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Studies Found: 1335

BRAIN - SURGERY/TRANSPLANTATION

Effects of Hydrogen-Rich Saline on Hepatectomy-Induced Postoperative Cognitive Dysfunction in Old ...

Year Published: 2017

This study aims to investigate the protective effects and underlying mechanisms of hydrogen-rich saline on the cognitive functions of elder mice with partial hepatectomy-induced postoperative cognitive dysfunction (POCD). Ninety-six old male Kunming mice were randomly divided into 4 groups (n = 24 each): control group (group C), hydrogen-rich saline group (group H), POCD group (group P), and POCD ...
LUNG - SURGERY/TRANSPLANTATION

Immersing lungs in hydrogen-rich saline attenuates lung ischaemia-reperfusion injury

Year Published: 2017

Objectives: Anti-oxidant effects of hydrogen have been reported in studies examining ischaemia-reperfusion injury (IRI). In this study, we evaluated the therapeutic efficacy of immersing lungs in hydrogen-rich saline on lung IRI. Methods: Lewis rats were divided into three groups: (i) sham, (ii) normal saline and (iii) hydrogen-rich saline. In the first experiment, the left thoracic cavity was ...

The Comparative Efficiency of Intraperitoneal and Intravitreous Injection of Hydrogen Rich Saline ...

Year Published: 2017

Retinitis pigmentosa (RP) comprises a heterogeneous group of inherited retinal diseases leading to blindness. The present study explored the protective effects of hydrogen rich saline (HRS) against the photoreceptor degeneration in the N-Methyl-N-nitrosourea (MNU) administrated rat, a pharmacologically induced RP model. The therapeutic effects of intraperitoneal (IP) and intravitreous (IV) ...
WHOLE BODY - EXCERCISE

Selective protective effect of hydrogen water on free radical injury of athletes after ...

Year Published: 2017

Objective: This study aims to investigate the selective protective effect of hydrogen water on the free radical injury of athletes after high-intensity exercise and to provide a reliable method for reducing oxidative stress injury of athletes. Methods: A total of 60 athletes from the swimming team in our city were selected as the research subjects. They were divided into the control group and ...
LUNG - ENVIRONMENTAL POLLUTION

Hydrogen-rich pure water prevents cigarette smoke-induced pulmonary emphysema in SMP30 knockout mice

Year Published: 2017

Chronic obstructive pulmonary disease (COPD) is predominantly a cigarette smoke (CS)-triggered disease with features of chronic systemic inflammation. Oxidants derived from CS can induce DNA damage and stress-induced premature cellular senescence in the respiratory system, which play significant roles in COPD. Therefore, antioxidants should provide benefits for the treatment of COPD; however, ...
WHOLE BODY - STRESS RESILIENCE

Molecular hydrogen modulates gene expression via histone modification and induces the mitochondrial ...

Year Published: 2017

Molecular hydrogen (H2) is a biologically active gas that is used medically to ameliorate various systemic pathological conditions. H2 also regulates gene expression involved in intracellular signaling and metabolic pathways. However, it is unclear whether H2 affects gene expression directly or through indirect effects as a consequence of health improvement. Therefore, we attempted to identify ...
LUNG - SURGERY/TRANSPLANTATION

Hydrogen alleviates hyperoxic acute lung injury related endoplasmic reticulum stress in rats through ...

Year Published: 2017

Hyperoxic acute lung injury (HALI) is a major clinical problem for patients undergoing supplemental oxygen therapy. Currently in clinical settings there exist no effective means of prevention or treatment methods. Our previous study found that: hydrogen could reduce HALI, as well as oxidative stress. This research will further explore the mechanism underlying the protective effect of hydrogen on ...
BRAIN - NEUROPROTECTION

Hydrogen gas attenuates sevoflurane neurotoxicity through inhibiting nuclear factor ...

Year Published: 2017

Anesthesia neurotoxicity in developing brain has gained increasing attention. However, knowledge regarding its mitigating strategies remains scant. Sevoflurane, a commonly used anesthetic, is responsible for learning and memory deficits in neonates. Molecular hydrogen is reported to be a potential neuroprotective agent because of its antioxidative and anti-inflammatory activities. This study aimed ...
WHOLE BODY - DIABETES (TYPE II)

Effectiveness of Alkali Water Consumption to Reduce Blood Sugar Levels in Diabetes Mellitus Type 2

Year Published: 2017

Background: Non-Communicable Diseases (NCDs) have become a public health problem, globally, regionally, nationally and locally. Non-Communicable Diseases (NCDs) that took a lot of attention was diabetes mellitus. In Indonesia diabetes mellitus is a serious threat to health development. Efforts developed to overcome the problems of diabetes mellitus type 2 is to apply four pillars of therapy namely ...

Effect of electrolyzed reduced water on Wistar rats with chronic periodontitis on malondialdehyde ...

Year Published: 2017

Background: Periodontal disease is a progressive destructive change that causes loss of bone and periodontal ligaments around the teeth that can eventually lead to its loss. The main bacteria in chronic periodontitis is Porphyromonas gingivalis. Aggregatibacter actinomycetemcomitans, a pathogen associated with aggressive periodontitis, initiates a proinflammatory response that causes tissue ...

Hydrogen-rich water protects against inflammatory bowel disease in mice by inhibiting endoplasmic ...

Year Published: 2017

Aim: To investigate the therapeutic effect of hydrogen-rich water (HRW) on inflammatory bowel disease (IBD) and to explore the potential mechanisms involved. Methods: Male mice were randomly divided into the following four groups: control group, in which the mice received equivalent volumes of normal saline (NS) intraperitoneally (ip); dextran sulfate sodium (DSS) group, in which the mice ...
BONE MARROW - SURGERY/TRANSPLANTATION

Therapeutic effects of hydrogen on chronic graft-versus-host disease

Year Published: 2017

The incidence of chronic graft-versus-host disease (cGVHD) is rising recent years, which has been the leading cause of non-transplantation mortality post allogenetic hematopoietic stem cell transplantation (HSCT). Imbalance of inflammatory cytokines and fibrosis plays critical roles in the pathogenesis of cGVHD. Recent studies showed that molecular hydrogen has anti-inflammatory, antioxidant, ...
BLOOD - SURGERY/TRANSPLANTATION

Antioxidants Attenuate Oxidative Stress-Induced Hidden Blood Loss in Rats

Year Published: 2017

Objective: Hidden blood loss (HBL), commonly seen after total knee or hip arthroplasty, causes postoperative anemia even after reinfusion or blood transfusion based on the visible blood loss volume. Recent studies demonstrated that oxidative stress might be involved in HBL. However, whether the antioxidants proanthocyanidin (PA) or hydrogen water (HW) can ameliorate HBL remains poorly understood. ...

Prevention of ischemia-induced hearing loss by intravenous administration of hydrogen-rich saline in ...

Year Published: 2017

Objective: Hydrogen-rich water, which is a potent antioxidant agent, was investigated for its protective effects against ischemic damage of the cochlea in gerbils. Methods: The animals were subjected to transient cochlear ischemia by occluding the bilateral vertebral arteries for l5min. Five milliliters of hydrogen-rich saline was then intravenously administered immediately after the insult. ...
BRAIN - STROKE

Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical ...

Year Published: 2017

Background: Molecular hydrogen (H2) acts as a therapeutic antioxidant. Inhalation of H2 gas (1-4%) was effective for the improvement of cerebral infarction in multiple animal experiments. Thus, for actual applications, a randomized controlled clinical study is desired to evaluate the effects of inhalation of H2 gas. Here, we evaluate the H2 treatment on acute cerebral infarction. Methods: Through ...
KIDNEY - HAEMODIALYSIS

Possible clinical effects of molecular hydrogen (H2) delivery during hemodialysis in chronic ...

Year Published: 2017

Background and aim: It is supposed that enhanced oxidative stress and inflammation are involved with the poor clinical outcomes in patients on chronic dialysis treatment. Recent studies have shown that molecular hydrogen (H2) is biologically active as an anti-inflammatory agent. Thus, we developed a novel hemodialysis (E-HD) system which delivers H2 (30 to 80 ppb)-enriched dialysis solution, to ...
PERITONIUM - PERITONEAL DIALYSIS

Dissolved molecular hydrogen (H2) in Peritoneal Dialysis (PD) solutions preserves mesothelial cells ...

Year Published: 2017

Background Peritoneal dialysis (PD) is used as renal replacement therapy in patients with end-stage kidney disease. However, peritoneal membrane failure remains problematic and constitutes a critical cause of PD discontinuation. Recent studies have revealed the unique biological action of molecular hydrogen (H2) as an anti-oxidant, which ameliorates tissue injury. In the present study, we aimed to ...
INTESTINE - HYDROGEN BIOLOGY

Sufficient intake of high amylose cornstarch maintains high colonic hydrogen production for 24 h in ...

Year Published: 2017

Colonic hydrogen (H2) can suppress oxidative stress and damage in the body. We examined the minimum requirement of high amylose cornstarch (HAS) to maintain high colonic H2 production for 24 h. Ileorectostomized and sham-operated rats were fed a control diet supplemented with or without 20% HAS for 7 days. Colonic starch utilization was determined. Next, rats were fed the control diet with or ...
BRAIN - ROS-SCAVENGING

Molecular hydrogen protects against oxidative stress-induced SH-SY5Y neuroblastoma cell death ...

Year Published: 2017

Inhalation of molecular hydrogen (H2) gas ameliorates oxidative stress-induced acute injuries in the brain. Consumption of water nearly saturated with H2 also prevents chronic neurodegenerative diseases including Parkinson's disease in animal and clinical studies. However, the molecular mechanisms underlying the remarkable effect of a small amount of H2 remain unclear. Here, we investigated the ...
WHOLE BODY - CANCER

Effect of electrolyzed water produced using carbon electrodes on HeLa cell proliferation

Year Published: 2017

We developed electrolyzed water (EW) using carbon electrodes and investigated the ability of the developed EW to inhibit the proliferation of human cervical carcinoma HeLa cells. We observed that EW-containing media inhibited HeLa cell proliferation. Many very small black dots were produced in EW and these were associated with the inhibitory effect on the cell proliferation. Furthermore, the very ...
WHOLE BODY - SHOCK

Hydrogen gas inhalation inhibits progression to the ‘irreversible’ stage of shock after ...

Year Published: 2017

Background: Mortality of hemorrhagic shock primarily depends on whether or not the patients can endure the loss of circulating volume until radical treatment is applied. We investigated whether hydrogen (H2) gas inhalation would influence the tolerance to hemorrhagic shock and improve survival. Methods: Hemorrhagic shock was achieved by withdrawing blood until the mean arterial blood pressure ...
STOMACH - GASTROENTERITIS

Efficacy of Neutral Electrolyzed Water for Inactivation of Human Norovirus

Year Published: 2017

Human norovirus (NoV) is the leading cause of acute gastroenteritis worldwide. Persistence on surfaces and resistance to many conventional disinfectants contribute to widespread transmission of norovirus. We examined the efficacy of neutral electrolyzed water (NEW; pH 7) for inactivation of human NoV GII.4 Sydney in suspension (ASTM method 1052-11) and on stainless steel surfaces (ASTM method ...
BLOOD - BLOOD COMPOSITION

Influence of redox potential of different water quality on the human blood

Year Published: 2017

The problem of influence of redox potential of water on human blood is considered and some of research results in this area are given. Results of clinical experiments indicate a positive therapeutic effect of water consumption with the negative value of the redox potential. However, the influence of salt content of such water on the human body isn’t analyzed. Distilled, tap and natural mineral ...
INTESTINE - HYDROGEN BIOLOGY

Effects of functional milk containing galactooligosaccharide, maltitol, and glucomannan on the ...

Year Published: 2017

Hydrogen gas (H2) reacts with strong oxidants, and the effectiveness of H2 inhalation or ingestion of H2 water has been demonstrated for many diseases. H2 produced by the intestinal microbiome from indigestible components is the major source of exogenous H2. In this study, we screened a wide variety of indigestible components that induce H2 production by the intestinal microbiome, which exhibits ...
SKIN - SHINGLES

Hydrogen-rich saline attenuates hyperalgesia and reduces cytokines in rats with post-herpetic ...

Year Published: 2017

Objective: To investigate the role of autophagy in hydrogen-rich saline attenuating post-herpetic neuralgia( PHN) in rats. Methods: A total of 100 male SD rats were randomly divided into the five groups( n = 20) : control group,PHN group,PHN group treated with hydrogen-rich saline( PHN-H2group),PHN group treated with hydrogen-rich saline and3-MA( PHN-H2-3-MA group),PHN group treated with ...