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Studies Found: 1335

LUNG - SEPSIS

Hydrogen alleviates cell damage and acute lung injury in sepsis via PINK1/Parkin-mediated mitophagy

Year Published: 2021

Background: Multiple organ failure (MOF) is the main cause of early death in septic shock. Lungs are among the organs that are affected in MOF, resulting in acute lung injury. Inflammation is an important factor that causes immune cell dysfunction in the pathogenesis of sepsis. Autophagy is involved in the process of inflammation and also occurs in response to cell and tissue injury in several ...
EYE - CORNEAL INJURY

Molecular Hydrogen Attenuated N-methyl-N-Nitrosourea Induced Corneal Endothelial Injury by ...

Year Published: 2021

Purpose: Previous work by our group has demonstrated the value of N-methyl-N-nitrosourea (MNU)-induced corneal endothelial decompensation in animal models. The aim of this study was to investigate the effect of molecular hydrogen (H2) on MNU-induced corneal endothelial cell (CEC) injury and the underlying mechanism. Methods: MNU-induced animal models of CEC injury were washed with hydrogen-rich ...
SKIN - RADIOPROTECTION

Protective effects of dissolved molecular hydrogen against hydrogen peroxide-, hydroperoxide-, and ...

Year Published: 2021

Molecular hydrogen (H2) is recognized as a gaseous antioxidant, and it is expected to ameliorate various disorders related to oxidative stress and inflammation. However, there are still many unclear points regarding its effectiveness in the skin. Therefore, the purpose of this study was to examine the protective effect of H2 against ultraviolet (UV) irradiation-related stress injury in human ...
MOUTH - PERIODONTITIS

Assessment of antibacterial effect of hydrogen water on plaque from patients with chronic ...

Year Published: 2021

Background: Periodontitis is an inflammatory disease causing destruction of tissues surrounding the teeth. The primary etiological factor for periodontitis is plaque. An inference could be drawn that an overall reduction in microorganisms halts disease progression. It is desirable to have natural agents with minimal side effects to reduce the microbial load. Aim: The aim of the study is to assess ...
LIVER - LIVER DISEASE

Electrolyzed Hydrogen Water Protects against Ethanol-Induced Cytotoxicity by Regulating Aldehyde ...

Year Published: 2021

Excessive alcohol consumption can cause multi-systemic diseases. Among them, alcoholic liver disease is the most frequent and serious disease. Electrolytic hydrogen water (EHW) is produced at the cathode during electrolysis of water and contains a large amount of molecular hydrogen and a low content of platinum nanoparticles with alkaline properties. In this study, we found that EHW inhibits ...
LUNG - LUNG INJURY

Hydrogen alleviates acute lung injury induced by limb ischaemia/reperfusion in mice

Year Published: 2021

Aims: Limb ischaemia/reperfusion (LIR) occurs in various clinical conditions including critical limb ischaemia, abdominal aortic aneurysm, and traumatic arterial injury. Reperfusion of the acutely ischemic limb can lead to a systemic inflammation response and multiple organ dysfunction syndrome, further resulting in significant morbidity and mortality. Molecular hydrogen exhibits therapeutic ...
CERVIX - CANCER

Mechanism of hydrogen on cervical cancer suppression revealed by high‑throughput RNA sequencing

Year Published: 2021

Cervical cancer is considered one of the diseases with the highest mortality among women and with limited treatment options. Hydrogen (H2) inhalation has been reported to have a variety of tumor‑suppressive effects, but the exact mechanism remains unclear. In the present study, HeLa cervical cancer cells and HaCaT keratinocytes treated with H2, and a HeLa xenograft mouse model subjected to H2 ...
WHOLE BODY - EXCERCISE

Effects of 7-day intake of hydrogen-rich water on physical performance of trained and untrained ...

Year Published: 2021

Hydrogen-rich water (HRW) is used as a supplement to improve performance and reduce fatigue in athletes. However, the potentially beneficial effects of HRW intake could be mediated by the training status of athletes. The purpose of the study was to analyse the ergogenic effect of intake of HRW for one week on aerobic and anaerobic performance, both in trained and untrained individuals. ...
INTESTINE - SURGERY/TRANSPLANTATION

Senn on the Diagnosis of Gastro-Intestinal Perforation by the Rectal Insufflation of Hydrogen Gas

Year Published: 1888

No abstract available
SPINE - SURGERY/TRANSPLANTATION

Protective effects of hydrogen gas against spinal cord ischemia-reperfusion injury

Year Published: 2021

Objective: This experimental study aimed to assess the efficacy of hydrogen gas inhalation against spinal cord ischemia–reperfusion injury and reveal its mechanism by measuring glutamate concentration in the ventral horn using an in vivo microdialysis method. Methods: Male Sprague-Dawley rats were divided into the following 6 groups: sham, only spinal ischemia, 3% hydrogen gas (spinal ischemia + ...
WHOLE BODY - CANCER

Response of five established solid transplantable mouse tumors and one mouse leukemia to hyperbaric ...

Year Published: 1978

A variety of transplantable mouse tumors were used in experiments to determine the efficacy of hyperbaric hydrogen treatment. After 7 continuous days of hyperbaric hydrogen treatment, no inhibition of tumor growth was observed.
SKIN - CANCER

Hyperbaric hydrogen therapy: A possible treatment for cancer

Year Published: 1975

Hairless albino mice with squamous cell carcinoma were exposed to a mixture of 2.5 percent oxygen and 97.5 percent hydrogen at a total pressure of 8 atmospheres for periods up to 2 weeks in order to see if a free radical decay catalyzer, such as hydrogen, would cause a regression of the skin tumors. Marked aggression of the tumors was found, leading to the possibility that hyperbaric hydrogen ...
PREGNANCY - OFFSPRING DEVELOPMENT

Effect of alkaline ionized water on reproduction in gestational and lactational rats

Year Published: 1995

Alkaline ionized water (AKW) produced by electrolysis was given to gestational and lactational rats, and its effect on dams, growth of fetuses and offsprings were investigated. The results showed that the intake of food and water in dams increased significantly when AKW was given from the latter half of the gestation period and from the former half of the lactation period. Body weight of the ...
WHOLE BODY - DIVING

Psychophysiological reactions in humans during an open sea dive to 500 m with a ...

Year Published: 1994

Six commercial divers were investigated for neurological and psychosensorimotor responses during an open sea dive to 500 m with a hydrogen-helium-oxygen mixture containing 49% hydrogen. Results showed only moderate neurological symptoms of high-pressure nervous syndrome, whereas the narcotic effect of hydrogen was detectable, as investigated by psychosensorimotor tests. Nevertheless, the divers ...
SKIN - WOUND HEALING

Treatment of Infectious Skin Defects or Ulcers with Electrolyzed Strong Acid Aqueous Solution

Year Published: 1997

A chronic ulcer with an infection such as methicillin-resistant Staphylococcus aureus is hard to heal. Plastic and reconstructive surgeons often encounter such chronic ulcers that are resistant to surgical or various conservative treatments. We applied conservative treatment using an electrolyzed strong acid aqueous solution and obtained satisfactory results. The lesion was washed with the ...
HEART - CARDIAC DEGENERATION

INFLUENCE OF ALKALINE IONIZED WATER ON RAT ERYTHROCYTE HEXOKINASE ACTIVITY AND MYOCARDIUM

Year Published: 1997

Alkaline ionized water (AKW) produced by the electrolysis of tap water (TPW) was given to pregnant rats throughout gestation. AKW was subsequently given to infants as a test group until 15 weeks old to determine changes in body and organ weights, erythrocyte hexokinase (HK) activity and histological preparations of myocardiac muscle. The results were compared with those for rats given TPW. Body ...
WHOLE BODY - DIVING

ECG changes during the experimental human dive HYDRA 10 (71 atm/7,200 kPa)

Year Published: 1995

Electrocardiogram (ECG) analysis was performed in three human divers during a 71 atm (7,200 kPa) saturation dive (COMEX HYDRA 10 experiment). The inhaled gas mixture was slightly hyperoxic; its composition was basically helium and oxygen. Hydrogen was introduced during compression and its partial pressure reached 20 atm. ECG changes were the same in the three divers. Marked bradycardia rapidly ...
PERITONIUM - SEPSIS

Trial of Electrolyzed Strong Acid Aqueous Solution Lavage in the Treatment of Peritonitis and ...

Year Published: 1997

Electrolyzed strong acid aqueous solution is acidic water that contains active oxygen and active chlorine and possesses a redox potential. We performed peritoneal and abscess lavages with an electrolyzed strong acid aqueous solution to treat 7 patients with peritonitis and intraperitoneal abscesses, who were seen in our department between December 1994 and April 1995. The underlying disease was ...
WHOLE BODY - DIVING

Decompression comparison of helium and hydrogen in rats

Year Published: 1997

The hypothesis that there are differences in decompression risk between He and H2 was examined in 1,607 unanesthetized male albino rats subjected to dives on 2% O2-balance He or 2% O2-balance H2 (depths < or = 50 ATA, bottom times < or = 60 min). The animals were decompressed to 10.8 ATA with profiles varying from rapid to slow, with up to four decompression stops of up to 60 min each. Maximum ...
HEART - CARDIAC DEGENERATION

Degradation of Myocardiac Myosin and Creatine Kinase in Rats Given Alkaline Ionized Water

Year Published: 1998

Recently, the authors have shown that marked necrosis and fibrosis of myocardium were observed in rats given alkaline ionized water (AKW). To clarify the cause of myocardial lesions, the activities of myosin ATPase, actomyosin ATPase and creatine kinase (CK) in myocardium of rats given AKW at 15 weeks-old were compared with those in myocardium of rats given tap water (TPW). Furthermore, sodium ...
WHOLE BODY - SURGERY/TRANSPLANTATION

Successful Treatment of Mediastinitis after Cardiovascular Surgery Using Electrolyzed Strong Acid ...

Year Published: 1997

Dilute povidone-iodine solution has been widely used as an irrigant for the treatment of mediastinitis. However, its use is not without adverse effects and often cause? poor growth of pinulation tissues. To avoid the problems seen with the use of povidone-iodine solution, we applied electrolyzed strong acid aqueous solution (ESAAS) to mediastinal irrigation in 4 patients (2 infants and 2 adults) ...
WHOLE BODY - AGING

Effect of electrolyzed water intake on lifespan of autoimmune disease prone mice

Year Published: 1998

Recent studies on electrolyzed water indicate that anode or acidic water is most effective as disinfectants; whereas, reduced or alkaline water processed through cathode is used as safe drinking water. The present drinking water study was undertaken in two strains of autoimmune disease prone mice to establish the spontaneous disease process and longevity. Weanling MRL/lpr and NZBxNZW [B/W] F1 ...
WHOLE BODY - CANCER

Electrolyzed Reduced Water Which Can Scavenge Active Oxygen Species Supresses Cell Growth and ...

Year Published: 1998

Active oxygen species are considered to cause extensive oxidative damage to biological macromolecules, which bring about a variety of diseases as well as aging. Reduced water produced near cathode during electrolysis of water exhibits high pH, low dissolved oxygen, extremely high dissolvedmolecular hydrogen, and extremely negative redox potential values. Recently we found that strongly ...
HEART - CARDIAC DEGENERATION

Histopathological influence of alkaline ionized water on myocardial muscle of mother rats

Year Published: 1999

We have reported that a marked necrosis and subsequent fibrosis of myocardium occurred among male rats 15 weeks old given alkaline ionized water (AKW) during gestation and suckling periods, and after weaning. In this study, it was examined whether similar lesions would occur in mother rats which were given AKW from day zero of gestation to day 20 of lactation. The myocardial lesion in the mother ...
PREGNANCY - MILK PRODUCTION

Influences of alkaline ionized water on milk yield, body weight of offspring and perinatal dam in ...

Year Published: 1999

The authors previously reported that male offspring of mothers rats given alkaline ionized water (AKW) showed a significantly higher body weight by day 14 after birth than did offspring of mother rats given tap water (TPW); furthermore, marked myocardial necrosis and fibrosis were observed particularly in the former male offspring at the age of 15 weeks. In the present experiment we looked for ...