Electrolyzed and Natural Reduced Water Exhibit Insulin-Like Activity on Glucose Uptake into Muscle Cells and Adipocytes

M Oda, K Kusumoto, K Teruya, T Hara, T Maki, S Kabayama, Y Katakura, K Otsubo, S Morisawa, H Hayashi, Y Ishii, Sanetaka Shirahata

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DOI: 10.1007/0-306-46875-1_90 DOI is the universal ID for this study.

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In the type 2 diabetes, it has become clear that reactive oxygen species (ROS) cause reduction of glucose uptake by inhibiting the insulin-signaling pathway in muscle cells and adipocytes. We demonstrated that electrolyzed-reduced water (ERW) scavenges ROS and protects DNA from oxidative damage1). Here we found that ERW scavenges ROS in insulin-responsive L6 myotubes and mouse3T3/L1 adipocytes. Uptake of 1-deoxy-D- glucose (2-DOG) into both L6 cells and 3T3/L1 cells was stimulated by ERW in the presence or absence of insulin. This insulin-like activity of ERW was mediated by the activation of PI-3 kinase, resulting in stimulation of translocation of glucose transporter GLUT4 from microsome to plasma membrane. These results suggest that ERW may be useful to improve insulin-independent type 2 diabetes.

Publish Year 1999
Country Japan
Rank Positive
Journal Animal Cell Technology: Products from Cells, Cells as Products
Primary Topic Whole Body
Secondary Topic Diabetes (Type II)
Model Cell Culture
Tertiary Topic Glucose Metabolism
Vehicle Water (Electrolysis)
pH Alkaline
Application Culture Media