Decompression comparison of helium and hydrogen in rats

R Lillo, E Parker, W Porter

Read more:

DOI: 10.1152/jappl.1997.82.3.892 DOI is the universal ID for this study.

This link will take you to the full study.

Abstract:

The hypothesis that there are differences in decompression risk between He and H2 was examined in 1,607 unanesthetized male albino rats subjected to dives on 2% O2-balance He or 2% O2-balance H2 (depths < or = 50 ATA, bottom times < or = 60 min). The animals were decompressed to 10.8 ATA with profiles varying from rapid to slow, with up to four decompression stops of up to 60 min each. Maximum likelihood analysis was used to estimate the relative decompression risk on a per unit pressure basis (termed 'potency') and the rate of gas uptake and elimination, both factors affecting the decompression sickness risk, from a specific dive profile. H2 potency for causing decompression sickness was found to be up to 35% greater than that for He. Uptake rates were unresolvable between the two gases with the time constant (TC) estimated at approximately 2-3 min, leading to saturation in both cases in < 15 min. Washout of both gases was significantly slower than uptake, with He washout (TC approximately 1.5-3 h) substantially slower than H2 washout (TC approximately 0.5 h). It is unknown whether the decompression advantage of the faster washout of H2 or the disadvantage of its increased potency, observed in the rat, would be important for human diving.

Publish Year 1997
Country United States
Rank Neutral
Journal Journal of Applied Physiology
Primary Topic Whole Body
Secondary Topic Diving
Model Rat
Tertiary Topic Decompression Sickness
Vehicle Gas
pH N/A
Application Inhalation
Comparison Helium
Complement

Related Articles

Fukuoka, Yoshiyuki

2021 - Whole Body - Excercise

We investigated effects of molecular hydrogen (H2) supplementation on acid-base status, pulmonary gas exchange responses, and local muscle oxygenation during incremental exercise. Eighteen healthy, trained subjects in a randomized, double-blind, ...

Hydrogen Rich Water Consumption Positively Affects Muscle Performance, Lactate Response, and ...

2021 - Whole Body - Excercise

Hydrogen rich water consumption positively affects muscle performance, lactate response, and alleviates delayed onset of muscle soreness after resistance training. J Strength Cond Res XX(X): 000-000, 2021-Positive outcomes of hydrogen rich water ...

High-flow hydrogen inhalation might suppresses the immune function of middle-aged participants: a ...

2021 - Whole Body - Aging

Hydrogen inhalation therapy has been proven to be safe and effective in disease treatment in multiple clinical reports, but the gas flow rates used in different studies vary greatly. Since there is no upper limit for the safe concentration of ...

Protective effect of hydrogen-rich saline on decompression sickness in rats

2011 - Whole Body - Diving

Introduction: Hydrogen (H2) has been reported to be effective in the treatment of oxidative injury, which plays an important role in the process of decompression sickness (DCS). This study was designed to test whether H2-rich saline (saline saturated ...

Saturated hydrogen saline protects the lung against oxygen toxicity

2010 - Whole Body - Diving

Exposure to high oxygen concentrations leads to acute lung injury, including lung tissue and alveolar edema formation, congestion, intra-alveolar hemorrhage, as well as endothelial and epithelial cell apoptosis or necrosis. Several studies have ...

On the Physiology of Hydrogen Diving and Its Implication for Hydrogen Biochemical Decompression

2000 - Whole Body - Diving

Biochemical decompression, a novel approach for decreasing decompression sickness (DCS) risk by increasing the tissue washout rate of the inert gas, was tested in pigs during simulated H2 dives. Since there is only limited physiological data on the ...