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Studies Found: 1335

WHOLE BODY - ROS-SCAVENGING

Antioxidant Activity of Hydrogen Nanobubbles in Water with Different Reactive Oxygen Species both in ...

Year Published: 2018

Hydrogen water as a new therapeutic antioxidant has been widely used in living organisms under stress. In this study, we applied nanobubble (NB) technology to hydrogen water. The antioxidant capacity of hydrogen NB water was studied with respect to different reactive oxygen species (ROS) both in vitro and in vivo. Using a relatively weak reduced dye, APF, we showed that hydrogen NB water can ...
LIVER - SURGERY/TRANSPLANTATION

Hydrogen-rich saline protects against small-scale liver ischemia-reperfusion injury by inhibiting ...

Year Published: 2018

Aim: Our research investigated the role of Hydrogen-rich saline (HRS) on the Endoplasmic reticulum stress (ERS) pathway and the effect of HRS on tissue injury in small Bama pig model of hepatic ischemia-reperfusion combined with partial hepatectomy. Main methods: Eighteen healthy Bama miniature pigs were randomly divided equally into three groups: Sham, IRI, and HRS. Laparoscopic technique was ...
WHOLE BODY - WOUND HEALING

Effects of hydrogen-occluding-silica microparticles on wound repair and cell migratory behavior of ...

Year Published: 2018

Many conventional studies on molecular hydrogen have not examined cell migration ability and the relationship between apoptosis and the cytoskeleton. Here we investigated the influence of hydrogen-occluding silica microparticles (H2-silica) on cell migration motility and changes of the cytoskeleton (F-actin) in normal human esophageal epithelial cells (HEEpiCs). As the results, cell migration was ...
BRAIN - DIABETES

Hydrogen‑rich medium alleviates high glucose‑induced oxidative stress and parthanatos in rat ...

Year Published: 2018

Diabetic peripheral neuropathy (DPN) is considered to be the most common cause of microvascular diabetic complications, for which no effective therapies currently exist. Previous studies have identified that oxidative stress is the common pathway in all possible hypotheses for the induction of DPN, and poly(ADP‑ribose) (PAR) polymerase‑1 (PARP‑1)‑dependent cell death (parthanatos) is key ...
WHOLE BODY - EXCERCISE

Anaerobic Performance and Acid-Base Balance in Basketball Players after the Consumption of Highly ...

Year Published: 2018

Many researchers have unequivocally demonstrated that water of higher pH has a positive effect on the human body. In terms of undertaken research, the adjustment of acid-base balance during anaerobic effort, a decrease in the concentration of free radicals as well as the improvement of connective tissue condition is of primary importance. The aim of this study was to evaluate an influence of high ...
MOUTH - CANCER

Acid-electrolyzed functional water induces extracellular matrix metalloproteinase inducer, a ...

Year Published: 2018

Extracellular matrix metalloproteinase inducer (EMMPRIN) secretion was induced in the oral squamous cell carcinoma cell line HSC3 cell by acid-electrolyzed functional water (FW) stimulation. Augmented EMMPRIN secretion was not under transcriptional control; rather, it was derived from the intracellular storages. EMMPRIN secretion was also induced under oxidative stress and accompanied by the ...
WHOLE BODY - OBESITY

Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in ...

Year Published: 2018

Background: Molecular hydrogen (H2) effectively treats obesity-related disorders in animal models, yet no studies have investigated the effectiveness and safety of H2 for improving biomarkers of obesity in humans. Aim: In this double blind, placebo-controlled, crossover pilot trial, we evaluated the effects of H2 intervention on body composition, hormonal status, and mitochondrial function in ten ...
WHOLE BODY - MITOCHONDRIAL FUNCTION

Effect of molecular hydrogen on coenzyme Q in plasma, myocardial tissue and mitochondria of rats

Year Published: 2018

Beneficial effects of molecular hydrogen (H2) in various experimental models of human diseases and in many clinical studies was documented. H2 can be administered by various ways, as a gas inhalation, drinking of H2-enriched water, or taking a H2-dissolved bath as well as in saline infusions. As antioxidant selectively scavenges hydroxyl and peroxynitrite radicals, decreases oxidative stress. ...
MUSCLE - EXCERCISE

Involvement of Neutrophil Dynamics and Function in Exercise-Induced Muscle Damage and Delayed-Onset ...

Year Published: 2018

The purpose of this study was to investigate the involvement of neutrophil dynamics and function in exercise-induced muscle damage (EIMD) and delayed-onset muscle soreness (DOMS), and the effect of molecular hydrogen (H₂) intake on these parameters. Nine healthy and active young men performed H₂ and placebo bath trial in a crossover design. They carried out downhill running (-8% slope) for 30 ...
LUNG - CANCER

Therapeutic efficacy of hydrogen‑rich saline alone and in combination with PI3K inhibitor in ...

Year Published: 2018

The aim of the present study was to investigate the effects of combination therapy of LY294002, a specific inhibitor of phosphatidylinositol 3‑kinase (PI3K), with hydrogen‑rich saline on the proliferation and apoptosis of the non‑small cell lung cancer (NSCLC) A549 cell line and the mechanisms underpinning this. Excessive production of reactive oxygen species (ROS) may induce DNA mutations, ...
NOSE - RHINITIS

Clinical study of hydrogen-rich saline in the treatment of moderate to severe allergic rhinitis

Year Published: 2018

Objective:To investigate the effectiveness and safety of nasal lavage with hydrogen-rich saline in the treatment of moderate to severe allergic rhinitis.Method:Twenty patients with moderate to severe persistent allergic rhinitis were treated with normal saline and hydrogen-rich saline lavage the nasal cavity. The study was randomized doubl-blind self-control study. The symptoms and signs score, ...

Effects of alkaline-electrolyzed and hydrogen-rich water, in a high-fat-diet nonalcoholic fatty ...

Year Published: 2018

AIM To identify the effect of hydrogen-rich water (HRW) and electrolyzed-alkaline water (EAW) on high-fat-induced non-alcoholic fatty acid disease in mice. METHODS Mice were divided into four groups: (1) Regular diet (RD)/regular water (RW); (2) high-fat diet (HFD)/RW; (3) RD/EAW; and (4) HFD/EAW. Weight and body composition were measured. After twelve weeks, animals were sacrificed, and livers ...
PREGNANCY - NEUROPROTECTION

Administration of molecular hydrogen during pregnancy improves behavioral abnormalities of offspring ...

Year Published: 2018

The aim of the present study was to investigate long-term outcomes of the offspring in a lipopolysaccharide (LPS)-induced maternal immune activation (MIA) model and the effect of maternal molecular hydrogen (H2) administration. We have previously demonstrated in the MIA mouse model that maternal administration of H2 attenuates oxidative damage and neuroinflammation, including induced ...
LIVER - SURGERY/TRANSPLANTATION

Post-reperfusion hydrogen gas treatment ameliorates ischemia reperfusion injury in rat livers from ...

Year Published: 2018

Background and purpose: We reported previously that hydrogen gas (H2) reduced hepatic ischemia and reperfusion injury (IRI) after prolonged cold storage (CS) of livers retrieved from heart-beating donors. The present study was designed to assess whether H2 reduced hepatic IRI during donation of a cardiac death (DCD) graft with subsequent CS. Methods: Rat livers were harvested after 30-min cardiac ...
INTESTINE - SEPSIS

Hydrogen-Rich Saline Regulates Intestinal Barrier Dysfunction, Dysbiosis, and Bacterial ...

Year Published: 2018

Bacterial translocation is a major cause of multiple organ dysfunction syndrome in critical illness, and its management is an important therapeutic strategy. In this study, we focused on the key factors responsible for bacterial translocation including the intestinal microbiome and investigated the impact of molecular hydrogen therapy as a countermeasure against bacterial translocation in a murine ...

Administration of hydrogen-rich water prevents vascular aging of the aorta in LDL receptor-deficient ...

Year Published: 2018

The main cause of arteriosclerosis is atherosclerosis in the aorta. Atherosclerosis is recognized as a chronic inflammatory condition that begins with the dysfunction or activation of arterial endothelium. Low-density lipoprotein (LDL) and especially its oxidized form play a key role in endothelial dysfunction and atherogenesis. Recent studies showed that senescent cells are involved in the ...

Hydrogen-rich water improves cognitive impairment gender-dependently in APP/PS1 mice without ...

Year Published: 2018

Alzheimer's disease (AD) is characterised as a provoked inflammatory response and oxidative stress along with amyloid β peptide (Aβ) deposition and neurofibrillary tangles in the brain, and effective treatment is greatly needed. Molecular hydrogen, which has been proposed to be an antioxidant that selectively reduces reactive oxygen species, was found to exert beneficial effects in Aβ ...
BRAIN - STROKE

Hydrogen inhalation improves mouse neurological outcomes after cerebral ischemia/reperfusion ...

Year Published: 2018

This study aimed to investigate the role of necroptosis in the neuroprotection of hydrogen in a mouse model of cerebral ischemia/reperfusion (I/R) injury. C57BL mice were randomly divided into sham group, I/R group, hydrogen/oxygen group (HO), nitrogen/oxygen group (NO). Middle cerebral artery occlusion (MCAO) for 1 hour followed by reperfusion was introduced to animals which were allowed to ...
BRAIN - CARDIOPULMONARY RESUSCITATION (CPR)

Inhalation of high concentration hydrogen gas improves short-term outcomes in a rat model of ...

Year Published: 2018

Cardiogenic global brain hypoxia-ischemia is a devastating medical problem that is associated with unfavorable neurologic outcomes. Low dose hydrogen gas (up to 2.9%) has been shown to be neuroprotective in a variety of brain diseases. In the present study, we investigated the protective effect of water by electrolysis-derived high concentration hydrogen gas (60%) in a rat model of asphyxia ...
INTESTINE - HYDROGEN BIOLOGY

Effects of molecular hydrogen-dissolved alkaline electrolyzed water on intestinal environment in ...

Year Published: 2018

Increasing evidence indicates that molecular hydrogen-dissolved alkaline electrolyzed water (AEW) has various physiological activities such as antioxidative activity. Gut microbiota are deeply associated with our health through a symbiotic relationship. Recent reports have described that most gastrointestinal microbial species encode the genetic capacity to metabolize molecular hydrogen, meaning ...
KIDNEY - SURGERY/TRANSPLANTATION

Hydrogen Gas Does Not Ameliorate Renal Ischemia Reperfusion Injury in a Preclinical Model

Year Published: 2018

In renal transplantation, ischemia reperfusion injury impairs early graft function and can reduce long term graft survival. Hydrogen has antioxidant and anti‐inflammatory properties that can reduce the effects of ischemic injury. The aim of this study was to examine the effects of hydrogen gas administered during reperfusion in a preclinical model of kidney ischemia reperfusion injury. Porcine ...
LUNG - SURGERY/TRANSPLANTATION

Hydrogen gas inhalation during ex vivo lung perfusion of donor lungs recovered after cardiac death

Year Published: 2018

Background: Ex vivo lung perfusion (EVLP) is a system that circulates normothermic perfusate into procured lungs, allowing for improved lung function and lung assessment. We investigated whether ventilation with hydrogen gas during EVLP improves the donation after cardiac death lung function and whether this effect persists after actual transplantation. Methods: Ten pigs were randomly divided into ...
LIVER - SURGERY/TRANSPLANTATION

Hydrogen-rich saline protects against hepatic injury induced by ischemia-reperfusion and ...

Year Published: 2018

Background Hydrogen-rich saline (HRS) has antioxidative, anti-inflammatory and anti-apoptotic properties. We investigated the effects of hydrogen on hepatic ischemia-reperfusion (I/R) and laparoscopic hepatectomy in swine. Methods Twenty-one healthy Bama miniature pigs were randomly divided into the sham group, ischemia-reperfusion injury (IRI) group, HRS-5 (5 mL/kg) group, and HRS-10 (10 mL/kg) ...
WHOLE BODY - HIGH BLOOD PRESSURE

Hydrogen gas reduces chronic intermittent hypoxia‐induced hypertension by inhibiting sympathetic ...

Year Published: 2018

Molecular hydrogen is reported to be used medically to ameliorate various systemic pathological conditions. This study aimed to investigate the effect of hydrogen (H2) gas on hypertension induced by intermittent hypoxia in rats. The adult rats were exposed to chronic intermittent hypoxia (CIH) 8 hours/day for 5 weeks and/or H 2 gas 2 hours/day. We found that the systolic and diastolic blood ...