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Studies Found: 200

BRAIN - PARKINSON'S DISEASE

Oral 'hydrogen water' induces neuroprotective ghrelin secretion in mice

Year Published: 2013

The therapeutic potential of molecular hydrogen (H₂) is emerging in a number of human diseases and in their animal models, including in particular Parkinson's disease (PD). H₂ supplementation of drinking water has been shown to exert disease-modifying effects in PD patients and neuroprotective effects in experimental PD model mice. However, H₂ supplementation does not result in detectable ...
BRAIN - BRAIN INJURY

The effect of hydrogen gas on a mouse bilateral common carotid artery occlusion

Year Published: 2013

In recent studies, molecular hydrogen selectively reduced the levels of hydroxyl radicals in vitro and exerted a therapeutic anti-oxidant activity in a rat middle cerebral artery occlusion model. The aim of this study was to investigate the effect of hydrogen gas on a mouse bilateral common carotid artery occlusion (BCCAO) model. Male C57BL/6J mice were subjected to transient BCCAO with a ...
BRAIN - STROKE

Safety of intravenous administration of hydrogen-enriched fluid in patients with acute cerebral ...

Year Published: 2013

Most of the results regarding hydrogen (H2) therapy for acute cerebral ischemia are derived from in vitro studies and animal experiments, with only a few obtained from human trials with a limited number of subjects. Thus, there is a paucity of information regarding both the beneficial therapeutic effects as well as the side effects of H2 on acute cerebral ischemia in humans. We designed a pilot ...
BRAIN - BRAIN INJURY

Delayed Neurovascular Dysfunction Is Alleviated by Hydrogen in Asphyxiated Newborn Pigs

Year Published: 2013

Background: The neurovascular unit encompasses the functional interactions of cerebrovascular and brain parenchymal cells necessary for the metabolic homeostasis of neurons. Previous studies indicated marked but only transient (1-4 h) reactive oxygen species-dependent neurovascular dysfunction in newborn pigs after severe hypoxic/ischemic (H/I) stress contributing to the neuronal injury after ...
BRAIN - ENVIRONMENTAL POLLUTION

Effects of hydrogen-rich saline on rats with acute carbon monoxide poisoning

Year Published: 2013

Background: Studies have shown that inhalation of hydrogen gas, which acts as an antioxidant, can protect the brain against free radicals in rats with ischemia-reperfusion. The neuronal damage caused by acute carbon monoxide (CO) poisoning is partly free radical mediated. We hypothesize that hydrogen may prevent neurological damage from CO poisoning. Objectives: This study is designed to test ...
BRAIN - NEUROPROTECTION

Coadministration of hydrogen gas as part of the carrier gas mixture suppresses neuronal apoptosis ...

Year Published: 2013

Background: In animal models, several anesthetics induce widespread increases in neuronal apoptosis in the developing brain with subsequent neurologic deficits. Although the mechanisms are largely unknown, the neurotoxicity may, at least in part, be due to elevated oxidative stress caused by mitochondrial dysfunction. In an investigation of potential therapies that could protect against this type ...
BRAIN - PARKINSON'S DISEASE

Pilot study of H-2 therapy in Parkinson's disease: A randomized double-blind placebo-controlled ...

Year Published: 2013

Background: Oxidative stress is involved in the progression of Parkinson's disease (PD). Recent studies have confirmed that molecular hydrogen (H₂) functions as a highly effective antioxidant in cultured cells and animal models. Drinking H₂-dissolved water (H₂-water) reduced oxidative stress and improved Parkinson's features in model animals. Methods: In this a placebo-controlled, ...
BRAIN - STROKE

Lactulose ameliorates cerebral ischemia-reperfusion injury in rats by inducing hydrogen by ...

Year Published: 2013

Molecular hydrogen has been proved effective in ameliorating cerebral ischemia/reperfusion (I/R) injury by selectively neutralizing reactive oxygen species. Lactulose can produce considerable amount of hydrogen through fermentation by the bacteria in the gastrointestinal tract. To determine the neuroprotective effects of lactulose against cerebral I/R injury in rats and explore the probable ...
BRAIN - BRAIN INJURY

Nuclear factor-κB/Bcl-XL pathway is involved in the protective effect of hydrogen-rich saline on ...

Year Published: 2013

Early brain injury (EBI), a significant contributor to poor outcome after subarachnoid hemorrhage (SAH), is intimately associated with neuronal apoptosis. Recently, the protective role of hydrogen (H2 ) in the brain has been widely studied, but the underlying mechanism remains elusive. Numerous studies have shown nuclear factor-κB (NF-κB) as a crucial survival pathway in neurons. Here we ...
BRAIN - BRAIN INJURY

Beneficial effect of hydrogen-rich saline on cerebral vasospasm after experimental subarachnoid ...

Year Published: 2012

Cerebral vasospasm (CV) remains a common and devastating complication in patients with subarachnoid hemorrhage (SAH). Despite its clinical significance and extensive research, the underlying pathogenesis and therapeutic perspectives of CV remain incompletely understood. Recently, it has been suggested that molecular hydrogen (H(2)) can selectively reduce levels of hydroxyl radicals (·OH) and ...
BRAIN - TRAUMATIC BRAIN INJURY

Hydrogen-rich saline protects against oxidative damage and cognitive deficits after mild traumatic ...

Year Published: 2012

Oxidative stress is the principal factor in traumatic brain injury (TBI) that initiates events that result in protracted neuronal dysfunction and remodeling. Importantly, antioxidants can protect the brain against oxidative damage and modulate the capacity of the brain to cope with synaptic dysfunction and cognitive impairment. However, no studies have investigated the effects of hydrogen-rich ...
BRAIN - PARKINSON'S DISEASE

Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous ...

Year Published: 2012

Lactulose is a synthetic disaccharide that can be catalyzed only by intestinal bacteria in humans and rodents, and a large amount of hydrogen is produced by bacterial catalysis of lactulose. We previously reported marked effects of ad libitum administration of hydrogen water on prevention of a rat model of Parkinson's disease (PD). End-alveolar breath hydrogen concentrations were measured in 28 ...
BRAIN - TRAUMATIC BRAIN INJURY

Protective effects of hydrogen-rich saline in a rat model of traumatic brain injury via reducing ...

Year Published: 2012

Background: Hydrogen gas (H(2)) has been considered as a novel antioxidant to selectively reduce the toxic reactive oxygen species (ROS) such as hydroxyl radical (•OH) without affecting the other signal ROS. Our recent study shows that H(2) inhalation is beneficial to traumatic brain injury (TBI) via reducing oxidative stress. In contrast to H(2), hydrogen-rich saline (HS) may be more suitable ...
BRAIN - STROKE

Protective effects of hydrogen-rich saline in a rat model of permanent focal cerebral ischemia via ...

Year Published: 2012

Hydrogen gas (H(2)) as a new medical gas exerts organ-protective effects through regulating oxidative stress, inflammation and apoptosis. In contrast to H(2), hydrogen-rich saline (HS) may be more suitable for clinical application. The present study was designed to investigate whether HS can offer a neuroprotective effect in a rat model of permanent focal cerebral ischemia and what mechanism(s) ...
BRAIN - BRAIN INJURY

Effect of Hydrogen Gas on the Survival Rate of Mice Following Global Cerebral Ischemia.

Year Published: 2012

Global cerebral ischemia and reperfusion (I/R) often result in high mortality. Free radicals have been reported to play an important role in global cerebral I/R, and therefore, reduction of these might improve the outcome. Here, we investigated the effect of hydrogen gas (H2) (a strong free radical scavenger) on the survival rate of mice following global cerebral I/R. We further examined the ...
BRAIN - HYDROGEN BIOLOGY

A basic study on molecular hydrogen (H2) inhalation in acute cerebral ischemia patients for safety ...

Year Published: 2012

Background: In animal experiments, use of molecular hydrogen ( H2) has been regarded as quite safe and effective, showing benefits in multiple pathological conditions such as ischemia-reperfusion injury of the brain, heart, kidney and transplanted tissues, traumatic and surgical injury of the brain and spinal cord, inflammation of intestine and lung , degenerative striatonigral tissue and also in ...
BRAIN - SEPSIS

Molecular hydrogen reduces LPS-induced neuroinflammation and promotes recovery from sickness ...

Year Published: 2012

Molecular hydrogen has been shown to have neuroprotective effects in mouse models of acute neurodegeneration. The effect was suggested to be mediated by its free-radical scavenger properties. However, it has been shown recently that molecular hydrogen alters gene expression and protein phosphorylation. The aim of this study was to test whether chronic ad libitum consumption of molecular ...
BRAIN - ENVIRONMENTAL POLLUTION

Hydrogen rich saline reduces immune-mediated brain injury in rats with acute carbon monoxide ...

Year Published: 2012

This experiment was designed to determine whether hydrogen (H(2)) rich saline can ameliorate brain abnormalities in a rat model with acute carbon monoxide (CO) poisoning. Sprague-Dawley male rats were used for CO poisoning and H(2) rich saline treatment. Changes in neurons, microglias, and myelin sheath were observed by electron microscope. Neuron loss was assessed by Nissl staining. Antioxidant ...
BRAIN - BRAIN INJURY

Hydrogen gas ameliorates oxidative stress in early brain injury after subarachnoid hemorrhage in ...

Year Published: 2012

Hydrogen gas has been demonstrated to neutralize free radicals and reduce oxidative stress recently. Our objective was to determine the therapeutic effect of H2 inhalation and its antioxidative activity on early brain injury after subarachnoid hemorrhage. Controlled in vivo laboratory study. Animal research laboratory. One hundred thirty-seven adult male Sprague-Dawley rats weighing 280-350 g. ...
BRAIN - SEPSIS

Hydrogen-rich saline reverses oxidative stress, cognitive impairment, and mortality in rats ...

Year Published: 2012

Background: Sepsis is associated with high morbidity and mortality, and survivors can present with cognitive dysfunction. The present study was performed to investigate the effects of hydrogen-rich saline (HRS) on oxidative stress in the brain, cognitive dysfunction, and mortality in a rat model of sepsis. Methods: A rat model of sepsis was induced by cecal ligation and puncture. Physiologic ...
BRAIN - BRAIN INJURY

Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema ...

Year Published: 2012

Background: Increasing experimental and clinical data indicate that early brain injury (EBI) after subarachnoid hemorrhage (SAH) largely contributes to unfavorable outcomes, and it has been proved that EBI following SAH is closely associated with oxidative stress and brain edema. The present study aimed to examine the effect of hydrogen, a mild and selective cytotoxic oxygen radical scavenger, on ...
BRAIN - BRAIN INJURY

Inhalation of hydrogen gas attenuates cognitive impairment in transient cerebral ischemia via ...

Year Published: 2012

To investigate the effects of inhalation of hydrogen gas on cognitive impairment induced by transient cerebral ischemia and its potential mechanism. Two-vessel occlusion rat model was used to produce 10-minute transient global cerebral ischemia. One hundred and twenty male Wistar rats were randomly divided into sham, sham+H(2), ischemia, and ischemia+H(2) groups (n = 30 each group). Inhalation of ...
BRAIN - STROKE

Hydrogen Gas Reduced Acute Hyperglycemia-Enhanced Hemorrhagic Transformation In A Focal Ischemia Rat ...

Year Published: 2011

Hyperglycemia is one of the major factors for hemorrhagic transformation after ischemic stroke. In this study, we tested the effect of hydrogen gas on hemorrhagic transformation in a rat focal cerebral ischemia model. Sprague-Dawley rats (n=72) were divided into the following groups: sham; sham treated with hydrogen gas (H(2)); Middle Cerebral Artery Occlusion (MCAO); and MCAO treated with H(2) ...
BRAIN - SURGERY/TRANSPLANTATION

Hydrogen is neuroprotective against surgically induced brain injury

Year Published: 2011

Neurosurgical operations cause unavoidable damage to healthy brain tissues. Direct surgical injury as well as surgically induced oxidative stress contributes to the subsequent formation of brain edema. Therefore, we tested the neuroprotective effects of hydrogen (H2) in an established surgical brain injury (SBI) model in rats. Adult male Sprague - Dawley rats (weight 300-350g) were divided into ...
BRAIN - STROKE

Hydrogen supplemented air inhalation reduces changes of prooxidant enzyme and gap junction protein ...

Year Published: 2011

Transient global cerebral ischemia (TGCI) occurs during acute severe hypotension depriving the brain of oxygen and glucose for a short period of time. During reperfusion, several mechanisms can induce secondary neuronal damage, including the increased production of reactive oxygen species (ROS). Hydrogen gas-enriched air inhalation is a neuroprotective approach with proven antioxidant potential, ...