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Studies Found: 1183

BRAIN - TRAUMATIC BRAIN INJURY

Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative ...

Year Published: 2010

Traumatic brain injury (TBI) is a leading cause of mortality and disability among the young population. It has been shown that hydrogen gas (H(2)) exerts a therapeutic antioxidant activity by selectively reducing hydroxyl radical (OH, the most cytotoxic ROS). Recently, we have found that H(2) inhalation significantly improved the survival rate and organ damage of septic mice. In the present study, ...
NOSE - RHINOSINUSITIS

Antibacterial effect of electrolysed acid water on the nasal discharge from patients with chronic ...

Year Published: 2010

This study was conducted to determine whether electrolysed acid water (EAW) increased the antibacterial effect of irrigating solution used in the management of chronic rhinosinusitis (CRS). One hundred CRS patients were recruited from April 2008 to February 2009. Four swab specimens were taken from the ipsilateral middle meatus of each patient and one was placed in a Thanswab tube, while the other ...
LUNG - SURGERY/TRANSPLANTATION

Inhaled Hydrogen Gas Therapy for Prevention of Lung Transplant-Induced Ischemia/Reperfusion Injury ...

Year Published: 2010

Successful abrogation of ischemia/reperfusion (I/R) injury of lung grafts could significantly improve short- and long-term outcomes for lung transplant (LTx) recipients. Hydrogen gas has potent antioxidant and antiapoptotic properties and has been recently used in number of experimental and clinical studies. The purpose of this research was to investigate whether inhaled hydrogen gas could reduce ...
BONE MARROW - SURGERY/TRANSPLANTATION

Hydrogen gas treatment prolongs replicative lifespan of bone marrow multipotential stromal cells in ...

Year Published: 2010

Cell therapy with bone marrow multipotential stromal cells/mesenchymal stem cells (MSCs) represents a promising approach in the field of regenerative medicine. Low frequency of MSCs in adult bone marrow necessitates ex vivo expansion of MSCs after harvest; however, such a manipulation causes cellular senescence with loss of differentiation, proliferative, and therapeutic potentials of MSCs. ...
KIDNEY - CANCER

Experimental verification of protective effect of hydrogen-rich water against cisplatin-induced ...

Year Published: 2010

Our aim was to assess the protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced CT (DCE-CT). DCE-CT studies were performed in 30 rats (8 weeks old) on days 0, 2, 4 and 7 using multidetector row CT. The rats were divided into three groups: a control group (n = 6) with free access to standard water and without cisplatin injection, a ...
BRAIN - ALZHEIMER'S DISEASE (AD)

Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer's ...

Year Published: 2010

This study is to examine if hydrogen-rich saline reduced amyloid beta (Abeta) induced neural inflammation, and learning and memory deficits in a rat model. S-D male rats (n=84, 280-330g) were divided into three groups, sham-operated, Abeta1-42 injected and Abeta1-42 plus hydrogen-rich saline-treated animals. Hydrogen-rich saline (5ml/kg, i.p., daily) was injected for 14days after ...
LIVER - OBSTRUCTIVE JAUNDICE

Hydrogen-rich saline protects against liver injury in rats with obstructive jaundice

Year Published: 2010

Hydrogen selectively reduces levels of hydroxyl radicals and alleviates acute oxidative stress in many models. Hydrogen-rich saline provides a high concentration of hydrogen that can be easily and safely applied. In this study, we investigated the effects of hydrogen-rich saline on the prevention of liver injury induced by obstructive jaundice in rats. Male Sprague-Dawley rats (n=56) were divided ...
BRAIN - STROKE

Protective effect of saturated hydrogen saline against cerebral ischemia-reperfusion injury in rats

Year Published: 2010

Objective To study the protective effect of saturated hydrogen saline against cerebral ischemia-reperfusion injury and the related mechanism. Methods Rat middle cerebral artery occlusion (MCAO) models were established by thread ligation of the middle cerebral artery. The rats were sacrificed 24 h later. The cerebral infarction volume was determined by TTC staining, the water content in brain ...
WHOLE BODY - CANCER

Growth Suppression of HL60 and L6 Cells by Atomic Hydrogen

Year Published: 2010

We previously reported electrolyzed reduced water (ERW) which produced near the cathode by electrolysis has a reductive activity. We also revealed that ERW contains both molecular hydrogen and platinum nanoparticles (Pt nps) derived from platinum-coated titanium electrodes. Pt nps have catalysis activity converting molecular hydrogen to atomic hydrogen. Thus, we regard a solution containing both ...
HEART - SURGERY/TRANSPLANTATION

Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon ...

Year Published: 2010

Recent advances in novel medical gases, including hydrogen and carbon monoxide (CO), have demonstrated significant opportunities for therapeutic use. This study was designed to evaluate the effects of inhaled hydrogen or CO, or both, on cold ischemia/reperfusion (I/R) injury of the myocardium. Syngeneic heterotopic heart transplantation was performed in rats after 6 or 18 hours of cold ischemia in ...
WHOLE BODY - METABOLIC SYNDROME

Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic ...

Year Published: 2010

Metabolic syndrome is characterized by cardiometabolic risk factors that include obesity, insulin resistance, hypertension and dyslipidemia. Oxidative stress is known to play a major role in the pathogenesis of metabolic syndrome. The objective of this study was to examine the effectiveness of hydrogen rich water (1.5-2 L/day) in an open label, 8-week study on 20 subjects with potential metabolic ...
KIDNEY - HAEMODIALYSIS

A novel bioactive haemodialysis system using dissolved dihydrogen (H2) produced by water ...

Year Published: 2010

Background: Chronic inflammation in haemodialysis (HD) patients indicates a poor prognosis. However, therapeutic approaches are limited. Hydrogen gas (H(2)) ameliorates oxidative and inflammatory injuries to organs in animal models. We developed an HD system using a dialysis solution with high levels of dissolved H(2) and examined the clinical effects. Methods: Dialysis solution with H(2) (average ...
EYE - RETINAL INJURY

Protection of the retina by rapid diffusion of hydrogen: administration of hydrogen-loaded eye drops ...

Year Published: 2010

Purpose: Retinal ischemia-reperfusion (I/R) injury by transient elevation of intraocular pressure (IOP) is known to induce neuronal damage through the generation of reactive oxygen species. Study results have indicated that molecular hydrogen (H(2)) is an efficient antioxidant gas that selectively reduces the hydroxyl radical (*OH) and suppresses oxidative stress-induced injury in several organs. ...
SKIN - WOUND HEALING

The healing effect of electrolytic-reduction ion water on burn wounds

Year Published: 2010

We prepared a lotion using electrolytic-reduction ion water (ERI), and evaluated the healing effects of this lotion (ERI lotion) on burn wounds. Third degree burn wounds were induced in the mouse dorsal skin, and ERI lotion or physiological salt (PS) lotion was applied to the wounds from immediately after injury [ERI (+) group and ERI (-) group as a control group, respectively]. The burn wound ...
WHOLE BODY - DIABETES (TYPE II)

Anti-Diabetes Effects of Hita Tenryou-Sui Water®, a Natural Reduced Water

Year Published: 2010

It has been reported that a natural reduced water derived from a deep well in Japan (trademark, Hita Tenryousui water®; Nakanoshima, Hita city, Oita, Japan) scavenged intracellular reactive oxygen species (ROS) and protected a hamster pancreas β cell line HIT-T15 from oxidative damage by alloxan, a type 1 diabetes inducer. Here we demonstrated that the water also suppressed the fasted blood ...
HEART - RADIOPROTECTION

The potential cardioprotective effects of hydrogen in irradiated mice

Year Published: 2010

Most ionizing radiation-induced damage is caused by hydroxyl radicals, and the selective reduction of hydroxyl by hydrogen in vitro has been demonstrated previously. Irradiation of the heart can cause chronic cardiac disease. This study was designed to test the hypothesis that hydrogen-rich water (pure water saturated with molecular hydrogen), which is easy to use, induces cardioprotection against ...
WHOLE BODY - RADIOPROTECTION

Hydrogen-rich PBS protects cultured human cells from ionizing radiation-induced cellular damage

Year Published: 2010

Hydroxyl radicals play an important role in ionizing radiation-induced cellular damage, while hydrogen can selectively reduce hydroxyl radicals in vitro. This study was designed to test the hypothesis that hydrogen-rich PBS may be an effective radioprotective agent in vitro. Compared to cells pretreated without hydrogen, we demonstrated that treating cells with hydrogen-rich PBS before irradiation ...
WHOLE BODY - RADIOPROTECTION

Radioprotective effect of hydrogen in cultured cells and mice

Year Published: 2010

It has been demonstrated that hydrogen can selectively reduce hydroxyl and peroxynitrite in vitro. Since most of the ionizing radiation-induced cellular damage is caused by hydroxyl radicals, this study was designed to test the hypothesis that hydrogen may be an effective radioprotective agent. This paper demonstrates that treating cells with hydrogen before irradiation could significantly inhibit ...
WHOLE BODY - HYDROGEN BIOLOGY

Biological safety of neutral-pH hydrogen-enriched electrolyzed water upon mutagenicity, genotoxicity ...

Year Published: 2010

Hydrogen-dissolved water has been suggested to be effective for alleviating the oxidative stress. In the present study, neutral-pH hydrogen-enriched electrolyzed water (NHE-water; dissolved hydrogen: 0.90-1.14 parts per million [ppm]; oxido-reduced potential: -150 approximately -80 mV), which was prepared with a water-electrolysis apparatus equipped with a non-diaphragm cell and a highly ...
KIDNEY - SURGERY/TRANSPLANTATION

Hydrogen-rich saline solution attenuates renal ischemia-reperfusion injury

Year Published: 2010

Renal ischemia-reperfusion (I/R), an important cause of acute kidney injury, is unavoidable during various types of operations, including renal transplantation, surgical revascularization of the renal artery, partial nephrectomy, and treatment of suprarenal aortic aneurysms. Exacerbation of I/R injury is mediated by reactive oxygen species (ROS). A recent study has shown that hydrogen has ...
HEART - SURGERY/TRANSPLANTATION

Hydrogen-containing preservation solution relieves oxidative stress and inflammatory damage of rat ...

Year Published: 2010

Objective: To study the effect of hydrogen-containing preservation solution against oxidative stress and inflammatory damage of rat donor heart. Methods: Thirty-two SD rats were evenly randomized into four groups(n = 8) : control group (the hearts were protected by HTK solution), H1 group (hydrogen concentration was about 0.2 mmol/L in the HTK solution), H2 group (hydrogen concentration was about ...
EAR - HEARING LOSS

Hydrogen protects vestibular hair cells from free radicals

Year Published: 2010

Hydrogen gas effectively protected against the morphological and functional vestibular hair cell damage by reactive oxygen species (ROS). ROS are generally produced by oxidative stress. In the inner ear, ROS levels increase as a result of noise trauma and ototoxic drugs and induce damage. It is thus important to control ROS levels in the inner ear. The protective effects of hydrogen gas in ...
BRAIN - ROS-SCAVENGING

Hydrogen-related enhancement of in vivo antioxidant ability in the brain of rats fed coral calcium ...

Year Published: 2010

This study explored the effect of coral calcium hydride (CCH) on rat intrahippocampal antioxidant ability by measuring the PCAM nitroxide radical decay ratio when CCH was (a) co-perfused into the hippocampus and (b) fed orally to the rats for 4 weeks under a freely moving state. Estimation of the in vivo antioxidant effect was obtained by administration of the blood-brain barrier-permeable PCAM ...
WHOLE BODY - SEPSIS

Effects of hydrogen gas inhalation on serum high mobility group box 1 levels in severe septic mice

Year Published: 2010

To investigate the effect of hydrogen gas inhalation on survival rate and serum high mobility group box 1 (HMGB1) levels in severe septic mice. Severe sepsis was induced by cecal ligation and puncture (CLP) operation in mice.A total of 248 mice were randomly divided into four groups: sham operation group (sham), sham operation with hydrogen gas inhalation group (sham+H2), severe CLP group (severe ...
WHOLE BODY - SEPSIS

Hydrogen Gas Improves Survival Rate and Organ Damage in Zymosan-Induced Generalized Inflammation ...

Year Published: 2010

Sepsis/multiple organ dysfunction syndrome is the leading cause of death in critically ill patients. Recently, it has been suggested that hydrogen gas (H2) exerts a therapeutic antioxidant activity by selectively reducing hydroxyl radical (•OH, the most cytotoxic reactive oxygen species). We have found that H2 inhalation significantly improved the survival rate and organ damage of septic mice ...