, hyperoxia, and ischemia-reperfusion. However, the molecular mechanisms by which H₂ ameliorates lung injury remain unclear. In the current study, we ...
BRAIN - SEPSIS

Molecular hydrogen reduces LPS-induced neuroinflammation and promotes recovery from sickness ...

Year Published: 2012

Molecular hydrogen has been shown to have neuroprotective effects in mouse models of acute neurodegeneration. The effect was suggested to be mediated by its free-radical scavenger properties. However, it has been shown recently that molecular hydrogen alters gene expression and protein phosphorylation. The aim of this study was to test whether chronic ad libitum consumption of molecular ...
BRAIN - HYDROGEN BIOLOGY

A basic study on molecular hydrogen (H2) inhalation in acute cerebral ischemia patients for safety ...

Year Published: 2012

Background: In animal experiments, use of molecular hydrogen ( H2) has been regarded as quite safe and effective, showing benefits in multiple pathological conditions such as ischemia-reperfusion injury of the brain, heart, kidney and transplanted tissues, traumatic and surgical injury of the brain and spinal cord, inflammation of intestine and lung , degenerative striatonigral tissue and also in ...
BONE - RHEUMATOID ARTHRITIS

Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress ...

Year Published: 2012

Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by the destruction of bone and cartilage. Although its etiology is unknown, the hydroxyl radical has been suggested to be involved in the pathogenesis of RA. Recently, molecular hydrogen (H2) was demonstrated to be a selective scavenger for the hydroxyl radical. Also, the method to prepare water containing ...
WHOLE BODY - SPACEFLIGHT

Molecular hydrogen protects human lymphocyte AHH-1 cells against 12C6+ heavy ion radiation

Year Published: 2013

Purpose: To investigate the potential protective role of molecular hydrogen (H(2)) against (12)C(6+) heavy ion radiation, which is a major hazard for space travel and has been also widely used in heavy ion radiotherapy. Materials and methods: H(2) was dissolved in Roswell Park Memorial Institute (RPMI) 1640 medium under high pressure (0.4 Mpa) to a saturated level by using an apparatus produced by ...
EYE - DIABETES

Molecular hydrogen regulates the expression of miR-9, miR-21 and miR-199 in LPS-activated retinal ...

Year Published: 2013

Aim: To explore the potential mechanism of molecular hydrogen in the regulation of miRNA expression and signal-modulating activities. Methods: Retinal microglia cells were activated by Lipopolysaccharides (LPS) and then treated with hydrogen-saturated medium or normal medium without hydrogen. qRT-PCR was used to detect the expression difference in miR-9, miR-21 and miR-199 between these two ...
WHOLE BODY - OBESITY

Molecular hydrogen attenuates fatty acid uptake and lipid accumulation through downregulating CD36 ...

Year Published: 2013

Background: There is accumulating evidence that obesity is closely associated with an impaired free fatty acid metabolism as well as with insulin resistance and inflammation. Excessive fatty acid uptake mediated by fatty acid translocase CD36 plays an important role in hepatic steatosis. Molecular hydrogen has been shown to attenuate oxidative stress and improve lipid, glucose and energy ...
WHOLE BODY - INFLAMMATION

Heme oxygenase-1 mediates the anti-inflammatory effect of molecular hydrogen in LPS-stimulated RAW ...

Year Published: 2013

Background: Molecular hydrogen (H2) as a new medical gas has an anti-inflammatory effect. In the present study, we investigated whether heme oxygenase-1 (HO-1) contributes to the anti-inflammatory effect of H2 in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Methods: RAW 264.7 macrophages were stimulated by LPS (1 μg/mL) with presence or absence of different concentrations of H2. ...
TENDON - EXCERCISE

Effectiveness Of Molecular Hydrogen In The Management Of Musculotendinous Injuries

Year Published: 2014

Muscle and tendon strains (MTS) are often accompanied by subsequent tissue hypoxia and overproduction of reactive oxygen species; this may aggravate the initial cellular damage caused by the actual mechanism of injury. Molecular hydrogen (H2) seems to be beneficial for treating ischemia-reperfusion injury, oxidative stress, and inflammation in human diseases; however, the effects of H2 as an ...
PREGNANCY - NEUROPROTECTION

Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage caused by in ...

Year Published: 2014

Molecular hydrogen (H2) scavenges hydroxyl radicals. Recently, H2 has been reported to prevent a variety of diseases associated with oxidative stress in model systems and in humans. Here, we studied the effects of H2 on rat fetal hippocampal damage caused by ischemia and reperfusion (IR) on day 16 of pregnancy with the transient occlusion of the bilateral utero-ovarian arteries. Starting 2 days ...
SPINE - SPINAL CORD INJURY

Molecular hydrogen suppresses reactive astrogliosis related to oxidative injury during spinal cord ...

Year Published: 2014

Aims: Spinal cord injury (SCI) can induce excessive astrocyte activation. Hydrogen has been deemed as a novel antioxidant. We investigated whether molecular hydrogen could act as an antiastrogliosis agent during SCI and oxidative injury in experimental rats and cultured astrocytes. Methods: Hydrogen-rich saline (HS, 8 mL/kg, i.p.) was injected every 12 h after SCI in rats. The expression of STAT3, ...
BRAIN - NEUROPATHIC PAIN

Molecular hydrogen attenuates neuropathic pain in mice

Year Published: 2014

Neuropathic pain remains intractable and the development of new therapeutic strategies are urgently required. Accumulating evidence indicates that overproduction of oxidative stress is a key event in the pathogenesis of neuropathic pain. However, repeated intra-peritoneal or intrathecal injections of antioxidants are unsuitable for continuous use in therapy. Here we show a novel therapeutic method ...
BONE - RHEUMATOID ARTHRITIS

Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, ...

Year Published: 2014

The aim of this study was to demonstrate the safety and efficacy of H2-saline infusion for treatment of rheumatoid arthritis (RA). We conducted a randomized, double-blind, placebo-controlled investigation of the infusion of 1 ppm H2-dissolved saline (H2-saline) in 24 RA patients. Patients were randomized 1:1 to receive 500 ml of either H2-saline or placebo-saline, which was drop infused ...
BRAIN - TRAUMATIC BRAIN INJURY

Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic ...

Year Published: 2014

Traumatic brain injury (TBI) in its various forms has emerged as a major problem for modern society. Acute TBI can transform into a chronic condition and be a risk factor for neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, probably through induction of oxidative stress and neuroinflammation. Here, we examined the ability of the antioxidant molecular hydrogen given in ...
EYE - RETINAL INJURY

Protective effect of molecular hydrogen against oxidative stress caused by peroxynitrite derived ...

Year Published: 2015

Background Oxidative and nitrative processes have an important role in the pathogenesis of glaucomatous neurodegeneration. Oxidative stress occurs when cellular production of reactive oxygen species outweighs the protective capacity of antioxidant defences. Reactive oxygen species are generated as by-products of cellular metabolism, primarily in the mitochondria. Herein, we present a novel ...
LIVER - SURGERY/TRANSPLANTATION

Molecular hydrogen attenuates hypoxia/reoxygenation injury of intrahepatic cholangiocytes by ...

Year Published: 2015

Hypoxia/reoxygenation (H/R) injury of cholangiocytes causes serious biliary complications during hepatobiliary surgeries. Molecular hydrogen (H2) has been shown to be effective in protecting various cells and organs against oxidative stress injury. Human liver cholangiocytes were used to determine the potential protective effects of hydrogen against cholangiocyte H/R injury and explore the ...
HEART - ATHEROSCLEROSIS

Molecular Hydrogen stabilizes atherosclerotic plaque in low-density lipoprotein receptor knockout ...

Year Published: 2015

Hydrogen (H2) attenuates the development of atherosclerosis in mouse models. We aimed to examine the effects of H2 on atherosclerotic plaque stability. Low-density lipoprotein receptor knockout (LDLR(-/-)) mice fed an atherogenic-diet were dosed daily with H2 and/or simvastatin. In vitro studies were carried out in oxidized-LDL (ox-LDL)-stimulated macrophage-derived foam cell model treated with or ...
WHOLE BODY - STRESS RESILIENCE

Simultaneous oral and inhalational intake of molecular hydrogen additively suppresses signaling ...

Year Published: 2015

Molecular hydrogen (H2) is an agent with potential applications in oxidative stress-related and/or inflammatory disorders. H2 is usually administered by inhaling H2-containing air (HCA) or by oral intake of H2-rich water (HRW). Despite mounting evidence, the molecular mechanism underlying the therapeutic effects and the optimal method of H2 administration remain unclear. Here, we investigated ...
BRAIN - BRAIN INJURY

Protective effect of molecular hydrogen against white matter ischemic injury

Year Published: 2015

The central nervous system (CNS) white matter (WM) ischemia is an important clinical problem and may produce injury, in part, by reactive oxygen species (ROS)-induced mitochondrial dysfunction. Using the mouse optic nerve (MON) WM model, we tested whether hydrogen (H2) in drinking water reduced functional WM ischemic injury. Functional integrity of MON was determined by quantitatively monitoring ...
PREGNANCY - NEUROPROTECTION

Maternal molecular hydrogen administration on lipopolysaccharide-induced mouse fetal brain injury

Year Published: 2015

Fetal brain injury is often related to prenatal inflammation; however, there is a lack of effective therapy. Recently, molecular hydrogen (H2), a specific antioxidant to hydroxyl radical and peroxynitrite, has been reported to have anti-inflammatory properties. The aim of this study was to investigate whether maternal H2 administration could protect the fetal brain against inflammation. Pregnant ...
LUNG - SEPSIS

Combination therapy with nitric oxide and molecular hydrogen in a murine model of acute lung injury

Year Published: 2015

Acute lung injury (ALI) is still a leading cause of morbidity and mortality in critically ill patients. Inhaled nitric oxide (NO) has been reported to ameliorate ALI. However, reactive nitrogen species produced by NO can cause lung injury. Because hydrogen gas (H2) is reported to eliminate peroxynitrite, it is expected to reduce the adverse effects of NO. Moreover, we have found that H2 inhalation ...