Hydrogen gas (XEN) inhalation ameliorates airway inflammation in asthma and COPD patients

Shao Wang, Cheng Bao, Yudi He, Xinlun Tian, Yanli Yang, Tengyue Zhang, Kai Xu

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DOI: 10.1093/qjmed/hcaa164 DOI is the universal ID for this study.

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Background: Hydrogen was proven to have anti-oxidative and anti-inflammation effects to various diseases. Aim: We wish to investigate the acute effects of inhaled hydrogen on airway inflammation in patients with asthma and chronic obstructive pulmonary disease (COPD). Design: Prospective study.

Methods: 2.4% hydrogen containing steam mixed gas (XEN) was inhaled once for 45 minutes in 10 patients with asthma and 10 patients with COPD. The levels of granulocyte-macrophage colony stimulating factor (GM-CSF), interferon-γ (IFNγ), interleukin-1β (IL-1β), interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-6 (IL-6), et al. in peripheral blood and exhaled breath condensate (EBC) before and after 'XEN' inhalation were measured.

Results: 45 minutes 'XEN' inhalation once decreased monocyte chemotactic protein 1 (MCP1) level in both COPD (564.70 to 451.51pg/mL, P = 0.019) and asthma (386.39 to 332.76 pg/mL, P = 0.033) group, while decreased IL-8 level only in asthma group (5.25 to 4.49pg/mL, P = 0.023). The level of EBC soluble cluster of differentiation-40 ligand (sCD40L) in COPD group increased after inhalation (1.07 to 1.16pg/mL, P = 0.031), while IL-4 and IL-6 levels in EBC were significantly lower after inhalation in the COPD (0.80 to 0.64pg/mL, P = 0.025) and asthma (0.06 to 0.05pg/mL, P = 0.007) group respectively. Conclusions: A single inhalation of hydrogen for 45 minitues attenuated inflammatory status in airways in patients with asthma and COPD.

Publish Year 2020
Country China
Rank Positive
Journal QJM
Primary Topic Lung
Secondary Topic Chronic Obstructive Pulmonary Disease (COPD)
Model Human
Tertiary Topic Inflammation
Vehicle Gas
pH N/A
Application Inhalation