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Studies Found: 446

SKIN - PSORIASIS

Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: ...

Year Published: 2015

Psoriasis, a chronic inflammatory skin disease, is caused by infiltrating lymphocytes and associated cytokines, including tumor necrosis factor (TNF)α, interleukin (IL)-6, and IL-17. Effective treatments, including pathogenesis-based biological agents against psoriasis, are currently under development. Although the role of reactive oxygen species (ROS) in the pathogenesis of psoriasis has been ...
PREGNANCY - PRETERM BIRTH

Maternal molecular hydrogen treatment attenuates lipopolysaccharide-induced rat fetal lung injury

Year Published: 2015

Maternal inflammation is associated with spontaneous preterm birth and respiratory impairment among premature infants. Recently, molecular hydrogen (H2) has been reported to have a suppressive effect on oxidative stress and inflammation. The aim of this study was to evaluate the effects of H2 on fetal lung injury caused by maternal inflammation. Cell viability and the production of interleukin-6 ...
PREGNANCY - PREECLAMPSIA

Effects of vitamin C, vitamin E, and molecular hydrogen on the placental function in trophoblast ...

Year Published: 2015

Aim: This study aimed to investigate the effects of three different antioxidants, namely vitamin C, vitamin E, and molecular hydrogen, on cytotrophoblasts in vitro. Methods: Two trophoblast cell lines, JAR and JEG-3, were exposed to different concentrations of vitamin C (0, 25, 50, 100, 500, 1,000, 5,000 μmol/L), vitamin E (0, 25, 50, 100, 500, 1,000, 5,000 μmol/L), and molecular hydrogen (0, ...
ENDOTHELIUM - SEPSIS

Molecular hydrogen protects mice against polymicrobial sepsis by ameliorating endothelial ...

Year Published: 2015

Endothelial injury is a primary cause of sepsis and sepsis-induced organ damage. Heme oxygenase-1 (HO-1) plays an essential role in endothelial cellular defenses against inflammation by activating nuclear factor E2-related factor-2 (Nrf2). We found that molecular hydrogen (H2) exerts an anti-inflammatory effect. Here, we hypothesized that H2 attenuates endothelial injury and inflammation via an ...
PREGNANCY - PREECLAMPSIA

Molecular hydrogen ameliorates several characteristics of preeclampsia in the Reduced Uterine ...

Year Published: 2016

Oxidative stress plays an important role in the pathogenesis of preeclampsia. Recently, molecular hydrogen (H2) has been shown to have therapeutic potential in various oxidative stress-related diseases. The aim of this study is to investigate the effect of H2 on preeclampsia. We used the reduced utero-placental perfusion pressure (RUPP) rat model, which has been widely used as a model of ...
WHOLE BODY - ROS-SCAVENGING

Molecular hydrogen inhibits lipopolysaccharide-triggered NLRP3 inflammasome activation in ...

Year Published: 2016

The NLRP3 inflammasome, an intracellular multi-protein complex controlling the maturation of cytokine interleukin-1β, plays an important role in lipopolysaccharide (LPS)-induced inflammatory cascades. Recently, the production of mitochondrial reactive oxygen species (mtROS) in macrophages stimulated with LPS has been suggested to act as a trigger during the process of NLRP3 inflammasome ...
BRAIN - BRAIN INJURY

Molecular hydrogen affords neuroprotection in a translational piglet model of hypoxic-ischemic ...

Year Published: 2016

Hypoxic-ischemic encephalopathy (HIE) is the major consequence of perinatal asphyxia (PA) in term neonates. Although the newborn piglet is an accepted large animal PA/HIE model, there is no consensus on PA-induction methodology to produce clinically relevant HIE. We aimed to create and to characterize a novel PA model faithfully reproducing all features of asphyxiation including severe hypercapnia ...
BONE - RHEUMATOID ARTHRITIS

Molecular hydrogen decelerates rheumatoid arthritis progression through inhibition of oxidative ...

Year Published: 2016

Rheumatoid arthritis (RA) is a chronic inflammatory disease which results in progressive destruction of the joint. In this study, we examined if the hydrogen could inhibit inflammation in a mouse model of collagen-induced arthritis (CIA) via oxidative stress on RA-FLSs. Moreover, to identify the mechanisms of action, we evaluated the effect of hydrogen on RA-FLSs development and the expression of ...
BONE - OSTEOARTHRITIS

Molecular hydrogen suppresses activated Wnt/β-catenin signaling

Year Published: 2016

Molecular hydrogen (H2) is effective for many diseases. However, molecular bases of H2 have not been fully elucidated. Cumulative evidence indicates that H2 acts as a gaseous signal modulator. We found that H2 suppresses activated Wnt/β-catenin signaling by promoting phosphorylation and degradation οf β-catenin. Either complete inhibition of GSK3 or mutations at CK1- and GSK3-phosphorylation ...
WHOLE BODY - ENVIRONMENTAL POLLUTION

The Effects of Molecular Hydrogen and Suberoylanilide Hydroxamic Acid on Paraquat-Induced Production ...

Year Published: 2016

The aim of this study is to investigate the effects of molecular hydrogen (H2) and suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, on paraquat (PQ)-stimulated production of reactive oxygen species (ROS) and tumor necrosis factor alpha (TNF-α) in macrophages. First, the PQ optimal concentration was determined in RAW264.7 macrophage by treating serum-starved cells with PQ ...
WHOLE BODY - OBESITY

Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1α to enhance ...

Year Published: 2016

We previously reported that molecular hydrogen (H2) acts as a novel antioxidant to exhibit multiple functions. Moreover, long-term drinking of H2-water (water infused with H2) enhanced energy expenditure to improve obesity and diabetes in db/db mice accompanied by the increased expression of fibroblast growth factor 21 (FGF21) by an unknown mechanism. H2 was ingested by drinking of H2-water or by ...
WHOLE BODY - GENE EXPRESSION

Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent ...

Year Published: 2016

We previously showed that H2 acts as a novel antioxidant to protect cells against oxidative stress. Subsequently, numerous studies have indicated the potential applications of H2 in therapeutic and preventive medicine. Moreover, H2 regulates various signal transduction pathways and the expression of many genes. However, the primary targets of H2 in the signal transduction pathways are unknown. ...
PREGNANCY - NEUROPROTECTION

Neuroprotective potential of molecular hydrogen against perinatal brain injury via suppression of ...

Year Published: 2016

Exposure to inflammation in utero is related to perinatal brain injury, which is itself associated with high rates of long-term morbidity and mortality in children. Novel therapeutic interventions during the perinatal period are required to prevent inflammation, but its pathogenesis is incompletely understood. Activated microglia are known to play a central role in brain injury by producing a ...
WHOLE BODY - SEPSIS

Combination therapy of molecular hydrogen and hyperoxia improves survival rate and organ damage in a ...

Year Published: 2016

Multiple organ dysfunction syndrome (MODS) is a leading cause of mortality in critically ill patients. Hyperoxia treatment may be beneficial to critically ill patients. However, the clinical use of hyperoxia is hindered as it may exacerbate organ injury by increasing reactive oxygen species (ROS). Hydrogen gas (H2) exerts a therapeutic antioxidative effect by selectively reducing ROS. Combination ...
PANCREAS - PANCREATITIS

MAPKs and Hsc70 are critical to the protective effect of molecular hydrogen during the early phase ...

Year Published: 2016

Molecular hydrogen (H2 ) has been proven to be an effective agent that can cure multiple organ diseases by reducing oxidative stress. Although the protective effect of hydrogen on acute pancreatitis (AP) has been confirmed, its molecular mechanism is still unclear. In this article, we aimed to investigate the changes in pancreatic cell protein expression associated with the protective effect of H2 ...
HEART - AGING

Molecular Hydrogen Alleviates Cellular Senescence in Endothelial Cells

Year Published: 2016

Background: Substantial evidence indicates that molecular hydrogen (H2) has beneficial vascular effects because of its antioxidant and/or anti-inflammatory effects. Thus, hydrogen-rich water may prove to be an effective anti-aging drink. This study examined the effects of H2on endothelial senescence and clarified the mechanisms involved. Methods and results: Hydrogen-rich medium was produced ...
WHOLE BODY - EXCERCISE

Is molecular hydrogen beneficial to enhance post-exercise recovery in female athletes?

Year Published: 2016

Summary Objectives The purpose of this double-blind, randomized, placebo-controlled crossover study was to determine the effects of pre-exercise hydrogen-rich water intake on biomarkers of acid-base homeostasis and post-exercise recovery in female athletes. Methods Eight young female judo athletes (21.4 ± 2.2 years) were randomly assigned to receive either hydrogen-rich water or placebo water ∼ ...
WHOLE BODY - RADIOPROTECTION

Molecular hydrogen attenuates radiation-induced nucleobase damage to DNA in aerated aqueous ...

Year Published: 2016

Purpose: The main aim of the present study is to gain mechanistic insights into the modulating effect of molecular hydrogen on the γ-radiation-induced alteration pathways of DNA nucleobases. Materials and methods: Aerated aqueous solutions of calf thymus DNA were exposed to a (60)Co source at doses ranging from 0 to 55 Gy under normoxic conditions, in the presence or not of 0.7 MPa hydrogen or ...
HEART - SURGERY/TRANSPLANTATION

Molecular hydrogen potentiates beneficial anti-infarct effect of hypoxic postconditioning in ...

Year Published: 2017

Generation of free radicals through incomplete reduction of oxygen during ischemia-reperfusion (I/R) is well described. On the other hand, molecular hydrogen (H2) reduces oxidative stress due to its ability to react with strong oxidants and easily penetrate cells by diffusion, without disturbing metabolic redox reactions. This study was designed to explore cardioprotective potential of hypoxic ...
BRAIN - PARKINSON'S DISEASE

Complexity of Stomach-Brain Interaction Induced by Molecular Hydrogen in Parkinson’s Disease ...

Year Published: 2017

Molecular hydrogen (H2), as a new medical gas, has protective effects in neurological disorders including Parkinson's disease (PD). In our previous report, the neuroprotective effect of drinking water with saturated H2 (H2 water) in PD mice might be due to stomach-brain interaction via release of gastric hormone, ghrelin. In the present study, we assessed the effect of H2-induced ghrelin more ...
BRAIN - SURGERY/TRANSPLANTATION

Molecular hydrogen inhalation attenuates postoperative cognitive impairment in rats

Year Published: 2017

Postoperative cognitive decline is a major clinical problem with high morbidity and mortality after surgery. Many studies have found that molecular hydrogen (H2) has significant neuroprotection against acute and chronic neurological injury by regulating inflammation and apoptosis. In this study, we hypothesized that H2 treatment could ameliorate the development of cognitive impairment following ...
WHOLE BODY - STRESS RESILIENCE

Molecular hydrogen modulates gene expression via histone modification and induces the mitochondrial ...

Year Published: 2017

Molecular hydrogen (H2) is a biologically active gas that is used medically to ameliorate various systemic pathological conditions. H2 also regulates gene expression involved in intracellular signaling and metabolic pathways. However, it is unclear whether H2 affects gene expression directly or through indirect effects as a consequence of health improvement. Therefore, we attempted to identify ...
KIDNEY - HAEMODIALYSIS

Possible clinical effects of molecular hydrogen (H2) delivery during hemodialysis in chronic ...

Year Published: 2017

Background and aim: It is supposed that enhanced oxidative stress and inflammation are involved with the poor clinical outcomes in patients on chronic dialysis treatment. Recent studies have shown that molecular hydrogen (H2) is biologically active as an anti-inflammatory agent. Thus, we developed a novel hemodialysis (E-HD) system which delivers H2 (30 to 80 ppb)-enriched dialysis solution, to ...
PERITONIUM - PERITONEAL DIALYSIS

Dissolved molecular hydrogen (H2) in Peritoneal Dialysis (PD) solutions preserves mesothelial cells ...

Year Published: 2017

Background Peritoneal dialysis (PD) is used as renal replacement therapy in patients with end-stage kidney disease. However, peritoneal membrane failure remains problematic and constitutes a critical cause of PD discontinuation. Recent studies have revealed the unique biological action of molecular hydrogen (H2) as an anti-oxidant, which ameliorates tissue injury. In the present study, we aimed to ...
BRAIN - ROS-SCAVENGING

Molecular hydrogen protects against oxidative stress-induced SH-SY5Y neuroblastoma cell death ...

Year Published: 2017

Inhalation of molecular hydrogen (H2) gas ameliorates oxidative stress-induced acute injuries in the brain. Consumption of water nearly saturated with H2 also prevents chronic neurodegenerative diseases including Parkinson's disease in animal and clinical studies. However, the molecular mechanisms underlying the remarkable effect of a small amount of H2 remain unclear. Here, we investigated the ...