Feasibility study of the sterilization of pigskin used as wound dressings by neutral electrolyzed water

Baozhong Lin, Chuan Cao, Liangpeng Ge, Lubin Liu, Xiaochun Zhang, Zhaobin Gu, Zuohua Liu

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DOI: 10.1097/TA.0b013e318243a1dc DOI is the universal ID for this study.

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Abstract:

Background: Neutral electrolyzed water (NEW) is considered to be a high-level biodegradable disinfectant with sporicidal, bactericidal, and virucidal activity. It has also been reported to accelerate wound healing; thus, it is particularly attractive for the elimination or minimization of the microbial population of skin grafts to be used as wound dressings.

Methods: Pigskins were sterilized with different concentrations of NEW and with different methods. The feasibility of pigskin sterilization by NEW was evaluated through microbiological analyses, viability assays, histologic assessments, contact cytotoxicity assays, and extract cytotoxicity assays.

Results: NEW has strong bactericidal effects on pigskin microorganisms, does not change skin graft histologic properties, and has no cytotoxicity; however, skin viability was significantly reduced after NEW treatment.

Conclusion: Although NEW treatment is a very safe and effective method for nonviable pigskin dressing sterilization, to obtain a complete sterilization of pigskin grafts, available chlorine concentration of NEW as well as sterilization time and methods should be optimized.


Publish Year 2012
Country China
Rank Positive
Journal Journal of Trauma and Acute Care Surgery
Primary Topic Skin
Secondary TopicWound Healing
Model Cell Culture
Tertiary TopicBacterial Infection
Vehicle Water (Electrolysis)
pH Neutral
Application Pack
Comparison
Complement