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Studies Found: 1120

BRAIN - ROS-SCAVENGING

Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted ...

Year Published: 2008

Hydrogen is an established anti-oxidant that prevents acute oxidative stress. To clarify the mechanism of hydrogen's effect in the brain, we administered hydrogen-rich pure water (H(2)) to senescence marker protein-30 (SMP30)/gluconolactonase (GNL) knockout (KO) mice, which cannot synthesize vitamin C (VC), also a well-known anti-oxidant. These KO mice were divided into three groups; recipients of ...
WHOLE BODY - CANCER

Inhibitory effect of electrolyzed reduced water on tumor angiogenesis

Year Published: 2008

Vascular endothelial growth factor (VEGF) is a key mediator of tumor angiogenesis. Tumor cells are exposed to higher oxidative stress compared to normal cells. Numerous reports have demonstrated that the intracellular redox (oxidation/reduction) state is closely associated with the pattern of VEGF expression. Electrolyzed reduced water (ERW) produced near the cathode during the electrolysis of ...
LIVER - SURGERY/TRANSPLANTATION

Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing ...

Year Published: 2007

We have recently showed that molecular hydrogen has great potential for selectively reducing cytotoxic reactive oxygen species, such as hydroxyl radicals, and that inhalation of hydrogen gas decreases cerebral infarction volume by reducing oxidative stress [I. Ohsawa, M. Ishikawa, K. Takahashi, M. Watanabe, K. Nishimaki, K. Yamagata, K.-I. Katsura, Y. Katayama, S. Asoh, S. Ohta, Hydrogen acts as a ...
PANCREAS - DIABETES (TYPE II)

Preservative effect of electrolyzed reduced water on pancreatic beta-cell mass in diabetic db/db ...

Year Published: 2007

Oxidative stress is produced under diabetic conditions and involved in progression of pancreatic beta-cell dysfunction. Both an increase in reactive oxygen free radical species (ROS) and a decrease in the antioxidant defense mechanism lead to the increase in oxidative stress in diabetes. Electrolyzed reduced water (ERW) with ROS scavenging ability may have a potential effect on diabetic animals, a ...
KIDNEY - HAEMODIALYSIS

Less-oxidative hemodialysis solution rendered by cathode-side application of electrolyzed water

Year Published: 2007

Electrolyzed water (EW) generated on the cathode side reportedly displays anti-oxidative properties, and application of EW to hemodialysis (HD) systems supposedly suppresses oxidative markers in patients on HD. However, most of the chemical properties and biological effects of such solutions remain unclear. This study aimed to examine those issues to clarify the scientific background for the ...
WHOLE BODY - ROS-SCAVENGING

Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals

Year Published: 2007

Acute oxidative stress induced by ischemia-reperfusion or inflammation causes serious damage to tissues, and persistent oxidative stress is accepted as one of the causes of many common diseases including cancer. We show here that hydrogen (H(2)) has potential as an antioxidant in preventive and therapeutic applications. We induced acute oxidative stress in cultured cells by three independent ...
WHOLE BODY - DIABETES (TYPE II)

Redox Regulation by Reduced Waters as Active Hydrogen Donors and Intracellular ROS Scavengers for ...

Year Published: 2007

The analysis using the DBNBS reduction method and the DCFH-DA intracellular reactive oxygen species (ROS) determination method revealed that ERW and diseases-improvable natural waters such as Nordenau water in Germany and Hita water in Japan were all reduced waters (RWs) which could function as active hydrogen donors and intracellular ROS scavengers. RWs suppressed the activity of protein tyrosine ...
WHOLE BODY - DIABETES (TYPE II)

Influence of natural reduced water on relevant tests parameters and reactive oxygen species ...

Year Published: 2006

The study examined changes in the relevant tests parameters of 320 diabetes patients (176 female, 144 male) drinking natural reduced water from the 'Nordenau Spring' in Nordenau, Germany as well as the correlation of these changes with the fluctuation of the reactive oxygen species concentration in their blood. The average age of the test persons was 71.8 years old and the daily consumption of ...
WHOLE BODY - ROS-SCAVENGING

Effects of Drinking a Water Product with Anti-Oxidant Activities In Vitro on the Blood Levels of ...

Year Published: 2006

The in vivo effects of drinking a water product, which had been confirmed to have antioxidant activi- ties in vitro, were preliminarily studied by monitoring the blood concentrations of oxidative stress marker substances in the two group subjects who ingested the same quantity of the water product and a tap water solution during the same time. The results indicated that hydrogen gas and reductive ...
KIDNEY - HAEMODIALYSIS

Electrolyzed-reduced water reduced hemodialysis-induced erythrocyte impairment in end-stage renal ...

Year Published: 2006

Chronic hemodialysis (HD) patients increase erythrocyte susceptibility to hemolysis and impair cell survival. We explored whether electrolyte-reduced water (ERW) could palliate HD-evoked erythrocyte impairment and anemia. Forty-three patients undergoing chronic HD were enrolled and received ERW administration for 6 month. We evaluated oxidative stress in blood and plasma, erythrocyte methemoglobin ...
WHOLE BODY - DIABETES

Anti-diabetic effect of alkaline-reduced water on OLETF rats

Year Published: 2006

Alkalin-reduced water (ARW) is known to exert several anti-cancer effects, as well as to scavenge reactive oxygen species (ROS) and reduce blood-glucose levels. This study was performed in order to determine the effects of ARW on the control of spontaneous diabetes in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. We assigned 16 male OLETF rats (4 wk) to two groups: an experimental group, which ...
WHOLE BODY - OBESITY

Effect of mineral-induced alkaline reduced water on sprague-dawley rats fed on high-fat diet

Year Published: 2006

Mineral-induced alkaline-reduced water (MRW) is generated by the chemical reaction of water with alkaline earth metals and characterized by high pH and low oxidation-reduction potential. As ROS are believed to have a role in the pathogenesis of obesity, we attempted to determine the effect of MRW on obesity in Sprague-Dawley (SD) rats fed on a high-fat diet. The body weight of the MRW group was ...
PANCREAS - DIABETES

Anti-diabetic effects of electrolyzed reduced water in streptozotocin-induced and genetic diabetic ...

Year Published: 2006

Oxidative stress is produced under diabetic conditions and is likely involved in progression of pancreatic beta-cell dysfunction found in diabetes. Both an increase in reactive oxygen free radical species (ROS) and a decrease in the antioxidant defense mechanism lead to the increase in oxidative stress in diabetes. Electrolyzed reduced water (ERW) with ROS scavenging ability may have a potential ...
WHOLE BODY - ROS-SCAVENGING

Electrolyzed-reduced water protects against oxidative damage to DNA, RNA, and protein

Year Published: 2006

The generation of reactive oxygen species is thought to cause extensive oxidative damage to various biomolecules such as DNA, RNA, and protein. In this study, the preventive, suppressive, and protective effects of in vitro supplementation with electrolyzed-reduced water on H2O2-induced DNA damage in human lymphocytes were examined using a comet assay. Pretreatment, cotreatment, and posttreatment ...
MOUTH - PERIODONTITIS

Antibacterial effect of electrolyzed water on oral bacteria

Year Published: 2006

This study investigated the antibacterial effect of electrolyzed water on oral bacteria both in vitro and in vivo. Tap water was electrolyzed in a water vessel using platinum cell technology. The electrolyzed tap water (called Puri-water) was put in contact with five major periodontopathogens or toothbrushes contaminated with these bacteria for 30 sec. In addition, Puri-water was used as a ...
WHOLE BODY - CANCER

Suppression of two-stage cell transformation by electrolyzed reduced water containing platinum ...

Year Published: 2006

According to the two-stage cell transformation theory, cancer cells first receive initiation, which is mainly caused by DNA damage and then promotion, which enhance transformation. Since murine Balb/c 3T3 cells lose contact inhibition by cell transformation, the cells have been widely used for transformation experiments. Electrolyzed reduced water (ERW) is a health beneficial alkaline drinking ...
MOUTH - DENTIN INTEGRITY

Cleaning efficacy and dentin micro-hardness after root canal irrigation with a strong acid ...

Year Published: 2006

The purpose of this study was to evaluate the cleaning effect of root canal walls using strong acid electrolytic water (SAEW) as a root canal irrigant, and to investigate the influence of SAEW on the root canal dentin by micro-hardness test. Forty-three single-rooted, single-canaled teeth were instrumented using standard step-back technique with K-files. Irrigation was performed using distilled ...
BRAIN - NEUROPROTECTION

Suppression of Oxidative Stress-Induced Apoptosis of Neuronal Cells by Electrolyzed-Reduced Water

Year Published: 2005

We have proposed an active hydrogen reduced water theory that active hydrogen produced by electrolysis of water is stabilized in the form of hydrogenated metal nanocolloids in electrolyzed reduced water (ERW) and scavenges intracellular reactive oxygen species (ROS). Because various brain diseases are caused by oxygen stress, we examined the effect of ERW on oxidative stress-induced apoptois of ...
PANCREAS - DIABETES (TYPE I)

Effect of Reduced Water on the Apoptotic Cell Death Triggered by Oxidative Stress in Pancreatic β ...

Year Published: 2005

Recent studies have demonstrated that reactive oxygen species9ROS9and the resulting oxidative stress play an important role in apoptosis. Apoptosis is implicated in pathophysiology of diabetes mellitus. Antioxidants can block or delay apoptosis. We have demonstrated that reduced water (RW) such as hydrogen-rich electrolysed-reduced water (ERW) and natural reduced waters (NRW) like Hita Tenryosui ...
WHOLE BODY - CANCER

Electrolyzed Reduced Water Supplemented with Platinum Nanoparticles Suppresses Promotion of ...

Year Published: 2005

In the two-stage cell transformation theory, cancer cells first receive initiation, which is mainly caused by DNA damage, and then promotion, which enhances transformation. Murine Balb/c 3T3 cells are widely used for transformation experiments because they lose contact inhibition ability when transformed. Electrolyzed reduced water (ERW), which is produced near a cathode during electrolysis of ...
WHOLE BODY - ROS-SCAVENGING

Electrolyzed hydrogen-saturated water for drinking use elicits an antioxidative effect: a feeding ...

Year Published: 2005

A new type of electrolyzed hydrogen-saturated (EHS) water was produced using a water-electrolyzing device equipped with a special cation exchanger. Use of the EHS water for drinking in a feeding test with rats elicited an antioxidative effect. After intraperitoneal injection of 2,2-azobis-amidinopropane dihydrochloride, urinary secretion of 8-hydroxydeoxyguanosine and hepatic formation of ...
SKIN - COSMETIC ISSUES

The Efficacy and Tolerability of Electrolyzed Oxidized Water in Treating Mild to Moderate Acne

Year Published: 2004

The purpose of this study was to determine the efficacy and the tolerability of the Charme™ system, a hand-held device that electrolyzes a water-based sodium chloride solution and delivers electrolyzed oxidized water (EOW) to the skin, in the treatment of mild to moderate acne. A total of 31 patients with mild to moderate acne vulgaris were enrolled in this 8-week, open-label, split-face pilot ...
WHOLE BODY - ROS-SCAVENGING

The mechanism of the enhanced antioxidant effects against superoxide anion radicals of reduced water ...

Year Published: 2004

We reported that reduced water produced by electrolysis enhanced the antioxidant effects of proton donors such as ascorbic acid (AsA) in a previous paper. We also demonstrated that reduced water produced by electrolysis of 2 mM NaCl solutions did not show antioxidant effects by itself. We reasoned that the enhancement of antioxidant effects may be due to the increase of the ionic product of water ...
WHOLE BODY - ROS-SCAVENGING

Studies on the Properties and Real Existence of Aqueous Solution Systems that are Assumed to Have ...

Year Published: 2004

We evaluated the properties and real existence of an electrolyzed-reduced water, which we prepared, and three commercially purchased water goods, that are advertised to have antioxidant activities by the action of 'active hydrogen,' on the basis of the results of examinations for inhibitory effects on the oxidative reactions of biomolecules, quantitative analyses of the minerals, and the ESR ...
WHOLE BODY - LIPID METABOLISM

The Suppressive Effect of Electrolyzed Reduced Water on Lipid Peroxidation

Year Published: 2003

We examined the suppressive effect on lipid peroxidation of electrolyzed reduced water (ERW), which exhibited reactive oxygen species (ROS)-scavenging activity in vitro and in cultured cells. The oxidation of linoleic acid by 2, 2’-azobis (2-amidinopropane) hydrochloride (AAPH) was suppressed by ERW in vitro. ERW also suppressed the lipid peroxidation in cell membrane of mouse lymphoblast YAC-1 ...