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Studies Found: 1120

HEART - ATHEROSCLEROSIS

Hydrogen-rich water prevents lipid deposition in the descending aorta in a rat periodontitis model

Year Published: 2012

Objective: Periodontitis has been causally linked to atherosclerosis, which is mediated by the oxidative stress. As hydrogen-rich water (HW) scavenges reactive oxygen species (ROS), we hypothesized that HW could prevent lipid deposition induced by periodontitis in the aorta. The aim of this study was to investigate the effects of HW on the initiation of atherosclerosis in a rat periodontitis ...
EYE - RADIOPROTECTION

Protective effect of saturated hydrogen saline against blue light-induced retinal damage in rats

Year Published: 2012

To explore the effect of saturated hydrogen saline on blue light-induced retinal damage in rats. The retinal damage of rats was induced by blue light exposure for 6 hours and examined 8 hours, 16 hours and 24 hours after the exposure. One hundred female Sprague-Dawley rats were randomly divided into four groups. Group 1 included 30 rats received light exposure without any other treatment. Group 2 ...
WHOLE BODY - SURGERY/TRANSPLANTATION

Insufflation of Hydrogen Gas Restrains the Inflammatory Response of Cardiopulmonary Bypass in a Rat ...

Year Published: 2012

Systemic inflammatory responses in patients receiving cardiac surgery with the use of the cardiopulmonary bypass (CPB) significantly contribute to CPB-associated morbidity and mortality. We hypothesized that insufflated hydrogen gas (H(2) ) would provide systemic anti-inflammatory and anti-apoptotic effects during CPB, therefore reducing proinflammatory cytokine levels. In this study, we examined ...
SKIN - WOUND HEALING

Feasibility study of the sterilization of pigskin used as wound dressings by neutral electrolyzed ...

Year Published: 2012

Background: Neutral electrolyzed water (NEW) is considered to be a high-level biodegradable disinfectant with sporicidal, bactericidal, and virucidal activity. It has also been reported to accelerate wound healing; thus, it is particularly attractive for the elimination or minimization of the microbial population of skin grafts to be used as wound dressings. Methods: Pigskins were sterilized with ...
BRAIN - BRAIN INJURY

Inhalation of hydrogen gas attenuates cognitive impairment in transient cerebral ischemia via ...

Year Published: 2012

To investigate the effects of inhalation of hydrogen gas on cognitive impairment induced by transient cerebral ischemia and its potential mechanism. Two-vessel occlusion rat model was used to produce 10-minute transient global cerebral ischemia. One hundred and twenty male Wistar rats were randomly divided into sham, sham+H(2), ischemia, and ischemia+H(2) groups (n = 30 each group). Inhalation of ...
SKIN - RADIOPROTECTION

Hydrogen-rich saline protects against ultraviolet B radiation injury in rats

Year Published: 2012

Exposure of skin to solar ultraviolet (UV) radiation induces photo-damage. Ultraviolet B (UVB) is the major component of UV radiation which induces the production of reactive oxygen species (ROS) and plays an important role in photo-damage. Hydrogen gas reduces ROS and alleviates inflammation. In this study, we sought to demonstrate that hydrogen-rich saline has the effect on skin injuries caused ...
HEART - CARDIAC ARREST

H2 gas improves functional outcome after cardiac arrest to an extent comparable to therapeutic ...

Year Published: 2012

All clinical and biological manifestations related to postcardiac arrest (CA) syndrome are attributed to ischemia-reperfusion injury in various organs including brain and heart. Molecular hydrogen (H(2)) has potential as a novel antioxidant. This study tested the hypothesis that inhalation of H(2) gas starting at the beginning of cardiopulmonary resuscitation (CPR) could improve the outcome of CA. ...
WHOLE BODY - DIABETES

Abstract: Anti-diabetes effect of water containing hydrogen molecule and Pt nanoparticles

Year Published: 2011

No abstract available
WHOLE BODY - HYDROGEN BIOLOGY

Abstract A48: Changes In Hydrogen Gas Release From The Skin During Inhalation Of Hydrogen-Rich Air

Year Published: 2011

No abstract available
WHOLE BODY - HYDROGEN BIOLOGY

Estimation of molecular hydrogen consumption in the human whole body after the ingestion of ...

Year Published: 2011

Recent studies have revealed that inhaled or ingested hydrogen gas (H 2) inactivates reactive oxygen species such as hydroxyl radicals in various kinds of diseases and disorders in animal models and that H2 reduces oxidative stress-induced damage in brain, heart, and other peripheral tissues. These reports suggested that exogenous H2 is partially trapped by oxygen radicals. This study was ...
INTESTINE - SURGERY/TRANSPLANTATION

Hydrogen-Enriched Preservation Protects the Isogeneic Intestinal Graft and Amends Recipient Gastric ...

Year Published: 2011

Inhaled hydrogen gas exerts antioxidant and anti-inflammatory effects in rat intestinal transplantation. Here, we investigated whether ex vivo donor organ treatment with dissolved hydrogen would prevent intestinal graft injury. Isogeneic intestinal transplantation was performed in Lewis rats with vascular flush, luminal preservation, and cold graft storage in nitrogen-bubbled (SITxN2) or ...
BRAIN - STROKE

Hydrogen Gas Reduced Acute Hyperglycemia-Enhanced Hemorrhagic Transformation In A Focal Ischemia Rat ...

Year Published: 2011

Hyperglycemia is one of the major factors for hemorrhagic transformation after ischemic stroke. In this study, we tested the effect of hydrogen gas on hemorrhagic transformation in a rat focal cerebral ischemia model. Sprague-Dawley rats (n=72) were divided into the following groups: sham; sham treated with hydrogen gas (H(2)); Middle Cerebral Artery Occlusion (MCAO); and MCAO treated with H(2) ...
HEART - CARDIOVASCULAR DISEASE (CVD)

Intravenous low redox potential saline attenuates FeCl3-induced vascular dysfunction via ...

Year Published: 2011

Exaggerated reactive oxygen species (ROS) may contribute to vascular injury by the enhancement of CX3CL1, intercellular adhesion molecule-1 (ICAM-1), and pro-apoptotic p53 expression. Reduced water with safely antioxidant activity may protect vascular tissue against oxidative injury. We established reduced water (RW) by using a modified magnesium alloy and evaluated the effects of an RW-made ...
INTESTINE - INTESTINAL INJURY

The Effects of Hydrogen-Rich Saline on the Contractile and Structural Changes of Intestine Induced ...

Year Published: 2011

Background: Hydrogen has been considered as a novel antioxidant that prevents injuries resulted from ischemia-reperfusion (I/R) injury in various tissues. The study was designed to determine the effect of hydrogen-rich saline on the smooth muscle contractile response to KCl, and on epithelial proliferation and apoptosis of intestine subjected to I/R. Methods: Intestinal I/R injury was induced in ...
LUNG - UPPER RESPIRATORY TRACT INFECTION

Effect of acid-electrolyzed water on bacteria of upper respiratory tract infections

Year Published: 2011

People are aware of the importance of health, especially the effect of electrolyzed water. So the market for electrolyzed water-related equipment has increased recently. People only know the importance of alkaline-electrolyzed water to health, but the effects of acid-electrolyzed water are not as well known. In this study, we evaluated the characteristics and functions of acid-electrolyzed water ...
TESTES - RADIOPROTECTION

Hydrogen-rich saline attenuates radiation-induced male germ cell loss in mice through reducing ...

Year Published: 2011

Our recent studies suggest that H2 (hydrogen) has a potential as a novel radioprotector without known toxic side effects. The present study was designed to examine the underlying radioprotective mechanism of H2 and its protective role on irradiated germ cells. Produced by the Fenton reaction and radiolysis of H2O, hydroxyl radicals (•OH) were identified as the free radical species that were ...
BRAIN - SURGERY/TRANSPLANTATION

Hydrogen is neuroprotective against surgically induced brain injury

Year Published: 2011

Neurosurgical operations cause unavoidable damage to healthy brain tissues. Direct surgical injury as well as surgically induced oxidative stress contributes to the subsequent formation of brain edema. Therefore, we tested the neuroprotective effects of hydrogen (H2) in an established surgical brain injury (SBI) model in rats. Adult male Sprague - Dawley rats (weight 300-350g) were divided into ...
LUNG - LUNG INJURY

Hydrogen-rich saline protects against acute lung injury induced by extensive burn in rat model

Year Published: 2011

Hydrogen has been reported to selectively quench detrimental reactive oxygen species, particularly hydroxyl radical, and to prevent myocardial or hepatic ischemia/reperfusion injury in multiple models. The aim of this study is to investigate whether hydrogen protects against severe burn-induced acute lung injury in rats. Rats were divided into four groups: sham plus normal saline, burn injury plus ...
MUSCLE - MUSCULAR DYSTROPHY

Effect of Molecular Hydrogen Saturated Alkaline Electrolyzed Water on Disuse Muscle Atrophy in ...

Year Published: 2011

The objectives of this paper were to determine the level of oxidative stress in atrophied gastrocnemius, and to verify the effect of molecular hydrogen (H2) saturated alkaline electrolyzed water (HSW) on gastrocnemius atrophy by modifying the redox status, indicated by 8-hydroxy-2'-deoxyguanosine (8-OHdG), malondialdehyde (MDA), and superoxide dismutase (SOD)-like activity. Female Wistar rats were ...
BONE - ROS-SCAVENGING

Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene ...

Year Published: 2011

Background: Molecular hydrogen (H2) functions as an extensive protector against oxidative stress, inflammation and allergic reaction in various biological models and clinical tests; however, its essential mechanisms remain unknown. H2 directly reacts with the strong reactive nitrogen species peroxynitrite (ONOO-) as well as hydroxyl radicals (•OH), but not with nitric oxide radical (NO•). We ...
KIDNEY - METABOLIC SYNDROME

Effects of hydrogen-rich water on abnormalities in a SHR.Cg-Lepr cp /NDmcr rat - A metabolic ...

Year Published: 2011

Hydrogen (H2), a potent free radical scavenger, selectively reduces the hydroxyl radical, which is the most cytotoxic of the reactive oxygen species (ROS). An increase in oxygen free radicals induces oxidative stress, which is known to be involved in the development of metabolic syndrome. Therefore, we investigated whether hydrogen-rich water (HRW) affects metabolic abnormalities in the metabolic ...
HEART - SLEEP APNEA

Inhalation of hydrogen gas attenuates left ventricular remodeling induced by intermittent hypoxia in ...

Year Published: 2011

Sleep apnea syndrome increases the risk of cardiovascular morbidity and mortality. We previously reported that intermittent hypoxia increases superoxide production in a manner dependent on nicotinamide adenine dinucleotide phosphate and accelerates adverse left ventricular (LV) remodeling. Recent studies have suggested that hydrogen (H(2)) may have an antioxidant effect by reducing hydroxyl ...
LUNG - SURGERY/TRANSPLANTATION

Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism ...

Year Published: 2011

We recently demonstrated the inhalation of hydrogen gas, a novel medical therapeutic gas, ameliorates ventilator-induced lung injury (VILI); however, the molecular mechanisms by which hydrogen ameliorates VILI remain unclear. Therefore, we investigated whether inhaled hydrogen gas modulates the nuclear factor-kappa B (NFκB) signaling pathway. VILI was generated in male C57BL6 mice by performing a ...
EYE - RETINAL INJURY

Hydrogen Saline Treatment Attenuates Hyperoxia-Induced Retinopathy by Inhibition of Oxidative Stress ...

Year Published: 2011

Retinal neovascularization or retinopathy is a proliferative disorder of the retinal capillaries and is the primary cause of blindness. Some studies have shown that oxidative stress plays an important role in hyperoxia-induced retinal neovascularization. Previous reports have indicated that hydrogen has a therapeutic, antioxidant activity by selectively reducing hydroxyl radicals. This study ...
SPINE - PARAPLEGIA

Beneficial effects of hydrogen gas against spinal cord ischemia-reperfusion injury in rabbits

Year Published: 2011

Recently, hydrogen gas (H₂) is reported to be a new therapeutic agent in organ damage induced by ischemia-reperfusion (I/R). The present study was designed to investigate the beneficial effects of H₂ against spinal cord I/R injury and its associated mechanisms. Spinal cord ischemia was induced by infrarenal aortic occlusion for 20 min in male New Zealand white rabbits. Treatment with 1%, 2% or ...