Hydrogen-bubbled platinum-colloid suppresses human esophagus- or tongue-carcinoma cells with intracellular platinum-uptake and the diminished normal-cell mortality

Shinya Kato, Yasukazu Saitoh, Nobuhiko Miwa

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DOI: 10.1007/s13577-020-00402-1 DOI is the universal ID for this study.

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Carcinostatic effects of combined use of hydrogen nano-bubbles (nano-H) and platinum–povidone (PVP-–Pt) were examined. Hydrogen-dissolved medium was prepared by hydrogen-gas bubbling with a microporous gas-emittance-terminal into a medium in the absence or presence of PVP–Pt (nano-H, nano-H/PVP–Pt). Human esophagus-derived carcinoma cells KYSE70 were repressed for cell proliferation with nano-H/PVP–Pt more markedly than with nano-H, indicating the hydrogen-intensification for PVP–Pt-alone-carcinostasis. However, the intensified carcinostasis required co-administration of nano-H and PVP–Pt, and no intensified carcinostasis was shown in two-step separate administration of nano-H and PVP–Pt. Furthermore, hydrogen bubbling into PVP–Pt-containing medium achieved more appreciable carcinostasis than mere addition of PVP–Pt into nano-H-containing medium, indicating the potent interaction of hydrogen and PVP–Pt. The nano-H/PVP–Pt-administered human tongue-derived carcinoma cells HSC-4 were repressed for cell proliferation more markedly than pre-malignant human tongue-derived epitheliocytes DOK, concurrently with more abundant intracellular Pt-intake into HSC-4 cells than DOK as analyzed by ICP-MS. Thus, PVP–Pt is able to adsorb hydrogen nano-bubbles on Pt and applicable for cancer therapy by diminishing the side-effects to normal cells.

Publish Year 2020
Country Japan
Rank Positive
Journal Human Cell
Primary Topic Mouth
Secondary Topic Cancer
Model Cell Culture
Tertiary Topic Novel Therapy
Vehicle Gas (Sustained Release)
pH N/A
Application Culture Media