Metal-Organic Framework Based Hydrogen Release Platform for Multi-Effective Helicobacter Pylori Targeting Therapy and Intestinal Flora Protective Capabilities

Wei Zhang, Yanan Zhou, Yating Fan, Rui Cao, Yingying Xu, Zhenzhen Weng, Jing Ye, Cong He, Yin Zhu, Xiaolei Wang

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DOI: 10.1002/adma.202105738 DOI is the universal ID for this study.

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Abstract:

Helicobacter pylori (H. pylori) infection is the leading cause of chronic gastritis, peptic ulcer and gastric cancer. Antibiotics, as traditional method for eliminating H. pylori, have no targeting effect, which cause serious bacterial resistance and gut dysbacteriosis. Moreover, antibiotics can hardly address hyperactive inflammatory response or damaged gastric mucosal barrier caused by H. pylori infection. Here, we report a pH-responsive metal-organic framework hydrogen generation nanoparticle (Pd(H)@ZIF-8), which is encapsulated with ascorbate palmitate (AP) hydrogel. Both in vitro and in vivo experiments demonstrate that the outer AP hydrogel can target and adhere to the inflammatory site through electrostatic interaction, and is then hydrolyzed by matrix metalloproteinase (MMP) enriching in inflammatory sites. The released Pd(H)@ZIF-8 nanoparticles are further decomposed by gastric acid to generate zinc ions (Zn2+ ) and hydrogen, thus effectively killing H. pylori, alleviating inflammation and restoring impaired gastric mucosa simultaneously. Unexpectedly, this metal-organic framework hydrogen generation platform (Pd(H)@ZIF-8@AP) also has an inappreciable impact toward intestinal flora, which thus provides a more precise, effective and healthy strategy for the treatment of H. pylori infection. This article is protected by copyright. All rights reserved.

Publish Year 2021
Country China
Rank Positive
Journal Advanced Materials
Primary Topic Stomach
Secondary Topic Gastric Mucosal Injury
Model Rat
Tertiary Topic Helicobacter pylori Infection
Vehicle Gas (Sustained Release)
pH N/A
Application Implant
Comparison
Complement