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Studies Found: 1179

LUNG - SEPSIS

Magnesium Hydride Ameliorates Endotoxin-Induced Acute Respiratory Distress Syndrome by Inhibiting ...

Year Published: 2022

Acute respiratory distress syndrome (ARDS) causes uncontrolled pulmonary inflammation, resulting in high morbidity and mortality in severe cases. Given the antioxidative effect of molecular hydrogen, some recent studies suggest the potential use of molecular hydrogen as a biomedicine for the treatment of ARDS. In this study, we aimed to explore the protective effects of magnesium hydride (MgH2) on ...
INTESTINE - CANCER

Molecular Hydrogen Inhibits Colorectal Cancer Growth via the AKT/SCD1 Signaling Pathway

Year Published: 2022

Objective: Molecular hydrogen (H2) has been considered a potential therapeutic target in many cancers. Therefore, we sought to assess the potential effect of H2 on colorectal cancer (CRC) in this study. Methods: The effect of H2 on the proliferation and apoptosis of RKO, SW480, and HCT116 CRC cell lines was assayed by CCK-8, colony formation, and flow cytometry assays. The effect of H2 on tumor ...
INTESTINE - HYDROGEN BIOLOGY

Different effects of hydrogen-rich water intake and hydrogen gas inhalation on gut microbiome and ...

Year Published: 2022

The potential for preventive and therapeutic applications of H2 have now been confirmed in various disease. However, the effects of H2 on health status have not been fully elucidated. Our previous study reported changes in the body weight and 13 serum biochemical parameters during the six-month hydrogen intervention. To obtain a more comprehensive understanding of the effects of long-term hydrogen ...
PREGNANCY - NEUROPROTECTION

Social Communication of Maternal Immune Activation-Affected Offspring Is Improved by Si-Based ...

Year Published: 2022

Maternal immune activation (MIA) is triggered by infection or autoimmune predisposition during pregnancy, and cytokines produced by MIA are transmitted through the placenta to the fetal brain, implicating at the onset risks and vulnerability for developmental and psychiatric disorders, such as autism spectrum disorder (ASD) and schizophrenia. To address these kinds of problem in child health, we ...
HEART - CARDIAC ARREST

Hydrogen therapy after resuscitation improves myocardial injury involving inhibition of autophagy in ...

Year Published: 2022

Hydrogen (H2) therapy is a therapeutic strategy using molecular H2. Due to its ability to regulate cell homeostasis, H2 therapy has exhibited marked therapeutic effects on a number of oxidative stress-associated diseases. The present study investigated the effectiveness of H2 therapy in protecting against myocardial injury in a rat model of asphyxial cardiac arrest and cardiopulmonary ...
WHOLE BODY - CANCER

Magnesium galvanic cells produce hydrogen and modulate the tumor microenvironment to inhibit cancer ...

Year Published: 2022

Hydrogen can be used as an anti-cancer treatment. However, the continuous generation of H2 molecules within the tumor is challenging. Magnesium (Mg) and its alloys have been extensively used in the clinic as implantable metals. Here we develop, by decorating platinum on the surface of Mg rods, a Mg-based galvanic cell (MgG), which allows the continuous generation of H2 in an aqueous environment ...
EAR - CANCER

Effect of Hydrogen Inhalation Therapy on Hearing Loss of Patients With Nasopharyngeal Carcinoma ...

Year Published: 2022

Objective: To evaluate the clinical efficacy and safety of hydrogen inhalation in improving hearing loss in patients with long-term survival of nasopharyngeal carcinoma after radiotherapy. Methods: The eustachian tube dysfunction score, pure tone air conduction threshold, bone conduction threshold, the score of tympanogram and otoscope were prospectively observed in patients with deafness after ...
INTESTINE - INFLAMMATORY BOWEL DISEASE (IBD)

A new therapy against ulcerative colitis via the intestine and brain using the Si-based agent

Year Published: 2022

Ulcerative colitis (UC) is a non-specific inflammatory bowel disease that causes ulcers and erosions in the colonic mucosa and becomes chronic with cycles of amelioration and exacerbation. Because its exact etiology remains largely unclear, and the primary therapy is limited to symptomatic treatment, the development of new therapeutic agent for UC is highly desired. Because one of the disease ...
LUNG - SEPSIS

Hydrogen Repairs LPS-Induced Endothelial Progenitor Cells Injury via PI3K/AKT/eNOS Pathway

Year Published: 2022

Endotoxins and other harmful substances may cause an increase in permeability in endothelial cells (ECs) monolayers, as well as ECs shrinkage and death to induce lung damage. Lipopolysaccharide (LPS) can impair endothelial progenitor cells (EPCs) functions, including proliferation, migration, and tube formation. EPCs can migrate to the damaged area, differentiate into ECs, and participate in ...
HEART - VASCULITIS

Hydrogen Gas Inhalation Regressed Coronary Artery Aneurysm in Kawasaki Disease-Case Report and ...

Year Published: 2022

Kawasaki disease (KD) is a systemic vasculitis that primarily affects children under the age of 5 years old and is among the most common acquired heart disease in developed countries, particularly in Asia. No effective treatment is currently available for aneurysm formation in KD. In this report, we showed a KD patient with an aneurysm over the right coronary artery with a size of 6.08 mm in ...
BONE - RHEUMATOID ARTHRITIS (RA)

Hydrogen alleviates collagen-induced arthritis (CIA) in mice by inhibiting IL-22 levels

Year Published: 2022

Objective To investigate the therapeutic effect and mechanism of hydrogen (H2) on collagen-induced arthritis (CIA) in mice. Methods DBA/1 mice were randomly divided into normal control group, CIA group and CIA mice treated with H2 group (H2 treated group), with 6 mice in each group. Following the preparation of CIA mouse model, the H2 treated group received H2 inhalation therapy (300 mL/L, 3 ...
WHOLE BODY - EXCERCISE

Fukuoka, Yoshiyuki

Year Published: 2021

We investigated effects of molecular hydrogen (H2) supplementation on acid-base status, pulmonary gas exchange responses, and local muscle oxygenation during incremental exercise. Eighteen healthy, trained subjects in a randomized, double-blind, crossover design received H2-rich calcium powder (HCP) (1500 mg/day, containing 2.544 µg/day of H2) or H2-depleted placebo (1500 mg/day) for three ...
WHOLE BODY - EXCERCISE

Hydrogen Rich Water Consumption Positively Affects Muscle Performance, Lactate Response, and ...

Year Published: 2021

Hydrogen rich water consumption positively affects muscle performance, lactate response, and alleviates delayed onset of muscle soreness after resistance training. J Strength Cond Res XX(X): 000-000, 2021-Positive outcomes of hydrogen rich water (HRW) supplementation on endurance performance have been shown, but the effects of HRW in resistance training are unclear. The aim of this study was to ...
BONE - OSTEOGENESIS

Molecular hydrogen enhances osteogenesis in Danio rerio embryos

Year Published: 2021

Molecular hydrogen (H2 ) has been reported to have important biological effects on bone tissue in several in vitro and in vivo models. Danio rerio (zebrafish) embryo is a good model to study osteogenesis because its transparency, size and rapid development. In zebrafish embryo, hydrogen rich water (HRW) do not affect vitality or growth rate up to 15%. In addition, 7% HRW treatment enhances ...
SPINE - SURGERY/TRANSPLANTATION

Protective effects of hydrogen gas against spinal cord ischemia-reperfusion injury

Year Published: 2021

Objective: This experimental study aimed to assess the efficacy of hydrogen gas inhalation against spinal cord ischemia–reperfusion injury and reveal its mechanism by measuring glutamate concentration in the ventral horn using an in vivo microdialysis method. Methods: Male Sprague-Dawley rats were divided into the following 6 groups: sham, only spinal ischemia, 3% hydrogen gas (spinal ischemia + ...
BRAIN - SEPSIS

Hydrogen alleviated neuronal injury and neuroinflammation induced by microglial activation via the ...

Year Published: 2021

Objective: Sepsis-associated encephalopathy (SAE) is characterized by diffuse cerebral and central nervous system (CNS) dysfunction. Microglia play a vital role in protecting the brain from neuronal damage, which is closely related to inflammatory responses. The Nrf2 signaling pathway has an impact on microglial and neuronal injury. Here, we mainly explored the molecular mechanism by which H2 ...
CERVIX - CANCER

Mechanism of hydrogen on cervical cancer suppression revealed by high‑throughput RNA sequencing

Year Published: 2021

Cervical cancer is considered one of the diseases with the highest mortality among women and with limited treatment options. Hydrogen (H2) inhalation has been reported to have a variety of tumor‑suppressive effects, but the exact mechanism remains unclear. In the present study, HeLa cervical cancer cells and HaCaT keratinocytes treated with H2, and a HeLa xenograft mouse model subjected to H2 ...
WHOLE BODY - AGING

High-flow hydrogen inhalation might suppresses the immune function of middle-aged participants: a ...

Year Published: 2021

Hydrogen inhalation therapy has been proven to be safe and effective in disease treatment in multiple clinical reports, but the gas flow rates used in different studies vary greatly. Since there is no upper limit for the safe concentration of hydrogen, this study tested the effects of high-flow (not high concentration) hydrogen inhalation on immune function. From October 2019 to January 2020, 20 ...
WHOLE BODY - EXCERCISE

Effects of 7-day intake of hydrogen-rich water on physical performance of trained and untrained ...

Year Published: 2021

Hydrogen-rich water (HRW) is used as a supplement to improve performance and reduce fatigue in athletes. However, the potentially beneficial effects of HRW intake could be mediated by the training status of athletes. The purpose of the study was to analyse the ergogenic effect of intake of HRW for one week on aerobic and anaerobic performance, both in trained and untrained individuals. ...
SKIN - COSMETIC ISSUES

Effects of Topical Hydrogen Purification on Skin Parameters and Acne Vulgaris in Adult Women

Year Published: 2021

Background: Acne vulgaris is a prevalent dermatological disease characterized by skin eruptions, which may decrease the sufferer's quality of life. Hydrogen purification treatment is a new procedure used in cosmetology to improve the skin parameters of the face. This study examined the effectiveness of hydrogen purification treatment to improve women's skin conditions with regard to acne vulgaris. ...
LIVER - LIVER DISEASE

Electrolyzed Hydrogen Water Protects against Ethanol-Induced Cytotoxicity by Regulating Aldehyde ...

Year Published: 2021

Excessive alcohol consumption can cause multi-systemic diseases. Among them, alcoholic liver disease is the most frequent and serious disease. Electrolytic hydrogen water (EHW) is produced at the cathode during electrolysis of water and contains a large amount of molecular hydrogen and a low content of platinum nanoparticles with alkaline properties. In this study, we found that EHW inhibits ...
HEART - EXCERCISE

Acute hydrogen-rich water ingestion stimulates cardiac autonomic activity in healthy females

Year Published: 2021

Background: Hydrogen-rich water (HRW) has been shown to have a stimulating effect on the human body. Objective: The aim of the study was to assess the influence of acute HRW intake on autonomic cardiac regulation during 50 min of rest sitting. Methods: Fourteen healthy females (age 21.7 ± 1.2 years, body mass 67.8 ± 8.7 kg, height 167 ± 5.5 cm) took part in this double-blind, randomized, ...
LUNG - LUNG INJURY

Hydrogen alleviates acute lung injury induced by limb ischaemia/reperfusion in mice

Year Published: 2021

Aims: Limb ischaemia/reperfusion (LIR) occurs in various clinical conditions including critical limb ischaemia, abdominal aortic aneurysm, and traumatic arterial injury. Reperfusion of the acutely ischemic limb can lead to a systemic inflammation response and multiple organ dysfunction syndrome, further resulting in significant morbidity and mortality. Molecular hydrogen exhibits therapeutic ...
PENIS - SURGERY/TRANSPLANTATION

Protective effects of hydrogen rich saline solution on ventral penile mathieu type flap with penile ...

Year Published: 2021

Introduction: Penile tourniquet (Pt) application aims to work in a bloodless field in penile surgery. When the tourniquet is released, reperfusion injury occurs with the resumption of blood flow. Molecular hydrogen can easily attach to biomembranes and enter cytosol, mitochondria and other organelles of the cell and convert the formed OH- to H₂O to prevent cell and tissue damage. Aim: We ...
SKIN - RADIOPROTECTION

Protective effects of dissolved molecular hydrogen against hydrogen peroxide-, hydroperoxide-, and ...

Year Published: 2021

Molecular hydrogen (H2) is recognized as a gaseous antioxidant, and it is expected to ameliorate various disorders related to oxidative stress and inflammation. However, there are still many unclear points regarding its effectiveness in the skin. Therefore, the purpose of this study was to examine the protective effect of H2 against ultraviolet (UV) irradiation-related stress injury in human ...