Hydrogen-rich water ameliorates neuropathological impairments in a mouse model of Alzheimer's disease through reducing neuroinflammation and modulating intestinal microbiota

Yi Lin, Qing Shi, Lei Zhang, Cai Yue, Zhi He, Xue Li, Qian He, Qiong Liu, Xiu Du

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DOI: 10.4103/1673-5374.317992 DOI is the universal ID for this study.

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Hydrogen exhibits the potential to treat Alzheimer's disease. Stereotactic injection has been previously used as an invasive method of administering active hydrogen, but this method has limitations in clinical practice. In this study, triple transgenic (3×Tg) Alzheimer's disease mice were treated with hydrogen-rich water for 7 months. The results showed that hydrogen-rich water prevented synaptic loss and neuronal death, inhibited senile plaques, and reduced hyperphosphorylated tau and neurofibrillary tangles in 3×Tg Alzheimer's disease mice. In addition, hydrogen-rich water improved brain energy metabolism disorders and intestinal flora imbalances and reduced inflammatory reactions. These findings suggest that hydrogen-rich water is an effective hydrogen donor that can treat Alzheimer's disease. This study was approved by the Animal Ethics and Welfare Committee of Shenzhen University, China (approval No. AEWC-20140615-002) on June 15, 2014.

Publish Year 2022
Country China
Rank Positive
Journal Neural Regeneration Research
Primary Topic Brain
Secondary Topic Alzheimer's Disease (AD)
Model Mouse
Tertiary Topic Amyloid Beta Toxicity
Vehicle Water (Electrolysis)
pH Neutral
Application Ingestion