Effect of electrolyzed reduced water on malondialdehyde levels and neutrophil cells in aggressive periodontitis

Markus B Rahardjo, Rini D Ridwan, Delaneira A Hikmah

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DOI: 10.4314/tjpr.v17i2.6 DOI is the universal ID for this study.

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Abstract:

Purpose: To evaluate the effects of electrolyzed reduced water (ERW) on malondialdehyde (MDA) levels and neutrophil cells in Wistar rats suffering from aggressive periodontitis.

Methods: Wistar rats (Rattus norvegicus) were infected with A. actinomycetemcomitans before being divided into a control group and a treatment group. The control group was treated orally with distilled water (pH 7.0), while the treatment group was administered with ERW (pH 9.8, 20 ml/day) for three successive days. Gingival tissue taken post-treatment was examined to determine the number of neutrophils and MDA level. Hematoxylin eosin staining was performed to identify neutrophil cells while MDA levels were determined by colorimetric assay.

Results: The number of neutrophils in the control group (30.04 ± 15.30) was higher than that of the treatment group (7.76 ± 2.52), while the MDA levels of the control and treatment groups were 4.58 ± 0.66 and 4.30 ± 0.81, respectively (p < 0.05).

Conclusion: ERW demonstrates the ability to reduce neutrophil cells without altering MDA levels in Wistar rats suffering from aggressive periodontitis. This is an indication that ERW was an effective material to manage aggressive periodontitis. © 2018, Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria.


Publish Year 2018
Country Indonesia
Rank Positive
Journal Tropical Journal of Pharmaceutical Research
Primary Topic Mouth
Secondary Topic Periodontitis
Model Rat
Tertiary Topic Inflammation
Vehicle Water (Electrolysis)
pH Alkaline
Application Irrigation
Comparison
Complement