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Studies Found: 1093

WHOLE BODY - EXCERCISE

Inhaled molecular hydrogen attenuates intense acute exercise-induced hippocampal inflammation in ...

Year Published: 2020

Physical exercise-induced inflammation may be beneficial when exercise is regular but it may be harmful when exercise is intense and performed by unaccustomed individuals/rats. Molecular hydrogen (H2) has recently emerged as a powerful anti-inflammatory, antioxidant and anti-apoptotic molecule in a number of pathological conditions, but little is known about its putative role under physiological ...
WHOLE BODY - EXCERCISE

Acute ingestion of hydrogen-rich water does not improve incremental treadmill running performance in ...

Year Published: 2020

There is emerging evidence that hydrogen-rich water (H2-water) has beneficial effects on the physiological responses to exercise. However, few studies investigate its ergogenic potential. This randomized controlled trial examined the effects of H2-water ingestion on physiological responses and exercise performance during incremental treadmill running. In a double-blind crossover design, 14 ...
LUNG - SURGERY/TRANSPLANTATION

Hydrogen water alleviates obliterative airway disease in mice

Year Published: 2020

Objective: Bronchiolitis obliterans syndrome arising from chronic airway inflammation is a leading cause of death following lung transplantation. Several studies have suggested that inhaled hydrogen can protect lung grafts from ischemia-reperfusion injury via anti-inflammatory and -oxidative mechanisms. We investigated whether molecular hydrogen-saturated water can preserve lung allograft function ...
BONE MARROW - SURGERY/TRANSPLANTATION

Hydrogen in Patients With Corticosteroid-Refractory/Dependent Chronic Graft-Versus-Host-Disease: A ...

Year Published: 2020

Chronic graft-versus-host-disease (cGVHD) is the leading cause of late non-relapse mortality after allogeneic hematopoietic stem cell transplantation(HSCT). There is no standard therapy for patients refractory or dependent to corticosteroid treatment. We hypothesized that hydrogen may exert therapeutic effects on cGVHD patients with few side effects. A prospective open-label phase 2 study of ...
OVARIES - CANCER

Biodegradable Mg Implants Suppress the Growth of Ovarian Tumor

Year Published: 2020

The common treatment of epithelial ovarian cancer is aggressive surgery followed by platinum-based cytotoxic chemotherapy. However, residual tumor cells are resistant to chemotherapeutic drugs during postoperative recurrence. The treatment of ovarian cancer requires new breakthroughs and advances. In recent years, magnesium alloy has been widely developed as a new biodegradable material because of ...
INTESTINE - OBESITY

Saturated hydrogen improves lipid metabolism disorders and dysbacteriosis induced by a high-fat diet

Year Published: 2020

Studies have shown that metabolic diseases, such as obesity, are significantly associated with intestinal flora imbalance. The amplification of opportunistic pathogens induced by the glyoxylic acid cycle contributes to intestinal flora imbalance. Promising, though, is that saturated hydrogen can effectively improve the occurrence and development of metabolic diseases, such as obesity. However, the ...
LUNG - ASTHMA

Effects of high-fat diet on the epithelial-mesenchymal transition of respiratory tract through the ...

Year Published: 2020

Background High fat diet is extensively studied to be associated with trending metabolic diseases. In addition to type 2 diabetes and hypertension, high fat diet is strongly associated with asthma and other respiratory diseases among children however, the pathogenicity regarding these pulmonary diseases begs for extensive research. This study investigated the mechanism of the ...
INTESTINE - CANCER

Hydrogen attenuates radiation-induced intestinal damage by reducing oxidative stress and ...

Year Published: 2020

The small intestine is known to be particularly sensitive to radiation, and the major limiting factor of radiotherapy is the gastrointestinal syndrome that subsequently develops after its administration. The detrimental effects of radiation are mostly mediated via the overproduction of reactive oxygen species (ROS), especially the hydroxyl radical (·OH). Because hydrogen is a selective ·OH ...
WHOLE BODY - PARASITE INFECTION

Electrolyzed Oxidizing Water Modulates the Immune Response in BALB/c Mice Experimentally Infected ...

Year Published: 2020

Chagas disease is a major public health problem in Latin America. The mixed Th1/Th2 immune response is required against Trypanosoma cruzi. Electrolyzed oxidizing water (EOW) has been shown to have germicidal efficacy. The objective of this study was to evaluate the EOW effectiveness in T. cruzi-infected BALB/c mice clinically, immunologically, and histologically. The severity of the infection was ...
SKIN - WOUND HEALING

Hydrogen generating patch improves skin cell viability, migration activity, and collagen expression

Year Published: 2020

Molecular hydrogen recently attracted lots of attention in biomedical community because of its abilities to modulate signal transduction, protein phosphorylation, and gene expression that enable its anti-inflammatory, anti-allergy, and anti-apoptotic activities. However, controllable and local delivery of hydrogen molecules to tissues still remains challenging. Here, we propose a new method of ...
SKIN - SURGERY/TRANSPLANTATION

Hydrogen-rich saline reduces tissue injury and improves skin flap survival on a rat hindlimb ...

Year Published: 2020

Background: Degloving injuries represent a challenge in plastic surgery. The aim of this study is to acknowledge the protective effects of hydrogen-rich saline (HRS) solution on a rat hindlimb degloved skin flap. Methods: Twenty-one Sprague-Dawley rats were divided into three groups (control, saline and HRS). Degloving injury model was established, and flaps were sutured back following 5 min of ...
ENDOTHELIUM - SHOCK

1.2% Hydrogen gas inhalation protects the endothelial glycocalyx during hemorrhagic shock: a ...

Year Published: 2020

Purpose Hydrogen gas (H2) inhalation improved the survival rate of hemorrhagic shock. However, its mechanisms are unknown. We hypothesized that H2 protected the endothelial glycocalyx during hemorrhagic shock and prolonged survival time. Methods 83 Sprague–Dawley rats were anesthetized with isoflurane. The animals were randomly assigned to 5 groups: room air with no shock, 1.2% H2 with no shock, ...
BLOOD - BLOOD COMPOSITION

Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells ...

Year Published: 2020

The evidence for the beneficial effects of drinking hydrogen-water (HW) is rare. We aimed to investigate the effects of HW consumption on oxidative stress and immune functions in healthy adults using systemic approaches of biochemical, cellular, and molecular nutrition. In a randomized, double-blind, placebo-controlled study, healthy adults (20-59 y) consumed either 1.5 L/d of HW (n = 20) or plain ...
PREGNANCY - OFFSPRING DEVELOPMENT

Effect of ionised (electrolysed) water on the rat embryo development

Year Published: 2020

The aim of this study was to investigate the effects ionised water has on embryonic development using Wistar rat animal model. For that purpose, alkaline and acidic water was prepared with a domestic water ioniser. It was found that the concentrations of Cl–, SO42– ions increased in acidic water, while in alkaline water, Ca2+ concentration decreased and halogenated hydrocarbon concentrations ...
HEART - HYPERTENSION

Daily inhalation of hydrogen gas has a blood pressure-lowering effect in a rat model of hypertension ...

Year Published: 2020

A recent clinical study demonstrated that haemodialysis with a dialysate containing hydrogen (H2) improves blood pressure control in end-stage kidney disease. Herein, we examined whether H2 has a salutary effect on hypertension in animal models. We subjected 5/6 nephrectomised rats to inhalation of either H2 (1.3% H2 + 21% O2 + 77.7% N2) or control (21% O2 + 79% N2) gas mixture for 1 h per day. H2 ...
MUSCLE - DIABETES

Evaluation of different type of electrolyzed water against bacterial colonization of diabetic foot ...

Year Published: 2020

Objective This study aims to evaluate the effect of electrolyzed water effect on bacterial colonization on diabetic foot ulcer (DFU) patients. Method This is an in vitro study. Eight bacteria are incubated into 5 types of electrolyzed water (ESAW), electrolyzed weak acid water (EWAW), electrolyzed neutral water (ENAW), electrolyzed weak alkaline water (EWAlW), and electrolyzed strong alkaline ...
LUNG - SARS/COVID

Acidic electrolyzed water potently inactivates SARS-CoV-2 depending on the amount of free available ...

Year Published: 2020

Alcohol-based disinfectant shortage is a serious concern in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Acidic electrolyzed water (EW) with a high concentration of free available chlorine (FAC) shows strong antimicrobial activity against bacteria, fungi, and viruses. Here, we assessed the SARS-CoV-2-inactivating efficacy of acidic EW for use as an alternative ...
HEART - CARDIAC ARREST

Hydrogen gas inhalation alleviates oxidative stress in patients with post-cardiac arrest syndrome

Year Published: 2020

Oxidative stress plays a key role in the pathophysiology of post-cardiac arrest syndrome. Molecular hydrogen reduces oxidative stress and exerts anti-inflammatory effects in an animal model of cardiac arrest. However, its effect on human post-cardiac arrest syndrome is unclear. We consecutively enrolled five comatose post-cardiac arrest patients (three males; mean age, 65 ± 15 years; four ...
ENDOTHELIUM - SHOCK

Hydrogen Gas Inhalation Attenuates Endothelial Glycocalyx Damage and Stabilizes Hemodynamics in a ...

Year Published: 2020

Background: Hydrogen gas (H2) inhalation during hemorrhage stabilizes post-resuscitation hemodynamics, improving short-term survival in a rat hemorrhagic shock and resuscitation (HS/R) model. However, the underlying molecular mechanism of H2 in HS/R is unclear. Endothelial glycocalyx (EG) damage causes hemodynamic failure associated with HS/R. In this study, we tested the hypothesis that H2 ...
WHOLE BODY - ROS-SCAVENGING

Dependencies of hydrogen-water on mineral-based hardness, temperatures and the container materials, ...

Year Published: 2020

Widely distributed electrolytic-generators for hydrogen-water are not fully considered for the dependencies of post-electrolytic values of the dissolved hydrogen concentration (DH) and the oxidation-reduction potential (ORP) on the properties of the pre-electrolytic water. We investigated the dependencies of DH and ORP on mineral-based hardness, temperatures and the container materials, and ...
WHOLE BODY - EXCERCISE

The Effects of Supersaturated Hydrogen-Rich Water Bathing on Biomarkers of Muscular Damage and ...

Year Published: 2020

High-intensity eccentric exercise can cause a delayed onset of muscle soreness (DOMS), a short-term condition characterized by muscle damage and tenderness that might hold up recovery and jeopardize exercise routine. Previous studies indicated that hydrogen-rich water (HRW) might be a helpful topical intervention to boost recovery in musculoskeletal medicine, yet no data are available concerning ...
MOUTH - PERIODONTITIS/PLAQUE/GINGIVITIS

Effects of Electrolyzed Water on the Growth of Oral Pathologic Bacteria Species and its Cytotoxic ...

Year Published: 2020

Background: Microbial plaque-induced oral diseases are among the most common diseases worldwide. The present study aimed to compare the antimicrobial effect of electrolyzed water (EW), (acidic, mildly basic, and basic) on the growth of bacterial species producing dental plaque and to assess their cytotoxicity on fibroblasts and epithelial cells. Methods: The study was performed at Shahid Beheshti ...
MOUTH - PERIODONTITIS/PLAQUE/GINGIVITIS

Effects of Electrolyzed Water on the Growth of Oral Pathologic Bacteria Species and its Cytotoxic ...

Year Published: 2020

Background: Microbial plaque-induced oral diseases are among the most common diseases worldwide. The present study aimed to compare the antimicrobial effect of electrolyzed water (EW), (acidic, mildly basic, and basic) on the growth of bacterial species producing dental plaque and to assess their cytotoxicity on fibroblasts and epithelial cells. Methods: The study was performed at Shahid Beheshti ...
HEART - HYPERTENSION

Hydrogen-rich saline mitigates pressure overload-induced cardiac hypertrophy and atrial fibrillation ...

Year Published: 2020

Objective To investigate if hydrogen-rich saline (HRS), which has been shown to have antioxidant and anti-inflammatory properties, could mitigate cardiac remodelling and reduce the incidence of atrial fibrillation (AF) in the rat model of cardiac hypertrophy. Methods Pressure overload was induced in rats by abdominal aortic constriction (AAC). The animals were separated into four groups: sham; AAC ...
BRAIN - BRAIN INJURY

Hydrogen Gas Attenuates Hypoxic-Ischemic Brain Injury via Regulation of the MAPK/HO-1/PGC-1a Pathway ...

Year Published: 2020

Neonatal hypoxic-ischemic encephalopathy (HIE) is a leading cause of death in neonates with no effective treatments. Recent advancements in hydrogen (H2) gas offer a promising therapeutic approach for ischemia reperfusion injury; however, the impact of this approach for HIE remains a subject of debate. We assessed the therapeutic effects of H2 gas on HIE and the underlying molecular mechanisms in ...