Oral ‘hydrogen water’ induces neuroprotective ghrelin secretion in mice
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DOI:
10.1038/srep03273
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Abstract:
The therapeutic potential of molecular hydrogen (H₂) is emerging in a number of human diseases and in their animal models, including in particular Parkinson's disease (PD). H₂ supplementation of drinking water has been shown to exert disease-modifying effects in PD patients and neuroprotective effects in experimental PD model mice. However, H₂ supplementation does not result in detectable changes in striatal H₂ levels, indicating an indirect effect. Here we show that H₂ supplementation increases gastric expression of mRNA encoding ghrelin, a growth hormone secretagogue, and ghrelin secretion, which are antagonized by the β1-adrenoceptor blocker, atenolol. Strikingly, the neuroprotective effect of H₂ water was abolished by either administration of the ghrelin receptor-antagonist, D-Lys(3) GHRP-6, or atenolol. Thus, the neuroprotective effect of H₂ in PD is mediated by enhanced production of ghrelin. Our findings point to potential, novel strategies for ameliorating pathophysiology in which a protective effect of H₂ supplementation has been demonstrated.| Publish Year | 2013 |
|---|---|
| Country | Japan |
| Rank | Positive |
| Journal | Nature Scientific Reports |
| Primary Topic | Brain |
| Secondary Topic | Parkinson's Disease |
| Model | Mouse |
| Tertiary Topic | Ghrelin Secretion |
| Vehicle | Water (Electrolysis) |
| pH | Alkaline |
| Application | Ingestion |
| Comparison | |
| Complement |