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Studies Found: 1138

INTESTINE - INFLAMMATORY BOWEL DISEASE (IBD)

Protective effects of hydrogen-rich saline on ulcerative colitis rat model

Year Published: 2013

Background: Ulcerative colitis (UC) is associated with enhanced production of reactive oxygen species and altered angiogenesis. Molecular hydrogen has been documented as a novel antioxidant to treat various reactive oxygen species-related diseases. The present study aimed to investigate the effects of hydrogen on UC using a rat model. Materials and methods: UC in rats was induced with ...
BRAIN - CARDIAC ARREST

The neuroprotective effects of intraperitoneal injection of hydrogen in rabbits with cardiac arrest

Year Published: 2013

Objective: The purpose of this study was to investigate the neuroprotective effects of intraperitoneal injection of hydrogen (H2) in rabbits with cardiac arrest (CA). Methods: A rabbit model of CA was established by the delivery of alternating current between the esophagus and chest wall to induce ventricular fibrillation. Before CA, the animals were randomly divided into four groups: a sham group ...
SKIN - DERMATITIS

The Drinking Effect of Hydrogen Water on Atopic Dermatitis Induced by Dermatophagoides farinae ...

Year Published: 2013

Hydrogen water (HW) produced by electrolysis of water has characteristics of extremely low oxidation-reduction potential (ORP) value and high dissolved hydrogen (DH). It has been proved to have various beneficial effects including antioxidant and anti-inflammatory effects; however, HW effect on atopic dermatitis (AD), an inflammatory skin disorder, is poorly documented. In the present study, we ...
SKIN - RADIOPROTECTION

The balneotherapy effect of hydrogen reduced water on UVB-mediated skin injury in hairless mice

Year Published: 2013

Exposure to UVB radiation induced skin damage that results to increase risk of skin cancer. Despite the clinical importance of skin-induced damage, antioxidants imposed limited therapeutic success. Hydrogen molecule (H2) has been known as a safe antioxidant in the prevention and therapeutic approach towards several diseases. Drinking hydrogen reduced water (HRW), inhalation of hydrogen gas, and ...
WHOLE BODY - OBESITY

Anti-obesity effect of alkaline reduced water in high fat-fed obese mice

Year Published: 2013

Whether or not alkaline reduced water (ARW) has a positive effect on obesity is unclear. This study aims to prove the positive effect of ARW in high-fat (HF) diet-induced obesity (DIO) in C57BL/6 mice model. Toward this, obesity was induced by feeding the C57BL/6 male mice with high-fat diet (w/w 45% fat) for 12 weeks. Thereafter, the animals were administered with either ARW or tap water. Next, ...
WHOLE BODY - OBESITY

Molecular hydrogen attenuates fatty acid uptake and lipid accumulation through downregulating CD36 ...

Year Published: 2013

Background: There is accumulating evidence that obesity is closely associated with an impaired free fatty acid metabolism as well as with insulin resistance and inflammation. Excessive fatty acid uptake mediated by fatty acid translocase CD36 plays an important role in hepatic steatosis. Molecular hydrogen has been shown to attenuate oxidative stress and improve lipid, glucose and energy ...
HEART - DIABETES

Hydrogen-rich medium suppresses the generation of reactive oxygen species, elevates the Bcl-2/Bax ...

Year Published: 2013

The purpose of the present study was to determine whether using hydrogen-rich medium (HRM) to increase hydrogen levels in endothelial cells (ECs) protects ECs from apoptosis induced by advanced glycation end products (AGEs). The thoracic aorta was removed from 2-3-year-old Sprague-Dawley rats, and ECs were isolated and cultured. After culturing ECs in the presence of AGEs and/or with HRM for 24 h, ...
TESTES - RADIOPROTECTION

Protection by Hydrogen Against Gamma Ray‐Induced Testicular Damage in Rats

Year Published: 2013

The aim of this study was to investigate the possible protective role of hydrogen‐rich saline solution (HRSS) and WR‐2721 on the testicular damage induced by irradiation. Sprague‐Dawley rats were randomly divided into four groups. Group I served as control group. Rats in group II were exposed to the irradiation. The animals in group III and IV were injected intraperitoneally with HRSS (5 ...
LIVER - NON-ALCOHOLIC STEATOHEPATITIS (NASH)

Hydrogen as a treatment candidate for non-alcoholic steatohepatitis

Year Published: 2013

No abstract available
LUNG - SURGERY/TRANSPLANTATION

Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway

Year Published: 2013

Hyperoxic lung injury is a major concern in critically ill patients who receive high concentrations of oxygen to treat lung diseases. Successful abrogation of hyperoxic lung injury would have a huge impact on respiratory and critical care medicine. Hydrogen can be administered as a therapeutic medical gas. We recently demonstrated that inhaled hydrogen reduced transplant-induced lung injury and ...
MOUTH - GINGIVITIS

Antibacterial Activity of Hydrogen-rich Water Against Oral Bacteria

Year Published: 2013

There are estimated to be about 700 species of bacteria inthe oral cavity. Based on epidemiological investigations,some of these strains have been proposed as the pathogensresponsible for oral diseases such as dental caries, gingivitisand periodontitis. Since electrolyzed hydrogen-rich waterhas been shown to have beneficial effects on human immunity,its use has increased. In our study, the ...
BONE - SURGERY/TRANSPLANTATION

Treatment with hydrogen molecules prevents RANKL-induced osteoclast differentiation associated with ...

Year Published: 2013

The bone protective effects of the hydrogen molecule (H2) have been demonstrated in several osteoporosis models while the underlying molecular mechanism has remained unclear. Osteoclast differentiation is an important factor related to the pathogenesis of bone-loss related diseases. In this work, we evaluated the effects of incubation with H2 on receptor activator of NFκB ligand (RANKL)-induced ...
KIDNEY - CANCER

Consumption of hydrogen-rich water protects against ferric nitrilotriacetate-induced nephrotoxicity ...

Year Published: 2013

The aim of this work was to test whether consumption with hydrogen-rich water (HW) alleviated renal injury and inhibited early tumor promotional events in Ferric nitrilotriacetate (Fe-NTA)-treated rats. Rats were injected with Fe-NTA solution (7.5mg Fe/kg body weight) intraperitoneally to induce renal injury and simultaneously treated with HW (1.3 ± 0.2mg/l). We found that consumption with HW ...
WHOLE BODY - SEPSIS

Effects of hydrogen-rich saline treatment on polymicrobial sepsis

Year Published: 2013

Background: Hydrogen has been reported to selectively reduce hydroxyl radicals and peroxynitrite anion in many pathologic processes. This study aimed to test the hypothesis that hydrogen-rich saline (HRS) may ameliorate organ dysfunction in a rat model of polymicrobial sepsis. Methods: Sepsis was induced in male Sprague-Dawley rats by cecal ligation and puncture (CLP). Twenty-four rats were ...
SKIN - WOUND HEALING

Hydrogen water intake via tube-feeding for patients with pressure ulcer and its reconstructive ...

Year Published: 2013

Background: Pressure ulcer (PU) is common in immobile elderly patients, and there are some research works to investigate a preventive and curative method, but not to find sufficient effectiveness. The aim of this study is to clarify the clinical effectiveness on wound healing in patients with PU by hydrogen-dissolved water (HW) intake via tube-feeding (TF). Furthermore, normal human dermal ...
EYE - DIABETES

Molecular hydrogen regulates the expression of miR-9, miR-21 and miR-199 in LPS-activated retinal ...

Year Published: 2013

Aim: To explore the potential mechanism of molecular hydrogen in the regulation of miRNA expression and signal-modulating activities. Methods: Retinal microglia cells were activated by Lipopolysaccharides (LPS) and then treated with hydrogen-saturated medium or normal medium without hydrogen. qRT-PCR was used to detect the expression difference in miR-9, miR-21 and miR-199 between these two ...
LUNG - SEPSIS

Combined early fluid resuscitation and hydrogen inhalation attenuates lung and intestine injury

Year Published: 2013

To study the effects of combined early fluid resuscitation and hydrogen inhalation on septic shock-induced lung and intestine injuries. Wistar male rats were randomly divided into four groups: control group (Group A, n = 15); septic shock group (Group B, n = 15); early fluid resuscitation-treated septic shock group (Group C, n = 15); and early fluid resuscitation and inhalation of 2% ...
BRAIN - STROKE

Hydrogen Inhalation Ameliorated Mast Cell–Mediated Brain Injury After Intracerebral Hemorrhage in ...

Year Published: 2013

Objective: Hydrogen inhalation was neuroprotective in several brain injury models. Its mechanisms are believed to be related to antioxidative stress. We investigated the potential neurovascular protective effect of hydrogen inhalation especially effect on mast cell activation in a mouse model of intracerebral hemorrhage. Design: Controlled in vivo laboratory study. Setting: Animal research ...
BRAIN - PARKINSON'S DISEASE

Oral 'hydrogen water' induces neuroprotective ghrelin secretion in mice

Year Published: 2013

The therapeutic potential of molecular hydrogen (H₂) is emerging in a number of human diseases and in their animal models, including in particular Parkinson's disease (PD). H₂ supplementation of drinking water has been shown to exert disease-modifying effects in PD patients and neuroprotective effects in experimental PD model mice. However, H₂ supplementation does not result in detectable ...
BLADDER - PAINFUL BLADDER SYNDROME

Effect of supplementation with hydrogen-rich water in patients with interstitial cystitis/painful ...

Year Published: 2013

To investigate the efficacy of hydrogen-rich water for the treatment of patients with interstitial cystitis/painful bladder syndrome (IC/PBS). We conducted a prospective, randomized, double-blind, placebo-controlled clinical trial of hydrogen-rich water in patients with IC/PBS. Inclusion criteria were stable symptoms of IC/PBS for ≥12 weeks after bladder hydrodistension, Interstitial Cystitis ...
SKIN - CANCER

Hydrogen Protects Mice From Dermatitis Caused by Local Radiation

Year Published: 2013

Abstract Background: Radiation therapy produced unwanted side effect on normal tissues, such as radiodermatitis. Hydrogen was previously shown capable of radiation protective in both animals and cell cultures. The effect of hydrogen was now to be investigated on radiation-induced cutaneous. Objective: Development of dermatitis is a frequent side effect of radiotherapy of patients with ...
BRAIN - BRAIN INJURY

The effect of hydrogen gas on a mouse bilateral common carotid artery occlusion

Year Published: 2013

In recent studies, molecular hydrogen selectively reduced the levels of hydroxyl radicals in vitro and exerted a therapeutic anti-oxidant activity in a rat middle cerebral artery occlusion model. The aim of this study was to investigate the effect of hydrogen gas on a mouse bilateral common carotid artery occlusion (BCCAO) model. Male C57BL/6J mice were subjected to transient BCCAO with a ...
BRAIN - STROKE

Safety of intravenous administration of hydrogen-enriched fluid in patients with acute cerebral ...

Year Published: 2013

Most of the results regarding hydrogen (H2) therapy for acute cerebral ischemia are derived from in vitro studies and animal experiments, with only a few obtained from human trials with a limited number of subjects. Thus, there is a paucity of information regarding both the beneficial therapeutic effects as well as the side effects of H2 on acute cerebral ischemia in humans. We designed a pilot ...
LUNG - ENVIRONMENTAL POLLUTION

Attenuation of Cigarette Smoke-Induced Airway Mucus Production by Hydrogen-Rich Saline in Rats

Year Published: 2013

Over-production of mucus is an important pathophysiological feature in chronic airway disease such as chronic obstructive pulmonary disease (COPD) and asthma. Cigarette smoking (CS) is the leading cause of COPD. Oxidative stress plays a key role in CS-induced airway abnormal mucus production. Hydrogen protected cells and tissues against oxidative damage by scavenging hydroxyl radicals. In the ...
WHOLE BODY - METABOLIC SYNDROME

Colonic Hydrogen Generated from Fructan Diffuses into the Abdominal Cavity and Reduces Adipose mRNA ...

Year Published: 2013

Hydrogen (H2) protects against inflammation-induced oxidative stress. Nondigestible saccharides (NDSs) enhance colonic H2 production. We examined whether colonic H2 transfers to tissues in the abdominal cavity and whether it affects expression of proinflammatory cytokines. In Expts. 1 and 2, rats were fed diets containing fructooligosaccharides [FOSs; 25 (Expt. 1) and 50 g/kg (Expts. 1 and 2)] for ...