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Studies Found: 189

BRAIN - MULTIPLE SCLEROSIS (MS)

Hydrogen-rich water improves neurological functional recovery in experimental autoimmune ...

Year Published: 2016

Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease of the central nervous system (CNS). The high costs, inconvenient administration, and side effects of current Food and Drug Administration (FDA)-approved drugs often lead to poor adherence to the long-term treatment of MS. Molecular hydrogen (H2) has been reported to exhibit anti-oxidant, anti-apoptotic, anti-inflammatory, ...
BRAIN - BRAIN INJURY

Hydrogen-rich saline mediates neuroprotection through the regulation of endoplasmic reticulum stress ...

Year Published: 2016

Hydrogen as a new medical gas exerts organ-protective effects through regulating oxidative stress, inflammation and apoptosis. Multiple lines of evidence reveal the protective effects of hydrogen in various models of brain injury. However, the exact mechanism underlying this protective effect of hydrogen against hypoxic-ischemic brain damage (HIBD) is not fully understood. The present study was ...
BRAIN - TRAUMATIC BRAIN INJURY

Effects of hydrogen-rich water on the expression of aquaporin 1 in the cerebral cortex of rat with ...

Year Published: 2016

Objective: To investigate the effect of hydrogen-rich water on cerebral edema and aquaporin 1 (AQP1) expression in rats with traumatic brain injury (TBI). Methods: Ninety male Sprague-Dawley (SD) rats were randomly divided into sham operation group, TBI model group, hydrogen-rich water treatment group (H group),with 30 rats in each group. TBI model was reproduced by weight dropping method. The ...
BRAIN - STROKE

Inhalation of water electrolysis-derived hydrogen ameliorates cerebral ischemia–reperfusion injury ...

Year Published: 2016

Hydrogen is a kind of noble gas with the character to selectively neutralize reactive oxygen species. Former researches proved that low-concentration of hydrogen can be used to ameliorating cerebral ischemia/reperfusion injury. Hydrogen electrolyzed from water has a hydrogen concentration of 66.7%, which is much higher than that used in previous studies. And water electrolysis is a potential new ...
BRAIN - ALZHEIMER'S DISEASE (AD)

Electrolyzed-reduced water mitigates amyloid beta toxicity via DAF-16 in C. elegans

Year Published: 2016

Alzheimer’s disease is an age-related neurodegenerative disease. Extracellular aggregation of amyloid beta is a well-known hallmark of Alzheimer’s disease and believed to be critical for the development of Alzheimer’s disease. Lots of efforts have been put on finding an intervention alleviating amyloid beta toxicity. Electrolyzed-reduced water is generated near cathode by electrolysis of ...
BRAIN - STROKE

Neuroprotective Effect of Hydrogen-Rich Saline in Global Cerebral Ischemia/Reperfusion Rats: ...

Year Published: 2016

Recently, it has been suggested that molecular hydrogen (H2) can selectively reduce the levels of hydroxyl radicals (.OH), and ameliorate oxidative and inflammatory injuries to organs in global cerebral ischemia reperfusion models. Global cerebral ischemia/reperfusion (I/R) can induce a sudden activation of inflammatory cytokines and later influence the systemic immunoreactivity which may ...
BRAIN - BRAIN INJURY

Molecular hydrogen affords neuroprotection in a translational piglet model of hypoxic-ischemic ...

Year Published: 2016

Hypoxic-ischemic encephalopathy (HIE) is the major consequence of perinatal asphyxia (PA) in term neonates. Although the newborn piglet is an accepted large animal PA/HIE model, there is no consensus on PA-induction methodology to produce clinically relevant HIE. We aimed to create and to characterize a novel PA model faithfully reproducing all features of asphyxiation including severe hypercapnia ...
BRAIN - NEUROPATHIC PAIN

H2 Treatment Attenuated Pain Behavior and Cytokine Release Through the HO-1/CO Pathway in a Rat ...

Year Published: 2015

Neuropathic pain (NP) is characterized by persistent pain, tactile allodynia, or hyperalgesia. Peripheral nerve injury contributes to rapid progress of inflammatory response and simultaneously generates neuropathic pain. Hydrogen (H2) has anti-inflammation, anti-apoptosis, and anti-oxidative stress effects. Therefore, we hypothesized that H2 treatment could alleviate allodynic and hyperalgesic ...
BRAIN - BRAIN INJURY

Hydrogen-rich water protects against ischemic brain injury in rats by regulating calcium buffering ...

Year Published: 2015

Hydrogen-rich water (HRW) has anti-oxidant activities, and it exerts neuroprotective effects during ischemia-reperfusion brain injury. Parvalbumin and hippocalcin are two calcium buffering proteins, which are involved in neuronal differentiation, maturation and apoptosis. The aim of this study was to investigate whether HRW could moderate parvalbumin and hippocalcin expression during ischemic ...
BRAIN - NEUROPATHIC PAIN

Abstract: Consumption of hydrogen water prevents the occurrence of neuropathic pain in mice

Year Published: 2015

No abstract available
BRAIN - ALZHEIMER'S DISEASE (AD)

Hydrogen-rich water attenuates amyloid β-induced cytotoxicity through upregulation of Sirt1-FoxO3a ...

Year Published: 2015

Amyloid β (Aβ) peptides are identified in cause of neurodegenerative diseases such as Alzheimer's disease (AD). Previous evidence suggests Aβ-induced neurotoxicity is linked to the stimulation of reactive oxygen species (ROS) production. The accumulation of Aβ-induced ROS leads to increased mitochondrial dysfunction and triggers apoptotic cell death. This suggests antioxidant therapies may be ...
BRAIN - TRAUMATIC BRAIN INJURY

Changes of immuno-inflammatory responses by intraperitoneal injection of hydrogen after diffuse ...

Year Published: 2015

To explore the role of immuno-inflammatory reaction in diffuse axonal injury (DAI) and the therapeutic action of hydrogen in DAI model. Methods Totally 96 adult male SD rats were divided into 8 groups (n=12 in each): normal group, sham group, DAI groups (6h, 1d and 3d) and DAI with hydrogen treatment groups(6h, 1d and 3d). Rat DAI model was induced by an experimental facility developed to make ...
BRAIN - BRAIN INJURY

Protective effect of molecular hydrogen against white matter ischemic injury

Year Published: 2015

The central nervous system (CNS) white matter (WM) ischemia is an important clinical problem and may produce injury, in part, by reactive oxygen species (ROS)-induced mitochondrial dysfunction. Using the mouse optic nerve (MON) WM model, we tested whether hydrogen (H2) in drinking water reduced functional WM ischemic injury. Functional integrity of MON was determined by quantitatively monitoring ...
BRAIN - BRAIN INJURY

Hydrogen-Rich Saline Attenuated Subarachnoid Hemorrhage-Induced Early Brain Injury in Rats by ...

Year Published: 2015

Early brain injury (EBI), highlighted with inflammation and apoptosis, occurring within 72 h after subarachnoid hemorrhage (SAH), is associated with the prognosis of SAH. Recent studies have revealed that hydrogen-rich saline (HS) exerted multiple neuroprotective properties in many neurological diseases including SAH, involved to anti-oxidative and anti-apoptotic effect. We have previously ...
BRAIN - STROKE

Hydrogen improves neurological function through attenuation of blood–brain barrier disruption in ...

Year Published: 2015

Enhanced oxidative stress occurs in spontaneously hypertensive stroke-prone rats (SHRSP), and is important in blood-brain barrier (BBB) disruption. Hydrogen can exert potent protective cellular effects via reduction in oxidative stress in various diseases. The present study investigated whether long-term hydrogen treatment can improve neurological function outcome in the SHRSP model, and the ...
BRAIN - TRAUMATIC BRAIN INJURY

Hydrogen-rich water attenuates brain damage and inflammation after traumatic brain injury in rats

Year Published: 2015

Inflammation and oxidative stress are the two major causes of apoptosis after traumatic brain injury (TBI). Most previous studies of the neuroprotective effects of hydrogen-rich water on TBI primarily focused on antioxidant effects. The present study investigated whether hydrogen-rich water (HRW) could attenuate brain damage and inflammation after traumatic brain injury in rats. A TBI model was ...
BRAIN - SURGERY/TRANSPLANTATION

Hydrogen Suppresses Hypoxia/Reoxygenation-Induced Cell Death in Hippocampal Neurons Through Reducing ...

Year Published: 2015

Deep hypothermic circulatory arrest (DHCA) is a cerebral protection technique that has been used in the operations involving the aortic arch and brain aneurysm for decades. We previous showed that DHCA treated rats developed a significant oxidative stress and apoptosis in neurons. We here intend to investigate the protective the effect of hydrogen against oxidative stress-induced cell injury and ...
BRAIN - DIABETES

Protective effect of hydrogen‑rich medium against high glucose‑induced apoptosis of Schwann ...

Year Published: 2015

Diabetic peripheral neuropathy (DPN) is considered to be one of the most prevalent and life threatening microvascular diabetic complications. DPN affects up to 50% of patients with diabetes mellitus and there are currently no efficacious therapeutic strategies available for its treatment. Previous studies have reported that oxidative stress and poly(ADP‑ribose) polymerase‑1 (PARP‑1) may be ...
BRAIN - TRAUMATIC BRAIN INJURY

Effects of hydrogen rich water on the expression of Nrf 2 and the oxidative stress in rats with ...

Year Published: 2015

Objective: To investigate the effects of hydrogen rich water on the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and oxidative stress in rats with traumatic brain injury (TBI). Methods: Ninety healthy male Sprague-Dawley (SD) rats were randomly divided into sham operation group, TBI group and hydrogen rich water treatment group (HW group), with 30 rats in each group. TBI model ...
BRAIN - AMYOTROPHIC LATERIAL SCLEROSIS (ALS)

Treatment with Hydrogen-Rich Saline Delays Disease Progression in a Mouse Model of Amyotrophic ...

Year Published: 2015

Amyotrophic lateral sclerosis (ALS) is the most frequent adult-onset motor neuron disease, and accumulating evidence indicates that oxidative mechanisms contribute to ALS pathology, but classical antioxidants have not performed well in clinical trials. The aim of this work was to investigate the effect of treatment with hydrogen molecule on the development of disease in mutant SOD1 G93A transgenic ...
BRAIN - STROKE

Role of FOXO3A in process of hydrogen-rich saline attenuating global cerebral ischemia-reperfusion ...

Year Published: 2015

To investigate the role of FOXO3a in process of hydrogen-rich saline attenuating global cerebral ischemia-reperfusion (I/R) injury in rats. Seventy-two male Sprague Dawley rats, weighing 280-320 g, were randomly divided into six groups (n = 12 each) : sham operation group (group I), cerebral ischemia-reperfusion group (group II), hydrogen-rich saline group (group III), vehicle group (group IV), ...
BRAIN - BRAIN INJURY

Hydrogen-rich saline attenuates neuronal ischemia - Reperfusion injury by protecting mitochondrial ...

Year Published: 2014

Background: Hydrogen, a popular antioxidant gas, can selectively reduce cytotoxic oxygen radicals and has been found to protect against ischemia–reperfusion (I/R) injury of multiple organs. Acute neuronal death during I/R has been attributed to loss of mitochondrial permeability transition coupled with mitochondrial dysfunction. This study was designed to investigate the potential therapeutic ...
BRAIN - TRAUMATIC BRAIN INJURY

Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic ...

Year Published: 2014

Traumatic brain injury (TBI) in its various forms has emerged as a major problem for modern society. Acute TBI can transform into a chronic condition and be a risk factor for neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, probably through induction of oxidative stress and neuroinflammation. Here, we examined the ability of the antioxidant molecular hydrogen given in ...
BRAIN - NEUROPATHIC PAIN

Intrathecal Infusion of Hydrogen-Rich Normal Saline Attenuates Neuropathic Pain via Inhibition of ...

Year Published: 2014

Background Reactive oxygen and nitrogen species are key molecules that mediate neuropathic pain. Although hydrogen is an established antioxidant, its effect on chronic pain has not been characterized. This study was to investigate the efficacy and mechanisms of hydrogen-rich normal saline induced analgesia. Methodology/Principal findings In a rat model of neuropathic pain induced by L5 spinal ...
BRAIN - CARDIOPULMONARY RESUSCITATION (CPR)

Hydrogen Inhalation During Normoxic Resuscitation Improves Neurological Outcome in a Rat Model of ...

Year Published: 2014

Background: We have previously shown that hydrogen (H2) inhalation, begun at the start of hyperoxic cardiopulmonary resuscitation, significantly improves brain and cardiac function in a rat model of cardiac arrest. Here, we examine the effectiveness of this therapeutic approach when H2 inhalation is begun on the return of spontaneous circulation (ROSC) under normoxic conditions, either alone or in ...