search - Hydrogen Studies

Drinking Molecular Hydrogen Water Is Beneficial to Cardiovascular Function in Diet-Induced Obesity ...

Year Published: 2021

Molecular hydrogen (MH) reportedly exerts therapeutic effects against inflammatory diseases as a suppressor of free radical chain reactions. Here, the cardiovascular protective effects of the intake of molecular hydrogen water (MHW) were investigated using high-fat diet-induced obesity (DIO) mice. MHW was prepared using supplier sticks and degassed water as control. MHW intake for 2 weeks did not ...

EYE - DRY EYE

Randomized, crossover clinical efficacy trial in humans and mice on tear secretion promotion and ...

Year Published: 2021

The incidence of dry eye disease is increasing worldwide because of the aging population and increasing use of information technology. Dry eye disease manifests as tear-layer instability and inflammation caused by osmotic hypersensitization in tear fluids; however, to our knowledge, no agent that treats both pathologies simultaneously is available. Molecular hydrogen (H2) is known to be effective ...

BONE - OSTEOGENESIS

Molecular hydrogen enhances osteogenesis in Danio rerio embryos

Year Published: 2021

Molecular hydrogen (H2 ) has been reported to have important biological effects on bone tissue in several in vitro and in vivo models. Danio rerio (zebrafish) embryo is a good model to study osteogenesis because its transparency, size and rapid development. In zebrafish embryo, hydrogen rich water (HRW) do not affect vitality or growth rate up to 15%. In addition, 7% HRW treatment enhances ...

WHOLE BODY - AGING

The effects of 6-month hydrogen-rich water intake on molecular and phenotypic biomarkers of aging in ...

Year Published: 2021

In this randomized controlled pilot trial, we investigated the effects of a 6-month intake of hydrogen-rich water (HRW) on several molecular and phenotypic biomarkers of aging in older adults aged 70 years and over. Forty older adults (20 women) were randomly allocated in a parallel-group design to receive 0.5 L per day of HRW (15 ppm of hydrogen) or control drink (0 ppm of hydrogen) during a ...

LUNG - SURGERY/TRANSPLANTATION

Profiling molecular changes induced by hydrogen treatment of lung allografts prior to procurement

Year Published: 2012

We previously demonstrated that donor treatment with inhaled hydrogen protects lung grafts from cold ischemia/reperfusion (I/R) injury during lung transplantation. To elucidate the mechanisms underlying hydrogen's protective effects, we conducted a gene array analysis to identify changes in gene expression associated with hydrogen treatment. Donor rats were exposed to mechanical ventilation with ...

EAR - HEARING LOSS

Molecular mechanisms underlying the protective effects of hydrogen-saturated saline on noise-induced ...

Year Published: 2017

Objectives: This study aimed to explore the molecular mechanism of the protective effects of hydrogen-saturated saline on NIHL. Methods: Guinea pigs were divided into three groups: hydrogen-saturated saline; normal saline; and control. For saline administration, the guinea pigs were given daily abdominal injections 3 d before and 1 h before noise exposure. ABR were tested to examine cochlear ...

LUNG - SEPSIS

Protection by Inhaled Hydrogen Therapy in a Rat Model of Acute Lung Injury Can be Tracked in vivo ...

Year Published: 2017

Inhaled hydrogen gas (H2) provides protection in rat models of human acute lung injury (ALI). We previously reported that biomarker imaging can detect oxidative stress and endothelial cell death in vivo in a rat model of ALI. Our objective was to evaluate the ability of Tc-hexamethylpropyleneamineoxime (HMPAO) and Tc-duramycin to track the effectiveness of H2 therapy in vivo in the hyperoxia rat ...

INTESTINE - FOOD POISONING

Morphological and molecular response of small intestine to lactulose and hydrogen-rich water in ...

Year Published: 2019

Background Following the intake of Fusarium mycotoxin-contaminated feed, small intestines may be exposed to high levels of toxic substances that can potentially damage intestinal functions in livestock. It is well known that Fusarium mycotoxins will lead a breakdown of the normally impeccable epithelial barrier, resulting in the development of a “leaky” gut. H2 administration with different ...

LUNG - INTERSTITIAL LUNG DISEASE

Efficacy and Safety of Hydrogen Therapy in Patients with Early-Stage Interstitial Lung Disease: A ...

Year Published: 2023

Purpose: Several in vivo experiments have shown that molecular hydrogen is a promising therapeutic agent for interstitial lung diseases (ILD). In this study, hydrogen therapy was investigated to determine whether it is superior to N-Acetylcysteine (NAC) for the treatment of patients with early-stage ILD. Patients and methods: A prospective, single-center, randomized, controlled clinical trial was ...

LIVER - FATTY LIVER DISEASE (ALCOHOLIC)

Hydrogen gas alleviates acute ethanol-induced hepatotoxicity in mice via modulating TLR4/9 innate ...

Year Published: 2023

Alcoholic liver disease (ALD), which is induced by chronic heavy alcohol consumption, accompanies complicated pathological mechanisms, including oxidative stress, inflammation, cell death, epigenetic changes and acetaldehyde-mediated toxicity. Hydrogen (H2) is the lightest gas with multiple biological effects such as high selective anti-oxidation, anti-inflammation and anti-apoptosis. However, the ...

WHOLE BODY - IMMUNE REGULATION

NIR-Activatable Heterostructured Nanoadjuvant Cop/Nicop Executing Lactate Metabolism Interventions ...

Year Published: 2023

Near-infrared (NIR) laser-induced photoimmunotherapy has aroused great interest due to its intrinsic non-invasiveness and spatiotemporal precision, while immune evasion evoked by lactic acid (LA) accumulation severely limits its clinical outcomes. Although several metabolic interventions have been devoted to ameliorate immunosuppression, intracellular residual LA still remains a potential energy ...

LUNG - SEPSIS

Hydrogen prevents lipopolysaccharide-induced pulmonary microvascular endothelial cell injury by ...

Year Published: 2023

Background: Sepsis is a type of life-threatening organ dysfunction that is caused by a dysregulated host response to infection. The lung is the most vulnerable target organ under septic conditions. Pulmonary microvascular endothelial cells (PMVECs) play a critical role in acute lung injury (ALI) caused by severe sepsis. The impairment of PMVECs during sepsis is a complex regulatory process ...

LUNG - SARS/COVID

The efficacy of hydrogen/oxygen therapy favored the recovery of omicron SARS-CoV-2 variant ...

Year Published: 2023

Clinical studies had found that hydrogen/oxygen mixed inhalation was beneficial to ameliorate the respiratory symptoms in the adjuvant treatment of patients with COVID-19. We aimed to explore the efficacy of hydrogen/oxygen therapy in favoring the recovery of Omicron SARS-CoV-2 variant infection. There were 64 patients who randomly assigned to receive hydrogen/oxygen inhalation (32 patients) and ...

BRAIN - RADIOPROTECTION

Comprehensive brain tissue metabolomics and biological network technology to decipher the mechanism ...

Year Published: 2023

Background: Hydrogen-rich water (HRW) has been shown to prevent cognitive impairment caused by ionizing radiation. This study aimed to investigate the pharmacological effects and mechanisms of HRW on ionizing radiation by coupling the brain metabolomics and biological target network methods. Methods and results: HRW significantly improves the cognitive impairment in rats exposed to ionizing ...

EYE - RETINAL INJURY

Inhibition of retinal ischemia-reperfusion injury in rats by inhalation of low-concentration ...

Year Published: 2023

Purpose: To investigate the inhibitory effect of hydrogen gas inhalation on retinal ischemia reperfusion (I/R) injury using a rat model. Methods: Six-week-old male Sprague-Dawley rats were used. A 27G needle connected by a tube to a saline bottle placed 200 cm above the eye was inserted into the anterior eye chamber to create a rat retinal I/R model. In the ischemia-plus-hydrogen-gas group (H2( +) ...

OVARIES - POLYCYSTIC OVARY SYNDROME

The effect of hydrogen-rich water on letrozole-induced polycystic ovary syndrome in rats

Year Published: 2023

Research question: What is the effect of hydrogen-rich water on rats with polycystic ovary syndrome (PCOS)? Design: Female rats were divided into four groups, each consisting of eight animals. The control group received a carboxymethyl cellulose (CMC) solution, the molecular hydrogen (H2) group was given hydrogen-rich water and a CMC solution, the PCOS group was administered letrozole dissolved in ...

UTERUS - CANCER

RNA sequencing analysis reveals apoptosis induction by hydrogen treatment in endometrial cancer via ...

Year Published: 2020

Background: To evaluate the activity of hydrogen in endometrial cancer and elucidate its underlying molecular mechanisms. Methods: Ishikawa, HEC1A and AN3CA cells were incubated in DMEM medium with or without hydrogen. RNA sequencing was used to explore the association of hydrogen treatment with signaling pathways and functional genes in endometrial cancer cells. The apoptotic rates of the three ...

WHOLE BODY - METABOLIC SYNDROME

Evaluation of the safety and potential lipid-lowering effects of oral hydrogen-rich coral calcium ...

Year Published: 2023

Background: Metabolic syndrome is characterized by a cluster-like occurrence of conditions such as hypertension, hyperglycaemia, elevated low-density lipoprotein (LDL) cholesterol or triglycerides (TG) and high visceral fat. Metabolic syndrome is linked to the build-up of plaque within the artery, which leads to disorders of the circulatory, nervous and immune systems. A variety of treatments ...

LUNG - AGING

Attenuation of pulmonary damage in aged lipopolysaccharide-induced inflammation mice through ...

Year Published: 2023

Introduction: With the global population aging, there is an increased prevalence of sepsis among the elderly, a demographic particularly susceptible to inflammation. This study aimed to evaluate the therapeutic potential of hydrogen gas, known for its anti-inflammatory and antioxidant properties, in attenuating inflammation specifically in the lungs and liver, and age-associated molecular markers ...

HEART - HEART FAILURE

Hydrogen-rich saline alleviates cardiomyocyte apoptosis by reducing expression of calpain1 via ...

Year Published: 2023

Aims: Molecular hydrogen has been exhibited a protective function in heart diseases. Our previous study demonstrated that hydrogen-rich saline (HRS) could scavenge free radicals selectively and alleviate the inflammatory response in the myocardial ischaemia/reperfusion (I/R) injury, but the underlying mechanism has not been fully clarified. Methods and results: Adult (10 weeks) C57BL/6 male mice ...

BRAIN - SEPSIS

Hydrogen-rich saline regulates NLRP3 inflammasome activation in sepsis-associated encephalopathy rat ...

Year Published: 2023

Sepsis-associated encephalopathy (SAE) is characterised by long-term cognitive impairment and psychiatric illness in sepsis survivors, associated with increased morbidity and mortality. There is a lack of effective therapeutics for SAE. Molecular hydrogen (H2) plays multiple roles in septic diseases by regulating neuroinflammation, reducing oxidative stress parameters, regulating signalling ...

SKIN - SURGERY/TRANSPLANTATION

Hydrogen Attenuates Inflammation by Inducing Early M2 Macrophage Polarization in Skin Wound Healing

Year Published: 2023

The heterogeneous and highly plastic cell populations of macrophages are important mediators of cellular responses during all stages of wound healing, especially in the inflammatory stage. Molecular hydrogen (H2), which has potent antioxidant and anti-inflammatory effects, has been shown to promote M2 polarization in injury and disease. However, more in vivo time series studies of the role of ...

BRAIN - ALZHEIMER'S DISEASE

Effects of Hydrogen Gas Inhalation on Community-Dwelling Adults of Various Ages: A Single-Arm, ...

Year Published: 2023

Molecular hydrogen (H2) is a versatile therapeutic agent. H2 gas inhalation is reportedly safe and has a positive impact on a range of illnesses, including Alzheimer's disease (AD). Herein, we investigated the effects of 4 weeks of H2 gas inhalation on community-dwelling adults of various ages. Fifty-four participants, including those who dropped out (5%), were screened and enrolled. The selected ...

INTESTINE - METABOLIC SYNDROME

Hydrogen-Rich Water Ameliorates Metabolic Disorder via Modifying Gut Microbiota in Impaired Fasting ...

Year Published: 2023

Objective: Molecular hydrogen (H2) exhibits antioxidant, anti-inflammatory and anti-apoptotic effects, and has shown benefits in glucose and lipid metabolism in certain animal metabolic disorder models. However, the potential benefits of H2 treatment in individuals with impaired fasting glucose (IFG) has seldom been studied. This randomized controlled study (RCT) aims to investigate the effects of ...

SKIN - COSMETIC SKIN ISSUES

Effect and mechanism of hydrogen-rich bath on mice with imiquimod-induced psoriasis

Year Published: 2023

The purpose of this study was to investigate whether hydrogen-rich bath has therapeutic effect on psoriasis and its molecular mechanism. Mice with imiquimod-induced psoriasis were established and divided into groups. The mice were respectively treated with hydrogen-rich water bath and distilled water bath. The changes of skin lesions and PSI scores of mice were compared after their treatments. HE ...