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Studies Found: 1335

BRAIN - STROKE

Gender-based differences in neuroprotective effects of hydrogen gas against intracerebral ...

Year Published: 2022

Background: Post-stroke depression (PSD) severely affects recovery in patients with intracerebral hemorrhage (ICH). Although hydrogen gas (H2) exerts excellent neuroprotective effects in patients with ICH, there are sex-based differences in H2 efficacy in several diseases. Herein, we determined whether estrogen increases susceptibility to the neuroprotective effects of H2 in males with ICH-induced ...
LIVER - LIVER INJURY

A Preliminary Study on the Effect of Hydrogen Gas on Alleviating Early CCl 4-Induced Chronic Liver ...

Year Published: 2021

As a small-molecule reductant substance, hydrogen gas has an obvious antioxidant function. It can selectively neutralize hydroxyl radicals (•OH) and peroxynitrite (ONOO•) in cells, reducing oxidative stress damage. The purpose of this study was to investigate the effect of hydrogen gas (3%) on early chronic liver injury (CLI) induced by CCl4 and to preliminarily explore the protective ...

Microbial hydrogen economy alleviates colitis by reprogramming colonocyte metabolism and reinforcing ...

Year Published: 2022

With the rapid development and high therapeutic efficiency and biosafety of gas-involving theranostics, hydrogen medicine has been particularly outstanding because hydrogen gas (H2), a microbial-derived gas, has potent anti-oxidative, anti-apoptotic, and anti-inflammatory activities in many disease models. Studies have suggested that H2-enriched saline/water alleviates colitis in murine models; ...
LUNG - SURGERY/TRANSPLANTATION

Protective effects of hydrogen inhalation during the warm ischemia phase against lung ...

Year Published: 2019

Background: Successful amelioration of long-term warm ischemia lung injury in donors after cardiac death (DCDs) can remarkably improve outcomes. Hydrogen gas provides potent anti-inflammatory and antioxidant effects against ischemia-reperfusion injury (IRI). This study observed the effects of hydrogen inhalation on lung grafts during the warm ischemia phase in cardiac death donors. Methods: After ...
LUNG - SURGERY/TRANSPLANTATION

Abstract 556: Protective Effect of a Hydrogen-Rich Preservation Solution During Cold Ischemia in Rat ...

Year Published: 2018

No abstract available
WHOLE BODY - HYDROGEN BIOLOGY

Response of Escherichia coli to hydrogen nanobubbles: an in vitro evaluation using synchrotron ...

Year Published: 2021

Hydrogen (H2)-rich water, an apparent source of molecular H2, is an emerging functional drink with many purported benefits for human health (Yang et al., 2020; Ostojic, 2021). The preventive and therapeutic effects of H2 on various pathological processes have been intensively investigated in numerous clinical trials; it is commonly believed that the beneficial effects are mainly attributed to its ...

Hydrogen-rich water partially alleviate inflammation, oxidative stress and intestinal flora ...

Year Published: 2021

Purpose: Oxidative damage and intestinal flora dysbiosis play important roles in the progression of chronic ulcerative colitis (UC). This study explored the effect and mechanism of molecular hydrogen in chronic UC. Materials and methods: Male C57BL/6 mice (19.6 ​± ​0.4 ​g, 7 weeks) were randomly divided into 3 groups: normal control (NC) group, UC (Dextran Sulfate Sodium, DSS) group, and ...
HEART - EXTRACORPOREAL CPR (ECPR)

Hydrogen gas with extracorporeal cardiopulmonary resuscitation improves survival after prolonged ...

Year Published: 2021

Background: Despite the benefits of extracorporeal cardiopulmonary resuscitation (ECPR) in cohorts of selected patients with cardiac arrest (CA), extracorporeal membrane oxygenation (ECMO) includes an artificial oxygenation membrane and circuits that contact the circulating blood and induce excessive oxidative stress and inflammatory responses, resulting in coagulopathy and endothelial cell ...
INTESTINE - CANCER

Controlled release of hydrogen by implantation of magnesium induces P53-mediated tumor cells ...

Year Published: 2021

Hydrogen has been used to suppress tumor growth with considerable efficacy. Inhalation of hydrogen gas and oral ingestion of hydrogen-rich saline are two common systemic routes of hydrogen administration. We have developed a topical delivery method of hydrogen at targeted sites through the degradation of magnesium-based biomaterials. However, the underlying mechanism of hydrogen's role in cancer ...
SKIN - WOUND HEALING

The Therapeutic Effects of Oral Intake of Hydrogen Rich Water on Cutaneous Wound Healing in Dogs

Year Published: 2021

This study explored the effects of drinking Hydrogen-rich water (HRW) on skin wound healing in dogs. Eight circular wounds were analyzed in each dog. The experimental group was treated with HRW thrice daily, while the control group was provided with distilled water (DW). The wound tissues of dogs were examined histopathologically. The fibroblasts, inflammatory cell infiltration, the average number ...
WHOLE BODY - HYDROGEN BIOLOGY

Pharmacokinetics of hydrogen after ingesting a hydrogen-rich solution: A study in pigs

Year Published: 2021

Drinking hydrogen (H2)-rich water is a common way to consume H2. Although many studies have shown efficacy of drinking H2-rich water in neuropsychiatric and endocrine metabolic disorders, their authenticity has been questioned because none examined the associated pharmacokinetics of H2. Therefore, we performed the first study to investigate the pharmacokinetics of H2 in pigs given an H2-rich ...

Hydrogen-rich bath with nano-sized bubbles improves antioxidant capacity based on oxygen radical ...

Year Published: 2021

This study compared the effects of hydrogen-water (HW) bath on the oxygen radical absorption-based antioxidant capacity and the inflammatory indicator, C-reactive protein (CRP), in serum between healthy volunteers and inflammatory/collagen disease-patients. The HW bath apparatus supplied nano-bubbles with a diameter of 110 ± 10 nm and 338-682 μg/L of dissolved hydrogen after 120 minutes ...
WHOLE BODY - HYDROGEN BIOLOGY

In vivo microelectrode monitoring of real-time hydrogen concentration in different tissues of rats ...

Year Published: 2021

Medical effects of hydrogen have been reported in many studies. Due to difficulties in measuring hydrogen concentration in vivo after intake and high explosive risks of hydrogen, studies about dose-response relationships and tissue concentrations of hydrogen are few. Here, for the first time, we monitored real-time hydrogen concentrations in different tissues in rats including brain, liver, ...

The condition of the hairline of Chinchilla lanigera after the introduction of a hydrogen ...

Year Published: 2021

It was found that the inclusion of water enriched with molecular hydrogen into the diet of a long-tailed chinchilla changed the fur quality indicators. In animals of the experimental group, the guard and downy hairs were thinner than in the control group. The length of downy hair in the experimental group was higher, the number of hairs in the follicle in the chinchillas of the experimental group ...
BRAIN - BRAIN INJURY

Molecular hydrogen alleviates lung injury after traumatic brain injury: Pyroptosis and apoptosis

Year Published: 2021

Background: Traumatic brain injury (TBI)-induced acute lung injury (ALI) is a critical condition, and inflammation and apoptosis play essential roles. Molecular hydrogen (H2) exerts anti-inflammatory and anti-apoptotic effects. Our previous work has shown that 42% H2 can improve TBI. In the current study, we tested the hypothesis that inhalation of hydrogen (42% H2, 21% O2, balanced nitrogen) for ...
INTESTINE - INTESTINAL INJURY

Hydrogen Promotes the M1 Macrophage Conversion During the Polarization of Macrophages in Necrotizing ...

Year Published: 2021

Background: Hydrogen is protective against intestinal injury in necrotizing enterocolitis (NEC), mainly through to alleviate inflammation response. The M1 macrophages can promote inflammation. We hypothesized that hydrogen would promote the M1 macrophages conversion during the polarization and reduce the inflammatory factors in NEC. Methods: We used M1 and M2 macrophages induced from RAW264.7 ...
LUNG - DIVING

Hydra V Hydrogen Experimental Dive To 450 Meters

Year Published: 1986

HYDRAV was performed in COMEX Marseille hyperbaric Research Center in May and June 1985.During this Experiment, 6 divers lived at a simulated depth of 450 meters in a hyperbaric atmosphere composed of hydrogen, helium and oxygen (hydreliox). Tradition deep diving with helium is limited by 2 Factor: – High Pressure Nervous syndrome (HENS) that causes Motricity disorders beyond 300 meters. – Gas ...
WHOLE BODY - EXCERCISE

Influence of molecular hydrogen on behavioral adaptation of Сhinchilla lanigera taking into account ...

Year Published: 2021

It was found that the inclusion of water enriched with molecular hydrogen in the diet of animals increased the overall proportion of active behavior. According to the form of behavior 'moving around the cage', it was found that males and females of the experimental group spent more time than animals of the control group. Males of the experimental group were 24% more active at night, and females ...
BRAIN - AGING

Effects of Natural Reduced Water on Cognitive Function, Body Composition, and Psychological Function ...

Year Published: 2021

Natural reduced water is natural water that contains active hydrogen and reduces oxidation. It is rare in the world, and in Japan, it is produced in the Hita area of Oita Prefecture (Hita Tenryosui water). Previous studies in humans have examined the effects of natural reduced water on diabetes, which is one of the known risks for dementia. Animal studies of natural reduced water have revealed ...
LIVER - SURGERY/TRANSPLANTATION

Effect of hydrogen gas inhalation on patient QOL after hepatectomy: protocol for a randomized ...

Year Published: 2021

Introduction: Molecular hydrogen had been considered inactive in vivo but is an antioxidant that selectively reduces highly toxic reactive oxygen species (ROS). Animal studies have reported that hydrogen gas inhalation helped alleviate cerebral and cardiac ischemia-reperfusion injuries. In humans, hydrogen inhalation therapy is presently approved as a treatment under Advanced Medical Care B in ...
BONE MARROW - SURGERY/TRANSPLANTATION

Hydrogen-Rich Water Ameliorates Murine Chronic Graft-versus-Host Disease through Antioxidation

Year Published: 2021

Background: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an important treatment option for various hematopoietic diseases and certain hereditary diseases. Chronic graft-versus-host disease (cGVHD) has become the main life-threatening complication and cause of death in later stage postallo-HSCT. Current treatment options for cGVHD are limited. Hydrogen gas (H2) has been ...
HEART - DIABETES

Effect of hydrogen-rich water on the lactic acid level in metformin-treated diabetic rats under ...

Year Published: 2021

The present study aims to investigate the impact of hydrogen-rich water on the lactic acid level in metformin-treated diabetic rats under hypoxia. Thirty Sprague-Dawley rats were randomly divided into five groups, including normal diet group, and diabetes model (DM) group, DM + metformin treatment (DMM) group, DMM + hypoxia treatment (DMMH) group and DMMH + hydrogenrich water (DMMHR) group. We ...
WHOLE BODY - ENVIRONMENTAL POLLUTION

Evaluation of the hydrogen-rich water alleviation potential on mercury toxicity in earthworms using ...

Year Published: 2021

The toxic effects of mercury in earthworms and the potential alleviation effect of hydrogen-rich water (HRW) using ATR-FTIR and LC-MS analysis methods were investigated. Different concentrations of mercury chloride (H1: 5 µg/mL, H2: 10 µg/mL, H3: 20 µg/mL, H4: 40 µg/mL, and C1: control) and mercury chloride prepared in hydrogen-rich water (H5: 5 µg/mL, H6: 10 µg/mL, H7: 20 µg/mL, H8: 40 ...
LUNG - CANCER

The effects of inhaling hydrogen gas on macrophage polarization, fibrosis, and lung function in mice ...

Year Published: 2021

Background: Acute respiratory distress syndrome, which is caused by acute lung injury, is a destructive respiratory disorder caused by a systemic inflammatory response. Persistent inflammation results in irreversible alveolar fibrosis. Because hydrogen gas possesses anti-inflammatory properties, we hypothesized that daily repeated inhalation of hydrogen gas could suppress persistent lung ...
WHOLE BODY - AGING

Protective Effect of Molecular Hydrogen Following Different Routes of Administration on ...

Year Published: 2021

Background: Molecular hydrogen (H2) has been recognized as an effective antioxidant with no or little side effects. While it is known that oxidative stress is closely associated with aging, the beneficial effect of H2 on oxidative stress-related aging is still unclear. In this study, a mouse model of D-galactose-induced aging was employed to investigate the protective effects of H2. Methods: The ...