Novel haemodialysis (HD) treatment employing molecular hydrogen (H 2)-enriched dialysis solution improves prognosis of chronic dialysis patients: A prospective observational study
Hirofumi Nakano, Hiromi Hamada, Hodaka Suzuki, Kazumasa Tsunoda, Mariko Miyazaki, Masaaki Nakayama, Naoyuki Osaka, Noritomo Itami, Ryo Yamamoto, Ryoichi Nakazawa, Sadayoshi Ito, Shigeru Kabayama, Yukio Maruyama
Abstract:
Recent studies have revealed unique biological characteristics of molecular hydrogen (H2) as an anti-inflammatory agent. We developed a novel haemodialysis (E-HD) system delivering an H2 (30-80 ppb)-enriched dialysis solution by water electrolysis, and conducted a non-randomized, non-blinded, prospective observational study exploring its clinical impact. Prevalent chronic HD patients were allocated to either the E-HD (n = 161) group or the conventional HD (C-HD: n = 148) group, and received the respective HD treatments during the study. The primary endpoint was a composite of all-cause mortality and development of non-lethal cardio-cerebrovascular events (cardiac disease, apoplexy, and leg amputation due to peripheral artery disease). During the 3.28-year mean observation period, there were no differences in dialysis parameters between the two groups; however, post-dialysis hypertension was ameliorated with significant reductions in antihypertensive agents in the E-HD patients. There were 91 events (50 in the C-HD group and 41 in the E-HD group). Multivariate analysis of the Cox proportional hazards model revealed E-HD as an independent significant factor for the primary endpoint (hazard ratio 0.59; [95% confidence interval: 0.38-0.92]) after adjusting for confounding factors (age, cardiovascular disease history, serum albumin, and C-reactive protein). HD applying an H2-dissolved HD solution could improve the prognosis of chronic HD patients.
| Publish Year |
2018 |
| Country |
Japan |
| Rank |
Positive |
| Journal |
Nature Scientific Reports |
| Primary Topic |
Kidney |
| Secondary Topic | Haemodialysis |
| Model |
Human |
| Tertiary Topic | Life Expectancy |
| Vehicle |
Solution (Dissolved) |
| pH |
Alkaline |
| Application |
Injection |
| Comparison |
|
| Complement |
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