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Studies Found: 1093

SKIN - WOUND HEALING

Effects of Strong Acidic Electrolyzed Water in Wound Healing via Inflammatory and Oxidative Stress ...

Year Published: 2020

Strong acidic electrolyzed water (StAEW) is known to inactivate microorganisms but is not fully explored in the medical field. This study is aimed at exploring StAEW as a potential wound care agent and its mechanism. StAEW (pH: 2.65, ORP: 1159 mV, ACC: 32.1 ppm) was sprayed three times a day to the cutaneous wounds of hairless mice for seven days. Wound morphological and histological features and ...
SKIN - VITILIGO

Molecular Hydrogen Protects Human Melanocytes from Oxidative Stress by Activating Nrf2 Signaling

Year Published: 2020

Oxidative stress is proven to be critical for the initiation and progression of vitiligo. Molecular hydrogen (H2) possesses potent antioxidant activity and has been shown to protect against various oxidative stress-related diseases. In this study, we first investigated the effects and mechanisms of H2 in human melanocytes damaged by hydrogen peroxide. We initially found that H2 reduced ...
HEART - MITOCHONDRIAL FUNCTION

A new insight into the molecular hydrogen effect on coenzyme Q and mitochondrial function of rats

Year Published: 2020

Mitochondria are the major source of cellular energy metabolism. In the cardiac cells, mitochondria produce by way of the oxidative phosphorylation more than 90% of the energy supply in the form of ATP, which is utilized in many ATP-dependent processes, like cycling of the contractile proteins or maintaining ion gradients. Reactive oxygen species (ROS) are by-products of cellular metabolism and ...
WHOLE BODY - MITOCHONDRIAL FUNCTION

Molecular Hydrogen Manages Mitochondrial Proteostatic Stress and Induces Cellular Response

Year Published: 2020

Molecular hydrogen (H2) has an anti‐oxidant effect on hundreds of animal models. However, the exact molecular mechanisms of molecular hydrogen still remains elusive. Mitochondrial unfolded protein response (mtUPR) is a known stress response to perturbed mitochondrial proteostasis caused by oxidative stress or mitochondrial dysfunction. We examined the effects of molecular hydrogen on mtUPR by ...
LIVER - EXCERCISE

Inhalation of molecular hydrogen increases breath acetone excretion during submaximal exercise: a ...

Year Published: 2020

Aerobic exercise is widely accepted as a beneficial option for reducing fat in humans. Recently, it has been suggested that molecular hydrogen (H2) augments mitochondrial oxidative phosphorylation. Therefore, the hypothesis that inhaling H2 could facilitate lipid metabolism during aerobic exercise was investigated in the current study by measuring the breath acetone levels, which could be used as ...
WHOLE BODY - EXCERCISE

Two-week continuous supplementation of hydrogen-rich water increases peak oxygen uptake during an ...

Year Published: 2020

The various beneficial effects of the intake of molecular hydrogen (H2) have been demonstrated in the field of sports science. Although supplementation of H2 has been reported to increase mitochondrial metabolism in animal studies, the effects of the administration of H2 on aerobic capacity during exercise in humans are still not clear. We investigated whether a single or 2-week continuous intake ...
KIDNEY - KIDNEY FAILURE

Efficacy of a Si-based agent against developing renal failure in a rat remnant kidney model

Year Published: 2020

Chronic renal failure is exacerbated by oxidative stress, and this condition is difficult to treat in advanced stages. Because of the lack of effective treatments, the disease is a global public health concern. We developed a Si-based agent that continuously generates hydrogen for more than 24 h by reacting with water under conditions similar to those in the gastrointestinal tract. Given the ...
HEART - ATHEROSCLEROSIS

Peripheral endothelial function can be improved by daily consumption of water containing over 7 ppm ...

Year Published: 2020

Background: Measurement of the reactive hyperemia index (RHI) using peripheral arterial tonometry (PAT) has shown benefits in the evaluation of vascular endothelial function and prediction of cardiovascular disease prognosis. Thus, it is important to examine the factors that promote the RHI. In this study, we aimed to investigate the effect of molecular hydrogen (H2) on reactive hyperemia-PAT of ...
LUNG - CANCER

Hydrogen therapy can be used to control tumor progression and alleviate the adverse events of ...

Year Published: 2020

Chemotherapy, targeted therapy, and immunotherapy are used against advanced non-small cell lung cancer. A clinically efficacious method for relieving the adverse events associated of such therapies is lacking. Fifty-eight adult patients were enrolled in our trial to relieve pulmonary symptoms or the adverse events of drugs. Twenty patients who refused drug treatment were assigned equally and ...
WHOLE BODY - MITOCHONDRIAL FUNCTION

Molecular hydrogen suppresses superoxide generation in the mitochondrial complex I and reduced ...

Year Published: 2020

Molecular hydrogen (H2) is recognized as a medical gas applicable to numerous diseases including neurodegenerative diseases, metabolic disorders, and rheumatoid arthritis. Although the efficacy of H2 is reportedly attributed to its scavenging capability against the hydroxyl radical, the mechanisms underlying its therapeutic efficacy are not fully understood. Herein, we estimated the role of H2 in ...
WHOLE BODY - EXCERCISE

Effects of electrolyzed hydrogen water ingestion during endurance exercise in a heated environment ...

Year Published: 2020

Electrolyzed hydrogen water (EHW) is generated at a cathode. It contains many hydrogen molecules with high alkaline properties. The physiological effects of ingesting EHW during endurance exercise are unclear. The purpose of this study was to determine the effects of ingesting EHW during endurance exercise in a heated environment on body fluid balance and exercise performance. Twelve triathletes ...
BONE - EXCERCISE

Hydrotherapy with hydrogen-rich water compared with RICE protocol following acute ankle sprain in ...

Year Published: 2020

We analysed the effects of an experimental novel protocol of intensive hydrotherapy with hydrogen-rich water (HRW) on injury recovery in athletic men who suffered an acute ankle sprain (AAS) and compared it with a RICE protocol (rest, ice, compression, elevation). Professional athletes (age 23.7 ± 4.0 years; weight 78.6 ± 5.7 kg, height 182.5 ± 4.3 cm; professional experience 5.9 ± 3.9 years) ...
BONE - EXCERCISE

Case Report: Acute hydrotherapy with super-saturated hydrogen-rich water for ankle sprain in a ...

Year Published: 2020

Background: The traditional treatment of soft tissue injuries consists of the RICE protocol - rest, ice, compression, and elevation, followed for up to 72 hours after a trauma. Although designed as an immediate therapy to reduce inflammation that occurs after an acute injury, the RICE protcol might not be the best way to promote healing due to limiting blood flow. Molecular hydrogen (H 2) has ...
BRAIN - SEPSIS

Chronic molecular hydrogen inhalation mitigates short and long-term memory loss in polymicrobial ...

Year Published: 2020

The central nervous system (CNS) is one of the first physiological systems to be affected in sepsis. During the exacerbated systemic inflammatory response at the early stage of sepsis, circulatory inflammatory mediators are able to reach the CNS leading to neuroinflammation and, consequently, long-term impairment in learning and memory formation is observed. The acute treatment with molecular ...
INTESTINE - INTESTINAL INJURY

Hydrogen-rich saline protects intestinal epithelial tight junction barrier in rats with intestinal ...

Year Published: 2020

Aim To investigate the effects of hydrogen-rich saline (HRS) on intestinal epithelial tight junction (TJ) barrier in rats with intestinal ischemia–reperfusion injury (IIRI). Materials and methods Thirty-two healthy male Sprague–Dawley (SD) rats were randomly divided into four groups (n = 8 each): Sham group, I/R group, HRS group and 4-PBA group. After 45 min of ischemia and 6 h of reperfusion, ...
BRAIN - SEPSIS

Molecular hydrogen alleviates brain injury and cognitive impairment in a chronic sequelae model of ...

Year Published: 2020

Sepsis-related encephalopathy (SAE), which causes a series of brain injuries and long-term, potentially irreversible cognitive dysfunction, is closely associated with increased morbidity and mortality. Hydrogen (H2) is a new type of medical gas molecule that has been widely used in the treatment of various diseases in recent years. The aim of the present study was to explore the protective effects ...
INTESTINE - SEPSIS

iTRAQ-Based Quantitative Proteomic Analysis of Intestines in Murine Polymicrobial Sepsis with ...

Year Published: 2020

Objective: Sepsis-associated intestinal injury has a higher morbidity and mortality in patients with sepsis, but there is still no effective treatment. Our research team has proven that inhaling 2% hydrogen gas (H2) can effectively improve sepsis and related organ damage, but the specific molecular mechanism of its role is not clear. In this study, isobaric tags for relative and absolute ...
BRAIN - STROKE

Longitudinal multiparametric MRI study of hydrogen-enriched water with minocycline combination ...

Year Published: 2020

Free radicals are downstream mediators of several cytotoxic cascades contributing to ischemic brain injury. Molecular hydrogen (H2) is an antioxidant potentially useful in the treatment of stroke. Hydrogen is easy to deliver, biologically non-toxic and diffuses freely through all biological structures including the blood-brain barrier and cellular membranes. This study evaluated the efficacy of ...
BRAIN - DIABETES

Protective effects of hydrogen‑rich saline against experimental diabetic peripheral neuropathy via ...

Year Published: 2020

It has previously been demonstrated that hyperglycemia‑induced oxidative stress and inflammation are closely associated with the development of diabetic complications, including diabetic neuropathy. Additionally, mitochondrial ATP‑sensitive potassium (Mito‑K‑ATP) channels play a homeostatic role on blood glucose regulation in organisms. Molecular hydrogen (H2) exhibits anti‑inflammatory, ...
NOSE - RHINITIS

Changes of nasal nitric oxide in the treatment of allergic rhinitis with hydrogen-rich saline lavage ...

Year Published: 2020

Objective:To observe the effect of hydrogen-rich saline on the concentration of nitric oxide in the nose, and to explore the mechanism of its treatment of allergic rhinitis. Method:Twenty patients with moderate to severe persistent allergic rhinitis were enrolled in a randomized, double-blind, self-controlled study. The nasal cavity was lavaged with hydrogen-rich normal saline and normal saline, ...
MOUTH - CANCER

Hydrogen-bubbled platinum-colloid suppresses human esophagus- or tongue-carcinoma cells with ...

Year Published: 2020

Carcinostatic effects of combined use of hydrogen nano-bubbles (nano-H) and platinum–povidone (PVP-–Pt) were examined. Hydrogen-dissolved medium was prepared by hydrogen-gas bubbling with a microporous gas-emittance-terminal into a medium in the absence or presence of PVP–Pt (nano-H, nano-H/PVP–Pt). Human esophagus-derived carcinoma cells KYSE70 were repressed for cell proliferation with ...
KIDNEY - SURGERY/TRANSPLANTATION

Oral Administration of Si-Based Agent Attenuates Oxidative Stress and Ischemia-Reperfusion Injury in ...

Year Published: 2020

Organ ischemia-reperfusion injury (IRI), which is unavoidable in kidney transplantation, induces the formation of reactive oxygen species and causes organ damage. Although the efficacy of molecular hydrogen (H2) in IRI has been reported, oral intake of H2-rich water and inhalation of H2 gas are still not widely used in clinical settings because of the lack of efficiency and difficulty in handling. ...
LUNG - SURGERY/TRANSPLANTATION

Protective effects of a hydrogen-rich preservation solution in a canine lung transplantation model

Year Published: 2020

Background: Molecular hydrogen (H2) has protective effects against ischemia-reperfusion injury in various organs. Because they are easier to transport and safer to use than inhaled H2, H2-rich solutions are suitable for organ preservation. In this study, we examined the protective effects of an H2-rich solution for lung preservation in a canine left lung transplantation (LTx) model. Methods: Ten ...
HEART - CARDIOVASCULAR DISEASE (CVD)

Constitutive hydrogen inhalation prevents vascular remodeling via reduction of oxidative stress

Year Published: 2020

Molecular hydrogen is thought to have an inhibitory effect on oxidative stress, thereby attenuating the onset and progression of various diseases including cardiovascular disease; however, few reports have assessed the preventive effect of constitutive inhalation of hydrogen gas on of vascular remodeling. Here, we investigated the effect of constitutive inhalation of hydrogen gas on vascular ...