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Studies Found: 1183

LUNG - CANCER

Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress

Year Published: 2011

Molecular hydrogen (H(2)) is an efficient antioxidant that diffuses rapidly across cell membranes, reduces reactive oxygen species (ROS), such as hydroxyl radicals and peroxynitrite, and suppresses oxidative stress-induced injury in several organs. ROS have been implicated in radiation-induced damage to lungs. Because prompt elimination of irradiation-induced ROS should protect lung tissue from ...
BRAIN - AGING

Hippocampal gene network analysis suggests that coral calcium hydride may reduce accelerated ...

Year Published: 2011

Recent studies strongly support the hypothesis that an antioxidant diet inhibits the pathologic aging process as shown in senescence-accelerated mouse prone 8 (SAM/P-8). In our previous study in coral calcium hydride (CCH), we reported that a diet rich in antioxidants inhibited the pathologic aging process, increased the endogenous antioxidant ability, and contributed to prolonging the lifespan of ...
BRAIN - ALZHEIMER'S DISEASE (AD)

Hydrogen-rich saline reduces oxidative stress and inflammation by inhibit of JNK and NF-kappa B ...

Year Published: 2011

This study is to examine if hydrogen-rich saline reduced amyloid-beta (A beta) induced neural inflammation and oxidative stress in a rat model by attenuation of activation of JNK and NF-kappa B. Sprague-Dawley male rats (n = 18,280-330 g) were divided into three groups, sham operated, A beta 1-42 injected and A beta 1-42 plus hydrogen-rich saline treated animals. Hydrogen-rich saline (5 ml/kg, ...
KIDNEY - SURGERY/TRANSPLANTATION

Hydrogen-Rich Saline Protects Against Renal Ischemia/Reperfusion Injury in Rats

Year Published: 2011

Recently it has been demonstrated that hydrogen, as a novel antioxidant, can selectively reduce hydroxyl radicals (·OH) and peroxynitrite anion (ONOO-) in vitro and exert therapeutic antioxidant activity in many diseases. This study was designed to investigate the effect of hydrogen-rich saline on renal ischemia/reperfusion (I/R) injury in rats. A rat model of renal I/R injury was induced by ...
HEART - HYPERTENSION

Protective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat ...

Year Published: 2011

Hydrogen-rich saline has been reported to have antioxidant and anti-inflammatory effects and effectively protect against organ damage. Oxidative stress and inflammation contribute to the pathogenesis and/or development of pulmonary hypertension. In this study, we investigated the effects of hydrogen-rich saline on the prevention of pulmonary hypertension induced by monocrotaline in a rat model. In ...
WHOLE BODY - AGING

Mechanism of the lifespan extension of Caenorhabditis elegans by electrolyzed reduced ...

Year Published: 2011

Electrolyzed reduced water (ERW) contains a large amount of molecular hydrogen and a small amount of Pt nanoparticles (Pt NPs). We have found that ERW significantly extended the lifespan of Caenorhabditis elegans in a novel culture medium designated Water Medium. In this study, we found that synthetic Pt NPs at ppb levels significantly extended the nematode lifespan and scavenged reactive oxygen ...
PREGNANCY - PREECLAMPSIA

Protective effects of hydrogen-rich saline in preeclampsia rat model

Year Published: 2011

Hydrogen has been reported as a novel antioxidant to selectively reduce levels of toxic reactive-oxygen species (ROS). We investigated the effects of hydrogen-rich saline on the prevention of oxidative injuries in N(omega)-nitro-L-arginine methyl ester (L-NAME) induced rat model of preeclampsia (PE). Sprague-Dawley rats (n = 50) were randomized into five groups: non-pregnant; normal pregnancy; ...
SKIN - RADIOPROTECTION

Histological study on the effect of electrolyzed reduced water-bathing on UVB radiation-induced skin ...

Year Published: 2011

Electrolyzed reduced water (ERW), functional water, has various beneficial effects via antioxidant mechanism in vivo and in vitro. However there is no study about beneficial effects of ERW bathing. This study aimed to determine the effect of ERW bathing on the UVB-induced skin injury in hairless mice. For this purpose, mice were irradiated with UVB to cause skin injury, followed by individually ...
KIDNEY - ENVIRONMENTAL POLLUTION

The melamine excretion effect of the electrolyzed reduced water in melamine-fed mice

Year Published: 2011

Our hypothesis is that the intake of functional water, electrolyzed reduced water (ERW) can excrete melamine in body was evoked by melamine-tainted feed (MTF). To address this issue, we investigated the effect of ERW in MTF-mice model by way of body weight gain, incidence of urinary crystals and bladder stone, biochemical and haematological examination, histopathologic finding of kidney and ...
SKIN - DIABETES

Hydrogen-rich medium protects human skin fibroblasts from high glucose or mannitol induced oxidative ...

Year Published: 2011

Reactive oxygen species (ROS) are an important factor in the development of skin lesions in diabetes. A new antioxidant, hydrogen, can selectively neutralize hydroxyl radicals (OH) and peroxynitrite (ONOO−) in cell-free systems, whereas it seldom reacts with other ROS. Fibroblasts are a key component of skin. In the present study, we investigated the protective effects of hydrogen-rich medium on ...
LUNG - ENVIRONMENTAL POLLUTION

Saturated hydrogen saline protects rats from acute lung injury induced by paraquat

Year Published: 2011

Background: Paraquat (PQ) intoxication causes lung oxidative stress damage. Saturated hydrogen saline, a newly explored antioxidant, has been documented to play a powerful antioxidant role in preventing oxidative stress damage. This study aimed to investigate the protective effects and the possible mechanisms of intoxication on rats with acute lung injury (ALI) caused by paraquat poisoning. ...
HEART - HEART ATTACK (MYOCARDIAL INFARCTION)

Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and ...

Year Published: 2011

To study the possible anti-inflammatory effect of hydrogen-rich saline (H(2) saline) on rat hearts with regional myocardial ischemia and reperfusion (I/R). Sixty-six rats were equally randomized to three groups: sham-operated group, I/R group (control group) and I/R plus H(2) saline treatment group. Myocardial I/R was established by occlusion of the left anterior descending (LAD) coronary artery ...
THYMUS - RADIOPROTECTION

Hydrogen protects mice from radiation induced thymic lymphoma in BALB/c mice

Year Published: 2011

Ionizing radiation (IR) is a well-known carcinogen, however the mechanism of radiation induced thymic lymphoma is not well known. Moreover, an easy and effective method to protect mice from radiation induced thymic lymphoma is still unknown. Hydrogen, or H(2), is seldom regarded as an important agent in medical usage, especially as a therapeutic gas. Here in this study, we found that H(2) protects ...
BRAIN - NEUROPROTECTION

Abstract: The neuroprotective effects of electrolyzed reduced water and its model water containing ...

Year Published: 2011

No abstract available
LUNG - SURGERY/TRANSPLANTATION

Abstract B95: Hydrogen Gas Inhalation Attenuates Ventilator-Induced Lung Injury In Mice

Year Published: 2010

No abstract available
WHOLE BODY - LIPID METABOLISM

Suppressive Effect of ERW on Lipid Peroxidation and Plasma Triglyceride Level

Year Published: 2010

Electrolyzed reduced water (ERW) containing hydrogen molecules and Pt nanoparticles is expected as a new antioxidant. Thiobarbituric acid reactive substances (TBARS) assay revealed that ERW had an inhibitory effect on the oxidation of low-density lipoproteins (LDL). In addition, ERW significantly suppressed LDL oxidation in the medium cultured J.774.A1 macrophage like cells. ERW inhibited Cu2+ ...
WHOLE BODY - PATHOGENIC BACTERIAL LOAD

Effect of Alkaline Ionized Water on Stabilization of Antioxidation, Antithrombosis and Antibacterial ...

Year Published: 2010

In this study, the stable maintenance of bioactivity in alkaline ionized water (AIW) and antibacterial effects of AIW were evaluated to confirm benefits of AIW. As controls, purified water (PW) and tap drinking water (DW) were used. The pH and ORP (oxidation-reduction potential) of AIW, PW and DW used were 9.5 and 120 mV, 7.2 and 144 mV, and 7.3 and 564 mV, respectively. High level of minerals was ...
WHOLE BODY - CANCER

Antitumor effects of nano-bubble hydrogen-dissolved water are enhanced by coexistent platinum ...

Year Published: 2010

In order to erase reactive oxygen species (ROS) related with the proliferation of tumor cells by reducing activity of hydrogen, we developed functional water containing nano-bubbles (diameters: <900 nm for 71%/population) hydrogen of 1.1-1.5 ppm (the theoretical maximum: 1.6 ppm) with a reducing ability (an oxidation-reduction potential -650 mV, normal water: +100-200 mV) using a ...
KIDNEY - SURGERY/TRANSPLANTATION

Oral hydrogen water prevents chronic allograft nephropathy in rats

Year Published: 2010

Reactive oxygen species (ROS) contribute to the development of interstitial fibrosis and tubular atrophy seen in chronic allograft nephropathy (CAN). As molecular hydrogen gas can act as a scavenger of ROS, we tested the effect of treatment with hydrogen water (HW) in a model of kidney transplantation, in which allografts from Lewis rats were orthotopically transplanted into Brown Norway ...
SPINE - SPINAL CORD INJURY

Hydrogen-Rich Saline Protects Against Spinal Cord Injury in Rats

Year Published: 2010

In the present study, we examined the mechanisms of hydrogen-rich saline, a reported therapeutic antioxidant, in the treatment of acute spinal cord contusion injury. Male Sprague-Dawley rats were used to produce a standardized model of contuses spinal cord injury (125 kdyn force). Hydrogen-rich saline was injected intraperitoneally (5 ml/kg) immediately, and at 24 and 48 h after injury. All rats ...
PANCREAS - PANCREATITIS

Hydrogen-rich saline ameliorates the severity of l-arginine-induced acute pancreatitis in rats

Year Published: 2010

Molecular hydrogen, which reacts with the hydroxyl radical, has been considered as a novel antioxidant. Here, we evaluated the protective effects of hydrogen-rich saline on the l-arginine (l-Arg)-induced acute pancreatitis (AP). AP was induced in Sprague-Dawley rats by giving two intraperitoneal injections of l-Arg, each at concentrations of 250mg/100g body weight, with an interval of 1h. ...
BRAIN - BRAIN INJURY

Hydrogen is neuroprotective and preserves cerebrovascular reactivity in asphyxiated newborn pigs

Year Published: 2010

Hydrogen (H2) has been reported to neutralize toxic reactive oxygen species. Oxidative stress is an important mechanism of neuronal damage after perinatal asphyxia. We examined whether 2.1% H2-supplemented room air (H2-RA) ventilation would preserve cerebrovascular reactivity (CR) and brain morphology after asphyxia/reventilation (A/R) in newborn pigs. Anesthetized, ventilated piglets were ...
BRAIN - AGING

Drinking hydrogen water ameliorated cognitive impairment in senescence-accelerated mice

Year Published: 2010

Hydrogen has been reported to have neuron protective effects due to its antioxidant properties, but the effects of hydrogen on cognitive impairment due to senescence-related brain alterations and the underlying mechanisms have not been characterized. In this study, we investigated the efficacies of drinking hydrogen water for prevention of spatial memory decline and age-related brain alterations ...
LUNG - SURGERY/TRANSPLANTATION

Hydrogen inhalation ameliorates ventilator-induced lung injury

Year Published: 2010

Mechanical ventilation (MV) can provoke oxidative stress and an inflammatory response, and subsequently cause ventilator-induced lung injury (VILI), a major cause of mortality and morbidity of patients in the intensive care unit. Inhaled hydrogen can act as an antioxidant and may be useful as a novel therapeutic gas. We hypothesized that, owing to its antioxidant and anti-inflammatory properties, ...
KIDNEY - HAEMODIALYSIS

Electrolysed-reduced water dialysate improves T-cell damage in end-stage renal disease patients with ...

Year Published: 2010

Background: T-cell damage by increased oxidative stress in end-stage renal disease (ESRD) patients undergoing chronic haemodialysis (HD) led to the increased T-cell apoptosis and the alteration of surface markers and Th1/Th2 ratio in CD4(+) T lymphocytes. Antioxidant electrolysed-reduced water (ERW) was used as the dialysate in ESRD patients undergoing chronic HD to test for improved oxidative ...