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Studies Found: 189

BRAIN - DEMENTIA

FoxO1-mediated autophagy plays an important role in the neuroprotective effects of hydrogen in a rat ...

Year Published: 2019

Vascular dementia (VD) is a heterogeneous group of brain disorders in which cognitive impairment is attributed to cerebrovascular pathologies. Autophagy, a self-cannibalization mechanism, has been demonstrated to be involved in VD progression. Molecular hydrogen is known for its powerful anti-oxidative, anti-apoptotic, and anti-inflammatory activities, and it is also involved in autophagy. ...
BRAIN - CANCER

Molecular hydrogen suppresses glioblastoma growth via inducing the glioma stem-like cell ...

Year Published: 2019

Background: Glioblastoma (GBM) is the most common type of primary malignant brain tumor. Molecular hydrogen has been considered a preventive and therapeutic medical gas in many diseases including cancer. In our study, we sought to assess the potential role of molecular hydrogen on GBM. Methods: The in vivo studies were performed using a rat orthotopic glioma model and a mouse subcutaneous ...
BRAIN - CANCER

Effect of Hydrogen-Rich Water on Radiation-Induced Cognitive Dysfunction in Rats

Year Published: 2019

The goal of this work was to determine whether hydrogen-rich water (HRW) could attenuate radiation-induced cognitive dysfunction in rats and to explore the underlying mechanisms. Rats received 30 Gy whole-brain irradiation using a 6-MeV electron beam. Either purified water or HRW (0.8-0.9 ppm) was administrated at 10 min prior to irradiation, as well as a daily HRW treatment after irradiation for ...
BRAIN - NEUROPROTECTION

Protective effect of hydrogen-rich water on oxidative stress cell model and the impact of the ...

Year Published: 2019

Objective: To explore the protective effect of hydrogen-rich water on the oxidative stress injury of astrocytes in mice and its effect on phosphatidylinositol 3 kinase/protein kinase B (PI3K/Akt) signal pathway. Methods: In vitro, mice astrocytes were cultured and the logarithmic growth period cells were taken for experiment. (1) Experiment one: some cells were acted by 1.25, 2.50, 5.00, 10.00 ...
BRAIN - ENVIRONMENTAL POLLUTION

Hydrogen gas protects against delayed encephalopathy after acute carbon monoxide poisoning in a rat ...

Year Published: 2019

Objective: The protective effects of 2%-4% hydrogen gas in delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) have been previously reported. This study aimed to assess the neuroprotective effects of high concentration hydrogen (HCH) on DEACMP. Methods: A total of 36 male Sprague-Dawley rats were divided into 3 groups. In the DEACMP group, rats were exposed to CO to induce CO ...
BRAIN - ADDICTION

Effects of Molecular Hydrogen on Methamphetamine-Induced Neurotoxicity and Spatial Memory Impairment

Year Published: 2019

Methamphetamine (METH) is a highly addictive stimulant, and METH exposure can induce irreversible neuronal damage and cause neuropsychiatric and cognitive disorders. The ever-increasing levels of METH abuse worldwide have necessitated the identification of effective intervention strategies to protect the brain against METH-induced neurotoxicity. The protective effects of molecular hydrogen on ...
BRAIN - BRAIN INJURY

Hydrogen inhalation protects hypoxic–ischemic brain damage by attenuating inflammation and ...

Year Published: 2019

Hypoxic–ischemic brain damage (HIBD) is one of the leading causes of brain injury in infant with high risk of mortality and disability; therefore, it is important to explore more feasible and effective treatment strategies. Here, we assessed the neuroprotective effects of different hydrogen inhalation times for the treatment of HIBD. We induced hypoxia–ischemia in Sprague–Dawley rats ...
BRAIN - STROKE

Neuroprotective effects of hydrogen inhalation in an experimental rat intracerebral hemorrhage model

Year Published: 2018

Objective: Hydrogen inhalation has been found to be neuroprotective and anti-oxidative in several brain injury models. Building on these studies, we investigated potential neuroprotective effects of hydrogen inhalation in a rat model of intracerebral hemorrhage (ICH), focusing on apoptosis and inflammation. Methods: Forty-five 8-week-old male Sprague-Dawley rats were randomly divided into three ...
BRAIN - TRAUMATIC BRAIN INJURY

Effect of hydrogen-rich water on the chondriosome damage and cytokines in brain tissue of rats with ...

Year Published: 2018

Objective: To observe the effect of hydrogen-rich water on the chondriosome damage and cytokines change in brain tissue of rats with traumatic brain injury (TBI). Methods: Fifty-four health male Sprague-Dawley (SD) rats were divided into three groups by random number table: sham group, trauma group (TBI group), and trauma+hydrogen-rich water group (TBI+HW group), the rats in each group were ...
BRAIN - AUTISM

Hydrogen-Rich Water Ameliorates Autistic-Like Behavioral Abnormalities in Valproic Acid-Treated ...

Year Published: 2018

Due to its anti-inflammatory and anti-oxidative effects, recent research has demonstrated that molecular hydrogen can serve as a new medical approach for depression, anxiety and traumatic brain injury. However, its potential effects on neurodevelopmental diseases, such as autism are still elusive. The present study aims to investigate the potential effects of hydrogen-rich water (HRW) ...
BRAIN - ALZHEIMER'S DISEASE (AD)

Hydrogen-rich water improves cognitive impairment gender-dependently in APP/PS1 mice without ...

Year Published: 2018

Alzheimer's disease (AD) is characterised as a provoked inflammatory response and oxidative stress along with amyloid β peptide (Aβ) deposition and neurofibrillary tangles in the brain, and effective treatment is greatly needed. Molecular hydrogen, which has been proposed to be an antioxidant that selectively reduces reactive oxygen species, was found to exert beneficial effects in Aβ ...
BRAIN - STROKE

Hydrogen inhalation improves mouse neurological outcomes after cerebral ischemia/reperfusion ...

Year Published: 2018

This study aimed to investigate the role of necroptosis in the neuroprotection of hydrogen in a mouse model of cerebral ischemia/reperfusion (I/R) injury. C57BL mice were randomly divided into sham group, I/R group, hydrogen/oxygen group (HO), nitrogen/oxygen group (NO). Middle cerebral artery occlusion (MCAO) for 1 hour followed by reperfusion was introduced to animals which were allowed to ...
BRAIN - CARDIOPULMONARY RESUSCITATION (CPR)

Inhalation of high concentration hydrogen gas improves short-term outcomes in a rat model of ...

Year Published: 2018

Cardiogenic global brain hypoxia-ischemia is a devastating medical problem that is associated with unfavorable neurologic outcomes. Low dose hydrogen gas (up to 2.9%) has been shown to be neuroprotective in a variety of brain diseases. In the present study, we investigated the protective effect of water by electrolysis-derived high concentration hydrogen gas (60%) in a rat model of asphyxia ...
BRAIN - DIABETES

Hydrogen‑rich medium alleviates high glucose‑induced oxidative stress and parthanatos in rat ...

Year Published: 2018

Diabetic peripheral neuropathy (DPN) is considered to be the most common cause of microvascular diabetic complications, for which no effective therapies currently exist. Previous studies have identified that oxidative stress is the common pathway in all possible hypotheses for the induction of DPN, and poly(ADP‑ribose) (PAR) polymerase‑1 (PARP‑1)‑dependent cell death (parthanatos) is key ...
BRAIN - SLEEP APNEA

Hydrogen ameliorates chronic intermittent hypoxia-induced neurocognitive impairment via inhibiting ...

Year Published: 2018

Obstructive sleep apnea (OSA) is a very common breathing and sleep disorder characterized by intermittent hypoxia (IH), which is often associated with behavioral and neurocognitive functions impairment. Hydrogen (H2), as a novel and effective antioxidant, is reported to be a potential neuroprotective agent. The aim of this study is to investigate whether H2 could improve CIH-induced neurocognitive ...
BRAIN - MULTIPLE SCLEROSIS (MS)

Hydrogen-Rich Saline Ameliorates Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice Via the ...

Year Published: 2018

Multiple sclerosis (MS) is a chronic and inflammatory disease of the central nervous system that is associated with demyelination, neurodegeneration, and sensitivity to oxidative stress. Hydrogen-rich saline (HRS) is efficacious in preventive and therapeutic applications for many disorders because of its antioxidant and anti-inflammatory properties. Here, we determined the effect of HRS in ...
BRAIN - NEUROPROTECTION

Effects of hydrogen-rich water on attenuating fatigue induced by daily activities or mental tasks

Year Published: 2018

Objectives In 2007, the first report that hydrogen removes active oxygen was published, and many clinical and non-clinical studies have since been conducted using hydrogen gas or water. Several diseases and symptoms are related to active oxygen, and fatigue is also induced by increases in oxidative stress. The current randomized, double-blind, placebo-controlled, crossover study was conducted to ...
BRAIN - ANXIETY

Hydrogen-rich water for improvements of mood, anxiety, and autonomic nerve function in daily life

Year Published: 2018

Health and a vibrant life are sought by everyone. To improve quality of life (QOL), maintain a healthy state, and prevent various diseases, evaluations of the effects of potentially QOL-increasing factors are important. Chronic oxidative stress and inflammation cause deteriorations in central nervous system function, leading to low QOL. In healthy individuals, aging, job stress, and cognitive load ...
BRAIN - STROKE

Effects of hydrogen on polarization of macrophages and microglia in a stroke model

Year Published: 2018

It has been confirmed that inflammation plays an important role in the pathogenesis of ischemic stroke. The polarization of microglia as an important participant in the inflammation following stroke is also found to be involved in stroke. This study aimed to investigate the effects of hydrogen gas on the polarization of macrophages/microglia in vitro. Raw264.7 cells were treated with ...
BRAIN - DEMENTIA

Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild ...

Year Published: 2018

Background: Oxidative stress is one of the causative factors in the pathogenesis of neurodegenerative diseases including mild cognitive impairment (MCI) and dementia. We previously reported that molecular hydrogen (H2) acts as a therapeutic and preventive antioxidant. Objective: We assess the effects of drinking H2-water (water infused with H2) on oxidative stress model mice and subjects with MCI. ...
BRAIN - TRAUMATIC BRAIN INJURY

Molecular Hydrogen Prevents Social Deficits and Depression-Like Behaviors Induced by Low-Intensity ...

Year Published: 2018

Detonation of explosive devices creates blast waves, which can injure brains even in the absence of external injuries. Among these, blast-induced mild traumatic brain injury (bmTBI) is increasing in military populations, such as in the wars in Afghanistan, Iraq, and Syria. Although the clinical presentation of bmTBI is not precisely defined, it is frequently associated with psycho-neurological ...
BRAIN - NEUROPROTECTION

Hydrogenized Water Effects on Protection of Brain Cells from Oxidative Stress and Glutamate Toxicity

Year Published: 2018

Hydrogenized water is known to have protective effects on cells and tissues, mainly through its antioxidant activities. Here we examined the protective effects of a commercial source of hydrogenized water on cultured human brain cells. Hydrogenized water was able to protect brain cells from oxidative stress and glutamate toxicity. At H 2 concentrations above 0.01 mM the glutathione levels ...
BRAIN - BRAIN INJURY

Molecular hydrogen alleviates asphyxia-induced neuronal cyclooxygenase-2 expression in newborn pigs

Year Published: 2018

Cyclooxygenase-2 (COX-2) has an established role in the pathogenesis of hypoxic-ischemic encephalopathy (HIE). In this study we sought to determine whether COX-2 was induced by asphyxia in newborn pigs, and whether neuronal COX-2 levels were affected by H2 treatment. Piglets were subjected to either 8 min of asphyxia or a more severe 20 min of asphyxia followed by H2 treatment (inhaling room air ...
BRAIN - NEUROPATHIC PAIN

Hydrogen-Rich Saline Activated Autophagy via HIF-1 α Pathways in Neuropathic Pain Model

Year Published: 2018

Background Neuropathic pain is a chronic and intractable pain, with very few effective analgesics. It involves an impaired cell autophagy process. Hydrogen-rich saline (HRS) reportedly reduces allodynia and hyperalgesia in a neuropathic pain model; however, it is unknown whether these effects involve autophagy induction. Methods We investigated the relationship between HRS and cell autophagy in a ...
BRAIN - TRAUMATIC BRAIN INJURY

Hydrogen Gas Treatment Improves the Neurological Outcome After Traumatic Brain Injury Via Increasing ...

Year Published: 2018

Hydrogen gas (H2) exerts a beneficial effect against traumatic brain injury (TBI). microRNA-21 (miR-21) is one of the most highly expressed members of small non-coding microRNA family in mammalian cells. miR-21 can improve the neurological outcome after TBI. In the present study, we investigated whether H2 treatment could improve the neurological outcome after TBI via increasing miR-21 expression. ...