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Studies Found: 1335

BRAIN - ALZHEIMER'S DISEASE

Hydrogen-rich water attenuates amyloid β-induced cytotoxicity through upregulation of Sirt1-FoxO3a ...

Year Published: 2015

Amyloid β (Aβ) peptides are identified in cause of neurodegenerative diseases such as Alzheimer's disease (AD). Previous evidence suggests Aβ-induced neurotoxicity is linked to the stimulation of reactive oxygen species (ROS) production. The accumulation of Aβ-induced ROS leads to increased mitochondrial dysfunction and triggers apoptotic cell death. This suggests antioxidant therapies may be ...
PERITONIUM - SURGERY/TRANSPLANTATION

Efficacy and safety of strong acid electrolyzed water for peritoneal lavage to prevent surgical site ...

Year Published: 2015

Purpose: Our previous experimental study of perforated peritonitis in rats proved that peritoneal lavage with strong acid electrolyzed water (SAEW) has no adverse effects, reduces the bacteria count in the ascitic fluid more effectively than saline, and increases the survival rate significantly. Thus, we conducted a randomized controlled study, applying SAEW in the treatment of perforated ...
HEART - HIGH BLOOD PRESSURE

Hydrogen ameliorates pulmonary hypertension in rats by anti-inflammatory and anti-oxidant effects

Year Published: 2015

Objective: The pathogenesis of pulmonary arterial hypertension (PAH) involves reactive oxygen species and inflammation. Beneficial effects of molecular hydrogen, which exerts both anti-inflammatory and antioxidative effects, have been reported for various pathologic conditions. We therefore hypothesized that molecular hydrogen would improve monocrotaline (MCT)-induced PAH in rats. Methods: ...
LUNG - SHOCK

Hydrogen inhalation protects against acute lung injury induced by hemorrhagic shock and ...

Year Published: 2015

Hemorrhagic shock followed by fluid resuscitation (HS/R) triggers an inflammatory response and causes pulmonary inflammation that can lead to acute lung injury (ALI). Hydrogen, a therapeutic gas, has potent cytoprotective, antiinflammatory, and antioxidant effects. This study examined the effects of inhaled hydrogen on ALI caused by HS/R. Rats were subjected to hemorrhagic shock by withdrawing ...
HEART - HEART ATTACK

Cardioprotective Effect of Hydrogen-rich Saline on Isoproterenol-induced Myocardial Infarction in ...

Year Published: 2015

Infusion with hydrogen gas-saturated saline has recently been reported to exert antioxidant and anti-inflammatory activity that may protect against organ damage induced by oxidative stress. Therefore because oxidative stress plays a significant role in the pathophysiology of myocardial infarction (MI), the aim of our study was to investigate whether hydrogen-rich saline has cardioprotective ...
WHOLE BODY - ROS-SCAVENGING

Antioxidant activities of nano-bubble hydrogen-dissolved water assessed by ESR and 2,2′-bipyridyl ...

Year Published: 2015

We prepared nano-bubble hydrogen-dissolved water (nano-H water) which contained hydrogen nano-bubbles of <717-nm diameter for 54% of total bubbles. In the DMPO-spin trap electron spin resonance (ESR) method, the DMPO-OH:MnO ratio, being attributed to amounts of hydroxyl radicals (OH), was 2.78 for pure water (dissolved hydrogen [DH]≤0.01ppm, oxidation-reduction potential [ORP]=+324mV), 2.73 for ...
WHOLE BODY - ROS-SCAVENGING

The Evaluation and Quantitation of Dihydrogen Metabolism Using Deuterium Isotope in Rats

Year Published: 2015

Purpose: Despite the significant interest in molecular hydrogen as an antioxidant in the last eight years, its quantitative metabolic parameters in vivo are still lacking, as is an appropriate method for determination of hydrogen effectivity in the mammalian organism under various conditions. Basic procedures: Intraperitoneally-applied deuterium gas was used as a metabolic tracer and deuterium ...
SKIN - PSORIASIS

Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: ...

Year Published: 2015

Psoriasis, a chronic inflammatory skin disease, is caused by infiltrating lymphocytes and associated cytokines, including tumor necrosis factor (TNF)α, interleukin (IL)-6, and IL-17. Effective treatments, including pathogenesis-based biological agents against psoriasis, are currently under development. Although the role of reactive oxygen species (ROS) in the pathogenesis of psoriasis has been ...
KIDNEY - SURGERY/TRANSPLANTATION

Inhalation of Hydrogen Gas Is Beneficial for Preventing Contrast-Induced Acute Kidney Injury in Rats

Year Published: 2015

Background: The present study aimed at investigating the effect of a novel antioxidant, hydrogen (H2) gas, on the severity of contrast-induced acute kidney injury (CIAKI) in a rat model. Methods: CIAKI was induced in rats by intravenous injection of a contrast medium, Ioversol, in addition to reagents inhibiting prostaglandin and nitric oxide synthesis. During the injection of these reagents, the ...
BONE - OSTEONECROSIS

Hydrogen-rich saline attenuates steroid-associated femoral head necrosis through inhibition of ...

Year Published: 2015

A growing body of evidence suggests that hydrogen is a novel, selective antioxidant that exerts a protective effect against organ damage. The present study investigated the effect of hydrogen-rich saline on corticosteroid‑induced necrosis of the femoral head in an animal model established using prednisolone. A total of 30 healthy, male, adult New Zealand white rabbits were randomly divided into ...
PREGNANCY - PRETERM BIRTH

Maternal molecular hydrogen treatment attenuates lipopolysaccharide-induced rat fetal lung injury

Year Published: 2015

Maternal inflammation is associated with spontaneous preterm birth and respiratory impairment among premature infants. Recently, molecular hydrogen (H2) has been reported to have a suppressive effect on oxidative stress and inflammation. The aim of this study was to evaluate the effects of H2 on fetal lung injury caused by maternal inflammation. Cell viability and the production of interleukin-6 ...
LUNG - SURGERY/TRANSPLANTATION

The effects of hydrogen gas inhalation during ex vivo lung perfusion on donor lungs obtained after ...

Year Published: 2015

Lung transplantation is a well-established treatment of end-stage lung disease; however, it is limited by a shortage of donor lungs. To overcome this problem, donation after cardiac death (DCD) and ex vivo lung perfusion (EVLP) are being widely investigated. In this study, the effect of hydrogen gas, a known antioxidant, was investigated on a DCD lung model during EVLP. Ten pigs were randomized ...
BRAIN - BRAIN INJURY

Hydrogen-rich water protects against ischemic brain injury in rats by regulating calcium buffering ...

Year Published: 2015

Hydrogen-rich water (HRW) has anti-oxidant activities, and it exerts neuroprotective effects during ischemia-reperfusion brain injury. Parvalbumin and hippocalcin are two calcium buffering proteins, which are involved in neuronal differentiation, maturation and apoptosis. The aim of this study was to investigate whether HRW could moderate parvalbumin and hippocalcin expression during ischemic ...
KIDNEY - ACUTE KIDNEY INJURY

Effects of hydrogen-rich saline on early acute kidney injury in severely burned rats by suppressing ...

Year Published: 2015

Early acute kidney injury (AKI) in severely burned patients predicts a high mortality that is multi-factorial. Hydrogen has been reported to alleviate organ injury via selective quenching of reactive oxygen species. This study investigated the potential protective effects of hydrogen against severe burn-induced early AKI in rats. Severe burn were induced via immersing the shaved back of rats into ...
SKIN - WOUND HEALING

Beneficial Effects of Hydrogen-Rich Saline on Early Burn-Wound Progression in Rats

Year Published: 2015

Introduction: Deep burn wounds undergo a dynamic process known as wound progression that results in a deepening and extension of the initial burn area. The zone of stasis is more likely to develop more severe during wound progression in the presence of hypoperfusion. Hydrogen has been reported to alleviate injury triggered by ischaemia/reperfusion and burns in various organs by selectively ...
MOUTH - WOUND HEALING

Electrolytically generated acid functional water inhibits NF-κB activity by attenuating ...

Year Published: 2015

Background: Human β-defensin 2 (hBD2) gene expression is dependent on nuclear factor kappa B (NF-κB) activity. We have previously demonstrated that electrolytically generated acid functional water (FW) induces the expression of hBD2 in the human oral squamous cell carcinoma (OSCC) cell line Ca9-22. However, the induction was not dependent on NF-κB activity; in fact, FW inhibited NF-κB ...
PREGNANCY - PREECLAMPSIA

Effects of vitamin C, vitamin E, and molecular hydrogen on the placental function in trophoblast ...

Year Published: 2015

Aim: This study aimed to investigate the effects of three different antioxidants, namely vitamin C, vitamin E, and molecular hydrogen, on cytotrophoblasts in vitro. Methods: Two trophoblast cell lines, JAR and JEG-3, were exposed to different concentrations of vitamin C (0, 25, 50, 100, 500, 1,000, 5,000 μmol/L), vitamin E (0, 25, 50, 100, 500, 1,000, 5,000 μmol/L), and molecular hydrogen (0, ...
KIDNEY - SURGERY/TRANSPLANTATION

Hydrogen-Rich Saline Attenuates Acute Kidney Injury After Liver Transplantation via Activating ...

Year Published: 2015

Background: Acute kidney injury (AKI) impacts the survival of liver transplant recipients severely. To date, the related mechanism and effective therapy have not been rigorously explored. The present study aimed to explore the role of p53-mediated autophagy in the protective effect of hydrogen-rich saline (HRS) on AKI after orthotropic liver transplantation (OLT). Methods: Adult male ...
INTESTINE - SHOCK

Three hydrogen-rich solutions protect against intestinal injury in uncontrolled hemorrhagic shock

Year Published: 2015

Intestinal tissue got largely decreased blood supply in uncontrolled hemorrhagic shock, because of limited blood mainly supporting brain, heart, kidney etc. This makes intestine as the primary injury target after uncontrolled hemorrhagic shock. However, limited studies focus on how to protect intestine against hemorrhagic shock. Ringer's solution, pentoxifylline and hypertonic saline are widely ...
LUNG - ENVIRONMENTAL POLLUTION

Protective Effects of Hydrogen-Rich Saline on Rats with Smoke Inhalation Injury

Year Published: 2015

Objective: To explore the protective effects of hydrogen-rich saline on rats with smoke inhalation injury. Methods: 36 healthy male Sprague-Dawley rats were randomly divided into 3 groups (n = 12 per group): sham group (S), inhalation injury plus normal saline treatment group (I+NS), and inhalation injury plus hydrogen-rich saline treatment group (I+HS). 30 min after injury, normal saline and ...
BRAIN - NEUROPATHIC PAIN

H2 Treatment Attenuated Pain Behavior and Cytokine Release Through the HO-1/CO Pathway in a Rat ...

Year Published: 2015

Neuropathic pain (NP) is characterized by persistent pain, tactile allodynia, or hyperalgesia. Peripheral nerve injury contributes to rapid progress of inflammatory response and simultaneously generates neuropathic pain. Hydrogen (H2) has anti-inflammation, anti-apoptosis, and anti-oxidative stress effects. Therefore, we hypothesized that H2 treatment could alleviate allodynic and hyperalgesic ...
ENDOTHELIUM - SEPSIS

Molecular hydrogen protects mice against polymicrobial sepsis by ameliorating endothelial ...

Year Published: 2015

Endothelial injury is a primary cause of sepsis and sepsis-induced organ damage. Heme oxygenase-1 (HO-1) plays an essential role in endothelial cellular defenses against inflammation by activating nuclear factor E2-related factor-2 (Nrf2). We found that molecular hydrogen (H2) exerts an anti-inflammatory effect. Here, we hypothesized that H2 attenuates endothelial injury and inflammation via an ...
TESTES - ENVIRONMENTAL POLLUTION

Effect of hydrogen injected subcutaneously on testicular tissues of rats exposed to cigarette smoke

Year Published: 2015

Smoking is one of the most common reasons inducing reactive oxygen species in semen. High concentration of active oxygen will cause decrease of sperm density and viability and induce oxidative injury of sperm DNA which has become the hot spot in male infertility. Although hydrogen was found to be an effective remover of active oxygen in liver, heart, kidney and brain, the same effect has not been ...
PANCREAS - PANCREATITIS

Protective Effects of Hydrogen Gas on Experimental Acute Pancreatitis

Year Published: 2016

Acute pancreatitis (AP) is an inflammatory disease mediated by damage to acinar cells and pancreatic inflammation. In patients with AP, subsequent systemic inflammatory responses and multiple organs dysfunction commonly occur. Interactions between cytokines and oxidative stress greatly contribute to the amplification of uncontrolled inflammatory responses. Molecular hydrogen (H2) is a potent free ...
MOUTH - PERIODONTITIS

Drinking Hydrogen-Rich Water Has Additive Effects on Non-Surgical Periodontal Treatment of Improving ...

Year Published: 2015

Oxidative stress is involved in the pathogenesis of periodontitis. A reduction of oxidative stress by drinking hydrogen-rich water (HW) might be beneficial to periodontal health. In this pilot study, we compared the effects of non-surgical periodontal treatment with or without drinking HW on periodontitis. Thirteen patients (3 women, 10 men) with periodontitis were divided into two groups: The ...