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Studies Found: 1104

BRAIN - NEUROPATHIC PAIN

Hydrogen-rich Saline Alleviated the Hyperpathia and Microglia Activation via Autophagy Mediated ...

Year Published: 2019

Neuropathic pain is a complication after a spinal nerve injury. The inflammasomes are now identified to be responsible for triggering inflammation in neuropathic pain. Autophagy participates in the process of neuropathic pain and can regulate the inflammasome activation in different diseases. Our previous research reported that hydrogen exerted a protective effect against neuropathic pain. ...
WHOLE BODY - SEPSIS

Hydrogen alleviated organ injury and dysfunction in sepsis: The role of cross-talk between autophagy ...

Year Published: 2019

Aims: Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated host response to infection. Although much progress has been made in understanding the pathophysiology of sepsis, further discussion and study of the detailed therapeutic mechanisms are needed. Autophagy and endoplasmic reticulum stress are two pathways of the complicated regulatory network of sepsis. ...
WHOLE BODY - SEPSIS

Hydrogen alleviates mitochondrial dysfunction and organ damage via autophagy‑mediated NLRP3 ...

Year Published: 2019

Sepsis is a highly heterogeneous syndrome that is caused by a dysregulated host response to infection. The disproportionate inflammatory response to invasive infection is a triggering event inducing sepsis. The activation of inflammasomes in sepsis can amplify inflammatory responses. It has been reported that damaged mitochondria contribute to NACHT, LRR and PYD domains‑containing protein 3 ...
BRAIN - CANCER

Brain Metastases Completely Disappear in Non-Small Cell Lung Cancer Using Hydrogen Gas Inhalation: A ...

Year Published: 2019

Lung cancer is the most common type of tumor, prone to contralateral lung, bone and brain metastasis. We report a 44-year-old woman diagnosed with lung cancer with multiple metastases in November 2015. Oral targeted drugs were initiated after the removal of brain metastases, and most lesions remained stable for 28 months. In March 2018, intracranial multiple metastases, as well as hydrocephalus ...
GALLBLADDER - CANCER

A Gallbladder Carcinoma Patient With Pseudo-Progressive Remission After Hydrogen Inhalation

Year Published: 2019

Background: Hydrogen therapy has been reported to convert exhausted programmed cell death receptor (PD-1)+CD8+ T cells to PD-1-CD8+ T cells, in advanced colorectal cancer patients, which is associated with significantly prolonged survival. Case presentation: A 72-year-old female patient presented with metastatic gallbladder cancer and underwent symptomatic treatment combined with hydrogen therapy. ...
GALLBLADDER - CANCER

Hydrogen gas therapy induced shrinkage of metastatic gallbladder cancer: A case report

Year Published: 2019

Background: We present the case of a 72-year-old female patient with gallbladder cancer (GBC) who developed in situ recurrence and liver metastases 9 mo after irreversible electroporation ablation and oral tegafur (a fluoropyrimidine derivative) chemotherapy, which failed to control the progression of the disease. The patient further developed metastases in the lymph nodes around the head of the ...
WHOLE BODY - CANCER

Real world survey' of hydrogen-controlled cancer: A follow-up report of 82 advanced cancer patients

Year Published: 2019

Advanced cancer treatment is a huge challenge and new ideas and strategies are required. Hydrogen exerts antioxidant and anti-inflammatory effects that may be exploited to control cancer, the occurrence and progression of which is closely related to peroxidation and inflammation. We conducted a prospective follow-up study of 82 patients with stage III and IV cancer treated with hydrogen inhalation ...
MOUTH - DENTIN INTEGRITY

Influence of the acidity of electrolyzed water on the microhardness of inner layer dentin

Year Published: 2019

Background/purpose: Electrolyzed water has been identified as an effective disinfectant that could represent as an alternative to sodium hypochlorite. Unfortunately, it remains unclear whether the texture or physical properties of dentin are affected by the application of electrolyzed water of different acidities. This study was aimed to assess the influence of electrolyzed waters with differing ...
BRAIN - STROKE

UPLC-QTOF/MS-Based Metabolomics Reveals the Protective Mechanism of Hydrogen on Mice with Ischemic ...

Year Published: 2019

As a reductive gas, hydrogen plays an antioxidant role by selectively scavenging oxygen free radicals. It has been reported that hydrogen has protective effects against nerve damage caused by ischemia–reperfusion in stroke, but the specific mechanism is still unclear. Therefore, this study aims to investigate the protective effects of hydrogen on stroke-induced ischemia–reperfusion injury and ...
BRAIN - BRAIN INJURY

Hydrogen-rich saline promotes microglia M2 polarization and complement-mediated synapse loss to ...

Year Published: 2019

Background Hypoxia-ischemia (HI) during the perinatal period is one of the most common causes of acute mortality and chronic neurologic morbidity. Hydrogen-rich saline (HS) treatment in neonatal mice has been reported to alleviate brain injury following HI, but the mechanisms involved are not known. Methods A modified version of the Rice-Vannucci method for the induction of neonatal HI brain ...
BRAIN - SURGERY/TRANSPLANTATION

Perioperatively Inhaled Hydrogen Gas Diminishes Neurologic Injury Following Experimental Circulatory ...

Year Published: 2019

Highlights • Inhaled hydrogen gas has been shown to temper the sequelae of ischemic insults. Its application in cardiopulmonary bypass has not been investigated. • Neonatal swine were cannulated to cardiopulmonary bypass and exposed to prolonged circulatory arrest (75 min at 25°C). Swine were randomized to treatment with or without inhaled 2.4% hydrogen gas mixtures for 24 h during and ...
WHOLE BODY - HYDROGEN BIOLOGY

Safety of inhaled hydrogen gas in healthy mice

Year Published: 2019

The purpose of this work was to determine the safety of inhaled hydrogen gas in healthy animals. Female mice were exposed to medical air with or without hydrogen gas (concentration 2.4%) for 72 hours (n = 25 mice/group). Mice underwent a standardized and validated neurobehavioral examination, SmithKline Beecham, Harwell, Imperial College, Royal London Hospital, Phenotype Assessment (SHIRPA) ...
WHOLE BODY - PATHOGENIC BACTERIAL LOAD

ANTIBACTERIAL, IN VITRO CYTOTOXIC, AND ANTIOXIDANT ACTIVITIES OF ELECTROLYZED OXIDIZING/REDUCING ...

Year Published: 2019

Objective: Electrolyzed oxidizing/reducing water is popular as health beneficial water in Indonesia. In this study, we examined the level of antibacterial,anticancer, and antioxidant activity of the electrolyzed water.Methods: The efficacy of electrolyzed water produced by Enagic® at six level pH (2.5, 6.0, 7.0, 8.5, 9.0, and 9.5) was investigated. Antibacterialactivity was evaluated using a ...
SKIN - SURGERY/TRANSPLANTATION

Postconditioning with inhaled hydrogen attenuates skin ischemia/reperfusion injury through the ...

Year Published: 2019

This study explored the flap-protective effects of high concentrations of hydrogen (HCH) inhalation in a rat flap ischemia/reperfusion (I/R) injury model and the potential mechanism of necroptosis. Forty-five male Sprague-Dawley rats were randomly divided into three groups: SH, IR and HCH groups. After undergoing 3 h of I/R management, the surgery groups were treated with ambient air (SH and IR) ...
INTESTINE - SURGERY/TRANSPLANTATION

The effects of hydrogen-rich saline solution on intestinal anastomosis performed after intestinal ...

Year Published: 2019

Aim We investigated the effects of hydrogen-rich saline solution (HRSS) on intestinal anastomosis performed after intestinal ischemia reperfusion injury (IRI). Materials and methods Thirty Wistar albino female rats were randomly divided into five groups. Only laparotomy was performed in the Sham group. In the other four groups, an intestinal IRI was performed for 45 min by clamping the superior ...
STOMACH - CANCER

Acid‐Responsive H2‐Releasing 2D MgB2 Nanosheet for Therapeutic Synergy and Side Effect ...

Year Published: 2019

The hydrogen molecule is recognized as a high potential to attenuate toxic side effects of chemotherapy and also enhance chemotherapeutic efficacy, and the development of a novel hydrogen‐generating prodrug for facile, safe, and efficient hydrogen delivery is vitally important for combined hydrogenochemotherapy but is still challenging. Here, targeting gastric cancer, a 2D magnesium boride ...
LUNG - ENVIRONMENTAL POLLUTION

Hydrogen ameliorates lung injury in a rat model of subacute exposure to concentrated ambient PM2.5 ...

Year Published: 2019

Background: Ambient fine particulate matter (PM2.5) could induce lung injury. Aryl hydrocarbon receptor (AhR) is involved in the molecular mechanisms of prooxidative and pro-inflammatory effect of PM2.5. Molecular hydrogen has antioxidant properties. The protective effect and mechanism of hydrogen on PM2.5-induced lung injury remain unclear. Objectives: This study aimed to determine whether ...
LUNG - CANCER

Hydrogen inhalation attenuated bleomycin‐induced pulmonary fibrosis by inhibiting TGF‐β1 and ...

Year Published: 2019

New findings: • What is the central question of this study? The aim was to explore the effects and underlying mechanisms of H2 on bleomycin (BLM)-induced pulmonary fibrosis. • What are the main findings and its importance? Our results indicate that, in BLM-induced pulmonary fibrosis, H2 inhalation could attenuate oxidative stress and reversed the formation of pulmonary EMT process by reducing ...
KIDNEY - SLEEP APNEA

Hydrogen Gas Alleviates Chronic Intermittent Hypoxia-Induced Renal Injury through Reducing Iron ...

Year Published: 2019

Iron-induced oxidative stress has been found to be a central player in the pathogenesis of kidney injury. Recent studies have indicated H2 can be used as a novel antioxidant to protect cells. The present study was designed to investigate the protective effects of H2 against chronic intermittent hypoxia (CIH)-induced renal injury and its correlation mechanism involved in iron metabolism. We found ...
KIDNEY - SLEEP APNEA

Hydrogen protects against chronic intermittent hypoxia induced renal dysfunction by promoting ...

Year Published: 2019

Aims Hydrogen gas (H2) has a diversity of effects such as anti-apoptotic, anti-inflammatory and anti-oxidative properties. However, molecular mechanism underlying the potential effect of H2 on chronic intermittent hypoxia (CIH) induced renal injury remains obscure. Materials and methods In the present study, adult male Sprague-Dawley rats were randomly allocated into four groups: control (CON) ...
WHOLE BODY - SLEEP APNEA

Hydrogen gas reduces chronic intermittent hypoxia-induced hypertension by inhibiting sympathetic ...

Year Published: 2019

Molecular hydrogen is reported to be used medically to ameliorate various systemic pathological conditions. This study aimed to investigate the effect of hydrogen (H2 ) gas on hypertension induced by intermittent hypoxia in rats. The adult rats were exposed to chronic intermittent hypoxia (CIH) 8 hours/day for 5 weeks and/or H 2 gas 2 hours/day. We found that the systolic and diastolic blood ...
BONE - SURGERY/TRANSPLANTATION

Storage solution containing hydrogen improves the preservation effect of osteochondral allograft

Year Published: 2019

As an ideal antioxidant and anti-apoptotic substance, hydrogen (H2) has protective effects on many isolated organs, such as the heart, lung and kidney. In this study, we explore whether H2 improves the preservation effect of osteochondral allograft by adding it to Dulbecco’s Modified Eagle Medium (DMEM) solution during the tissue culture stage. The osteochondral allograft apparatus was used to ...
SKIN - SURGERY/TRANSPLANTATION

Preconditioning with one-time hydrogen gas does not attenuate skin flap ischemia-reperfusion injury ...

Year Published: 2019

Background: Hydrogen gas exists in the atmosphere and was previously considered an inert gas. It has been reported to have protective effects on tissue ischemia-reperfusion (IR) injuries in animal models. The protective mechanism of hydrogen molecules is based on selectively reducing highly strong oxidants in cells, thereby reducing inflammation and decreasing the contents of MDA, FOXO3a, and ...
BONE MARROW - CANCER

Hydrogen Gas Inhalation Alleviates Radiation-Induced Bone Marrow Damage in Cancer Patients

Year Published: 2019

Abstract: Background: Radiotherapy for cancer patients is one of the useful methods; however, it not only impairs the targeted tumor tissues but also damage the normal surrounding tissues. Intensity modulated radiation therapy (IMRT) for cancer patients has been recently performed to alleviate the adverse effects, but reducing bone marrow damage is limited in the patients with multiple tumor ...
BRAIN - PARKINSON'S DISEASE

Inhalation of hydrogen gas elevates urinary 8-hydroxy-2'-deoxyguanine in Parkinson's disease

Year Published: 2019

Hyposmia is one of the earliest and the most common symptoms in Parkinson's disease (PD). The benefits of hydrogen water on motor deficits have been reported in animal PD models and PD patients, but the effects of hydrogen gas on PD patients have not been studied. We evaluated the effect of inhalation of hydrogen gas on olfactory function, non-motor symptoms, activities of daily living, and ...