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Studies Found: 1120

LIVER - SURGERY/TRANSPLANTATION

Pectin and high-amylose maize starch increase caecal hydrogen production and relieve hepatic ...

Year Published: 2011

We investigated whether the feeding of high H2-generating dietary fibre and resistant starch (RS) could suppress hepatic ischaemia-reperfusion (IR) injury, which results from oxidative stress, in rats fed a pectin (Pec) or high-amylose maize starch (HAS) diet. Male Sprague-Dawley rats were fed a control (C) diet, with or without Pec (0-5 % Pec) or HAS (0-30 % HAS) supplementation for 7 d. Portal ...
MOUTH - PERIODONTITIS

In vitro bactericidal activity against periodontopathic bacteria by electrolyzed ion-reduced water

Year Published: 2011

As typical periodontopathic bacteria, Porphyromonas gingivalis (P. gingivalis) and Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) were exposed to electrolyzed ion-reduced water (ERI) and ERI containing 1% sodium carboxymethylcellulose (CMC-Na) (ERI-1% CMC-Na), and the time course of their bactericidal action was evaluated. More than 99% of each bacteria species were killed after ...
BRAIN - BRAIN INJURY

Improved brain MRI indices in the acute brain stem infarct sites treated with hydroxyl radical ...

Year Published: 2011

In acute stage of cerebral infarction, MRI indices (rDWI & rADC) deteriorate during the first 3-7 days after the ictus and then gradually normalize in approximately 10 days (pseudonormalization time), although the tissue is already infarcted. Since effective treatments improve these indices significantly and in less than the natural pseudonormalization time, a combined analysis of these changes ...
WHOLE BODY - EXCERCISE

DRINKS WITH ALKALINE NEGATIVE OXIDATIVE REDUCTION POTENTIAL IMPROVE EXERCISE PERFORMANCE IN ...

Year Published: 2011

In the current study we tested the hypothesis that an acute (7 days) intake of an alkaline negative oxidative reduction potential formulation (NORP) drink would reduce the rate of blood lactate accumulation during and after exercise, increase time to exhaustion, increase serum buffering capacity and not increase prevalence of adverse effects as compared to the control drink. Eleven participants (9 ...
LUNG - SEPSIS

Hydrogen inhalation ameliorates lipopolysaccharide-induced acute lung injury in mice

Year Published: 2011

Acute lung injury (ALI) is a serious illness, the incidence and mortality of which are very high. Free radicals, such as hydroxyl radicals (OH) and peroxynitrite (ONOO(-)), are considered to be the final causative molecules in the pathogenesis of ALI. Hydrogen, a new antioxidant, can selectively reduce OH and ONOO(-). In the present study, we investigated the hypothesis that hydrogen inhalation ...
EAR - CANCER

Inhalation of hydrogen gas attenuates cisplatin-induced ototoxicity via reducing oxidative stress

Year Published: 2011

Cisplatin, an anticancer drug used extensively to treat a broad range of tumors, has strong ototoxic side effects induced by reactive oxygen species (ROS). Recently, it has been reported that hydrogen gas (H(2)) is a new antioxidant by selectively reducing hydroxyl radical, the most cytotoxic ROS. The present study was designed to investigate whether H(2) treatment is beneficial to ...
BRAIN - SURGERY/TRANSPLANTATION

Hydrogen-Rich Saline is Cerebroprotective in a Rat Model of Deep Hypothermic Circulatory Arrest

Year Published: 2011

Deep hypothermic circulatory arrest (DHCA) has been widely used in the operations involving the aortic arch and brain aneurysm since 1950s; but prolonged DHCA contributes significantly to neurological deficit which remains a major cause of postoperative morbidity and mortality. It has been reported that hydrogen exerts a therapeutic antioxidant activity by selectively reducing hydroxyl radical. In ...
HEART - ATHEROSCLEROSIS

H2 inhibits TNF-α-induced lectin-like oxidized LDL receptor-1 expression by inhibiting nuclear ...

Year Published: 2011

H(2) is a therapeutic antioxidant that can reduce oxidative stress. Oxidized low-density lipoprotein, which plays roles in atherosclerosis, may promote endothelial dysfunction by binding the cell-surface receptor LOX-1. LOX-1 expression can be upregulated by various stimuli, including TNF-α. Thus, we aimed to examine whether the upregulation of LOX-1 by different stimuli could be blocked by H(2) ...
LIVER - LIVER FAILURE

The Protective Role of Hydrogen -Rich Saline in Experimental Liver Injury in Mice

Year Published: 2011

Reactive oxygen species (ROS) are considered to play a prominent causative role in the development of various hepatic disorders. Antioxidants have been effectively demonstrated to protect against hepatic damage. Hydrogen (H(2)), a new antioxidant, was reported to selectively reduce the strongest oxidants, such as hydroxyl radicals (·OH) and peroxynitrite (ONOO(-)), without disturbing metabolic ...
LUNG - SURGERY/TRANSPLANTATION

Hydrogen-Rich Saline Provides Protection Against Hyperoxic Lung Injury

Year Published: 2011

Hydrogen has been proven to be a novel antioxidant through its selectively reducing of the hydroxyl radical. In this study, we investigated the effects of hydrogen-rich saline on the prevention of acute lung injury induced by hyperoxia (HALI) in rats. Physiologic saline, hydrogen-rich saline, or nitrogen-rich saline was administered through intraperitoneal (i.p.) injection during exposure to ...
BRAIN - ENVIRONMENTAL POLLUTION

Hydrogen-rich saline reduces delayed neurologic sequelae in experimental carbon monoxide toxicity

Year Published: 2011

Objective: We investigated the feasibility and efficacy of hydrogen-rich saline therapy on delayed neurologic sequelae in a rat model of severe acute carbon monoxide (CO) poisoning. Design: Controlled animal study. Setting: University research laboratory for Diving Medicine. Subjects: Sprague-Dawley rats weighing 250 ± 20 g. Interventions: The rats were exposed to 1000 ppm CO in air for 40 min ...
INTESTINE - WOUND HEALING

Application of an Electrolyzed Strongly Acidic Aqueous Solution Before Wound Closure in Colorectal ...

Year Published: 2011

Electrolyzed strongly acidic aqueous solution which is produced by electrolysis of a sodium chloride solution has been used in Japan for the irrigation of wounds or body cavities even in the absence of particular evidence. The purpose of this study is to investigate the efficacy or harmful effects of the disinfectant when applied before wound closure in colorectal surgery. We performed a ...
LUNG - CANCER

Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress

Year Published: 2011

Molecular hydrogen (H(2)) is an efficient antioxidant that diffuses rapidly across cell membranes, reduces reactive oxygen species (ROS), such as hydroxyl radicals and peroxynitrite, and suppresses oxidative stress-induced injury in several organs. ROS have been implicated in radiation-induced damage to lungs. Because prompt elimination of irradiation-induced ROS should protect lung tissue from ...
BRAIN - AGING

Hippocampal gene network analysis suggests that coral calcium hydride may reduce accelerated ...

Year Published: 2011

Recent studies strongly support the hypothesis that an antioxidant diet inhibits the pathologic aging process as shown in senescence-accelerated mouse prone 8 (SAM/P-8). In our previous study in coral calcium hydride (CCH), we reported that a diet rich in antioxidants inhibited the pathologic aging process, increased the endogenous antioxidant ability, and contributed to prolonging the lifespan of ...
BRAIN - ALZHEIMER'S DISEASE (AD)

Hydrogen-rich saline reduces oxidative stress and inflammation by inhibit of JNK and NF-kappa B ...

Year Published: 2011

This study is to examine if hydrogen-rich saline reduced amyloid-beta (A beta) induced neural inflammation and oxidative stress in a rat model by attenuation of activation of JNK and NF-kappa B. Sprague-Dawley male rats (n = 18,280-330 g) were divided into three groups, sham operated, A beta 1-42 injected and A beta 1-42 plus hydrogen-rich saline treated animals. Hydrogen-rich saline (5 ml/kg, ...
KIDNEY - SURGERY/TRANSPLANTATION

Hydrogen-Rich Saline Protects Against Renal Ischemia/Reperfusion Injury in Rats

Year Published: 2011

Recently it has been demonstrated that hydrogen, as a novel antioxidant, can selectively reduce hydroxyl radicals (·OH) and peroxynitrite anion (ONOO-) in vitro and exert therapeutic antioxidant activity in many diseases. This study was designed to investigate the effect of hydrogen-rich saline on renal ischemia/reperfusion (I/R) injury in rats. A rat model of renal I/R injury was induced by ...
HEART - HYPERTENSION

Protective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat ...

Year Published: 2011

Hydrogen-rich saline has been reported to have antioxidant and anti-inflammatory effects and effectively protect against organ damage. Oxidative stress and inflammation contribute to the pathogenesis and/or development of pulmonary hypertension. In this study, we investigated the effects of hydrogen-rich saline on the prevention of pulmonary hypertension induced by monocrotaline in a rat model. In ...
WHOLE BODY - AGING

Mechanism of the lifespan extension of Caenorhabditis elegans by electrolyzed reduced ...

Year Published: 2011

Electrolyzed reduced water (ERW) contains a large amount of molecular hydrogen and a small amount of Pt nanoparticles (Pt NPs). We have found that ERW significantly extended the lifespan of Caenorhabditis elegans in a novel culture medium designated Water Medium. In this study, we found that synthetic Pt NPs at ppb levels significantly extended the nematode lifespan and scavenged reactive oxygen ...
PREGNANCY - PREECLAMPSIA

Protective effects of hydrogen-rich saline in preeclampsia rat model

Year Published: 2011

Hydrogen has been reported as a novel antioxidant to selectively reduce levels of toxic reactive-oxygen species (ROS). We investigated the effects of hydrogen-rich saline on the prevention of oxidative injuries in N(omega)-nitro-L-arginine methyl ester (L-NAME) induced rat model of preeclampsia (PE). Sprague-Dawley rats (n = 50) were randomized into five groups: non-pregnant; normal pregnancy; ...
SKIN - RADIOPROTECTION

Histological study on the effect of electrolyzed reduced water-bathing on UVB radiation-induced skin ...

Year Published: 2011

Electrolyzed reduced water (ERW), functional water, has various beneficial effects via antioxidant mechanism in vivo and in vitro. However there is no study about beneficial effects of ERW bathing. This study aimed to determine the effect of ERW bathing on the UVB-induced skin injury in hairless mice. For this purpose, mice were irradiated with UVB to cause skin injury, followed by individually ...
KIDNEY - ENVIRONMENTAL POLLUTION

The melamine excretion effect of the electrolyzed reduced water in melamine-fed mice

Year Published: 2011

Our hypothesis is that the intake of functional water, electrolyzed reduced water (ERW) can excrete melamine in body was evoked by melamine-tainted feed (MTF). To address this issue, we investigated the effect of ERW in MTF-mice model by way of body weight gain, incidence of urinary crystals and bladder stone, biochemical and haematological examination, histopathologic finding of kidney and ...
SKIN - DIABETES

Hydrogen-rich medium protects human skin fibroblasts from high glucose or mannitol induced oxidative ...

Year Published: 2011

Reactive oxygen species (ROS) are an important factor in the development of skin lesions in diabetes. A new antioxidant, hydrogen, can selectively neutralize hydroxyl radicals (OH) and peroxynitrite (ONOO−) in cell-free systems, whereas it seldom reacts with other ROS. Fibroblasts are a key component of skin. In the present study, we investigated the protective effects of hydrogen-rich medium on ...
LUNG - ENVIRONMENTAL POLLUTION

Saturated hydrogen saline protects rats from acute lung injury induced by paraquat

Year Published: 2011

Background: Paraquat (PQ) intoxication causes lung oxidative stress damage. Saturated hydrogen saline, a newly explored antioxidant, has been documented to play a powerful antioxidant role in preventing oxidative stress damage. This study aimed to investigate the protective effects and the possible mechanisms of intoxication on rats with acute lung injury (ALI) caused by paraquat poisoning. ...
HEART - HEART ATTACK (MYOCARDIAL INFARCTION)

Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and ...

Year Published: 2011

To study the possible anti-inflammatory effect of hydrogen-rich saline (H(2) saline) on rat hearts with regional myocardial ischemia and reperfusion (I/R). Sixty-six rats were equally randomized to three groups: sham-operated group, I/R group (control group) and I/R plus H(2) saline treatment group. Myocardial I/R was established by occlusion of the left anterior descending (LAD) coronary artery ...
THYMUS - RADIOPROTECTION

Hydrogen protects mice from radiation induced thymic lymphoma in BALB/c mice

Year Published: 2011

Ionizing radiation (IR) is a well-known carcinogen, however the mechanism of radiation induced thymic lymphoma is not well known. Moreover, an easy and effective method to protect mice from radiation induced thymic lymphoma is still unknown. Hydrogen, or H(2), is seldom regarded as an important agent in medical usage, especially as a therapeutic gas. Here in this study, we found that H(2) protects ...