Case Report: Buccal administration of hydrogen-producing blend after a mild traumatic brain injury in a professional athlete

Dejan Javorac, Valdemar Stajer, Sergej M Ostojic

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DOI: 10.12688/f1000research.19739.1 DOI is the universal ID for this study.

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Background: Sport-related mild traumatic brain injury (TBI) is a serious trauma that could impair brain function of an injured athlete. Treatment solutions for mild TBI typically concentrate on complete rest, while non-traditional therapeutic options remain largely ineffective. Molecular hydrogen (H 2 ) is an innovative neuroprotective agent that can easily reach the brain, yet no data are available concerning its value as a first-aid intervention after a mild TBI. Case report: This case report demonstrates the efficacy and safety of a hydrogen-producing dissolving tablet administered buccally during the first 24 hours post-injury in a professional soccer player who suffered a mild TBI. The patient received a formulated dosage of hydrogen every 2 hours, with the first intervention given immediately after an initial examination (~ 15 min after the injury). The overall score for Sport Concussion Assessment Tool 2 (SCAT2), a standardized method of evaluating injured athletes for concussion, increased from 68 points (severe disruption) at baseline to 84 points (mild disruption) at 24-h follow-up. The patient reported no side effects of hydrogen intervention. Conclusions: This case has demonstrated that intensive consecutive therapy with oral transmucosal hydrogen formulation is a beneficial strategy with regard to the reduction of presence and severity of symptoms of sport-related mild TBI.

Publish Year 2019
Country Serbia
Rank Positive
Journal F1000 Research
Primary Topic Brain
Secondary Topic Traumatic Brain Injury
Model Human
Tertiary Topic Novel Therapy
Vehicle Gas (Sustained Release)
pH N/A
Application Ingestion