search - Hydrogen Studies

Protective effects of molecular hydrogen on steroid-induced osteonecrosis in rabbits via reducing ...

Year Published: 2017

Background: The objective of this study was to investigate the protective effects of molecular hydrogen, a novel and selective antioxidant, on steroid-induced osteonecrosis (ON) in a rabbit model. Methods: Sixty rabbits were randomly divided into two groups (model group and hydrogen group). Osteonecrosis was induced according to an established protocol of steroid-induced ON. Rabbits in the ...

WHOLE BODY - BACTERIAL INFECTION

Impact of molecular hydrogen treatments on the innate immune activity and survival of zebrafish ...

Year Published: 2017

Recently, molecular hydrogen has been reported to have a suppressive effect on inflammation in human and rodent models. The aim of this study was to evaluate the preventive effects of hydrogen-rich water (HRW) on zebrafish challenged by A. hydrophila. We have found an increased survival rate of bacteria-challenged zebrafish subjected to the HRW immersion treatment. Furthermore, we have revealed ...

MUSCLE - MUSCULAR DYSTROPHY

Molecular hydrogen alleviates motor deficits and muscle degeneration in mdx mice

Year Published: 2017

Objective: Duchenne muscular dystrophy (DMD) is a devastating muscle disease caused by a mutation in DMD encoding dystrophin. Oxidative stress accounts for dystrophic muscle pathologies in DMD. We examined the effects of molecular hydrogen in mdx mice, a model animal for DMD. Methods: The pregnant mother started to take supersaturated hydrogen water (>5 ppm) ad libitum from E15.5 up to weaning of ...

BRAIN - STRESS RESILIENCE

Molecular hydrogen increases resilience to stress in mice

Year Published: 2017

The inability to successfully adapt to stress produces pathological changes that can lead to depression. Molecular hydrogen has anti-oxidative and anti-inflammatory activities and neuroprotective effects. However, the potential role of molecular hydrogen in stress-related disorders is still poorly understood. The present study aims to investigate the effects of hydrogen gas on resilience to stress ...

EYE - CORNEAL INJURY

Retracted: Molecular Hydrogen Effectively Heals Alkali-Injured Cornea via Suppression of Oxidative ...

Year Published: 2017

The aim of this study was to examine the effect of molecular hydrogen (H2) on the healing of alkali-injured cornea. The effects of the solution of H2 in phosphate buffered saline (PBS) or PBS alone topically applied on the alkali-injured rabbit cornea with 0.25 M NaOH were investigated using immunohistochemical and biochemical methods. Central corneal thickness taken as an index of corneal ...

EYE - RADIOPROTECTION

Retracted: Therapeutic effect of molecular hydrogen in corneal UVB-induced oxidative stress and ...

Year Published: 2017

The aim of this study is to examine whether molecular hydrogen (H2) is able to reduce oxidative stress after corneal damage induced by UVB irradiation. We previously found that UVB irradiation of the cornea caused the imbalance between the antioxidant and prooxidant enzymes in the corneal epithelium, followed by the imbalance between metalloproteinases and their physiological inhibitors ...

BRAIN - BRAIN INJURY

Molecular hydrogen alleviates asphyxia-induced neuronal cyclooxygenase-2 expression in newborn pigs

Year Published: 2018

Cyclooxygenase-2 (COX-2) has an established role in the pathogenesis of hypoxic-ischemic encephalopathy (HIE). In this study we sought to determine whether COX-2 was induced by asphyxia in newborn pigs, and whether neuronal COX-2 levels were affected by H2 treatment. Piglets were subjected to either 8 min of asphyxia or a more severe 20 min of asphyxia followed by H2 treatment (inhaling room air ...

OVARIES - CANCER

Therapeutic potential of molecular hydrogen in ovarian cancer

Year Published: 2018

Background: To investigate the potential effects of molecular hydrogen on ovarian cancer. Methods: The in vivo study was performed using Hs38.T xenografted BALB/c nude mice. The mean tumor volume was monitored during 6 weeks of hydrogen inhalation. Immunohistochemistry (IHC) staining was performed to determine the Ki67 and CD34 expression. The in vitro effects of molecular hydrogen on ...

BRAIN - TRAUMATIC BRAIN INJURY

Molecular Hydrogen Prevents Social Deficits and Depression-Like Behaviors Induced by Low-Intensity ...

Year Published: 2018

Detonation of explosive devices creates blast waves, which can injure brains even in the absence of external injuries. Among these, blast-induced mild traumatic brain injury (bmTBI) is increasing in military populations, such as in the wars in Afghanistan, Iraq, and Syria. Although the clinical presentation of bmTBI is not precisely defined, it is frequently associated with psycho-neurological ...

WHOLE BODY - EXCERCISE

Molecular hydrogen reduces acute exercise-induced inflammatory and oxidative stress status

Year Published: 2018

Physical exercise induces inflammatory and oxidative markers production in the skeletal muscle and this process is under the control of both endogenous and exogenous modulators. Recently, molecular hydrogen (H2) has been described as a therapeutic gas able to reduced oxidative stress in a number of conditions. However, nothing is known about its putative role in the inflammatory and oxidative ...

BRAIN - DEMENTIA

Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild ...

Year Published: 2018

Background: Oxidative stress is one of the causative factors in the pathogenesis of neurodegenerative diseases including mild cognitive impairment (MCI) and dementia. We previously reported that molecular hydrogen (H2) acts as a therapeutic and preventive antioxidant. Objective: We assess the effects of drinking H2-water (water infused with H2) on oxidative stress model mice and subjects with MCI. ...

PERITONIUM - PERITONEAL DIALYSIS

Translational Research of Peritoneal Dialysis Solution with Dissolved Molecular Hydrogen

Year Published: 2018

Background: Improved biocompatibility of peritoneal dialysis solution (PDS) is crucial for peritoneal membrane preservation, thereby ensuring long-term peritoneal dialysis (PD) and preventing encapsulating peritoneal sclerosis. We previously reported the protective effect of molecular hydrogen (H2) on mesothelial cells from PDS in nonuremic rats. Summary: In the present study, we examined the ...

KIDNEY - HAEMODIALYSIS

Novel haemodialysis (HD) treatment employing molecular hydrogen (H 2)-enriched dialysis solution ...

Year Published: 2018

Recent studies have revealed unique biological characteristics of molecular hydrogen (H2) as an anti-inflammatory agent. We developed a novel haemodialysis (E-HD) system delivering an H2 (30-80 ppb)-enriched dialysis solution by water electrolysis, and conducted a non-randomized, non-blinded, prospective observational study exploring its clinical impact. Prevalent chronic HD patients were ...

PREGNANCY - PRETERM BIRTH

Effect of molecular hydrogen on uterine inflammation during preterm labour

Year Published: 2018

Intrauterine inflammation causes preterm birth and is associated with complications in preterm neonates. Thus, strategies aimed at suppressing inflammation are expected to be effective for reducing the risk of preterm birth and associated complications. Our previous studies demonstrated that molecular hydrogen (H2), an anti-inflammatory agent, prevented inflammation-induced impairment in foetal ...

LIVER - FATTY LIVER DISEASE (NONALCOHOLIC)

Molecular hydrogen protects against ischemia-reperfusion injury in a mouse fatty liver model via ...

Year Published: 2018

Fatty liver has lower tolerance against ischemia-reperfusion (I/R) injury in liver operations, including liver transplantation. Seeking to ameliorate liver injury following I/R in fatty liver, we examined the protective effect of hydrogen (H2) saline on I/R liver injury in a methionine and choline-deficient plus high fat (MCDHF) diet-induced fatty liver mouse model. Saline containing 7 ppm H2 was ...

WHOLE BODY - OBESITY

Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in ...

Year Published: 2018

Background: Molecular hydrogen (H2) effectively treats obesity-related disorders in animal models, yet no studies have investigated the effectiveness and safety of H2 for improving biomarkers of obesity in humans. Aim: In this double blind, placebo-controlled, crossover pilot trial, we evaluated the effects of H2 intervention on body composition, hormonal status, and mitochondrial function in ten ...

WHOLE BODY - MITOCHONDRIAL FUNCTION

Effect of molecular hydrogen on coenzyme Q in plasma, myocardial tissue and mitochondria of rats

Year Published: 2018

Beneficial effects of molecular hydrogen (H2) in various experimental models of human diseases and in many clinical studies was documented. H2 can be administered by various ways, as a gas inhalation, drinking of H2-enriched water, or taking a H2-dissolved bath as well as in saline infusions. As antioxidant selectively scavenges hydroxyl and peroxynitrite radicals, decreases oxidative stress. ...

PREGNANCY - NEUROPROTECTION

Administration of molecular hydrogen during pregnancy improves behavioral abnormalities of offspring ...

Year Published: 2018

The aim of the present study was to investigate long-term outcomes of the offspring in a lipopolysaccharide (LPS)-induced maternal immune activation (MIA) model and the effect of maternal molecular hydrogen (H2) administration. We have previously demonstrated in the MIA mouse model that maternal administration of H2 attenuates oxidative damage and neuroinflammation, including induced ...

INTESTINE - HYDROGEN BIOLOGY

Effects of molecular hydrogen-dissolved alkaline electrolyzed water on intestinal environment in ...

Year Published: 2018

Increasing evidence indicates that molecular hydrogen-dissolved alkaline electrolyzed water (AEW) has various physiological activities such as antioxidative activity. Gut microbiota are deeply associated with our health through a symbiotic relationship. Recent reports have described that most gastrointestinal microbial species encode the genetic capacity to metabolize molecular hydrogen, meaning ...

STOMACH - GASTROESOPHAGEAL REFLUX DISEASE

Modulation of the oxidative plasmatic state in gastroesophageal reflux disease with the addition of ...

Year Published: 2018

Gastroesophageal reflux disease (GERD), a clinical condition characterized by reflux of gastroduodenal contents in the oesophagus, has proved to demonstrate a strong link between oxidative stress and the development of GERD. Proton pump inhibitors (PPIs) have been universally accepted as first-line therapy for management of GERD. The potential benefits of electrolysed reduced water (ERW), rich in ...

KIDNEY - CHRONIC KIDNEY DISEASE

Molecular Hydrogen Suppresses Renal Injury in Chronic Kidney Disease Rats

Year Published: 2018

Background: Cathode side commercial hydrogen dissolved water (HW) exhibits low dissolved oxygen, high dissolved hydrogen and significant negative redox potential. Therapeutic applications of HW have recently been reported. Thus, the present study aimed to examine effects of HW consumption on renal injury in a rat model of chronic kidney disease.Methods: Twenty Dahl S rats were given HW and tap ...

LIVER - OBSTRUCTIVE JAUNDICE

Molecular hydrogen accelerates the reversal of acute obstructive cholangitis‑induced liver ...

Year Published: 2019

Gap junctions (GJs) and tight junctions (TJs) are essential to maintain the function of hepatocytes. Changes in biliary tract pressure and the effect of lipopolysaccharide (LPS) may lead to acute obstructive cholangitis (AOC) and cause liver injury via GJ and TJ dysfunction. Hydrogen has been confirmed to have a protective role in various organs during pathological conditions and inflammation. The ...

LIVER - LIVER FUNCTION

Intake of Molecular Hydrogen in Drinking Water Increases Membrane Transporters, p-Glycoprotein, and ...

Year Published: 2019

Molecular hydrogen (H2) has been shown to have antioxidant and anti-inflammatory activities that may reduce the development and progression of many diseases. In this study, hydrogen-rich water (HRW) was obtained by reacting hybrid magnesium-carbon hydrogen storage materials with water. Then, the effects of intake of HRW on the activities of xenobiotic-metabolizing enzymes, membrane transporters, ...

BRAIN - ADDICTION

Effects of Molecular Hydrogen on Methamphetamine-Induced Neurotoxicity and Spatial Memory Impairment

Year Published: 2019

Methamphetamine (METH) is a highly addictive stimulant, and METH exposure can induce irreversible neuronal damage and cause neuropsychiatric and cognitive disorders. The ever-increasing levels of METH abuse worldwide have necessitated the identification of effective intervention strategies to protect the brain against METH-induced neurotoxicity. The protective effects of molecular hydrogen on ...

LUNG - CANCER

Molecular hydrogen attenuates gefitinib-induced exacerbation of naphthalene-evoked acute lung injury ...

Year Published: 2019

Although inhibition of epidermal growth factor receptor (EGFR)-mediated cell signaling by the EGFR tyrosine kinase inhibitor gefitinib is highly effective against advanced non-small cell lung cancer, this drug might promote severe acute interstitial pneumonia. We previously reported that molecular hydrogen (H2) acts as a therapeutic and preventive anti-oxidant. Here, we show that treatment with H2 ...