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Studies Found: 1335

BRAIN - CARDIOPULMONARY RESUSCITATION (CPR)

Hydrogen-rich saline improves survival and neurological outcome after cardiac arrest and ...

Year Published: 2014

Background: Sudden cardiac arrest is a leading cause of death worldwide. Three-fourths of cardiac arrest patients die before hospital discharge or experience significant neurological damage. Hydrogen-rich saline, a portable, easily administered, and safe means of delivering hydrogen gas, can exert organ-protective effects through regulating oxidative stress, inflammation, and apoptosis. We ...
BRAIN - CARDIOPULMONARY RESUSCITATION (CPR)

Hydrogen Inhalation During Normoxic Resuscitation Improves Neurological Outcome in a Rat Model of ...

Year Published: 2014

Background: We have previously shown that hydrogen (H2) inhalation, begun at the start of hyperoxic cardiopulmonary resuscitation, significantly improves brain and cardiac function in a rat model of cardiac arrest. Here, we examine the effectiveness of this therapeutic approach when H2 inhalation is begun on the return of spontaneous circulation (ROSC) under normoxic conditions, either alone or in ...
BRAIN - BRAIN INJURY

Neuroprotective Effect of Hydrogen-Rich Saline against Neurologic Damage and Apoptosis in Early ...

Year Published: 2014

Backgrounds: Early brain injury (EBI) plays a key role in the pathogenesis of subarachnoid hemorrhage (SAH). Neuronal apoptosis is involved in the pathological process of EBI. Hydrogen can inhibit neuronal apoptosis and attenuate EBI following SAH. However, the molecular mechanism underlying hydrogen-mediated anti-apoptotic effects in SAH has not been elucidated. In the present study, we aimed to ...
MUSCLE - SURGERY/TRANSPLANTATION

Hydrogen-rich saline attenuates ischemia–reperfusion injury in skeletal muscle

Year Published: 2014

Background: To investigate the potential beneficial effect of hydrogen-rich saline (HRS) in ischemia-reperfusion (IR) injury of skeletal muscle. Methods: Three experimental groups were established in male Sprague-Dawley rats: (1) sham group, (2) IR with normal saline group, (3) and IR with HRS group. A rat model of skeletal muscle IR injury was induced by 3-h tourniquet occlusion on its left hind ...

Pretreatment with hydrogen-rich saline reduces the damage caused by glycerol-induced rhabdomyolysis ...

Year Published: 2014

Background: Rhabdomyolysis is a leading cause of acute kidney injury. The pathophysiological process involves oxidative stress and inflammation. Hydrogen-rich saline (HRS) is an antioxidant and anti-inflammatory. This study explored the protective effect of pretreatment with HRS on the development of glycerol-induced rhabdomyolysis acute kidney injury. Materials and methods: Forty-eight rats were ...
KIDNEY - RADIOPROTECTION

Protective effects of hydrogen-rich saline against γ-ray irradiation injury in HK-2 cells

Year Published: 2014

Objective To investigate the protective effects and mechanism of Hydrogen-rich saline against γ irradiation-induced injury in HK-2 cells. Methods HK-2 cells were separated into 4 groups: the contral group, the Hydrogen-treated group, the irradiated group, the irradiated Hydrogen-treated group. The Hydrogen-treated group and the irradiated Hydrogen-treated group were pretreated with Hydrogen-rich ...

Intrathecal Infusion of Hydrogen-Rich Normal Saline Attenuates Neuropathic Pain via Inhibition of ...

Year Published: 2014

Background Reactive oxygen and nitrogen species are key molecules that mediate neuropathic pain. Although hydrogen is an established antioxidant, its effect on chronic pain has not been characterized. This study was to investigate the efficacy and mechanisms of hydrogen-rich normal saline induced analgesia. Methodology/Principal findings In a rat model of neuropathic pain induced by L5 spinal ...
MOUTH - WOUND HEALING

Distinct signaling pathways leading to the induction of human β-defensin 2 by stimulating an ...

Year Published: 2014

Abstract Defensins, a major family of cationic antimicrobial peptides, play important roles in innate immunity. In the present study, we investigated whether double-stranded RNA (dsRNA), a by-product of RNA virus replication, can induce human β-defensins-2 (hBD-2) expression in oral epithelial cells (OECs). We also examined the hBD-2-inducible activity of acid-electrolyzed functional water (FW). ...
LUNG - SHOCK

Effects of three hydrogen-rich liquids on hemorrhagic shock in rats

Year Published: 2014

Background Hydrogen-rich saline provides a high concentration of hydrogen which selectively reduces levels of hydroxyl radicals and alleviates acute oxidative stress in many models. We investigated the protective effects and mechanisms of three different hydrogen-rich liquid resuscitation preparations on lung injury-induced uncontrolled hemorrhagic shock (UHS) in rats. Materials and methods A UHS ...
WHOLE BODY - SHOCK

Protective effects of hydrogen-rich saline in uncontrolled hemorrhagic shock

Year Published: 2014

Hydrogen is considered to be a novel antioxidant as it inhibits inflammation, removes oxygen-derived free radicals and reduces oxidative damage. This study investigated the effects of hydrogen-rich saline on plasma interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), superoxide dismutase (SOD) and malondialdehyde (MDA) in rats with uncontrolled hemorrhagic shock (UHS). The UHS model was ...
BRAIN - BRAIN INJURY

Hydrogen-rich saline attenuates neuronal ischemia – Reperfusion injury by protecting ...

Year Published: 2014

Background: Hydrogen, a popular antioxidant gas, can selectively reduce cytotoxic oxygen radicals and has been found to protect against ischemia–reperfusion (I/R) injury of multiple organs. Acute neuronal death during I/R has been attributed to loss of mitochondrial permeability transition coupled with mitochondrial dysfunction. This study was designed to investigate the potential therapeutic ...

Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic ...

Year Published: 2014

Traumatic brain injury (TBI) in its various forms has emerged as a major problem for modern society. Acute TBI can transform into a chronic condition and be a risk factor for neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, probably through induction of oxidative stress and neuroinflammation. Here, we examined the ability of the antioxidant molecular hydrogen given in ...
WHOLE BODY - ENVIRONMENTAL POLLUTION

Cigarette smoke exposure impairs reverse cholesterol transport which can be minimized by treatment ...

Year Published: 2015

Background Cigarette smoke (CS) exposure impaired plasma lipid profiles by modification of apolipoproteins. Hydrogen (H2) has been proved effective on reducing oxidative stress or improving HDL functionalities in animal models or metabolic syndrome volunteers. This study was undertaken to explore the effects of CS exposure on reverse cholesterol transport (RCT) and the antioxidative effects of H2 ...

Hydrogen-Saturated Saline Protects Intensive Narrow Band Noise-Induced Hearing Loss in Guinea Pigs ...

Year Published: 2014

The purpose of the current study was to evaluate hydrogen-saturated saline protecting intensive narrow band noise-induced hearing loss. Guinea pigs were divided into three groups: hydrogen-saturated saline; normal saline; and control. For saline administration, the guinea pigs were given daily abdominal injections (1 ml/100 g) 3 days before and 1 h before narrow band noise exposure (2.5-3.5 kHz ...

Treatment with Hydrogen-Rich Saline Delays Disease Progression in a Mouse Model of Amyotrophic ...

Year Published: 2015

Amyotrophic lateral sclerosis (ALS) is the most frequent adult-onset motor neuron disease, and accumulating evidence indicates that oxidative mechanisms contribute to ALS pathology, but classical antioxidants have not performed well in clinical trials. The aim of this work was to investigate the effect of treatment with hydrogen molecule on the development of disease in mutant SOD1 G93A transgenic ...
BRAIN - STROKE

Role of FOXO3A in process of hydrogen-rich saline attenuating global cerebral ischemia-reperfusion ...

Year Published: 2015

To investigate the role of FOXO3a in process of hydrogen-rich saline attenuating global cerebral ischemia-reperfusion (I/R) injury in rats. Seventy-two male Sprague Dawley rats, weighing 280-320 g, were randomly divided into six groups (n = 12 each) : sham operation group (group I), cerebral ischemia-reperfusion group (group II), hydrogen-rich saline group (group III), vehicle group (group IV), ...
LIVER - LIVER INJURY

Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice

Year Published: 2015

Aim: To investigate the hepatoprotective effects and mechanisms of hydrogen-rich water (HRW) in acetaminophen (APAP)-induced liver injury in mice. Methods: Male mice were randomly divided into the following four groups: normal saline (NS) control group, mice received equivalent volumes of NS intraperitoneally (ip); HRW control group, mice were given HRW (same volume as the NS group); APAP + NS ...
LUNG - SEPSIS

Saturated hydrogen saline attenuates lps-induced lung disfuction

Year Published: 2015

Acute lung injury induced by lipopolysaccharides (LPSs) is caused by pulmonary inflammation and pulmonary vascular permeability. Activation of p38 mitogen-activated protein kinase causes inflammation, and proinflammatory cytokines and oxidative stress induce autophagy, a catabolic mechanism responsible for protein degradation and recycling of damaged proteins and cytoplasmic organelles. If not ...
MUSCLE - SURGERY/TRANSPLANTATION

Hydrogen-rich saline promotes motor functional recovery following peripheral nerve autografting in ...

Year Published: 2015

Despite the application of nerve grafts and considerable microsurgical innovations, the functional recovery across a long peripheral nerve gap is generally partial and unsatisfactory. Thus, additional strategies are required to improve nerve regeneration across long nerve gaps. Hydrogen possesses antioxidant and anti-apoptotic properties, which could be neuroprotective in the treatment of ...
HEART - SURGERY/TRANSPLANTATION

Pharmacological Postconditioning with Lactic Acid and Hydrogen Rich Saline Alleviates Myocardial ...

Year Published: 2015

This study investigated whether pharmacological postconditioning with lactic acid and hydrogen rich saline can provide benefits similar to that of mechanical postconditioning. To our knowledge, this is the first therapeutic study to investigate the co-administration of lactic acid and hydrogen. SD rats were randomly divided into 6 groups: Sham, R/I, M-Post, Lac, Hyd, and Lac + Hyd. The left ...
INTESTINE - SEPSIS

Effects of hydrogen inhalation on serum pro-inflammatory factors and intestinal injury in mice with ...

Year Published: 2015

To investigate the effects and mechanisms of hydrogen inhalation on serum levels of pro-inflammatory factors and intestinal injury in severe septic mice. 176 male ICR mice were randomly divided into four groups: sham operation group, hydrogen control group ( sham + hydrogen inhalation ), model group ( severe sepsis model ) and hydrogen treatment group ( severe sepsis model + hydrogen inhalation ), ...
HEART - SURGERY/TRANSPLANTATION

Pharmacological post-conditioning with lactic acid and saturated hydrogen saline could attenuate ...

Year Published: 2015

Objective: To study the hypothesis about the pharmacological post-conditioning with lactic acid and saturated hydrogen saline after ischemic injury of myocardium instead of post-conditioning with mechanical dilatation of severely occluded coronary vessels to attenuate apoptosis of cardiocyte by mitogenactivated protein kinases (MAPK) pathway. Methods: A total of 108 rats were randomly (random ...
HEART - HEART ATTACK

Effects of hydrogen-rich saline on Akt/GSK3β signaling pathways and cardiac function during ...

Year Published: 2015

To explore the effects of hydrogen-rich saline on Akt/GSK3β signaling pathways and cardiac function during myocardial ischemia-reperfusion (I/R) in rats. A total of 150 healthy male Sprague-Dawley rats were selected and divided randomly into 5 groups of normal control (I), sham operation (II), myocardial ischemia-reperfusion (III), hydrogen-rich saline (IV) and normal saline group (V) (n = 30 ...
LUNG - SEPSIS

Hydrogen-rich saline ameliorates lung injury associated with cecal ligation and puncture-induced ...

Year Published: 2015

Aims: Although hydrogen has been proved to be a novel therapeutic medical gas in several lung injury animal models, to our knowledge, it has not been tested yet in acute lung injury (ALI) induced by cecal ligation and puncture (CLP). This study was to investigate the hypothesis that hydrogen could ameliorate CLP-induced lung injury in rats. Methods and results: Our experiments exhibited that gas ...
LIVER - SURGERY/TRANSPLANTATION

Hydrogen gas inhalation protects against liver ischemia/reperfusion injury by activating the NF-κB ...

Year Published: 2015

Hydrogen has been demonstrated to function as a novel antioxidant and exert therapeutic antioxidant activity in a number of diseases. The present study was designed to investigate the effect of hydrogen inhalation on liver ischemia/reperfusion (I/R) injury in rats. The portal triad to the left lobe and the left middle lobe of the liver were completely occluded for 90 min. This was followed by ...