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Studies Found: 1335

LUNG - SEPSIS

Hydrogen gas alleviates lipopolysaccharide-induced acute lung injury and inflammatory response in ...

Year Published: 2022

Background: Chronic inflammation and oxidant/antioxidant imbalance are two main pathological features associated with lipopolysaccharide (LPS)-induced acute lung injury (ALI). The following study investigated the protective role of hydrogen (H2), a gaseous molecule without known toxicity, in LPS-induced lung injury in mice and explored its potential molecular mechanisms. Methods: Mice were ...

Treatment with Hydrogen-Rich Water Improves the Nociceptive and Anxio-Depressive-like Behaviors ...

Year Published: 2022

Chronic inflammatory pain is manifested in many diseases. The potential use of molecular hydrogen (H2) as a new therapy for neurological disorders has been demonstrated. Recent studies prove its analgesic properties in animals with neuropathic pain, but the possible antinociceptive, antidepressant, and/or anxiolytic actions of H2 during persistent inflammatory pain have not been investigated. ...

Efficacy of Hydrogen Purification and Cosmetic Acids in the Treatment of Acne Vulgaris: A ...

Year Published: 2022

Acne and skin lesions that appear in its course deteriorate the quality of life of patients, cause depression and the emergence of suicidal thoughts. Cosmetic treatments can have a positive effect on improving skin condition by cleaning up skin eruptions, thus improving the well-being of affected people. Hydrogen purification is a treatment that uses alkaline water generated by a device, which ...
WHOLE BODY - HANGOVER

Hydrogen Intake Relieves Alcohol Consumption and Hangover Symptoms in Healthy Adults: a Randomized ...

Year Published: 2022

Background: Alcohol-induced hangover represents a significant, yet understudied, global hazard and a large socio-economic burden. Objectives: The aim of this study was to investigate the effects of hydrogen (H2) on relieving drinking and hangover symptoms in 20 healthy volunteers. Methods: In this pilot, randomized, double-blinded, placebo-controlled, matched, crossover interventional trial, ...

Hydrogen-Rich Water as a Novel Therapeutic Strategy for the Affective Disorders Linked with Chronic ...

Year Published: 2022

Neuropathic pain manifested with allodynia and hyperalgesia usually becomes a chronic condition accompanied with mood disorders. Clinical therapies for neuropathic pain are still unsatisfactory with notable side effects. Recent studies have reported the protective role of molecular hydrogen (H2) in different diseases including neurological disorders, such as Alzheimer's as well as its ...
PREGNANCY - IMMUNE REGULATION

Molecular hydrogen has a positive impact on pregnancy maintenance through enhancement of ...

Year Published: 2022

Aims: Molecular hydrogen (H2) has attracted growing interest because of its implications in various diseases. However, the molecular mechanisms underlying the remarkable effect of a small amount of H2 remain elusive. No knowledge has been available on the role of H2 in the etiology of pregnancy disorders or its direct influence on human immune cells. Since maternal immunity, T cells in particular, ...
BONE - WOUND HEALING

Hydrogen saline water accelerates fracture healing by suppressing autophagy in ovariectomized rats

Year Published: 2022

Objective: The treatment of osteoporotic fractures is difficult, and to minimize the negative result or poor functional rehabilitation, this study focuses on hydrogen water (HRW) to test its effect on the process of menopausal osteoporotic fracture healing and its relationship with autophagy and to try to reveal the potential mechanism of action of HRW on osteoporotic fractures. Materials and ...
WHOLE BODY - HYDROGEN BIOLOGY

Molecular Hydrogen Promotes Adipose-derived Stem Cell Myogenic Differentiation via Regulation of ...

Year Published: 2022

Background: Acute skeletal muscle injuries are common physical or sports traumas. Cellular therapy has excellent potential for regeneration after skeletal muscle injury. Adipose-derived stem cells (ADSCs) are a more accessible type of stem cell. However, it has a low survival rate and differentiation efficiency in the oxidative stress-rich microenvironment after transplantation. Although molecular ...

Inhalation of 4% and 67% hydrogen ameliorates oxidative stress, inflammation, apoptosis, and ...

Year Published: 2023

Acute kidney injury (AKI) is the major complication of rhabdomyolysis (RM) clinically, which is usually mimicked by glycerol injection in basic research. Oxidative stress, inflammatory response and apoptosis are recognized to play important roles in development of this disease. Recently, numerous studies have reported the therapeutic effects of molecular hydrogen (H2) on oxidative stress and ...
LUNG - CANCER

Hydrogen gas promotes apoptosis of lung adenocarcinoma A549 cells through X-linked inhibitor of ...

Year Published: 2022

Objective: Lung cancer is currently the cancer with the highest incidence and death toll worldwide. Hydrogen gas has been found to affect a variety of diseases; however, the effect of hydrogen gas on patients with lung cancer has not been reported. Therefore, we determined the effect of hydrogen gas on apoptosis of lung adenocarcinoma in vivo and in vitro. Materials and methods: A549 cells in the ...
SKIN - RADIOPROTECTION

Effect of hydrogen intervention on refractory wounds after radiotherapy: A case report

Year Published: 2022

Background: Patients with keloids who receive radiotherapy (RT) after surgery can develop refractory wounds that cannot be healed by the patient's own repair system. Such chronic wounds are uneven and complex due to persistent abscess and ulceration. Without external intervention, they can easily result in local tissue necrosis or, in severe cases, large area tissue resection, amputation, and even ...
HEART - SURGERY/TRANSPLANTATION

Molecular hydrogen exposure improves functional state of red blood cells in the early postoperative ...

Year Published: 2023

Molecular hydrogen (H2) has been considered a preventive and therapeutic medical gas in numerous diseases. The study aimed to investigate the potential role of molecular hydrogen as a component of anesthesia in surgical treatment with cardiopulmonary bypass (CPB) of acquired valve defects on the functional state of red blood cells (RBC) and functional indicators of cardiac activity. This clinical ...
BRAIN - DIABETES

Hydrogen exerts neuroprotective effects by inhibiting oxidative stress in experimental diabetic ...

Year Published: 2023

Diabetic peripheral neuropathy (DPN) is a complex disorder caused by long-standing diabetes. Oxidative stress was considered the critical creed in this DPN pathophysiology. Hydrogen has antioxidative effects on diabetes mellitus and related complications. However, there is still no concern on the beneficial effects of hydrogen in DPN. This paper aimed to evaluate the effects of exogenous hydrogen ...
WHOLE BODY - HYDROGEN BIOLOGY

Accurate in vivo real-time determination of the hydrogen concentration in different tissues of mice ...

Year Published: 2022

As an antioxidant, anti-inflammatory and anti-apoptotic agent, hydrogen (H2) shows a promising potential in basic and clinical research against various diseases owing to its safety and efficacy. However, knowledge involving its underlying mechanisms of action, dosage effects, and dose duration remains limited. Previously, the dynamics of H2 concentrations in different tissues of rats after ...

Dynamics of Metabolic and Oxidative Parameters of Erythrocytes during Treatment of Chronic Heart ...

Year Published: 2022

We studied the effect of molecular hydrogen (H2) on the content of 2,3-diphosphoglyceric acid (2,3-DPG), ATP, malondialdehyde, and catalase activity in erythrocytes in chronic heart failure. Inhalation of 2% molecular hydrogen H2 was carried out for 40 min repeatedly (5 days) or once. Inhalation of H2 caused an increase in ATP concentration in both research groups, but was more pronounced after ...
TESTES - INFERTILITY

Molecular Hydrogen Reduces Electromagnetic Pulse-Induced Male Rat Reproductive System Damage in a ...

Year Published: 2022

Infertility has got to be a broadly concerned social issue these days, in which the malefactor cannot be overlooked. Numerous studies have shown that electromagnetic pulse (EMP) radiation may have seriously damaging effects on reproductive health, through nonthermal effects and oxidative stress. Molecular hydrogen, a selective hydroxyl radical scavenger, explains the protective effects against ...
WHOLE BODY - ROS-SCAVENGING

Antioxidation activity of molecular hydrogen via protoheme catalysis in vivo: an insight from ab ...

Year Published: 2022

Recently, molecular hydrogen has been found to exhibit antioxidation activity through many clinical experiments, but the mechanism has not been fully understandable at atomic level. In this work, we perform systematic ab initio calculations of protoheme-hydrogen complexes to clarify the antioxidation mechanism of molecular hydrogen. We make molecular modeling of iron-protoporphyrin coordinated by ...
WHOLE BODY - EXCERCISE

The Acute Effects of a Single Dose of Molecular Hydrogen Supplements on Responses to Ergogenic ...

Year Published: 2022

This research examined the effects of single-dose molecular hydrogen (H2) supplements on acid-base status and local muscle deoxygenation during rest, high-intensity intermittent training (HIIT) performance, and recovery. Ten healthy, trained subjects in a randomized, double-blind, crossover design received H2-rich calcium powder (HCP) (1500 mg, containing 2.544 μg of H2) or H2-depleted placebo ...
WHOLE BODY - HYDROGEN BIOLOGY

Synergistic Effect of Hydrogen and 5-Aza on Myogenic Differentiation through the p38 MAPK Signaling ...

Year Published: 2022

Background and objectives: This study aims to clarify the systems underlying regulation and regulatory roles of hydrogen combined with 5-Aza in the myogenic differentiation of adipose mesenchymal stem cells (ADSCs). Methods and results: In this study, ADSCs acted as an in vitro myogenic differentiating mode. First, the Alamar blue Staining and mitochondrial tracer technique were used to verify ...
WHOLE BODY - ROS-SCAVENGING

Enhanced Removal of Free Radicals by Aqueous Hydrogen Nanobubbles and Their Role in Oxidative Stress

Year Published: 2022

Elevated levels of reactive oxygen radicals caused by environmental stress are the key triggers of inflammation, aging, and disease; thus, it is critical to develop novel reactive oxygen radical scavenging methods with high efficiency and low toxicity. As a result of their selective reactive oxygen radical removal, hydrogen molecules are strong candidates, but their application is limited by the ...

Prophylactic Instillation of Hydrogen-Rich Water Decreases Corneal Inflammation and Promotes Wound ...

Year Published: 2022

Many studies have demonstrated the therapeutic effects of hydrogen in pathological conditions such as inflammation; however, little is known about its prophylactic effects. The purpose of this study is to investigate the prophylactic effects of hydrogen-rich water instillation in a rat corneal alkali burn model. Hydrogen-rich water (hydrogen group) or physiological saline (vehicle group) was ...
LUNG - SARS/COVID

Abstract: Effect of hydrogen therapy on the proteomic profile of exhaled breath condensate after ...

Year Published: 2022

Exhaled breath condensate (EBC) is a promising object for biomarkers search as it contains compounds reflecting changes of biological processes caused by various respiratory diseases including COVID-19. Molecular hydrogen was recently discovered as a new effective antioxidant that can restore lung function after COVID-19. The effect of molecular hydrogen on lung function was studied by comparing ...
NOSE - RHINITIS

The Beneficial Effects of Hydrogen-Rich Saline Irrigation on Chronic Rhinitis: A Randomized, ...

Year Published: 2022

Purpose: Chronic rhinitis (CR) is a common chronic inflammation of the nasal mucosa. Nasal saline irrigation has been demonstrated to be an effective treatment for CR. In this study, we investigated the beneficial effects of hydrogen-rich saline irrigation as an anti-inflammatory irrigation therapy for CR and compared its effectiveness over saline irrigation. Hydrogen-rich saline (HRS) was ...
BRAIN - DIABETES

Molecular Hydrogen Mediates Neurorestorative Effects After Stroke in Diabetic Rats: the TLR4/NF-κB ...

Year Published: 2022

Diabetes is an independent risk factor for stroke and amplifies inflammation. Diabetic stroke is associated with a higher risk of death and worse neural function. The identification of effective anti-inflammatory molecules with translational advantages is particularly important to promote perioperative neurorestorative effects. Applying molecular hydrogen, we measured blood glucose levels before ...
WHOLE BODY - SARS/COVID

Hydrogen-rich water alleviates inflammation and fatigue in COVID-19: A pilot study

Year Published: 2022

No abstract available