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Studies Found: 1093

BRAIN - PARKINSON'S DISEASE

Renoprotective and neuroprotective effects of enteric hydrogen generation from Si-based agent

Year Published: 2020

We have developed Si-based agent which can generate a large amount of hydrogen. Si-based agent continues generating hydrogen for more than 24 h by the reaction with water under conditions similar to those in bowels, i.e., pH8.3 and 36 °C, and generates ~400 mL hydrogen. To investigate beneficial effects for diseases associated with oxidative stress, Si-based agent is administered to remnant ...
BRAIN - AGING

Short-Term H2 Inhalation Improves Cognitive Function in Older Women: A Pilot Study

Year Published: 2020

We analyzed the effects of 4-week H2 inhalation on cognitive performance in women aged 65 and above. The participants (n = 13) were community-dwelling older women (age 68.0 ± 3.0 years; weight 66.9 ± 10.3 kg; height 161.1 ± 5.8 cm) who volunteered to participate in this open-label pilot trial (ClinicalTrials.gov, NCT02830854). The participants received H2 by inhalation for 15 min once per day ...
BRAIN - BRAIN INJURY

Inhaled H2 or CO2 Do Not Augment the Neuroprotective Effect of Therapeutic Hypothermia in a Severe ...

Year Published: 2020

Hypoxic-ischemic encephalopathy (HIE) is still a major cause of neonatal death and disability as therapeutic hypothermia (TH) alone cannot afford sufficient neuroprotection. The present study investigated whether ventilation with molecular hydrogen (2.1% H2) or graded restoration of normocapnia with CO2 for 4 h after asphyxia would augment the neuroprotective effect of TH in a subacute (48 h) HIE ...
TESTES - INFERTILITY

Combination of Korean Red Ginseng Extract and Hydrogen-Rich Water Improves Spermatogenesis and Sperm ...

Year Published: 2020

Objective: To investigate the effect of hydrogen-rich Korean Red Ginseng (KRG) water (HRGW) mixture on the spermatogenesis and sperm motility of mice of different ages. Methods: Eighty young (3 month-old) and aged (12 month-old) male mice were randomly assigned to 4 groups (n =10 per group) including control group, hydrogen-rich water (HRW) group (10 mL/kg daily), KRG group (50 mg/kg daily) and ...
BRAIN - BRAIN INJURY

Hydrogen gas inhalation improves delayed brain injury by alleviating early brain injury after ...

Year Published: 2020

Molecular hydrogen (H2) protect neurons against reactive oxygen species and ameliorates early brain injury (EBI) after subarachnoid hemorrhage (SAH). This study investigated the effect of H2 on delayed brain injury (DBI) using the rat SAH + unilateral common carotid artery occlusion (UCCAO) model with the endovascular perforation method. 1.3% H2 gas (1.3% hydrogen premixed with 30% oxygen and ...
SKIN - AGING

Antioxidant Activity of Hydrogen Water Mask Pack Composed of Gel-Type Emulsion and Hydrogen ...

Year Published: 2020

In this study, hydrogen generation powder samples were prepared using zinc carbonate as a precursor, at a temperature varying from 400 to 700 °C in H2 atmosphere, and were characterized in terms of antioxidant activity. The concentration of dissolved hydrogen obtained by the powder samples was measured using a dissolved hydrogen meter as a function of time. In addition, the antioxidant activity ...
WHOLE BODY - METABOLIC SYNDROME

The Effects of 24-Week, High-Concentration Hydrogen-Rich Water on Body Composition, Blood Lipid ...

Year Published: 2020

Purpose: Metabolic syndrome is associated with several medical risk factors including dyslipidemia, hyperglycemia, and obesity, which has become a worldwide pandemic. The sequelae of this condition increase the risk of cardiovascular and neurological disease and increased mortality. Its pathophysiology is associated with redox dysregulation, excessive inflammation, and perturbation of cellular ...
WHOLE BODY - RADIOPROTECTION

Hydrogen-rich water attenuates the radiotoxicity induced by tritium exposure in vitro and in vivo

Year Published: 2020

Radionuclide tritium is widely used in the nuclear energy production industry and creates a threat to human health through radiation exposure. Herein, the radioactive elimination and radioprotective effect of hydrogen-rich water (HRW), a potential antioxidant with various medical applications, on tritiated water (HTO) exposure, was studied in vitro and in vivo. Results showed that intragastric ...
PANCREAS - PANCREATITIS

Pre-inhalation of Hydrogen-rich Gases Protect Against Caerulein-induced Mouse Acute Pancreatitis ...

Year Published: 2020

Background: Acute pancreatitis (AP) lacks targeted prevention and treatment measures. Some key points in the pathogenesis of AP remain unclear, such as early activation of pancreatic enzymes. Several recent reports have shown the protective effect of hydrogen on several AP animal models, and the mechanism is related to antioxidant activity. Heat shock protein 60 (Hsp60) is known to accompany ...
HEART - HEART ATTACK (MYOCARDIAL INFARCTION)

Effects of Hydrogen-rich Water on the PI3K/AKT Signaling Pathway in Rats with Myocardial ...

Year Published: 2020

Background: The effects of hydrogen-rich water on PI3K/AKT-mediated apoptosis were studied in rats subjected to myocardial ischemia-reperfusion injury (MIRI). Methdos: Sixty rats were divided randomly into a hydrogen-rich water group and a control group. The hearts were removed and fixed in a Langendorff device. Hearts from the control group were perfused with K-R solution, and hearts from the ...
HEART - HEART ATTACK (MYOCARDIAL INFARCTION)

Metabolomics Analysis of the Effect of Hydrogen-Rich Water on Myocardial Ischemia-Reperfusion Injury ...

Year Published: 2020

To investigate the effect of hydrogen-rich water on myocardial tissue metabolism in a myocardial ischemia-reperfusion injury (MIRI) rat model. Twelve rats were randomly divided into a hydrogen-rich water group and a control group of size 6 each. After the heart was removed, it was fixed in the Langendorff device, and the heart was perfused with 37 °C perfusion solution pre-balanced with oxygen. ...
LUNG - ENVIRONMENTAL POLLUTION

Hydrogen water alleviates paraquat-induced lung fibroblast injury in vitro by enhancing Nrf2 ...

Year Published: 2020

Objective: To investigate the effects of hydrogen water on proliferation, differentiation, collagen secretion and Nrf2 expression in paraquat-induced human lung fibroblasts. Methods: In vitro cultured human lung fibroblasts (HFL1) exposed to 600 μmol/L paraquat (PQ) for 24 h were treated with hydrogen water with or without RNA interference of Nrf2 expression. The changes in the cell proliferation ...
BRAIN - DIABETES (TYPE II)

Effects of a high concentration of hydrogen on neurological function after traumatic brain injury in ...

Year Published: 2020

Reactive oxygen species, inflammation, and apoptosis are major contributors to secondary injuries that follow traumatic brain injury (TBI) in diabetic patients. Hydrogen (H2) can selectively neutralize reactive oxygen species and downregulate inflammatory and apoptotic factors. Therefore, we investigated the effects of inhaled high and low concentrations of hydrogen on neurological function after ...
LIVER - METABOLIC SYNDROME

Hydrogen inhalation alleviates nonalcoholic fatty liver disease in metabolic syndrome rats

Year Published: 2020

Hydrogen exhibits therapeutic and preventive effects against various diseases. The present study investigated the potential protective effect and dose‑dependent manner of hydrogen inhalation on high fat and fructose diet (HFFD)‑induced nonalcoholic fatty liver disease (NAFLD) in Sprague‑Dawley rats. Rats were randomly divided into four groups: i) Control group, regular diet/air inhalation; ...
LUNG - CANCER

Suppression of autophagy facilitates hydrogen gas-mediated lung cancer cell apoptosis

Year Published: 2020

Our previous study found that hydrogen gas (H2) could efficiently inhibit lung cancer progression; however, the underlying mechanisms still remains to be elucidated. The present study aimed to explore the roles of H2 in lung cancer cell autophagy, and reveal the effects of autophagy on H2-mediated lung cancer cell apoptosis and the underlying mechanisms. The expression levels of proteins ...
BONE - SURGERY/TRANSPLANTATION

Hydrogen inhibits the osteoclastogenesis of mouse bone marrow mononuclear cells

Year Published: 2020

Hydrogen (H2) is one of the major biodegradation products of magnesium (Mg) alloys implanted for bony fracture healing and reconstruction; H2 thus plays a significant role in the regulation of local microenvironment and the biology of resident cells. The interactions between the H2 and the local cells are of great interest, and a full understanding of the effect of H2 on bone marrow mononuclear ...
WHOLE BODY - AGING

In vivo antiaging effects of alkaline water supplementation

Year Published: 2020

Telomeres length and telomerase activity are currently considered aging molecular stigmata. Water is a major requirement for our body and water should be alkaline. Recent reports have shown that aging is related to a reduced water intake. We wanted to investigate the effect of the daily intake of alkaline water on the molecular hallmark of aging and the anti-oxidant response. We watered a mouse ...
PERITONIUM - PERITONEAL DIALYSIS

Molecular hydrogen regulates PTEN-AKT-mTOR signaling via ROS to alleviate peritoneal ...

Year Published: 2020

As a convenient, effective and economical kidney replacement therapy for end-stage renal disease (ESRD), peritoneal dialysis is available in approximately 11% of ESRD patients worldwide. However, long-term peritoneal dialysis treatment causes peritoneal fibrosis. In recent years, the application potential of molecular hydrogen in the biomedicine has been well recognized. Molecular hydrogen ...
KIDNEY - SURGERY/TRANSPLANTATION

Hydrogen-rich water alleviates cyclosporine A-induced nephrotoxicity via the Keap1/Nrf2 signaling ...

Year Published: 2020

Oxidative stress induced by long-term cyclosporine A (CsA) administration is a major cause of chronic nephrotoxicity, which is characterized by tubular atrophy, tubular cell apoptosis, and interstitial fibrosis in the progression of organ transplantation. Although hydrogen-rich water (HRW) has been used to prevent various oxidative stress-related diseases, its underlying mechanisms remain unclear. ...
LUNG - CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

Effect of hydrogen inhalation on IL-40 and SIgA in a Rat Model of Pulmonary Mucosal Immunity

Year Published: 2020

Background Recently, some researchers have reported that PIgR expression is down-regulated in Chronic Obstructive Pulmonary Disease (COPD) and SIgA deficiency correlates with severity of airflow obstruction. What’ s more, some studies have demonstrated that 2 percent of hydrogen or hydrogen water is effective in treating and preventing various diseases. Objectives The aim of this study was to ...
LUNG - CANCER

Hydrogen gas represses the progression of lung cancer via downregulating CD47

Year Published: 2020

Hydrogen gas (H2) has been identified to play an anti-tumor role in several kinds of cancers, but the molecular mechanisms remains largely unknown. In our previous study, our project group found that H2 could decreased the expression of CD47 in lung cancer A549 cells via using the next generation sequencing, indicating that CD47 might be involved in H2-mediated lung cancer repression. Therefore, ...
WHOLE BODY - DIABETES (TYPE II)

Molecular hydrogen improves type 2 diabetes through inhibiting oxidative stress

Year Published: 2020

The aim of the present study was to investigate the potential therapeutic effects of molecular hydrogen on type 2 diabetes mellitus (T2DM) in rats. Following maintenance on a high-fat diet for 4 weeks, a T2DM model was established using an injection of 30 mg/kg streptozotocin via the caudal vein into Sprague-Dawley rats. On day 0 and Day 80, the blood samples were obtained from each rat for the ...
WHOLE BODY - EXCERCISE

The role of drinking hydrogen-rich water produced by alkaline stick on resistance exercise in ...

Year Published: 2020

In the double-blind study, the effect of drinking Hydrogen-Rich Water (HRW) producing by alkaline stick and tap water (placebo) on 9 male athletes in resistance training during 24 h were studied, and Lactate Dehydrogenase (LDH), Creatine Kinase (CPK) and Lactic Acid (LAC) levels in their blood samples were tested. The decrease of LAC and LDH values in the HRW group compared with the placebo were ...
LUNG - ASTHMA

Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch

Year Published: 2020

Mechanisms mediating the protective effects of molecular hydrogen (H2) are not well understood. This study explored the possibility that H2 exerts its anti-inflammatory effect by modulating energy metabolic pathway switch. Activities of glycolytic and mitochondrial oxidative phosphorylation systems were assessed in asthmatic patients and in mouse model of allergic airway inflammation. The effects ...
MUSCLE - EXCERCISE

Molecular hydrogen downregulates acute exhaustive exercise-induced skeletal muscle damage

Year Published: 2020

Physical exercise-induced skeletal muscle damage may be characterized by increased oxidative stress, inflammation, and apoptosis which may be beneficial when exercise is regular, but it is rather harmful when exercise is exhaustive and performed acutely by unaccustomed individuals. Molecular hydrogen (H2) has emerged as a potent antioxidant, anti-inflammatory, and anti-apoptotic agent, but its ...