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Studies Found: 446

EAR - HEARING LOSS

Space Station-like Composite Nanoparticles for Co-Delivery of Multiple Natural Compounds from ...

Year Published: 2023

Ototoxic drugs such as aminoglycoside antibiotics and cisplatin (CDDP) can cause sensorineural hearing loss (SNHL), which is closely related to oxidative stress and the acidification of the inner ear microenvironment. Effective treatment of SNHL often requires multifaceted approach due to the complex pathology, and drug combination therapy is expected to be at the forefront of modern hearing loss ...
EYE - CANCER

Hydrogen nanobubbles: A novel approach toward radio-sensitization agents

Year Published: 2023

Background: Ocular melanoma is a rare kind of eye malignancy that threatens the patient's eyesight. Radiotherapy and surgical removal are the most commonly used therapeutic modalities, and nanomedicine has lately entered this field. Brachytherapy using Ruthenium-106 (106 Ru) ophthalmic plaques has been used for decades to treat ocular melanoma, with the applicator placed on the patient's eyes ...
SPINE - SPINAL CORD INJURY

Protective Effect of Hydrogen-Rich Saline on Spinal Cord Damage in Rats

Year Published: 2023

The anti-inflammatory and anti-apoptotic effects of molecular hydrogen, delivered as hydrogen-rich saline (HRS), on spinal cord injury was investigated. Four-month-old male Sprague Dawley rats (n = 24) were classified into four groups: (1) control-laminectomy only at T7-T10; (2) spinal injury-dura left intact, Tator and Rivlin clip compression model applied to the spinal cord for 1 min, no ...
SKIN - AGING

Intermittent environmental exposure to hydrogen prevents skin photoaging through reduction of ...

Year Published: 2023

Aim: Molecular hydrogen is not only expected to be used as an energy-generating resource, but also to have preventive effects on a variety of clinical manifestations related to oxidative stress through scavenging radicals or regulating gene expression. In the current study, we investigated the influence of intermittent environmental exposure to hydrogen gas at a safe concentration (1.3%) on ...
BRAIN - CARDIAC ARREST

Efficacy of inhaled hydrogen on neurological outcome following brain ischaemia during post-cardiac ...

Year Published: 2023

Background: Inhaled molecular hydrogen gas (H2) has been shown to improve outcomes in animal models of cardiac arrest (CA). H2 inhalation is safe and feasible in patients after CA. We investigated whether inhaled H2 would improve outcomes after out-of-hospital CA (OHCA). Methods: HYBRID II is a prospective, multicentre, randomised, double-blind, placebo-controlled trial performed at 15 hospitals ...
WHOLE BODY - CANCER

Rational Design of Platinum-Bismuth Sulfide Schottky Heterostructure for Sonocatalysis-Mediated ...

Year Published: 2022

Conventional sonodynamic therapy (SDT) is unavoidably limited by the tumor microenvironment although many sonosensitizers have been developed to improve them to a certain extent. Given this, we propose a concept of sonocatalytic hydrogen evolution and define it as an oxygen-independent therapeutics. To demonstrate the feasibility of the concept, narrow-bandgap semiconductor bismuth sulfide (Bi2 S3 ...
SPINE - NEUROPATHIC PAIN

Hydrogen-Rich Saline Attenuates Chronic Allodynia after Bone Fractures via Reducing Spinal ...

Year Published: 2022

Purpose: Neuroinflammation often initiates iron overload in the pathogenesis of neurological disorders. Chemokine-driven neuroinflammation is required for central sensitization and chronic allodynia following fractures, but specific molecular modulations are elusive. This present study explored whether hydrogen-rich saline, as one potent anti-inflammatory pharmaceutical, could alleviate ...
KIDNEY - ACUTE KIDNEY INJURY

Effect of water diuresis with hydrogen saturation on the course of acute kidney damage during the ...

Year Published: 2022

Molecular hydrogen has the ability to penetrate cells, easily reach mitochondria, overcome body barriers, penetrate areas of ischemia, edema and inflammation, improve energy supply by supplying additional electrons and have antioxidant and anti-inflammatory effects by neutralizing highly reactive hydroxyl radical and peroxynitrite. In this experiment, we included 60 nonlinear male rats weighing ...
WHOLE BODY - HYDROGEN BIOLOGY

Hydroxyl-radical scavenging activity of hydrogen does not significantly contribute to its biological ...

Year Published: 2021

Since Ohsawa et al. reported a biological antioxidant function of hydrogen in 2007, researchers have now shown it to exert protective effects in a wide range of human and animal disease models. Clinical observations and scientific arguments suggest that a selective scavenging property of H2 cannot adequately explain the beneficial effects of hydrogen. However, there is no experiment challenging ...
BRAIN - SEPSIS

Effects of hydrogen-rich saline in neuroinflammation and mitochondrial dysfunction in rat model of ...

Year Published: 2022

Background: Sepsis-associated encephalopathy (SAE) is one of the most common types of sepsis-related organ dysfunction without overt central nervous system (CNS) infection. It is associated with higher mortality, low quality of life, and long-term neurological sequelae in suspected patients. At present there is no specific treatment for SAE rather than supportive therapy and judicious use of ...
LUNG - CHRONIC OBSTRUCTIVE PULMONARY DISEASE

The effects of hydrogen treatment in a cigarette smoke solution-induced chronic obstructive ...

Year Published: 2022

Background: Molecular hydrogen, with its antioxidant and anti-inflammatory properties, may be suitable for the prevention and treatment of chronic obstructive pulmonary disease (COPD). This study aims to investigate the therapeutic efficacy of hydrogen-oxygen (H2/O2) treatment in cigarette smoke solution (CSS)-induced COPD-like injury in a female BALB/c mouse model. Methods: Thirty mice were ...
INTESTINE - EXCERCISE

Hydrogen improves exercise endurance in rats by promoting mitochondrial biogenesis

Year Published: 2022

Background: Previous studies have shown that hydrogen water has antioxidant and anti-inflammatory effects on exercise-induced fatigue; however, its molecular mechanism remains unclar. Methods: Adult male Sprague-Dawley rats were randomly divided into a pure water drinking group (NC) and a hydrogen water drinking group (HW) (n = 7), and 2-week treadmill training was used to establish a sports ...
LUNG - SEPSIS

Hydrogen gas alleviates lipopolysaccharide-induced acute lung injury and inflammatory response in ...

Year Published: 2022

Background: Chronic inflammation and oxidant/antioxidant imbalance are two main pathological features associated with lipopolysaccharide (LPS)-induced acute lung injury (ALI). The following study investigated the protective role of hydrogen (H2), a gaseous molecule without known toxicity, in LPS-induced lung injury in mice and explored its potential molecular mechanisms. Methods: Mice were ...
BRAIN - NEUROPATHIC PAIN

Treatment with Hydrogen-Rich Water Improves the Nociceptive and Anxio-Depressive-like Behaviors ...

Year Published: 2022

Chronic inflammatory pain is manifested in many diseases. The potential use of molecular hydrogen (H2) as a new therapy for neurological disorders has been demonstrated. Recent studies prove its analgesic properties in animals with neuropathic pain, but the possible antinociceptive, antidepressant, and/or anxiolytic actions of H2 during persistent inflammatory pain have not been investigated. ...
BRAIN - NEUROPATHIC PAIN

Hydrogen-Rich Water as a Novel Therapeutic Strategy for the Affective Disorders Linked with Chronic ...

Year Published: 2022

Neuropathic pain manifested with allodynia and hyperalgesia usually becomes a chronic condition accompanied with mood disorders. Clinical therapies for neuropathic pain are still unsatisfactory with notable side effects. Recent studies have reported the protective role of molecular hydrogen (H2) in different diseases including neurological disorders, such as Alzheimer's as well as its ...
KIDNEY - ACUTE KIDNEY INJURY

Inhalation of 4% and 67% hydrogen ameliorates oxidative stress, inflammation, apoptosis, and ...

Year Published: 2023

Acute kidney injury (AKI) is the major complication of rhabdomyolysis (RM) clinically, which is usually mimicked by glycerol injection in basic research. Oxidative stress, inflammatory response and apoptosis are recognized to play important roles in development of this disease. Recently, numerous studies have reported the therapeutic effects of molecular hydrogen (H2) on oxidative stress and ...
EYE - CORNEAL INJURY

Prophylactic Instillation of Hydrogen-Rich Water Decreases Corneal Inflammation and Promotes Wound ...

Year Published: 2022

Many studies have demonstrated the therapeutic effects of hydrogen in pathological conditions such as inflammation; however, little is known about its prophylactic effects. The purpose of this study is to investigate the prophylactic effects of hydrogen-rich water instillation in a rat corneal alkali burn model. Hydrogen-rich water (hydrogen group) or physiological saline (vehicle group) was ...
LUNG - SARS/COVID

Abstract: Effect of hydrogen therapy on the proteomic profile of exhaled breath condensate after ...

Year Published: 2022

Exhaled breath condensate (EBC) is a promising object for biomarkers search as it contains compounds reflecting changes of biological processes caused by various respiratory diseases including COVID-19. Molecular hydrogen was recently discovered as a new effective antioxidant that can restore lung function after COVID-19. The effect of molecular hydrogen on lung function was studied by comparing ...
EAR - ENVIRONMENTAL POLLUTION

Hydrogen Gas Inhalation Attenuates Acute Impulse Noise Trauma: A Preclinical In Vivo Study

Year Published: 2022

Objective: Molecular hydrogen (H2) has shown therapeutic potential in several oxidative stress-related conditions in humans, is well-tolerated, and is easily administered via inhalation.The aim of this preclinical in vivo study was to investigate whether impulse noise trauma can be prevented by H2 when inhaled immediately after impulse noise exposure. Methods: Guinea pigs (n = 26) were subjected ...
LIVER - LIVER DISEASE

A randomized, placebo-controlled clinical trial of hydrogen/oxygen inhalation for non-alcoholic ...

Year Published: 2022

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide with increasing incidence consistent with obesity, type 2 diabetes and cardiovascular diseases. No approved medication was currently available for NAFLD treatment. Molecular hydrogen (H2 ), an anti-oxidative, anti-inflammatory biomedical agent is proved to exhibit therapeutic and preventive effect in ...
BONE - RHEUMATOID ARTHRITIS

Retracted: Hydrogen alleviates collagen-induced arthritis (CIA) in mice by inhibiting IL-22 levels

Year Published: 2022

Objective To investigate the therapeutic effect and mechanism of hydrogen (H2) on collagen-induced arthritis (CIA) in mice. Methods DBA/1 mice were randomly divided into normal control group, CIA group and CIA mice treated with H2 group (H2 treated group), with 6 mice in each group. Following the preparation of CIA mouse model, the H2 treated group received H2 inhalation therapy (300 mL/L, 3 ...
WHOLE BODY - EXCERCISE

Impact of hydrogen-rich gas mixture inhalation through nasal cannula during post-exercise recovery ...

Year Published: 2020

Molecular hydrogen has been suggested to have a cytoprotective effect on the whole body and to enhance exercise performances. However, the effect of hydrogen-rich gas mixture (HG) inhalation on physiological responses has been poorly investigated. We examined the impact of acute HG inhalation on subsequent oxidative stress, muscle damage, and exercise performances during the recovery period after ...
HEART - CARDIAC ARREST

Hydrogen therapy after resuscitation improves myocardial injury involving inhibition of autophagy in ...

Year Published: 2022

Hydrogen (H2) therapy is a therapeutic strategy using molecular H2. Due to its ability to regulate cell homeostasis, H2 therapy has exhibited marked therapeutic effects on a number of oxidative stress-associated diseases. The present study investigated the effectiveness of H2 therapy in protecting against myocardial injury in a rat model of asphyxial cardiac arrest and cardiopulmonary ...
INTESTINE - HYDROGEN BIOLOGY

Different effects of hydrogen-rich water intake and hydrogen gas inhalation on gut microbiome and ...

Year Published: 2022

The potential for preventive and therapeutic applications of H2 have now been confirmed in various disease. However, the effects of H2 on health status have not been fully elucidated. Our previous study reported changes in the body weight and 13 serum biochemical parameters during the six-month hydrogen intervention. To obtain a more comprehensive understanding of the effects of long-term hydrogen ...
BRAIN - SEPSIS

PPARα contributes to the therapeutic effect of hydrogen gas against sepsis-associated ...

Year Published: 2022

Sepsis-associated encephalopathy (SAE), a fatal complication of sepsis, contributes to cognitive impairment, high morbidity, and mortality. The molecular mechanism of hydrogen (H2) administration, as a promising strategy for the treatment of SAE, is still unclear. Peroxisome proliferator-activated receptor α (PPARα) is essential for alleviating symptoms and complications of SAE. However, little ...