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Studies Found: 1138

SKIN - ENVIRONMENTAL POLLUTION

Hydrogen-enriched water restoration of impaired calcium propagation by arsenic in primary ...

Year Published: 2013

Endemic contamination of artesian water for drinking by arsenic is known to cause several human cancers, including cancers of the skin, bladder, and lungs. In skin, multiple arsenic-induced Bowen's disease (As-BD) can develop into invasive cancers after decades of arsenic exposure. The characteristic histological features of As-BD include full-layer epidermal dysplasia, apoptosis, and abnormal ...
BRAIN - STROKE

Lactulose ameliorates cerebral ischemia-reperfusion injury in rats by inducing hydrogen by ...

Year Published: 2013

Molecular hydrogen has been proved effective in ameliorating cerebral ischemia/reperfusion (I/R) injury by selectively neutralizing reactive oxygen species. Lactulose can produce considerable amount of hydrogen through fermentation by the bacteria in the gastrointestinal tract. To determine the neuroprotective effects of lactulose against cerebral I/R injury in rats and explore the probable ...
PANCREAS - PANCREATITIS

Effects of Hydrogen-Rich Saline on Taurocholate-Induced Acute Pancreatitis in Rat

Year Published: 2013

Oxidative stress plays an important role in the pathogenesis of acute pancreatitis (AP). As an ideal exterminator of poisonous free radicals, hydrogen can clearly reduce the degree of oxidative damage caused by severe acute pancreatitis (SAP) and lessen the presence of inflammatory cytokines. The aim of this study was to investigate the effects and mechanism of hydrogen-rich saline on SAP in rats. ...
SKIN - SURGERY/TRANSPLANTATION

Protective effect of hydrogen-rich saline on ischemia/reperfusion injury in rat skin flap

Year Published: 2013

Objective: Skin damage induced by ischemia/reperfusion (I/R) is a multifactorial process that often occurs in plastic surgery. The mechanisms of I/R injury include hypoxia, inflammation, and oxidative damage. Hydrogen gas has been reported to alleviate cerebral I/R injury by acting as a free radical scavenger. Here, we assessed the protective effect of hydrogen-rich saline (HRS) on skin flap I/R ...
BONE MARROW - IMMUNE DYSFUNCTION

Therapeutic Effects of Hydrogen-Rich Solution on Aplastic Anemia in Vivo

Year Published: 2013

Background: Aplasitc anemia (AA) is a bone marrow failure syndrome characterized by an immune-mediated destruction of hematopoietic stem cells. Though clinical symptoms could be ameliorated by bone marrow transplantation and/or immunosuppressive therapy, frequent recurrence and especially evolution of clonal hematologic diseases remains problematic clinically. Cytokines such as interferon-γ ...
LUNG - SURGERY/TRANSPLANTATION

Hydrogen inhalation decreases lung graft injury in brain-dead donor rats

Year Published: 2013

BACKGROUND: The process of brain death induces acute lung injury in donors and aggravates ischemia-reperfusion injury (IRI) in grafts. Hydrogen, a new anti-oxidant, attenuates IRI in several organ transplant models. We examined whether 2% inhaled hydrogen would show favorable effects on lung grafts from brain-dead donor rats. METHODS: Brain-dead donor rats inhaled mixed gases with either 50% ...
SPINE - SURGERY/TRANSPLANTATION

Beneficial effects of hydrogen-rich saline against spinal cord ischemia-reperfusion injury in ...

Year Published: 2013

Hydrogen-rich saline (HS) is reported to be a new therapeutic agent in ischemia-reperfusion (I/R)-induced organ damage. The present study was designed to investigate the beneficial effects of HS against spinal cord I/R injury and its associated mechanisms. Spinal cord ischemia was induced by infrarenal aortic occlusion for 20min in male New Zealand white rabbits. Different doses of HS were ...
KIDNEY - HYPERTENSION

Amelioration of cardio-renal injury with aging in dahl salt-sensitive rats by H2-enriched ...

Year Published: 2013

Recent studies have revealed the biological effects of H2 in suppressing organ injuries due to acute inflammation and oxidative stress. Dahl salt-sensitive (SS) rats naturally develop elevated blood pressure (BP) and kidney injury with aging. The present study examined the effect of long-term supplementation of H2 in drinking water on age-related changes.Four-week-old male Dahl SS rats were fed 3 ...
BRAIN - BRAIN INJURY

Nuclear factor-κB/Bcl-XL pathway is involved in the protective effect of hydrogen-rich saline on ...

Year Published: 2013

Early brain injury (EBI), a significant contributor to poor outcome after subarachnoid hemorrhage (SAH), is intimately associated with neuronal apoptosis. Recently, the protective role of hydrogen (H2 ) in the brain has been widely studied, but the underlying mechanism remains elusive. Numerous studies have shown nuclear factor-κB (NF-κB) as a crucial survival pathway in neurons. Here we ...
BRAIN - BRAIN INJURY

Beneficial effect of hydrogen-rich saline on cerebral vasospasm after experimental subarachnoid ...

Year Published: 2012

Cerebral vasospasm (CV) remains a common and devastating complication in patients with subarachnoid hemorrhage (SAH). Despite its clinical significance and extensive research, the underlying pathogenesis and therapeutic perspectives of CV remain incompletely understood. Recently, it has been suggested that molecular hydrogen (H(2)) can selectively reduce levels of hydroxyl radicals (·OH) and ...
BRAIN - TRAUMATIC BRAIN INJURY

Hydrogen-rich saline protects against oxidative damage and cognitive deficits after mild traumatic ...

Year Published: 2012

Oxidative stress is the principal factor in traumatic brain injury (TBI) that initiates events that result in protracted neuronal dysfunction and remodeling. Importantly, antioxidants can protect the brain against oxidative damage and modulate the capacity of the brain to cope with synaptic dysfunction and cognitive impairment. However, no studies have investigated the effects of hydrogen-rich ...
BONE - RHEUMATOID ARTHRITIS (RA)

Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress ...

Year Published: 2012

Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by the destruction of bone and cartilage. Although its etiology is unknown, the hydroxyl radical has been suggested to be involved in the pathogenesis of RA. Recently, molecular hydrogen (H2) was demonstrated to be a selective scavenger for the hydroxyl radical. Also, the method to prepare water containing ...
BRAIN - PARKINSON'S DISEASE

Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous ...

Year Published: 2012

Lactulose is a synthetic disaccharide that can be catalyzed only by intestinal bacteria in humans and rodents, and a large amount of hydrogen is produced by bacterial catalysis of lactulose. We previously reported marked effects of ad libitum administration of hydrogen water on prevention of a rat model of Parkinson's disease (PD). End-alveolar breath hydrogen concentrations were measured in 28 ...
BRAIN - TRAUMATIC BRAIN INJURY

Protective effects of hydrogen-rich saline in a rat model of traumatic brain injury via reducing ...

Year Published: 2012

Background: Hydrogen gas (H(2)) has been considered as a novel antioxidant to selectively reduce the toxic reactive oxygen species (ROS) such as hydroxyl radical (•OH) without affecting the other signal ROS. Our recent study shows that H(2) inhalation is beneficial to traumatic brain injury (TBI) via reducing oxidative stress. In contrast to H(2), hydrogen-rich saline (HS) may be more suitable ...
TESTES - TESTICULAR INJURY

Protective Effects of Hydrogen Rich Saline Solution on Experimental Testicular Ischemia-Reperfusion ...

Year Published: 2012

We examined the effectiveness of hydrogen rich saline solution on the prevention of testicular damage induced by ischemia/reperfusion in rats. Male Sprague-Dawley® rats were divided randomly into 4 groups, including group 1-sham operated, group 2-torsion-detorsion, group 3-torsion-detorsion plus saline and group 4-torsion-detorsion plus hydrogen rich saline solution. Testicular torsion was ...
INTESTINE - SHOCK

Protective effect of hydrogen-lactated Ringer's solution against extensive burn-induced intestine ...

Year Published: 2012

Objective To investigate the protective effect of hydrogen-rich lactated Ringer’s solution (HRS) against intestine injury induced by extensive burn in Sprague-Dewley (SD) rat model after delayed fluid resuscitation. Methods Thirty-six male SD rats were randomly divided into three groups (n=12): sham-burn group(S group), burn plus normal lactated Ringer’s solution(NRS) group (BR group) and burn ...
WHOLE BODY - CANCER

Influence of Hydrogen Discharged from Palladium Base Hydrogen Storage Alloys on Cancer Cells

Year Published: 2012

The influence of discharged hydrogen from Pd-Ni based hydrogen storage alloys (HSAs) on cultured cells has been investigated. The susceptibility of cells to discharged hydrogen varied with the kind of cells. No influence was seen in the normal cells, while an effect of killing cancer cells was observed near the HAS and the region where the cell death was observed was limited to an extent of a few ...
KIDNEY - DIABETES (TYPE II)

Hydrogen-rich water inhibits glucose and α,β -dicarbonyl compound-induced reactive oxygen species ...

Year Published: 2012

Reactive oxygen species (ROS) production induced by α,β-dicarbonyl compounds and advanced glycation end products causes renal dysfunction in patients with type 2 diabetes and metabolic syndrome. Hydrogen-rich water (HRW) increases the H2 level in blood and tissues, thus reducing oxidative stress in animals as well as humans. In this study, we investigated the effects of HRW on glucose- and ...
BLOOD - BLOOD COMPOSITION

Colloidal platinum in hydrogen-rich water exhibits radical-scavenging activity and improves blood ...

Year Published: 2012

The 'colloidal platinum' stabilized with polyvinylpyrrolidone (Pt/PVP-colloid) was dispersed in hydrogen-rich water (HW; hydrogen concentration, 0.82 ppm; oxidation-reduction potential, -583 mV) or regular water (RW; <0.01 ppm, +218 mV). And we evaluated the antioxidant activity of Pt/PVP-colloid in HW or RW on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and improvement of blood ...
SKIN - RADIOPROTECTION

Hydrogen-rich electrolyzed warm water represses wrinkle formation against UVA ray together with ...

Year Published: 2012

Hydrogen-rich electrolyzed warm water (HW) was prepared at 41°C and exhibited dissolved hydrogen (DH) of 1.13 ppm and an oxidation-reduction potential (ORP) of -741 mV in contrast to below 0.01 ppm and+184 mV for regular warm water (RW). Fibroblasts OUMS-36 and keratinocytes HaCaT were used to examine effects of HW against UVA-ray irradiation. Type-I collagen was synthesized 1.85- to 2.03-fold ...
LIVER - NON-ALCOHOLIC STEATOHEPATITIS (NASH)

Hydrogen-rich water prevents progression of nonalcoholic steatohepatitis and accompanying ...

Year Published: 2012

Oxidative stress is a strong contributor to the progression from simple fatty liver to nonalcoholic steatohepatitis (NASH). Molecular hydrogen is an effective antioxidant that reduces cytotoxic reactive oxygen species. In this study, we investigated the effects of hydrogen-rich water and the drug pioglitazone on the progression of NASH in mouse models. A methionine-choline-deficient (MCD) diet ...
WHOLE BODY - EXCERCISE

Effects of ionized alkali water intake on oxidative stress and its related gene expression induced ...

Year Published: 2012

The purpose of this study was to investigate the effects of ionized alkali water supplement on oxidative stress and proinflammatory cytokines in highly trained high school and college track athletes (n=18). In an single group and cross-over design, all subjects consumed tap water and ionized alkali water for 2 weeks in a random order, and they underwent an acute and exhaustive treadmill running at ...
INTESTINE - CANCER

Effect of Reconstituted Apple Juice with Alkaline Electrolyzed Water on Cell Proliferation and ...

Year Published: 2012

Apple juice, known as a good antioxidant source, may partially protect the body from oxidative stress. In this report, the effect of apple juice reconstituted with alkaline electrolyzed water (EO-apple juice) on HT-29 cells was investigated. Specifically, the total antioxidant capacity (ORAC and TEAC) of EO-apple juice, and the effects this EO-apple juice on cell proliferation (MTT assay), DNA ...
WHOLE BODY - CANCER

Suppressive effects of electrochemically reduced water on matrix metalloproteinase-2 activities and ...

Year Published: 2012

It has been demonstrated that hydrogen peroxide (H(2)O(2)) is directly associated with elevated matrix metalloproteinase-2 (MMP-2) expression in several cell lines. Electrochemically reduced water (ERW), produced near the cathode during electrolysis, and scavenges intracellular H(2)O(2) in human fibrosarcoma HT1080 cells. RT-PCR and zymography analyses revealed that when HT1080 cells were treated ...
TESTES - TESTICULAR INJURY

Inhaled hydrogen gas therapy for prevention of testicular ischemia/reperfusion injury in rats

Year Published: 2012

This study evaluated whether 2% hydrogen (H(2)) gas therapy protects against testicular ischemia/reperfusion injury which results in increased formation of reactive oxygen species and/or reactive nitrogen species, leading to testicular apoptosis and impaired spermatogenesis. Pubertal six-week-old Spraque-Dawley rats were assigned to 5 groups (10 animals/group) as follows: group A was a sham ...