In vitro bactericidal activity against periodontopathic bacteria by electrolyzed ion-reduced water

Masahiro Okajima, M Kanzaki, Y Ishibashi, Y Wada, F hino, Y Kitahara, K Shimokawa, Fumiyoshi Ishii

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DOI: 10.5582/ddt.2011.v5.6.306 DOI is the universal ID for this study.

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As typical periodontopathic bacteria, Porphyromonas gingivalis (P. gingivalis) and Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) were exposed to electrolyzed ion-reduced water (ERI) and ERI containing 1% sodium carboxymethylcellulose (CMC-Na) (ERI-1% CMC-Na), and the time course of their bactericidal action was evaluated. More than 99% of each bacteria species were killed after exposure to each solution for 15 sec. In addition, 1% CMC-Na, which was added to prolong bactericidal action, did not affect the bactericidal action of ERI. Its bactericidal action was concentration-dependent. No viable P. gingivalis bacteria were observed at a concentration of 15% of the undiluted solution and no viable A. actinomycetemcomitans bacteria were observed at a concentration of 50%, indicating differences in the bactericidal action of ERI for the two bacteria species. These results suggest that ERI may be extremely useful in preventing and treating periodontal diseases.

Publish Year 2011
Country Japan
Rank Positive
Journal Drug Discoveries and Therapeutics
Primary Topic Mouth
Secondary Topic Periodontitis
Model Cell Culture
Tertiary Topic Pathogenic Bacterial Load
Vehicle Water (Electrolysis)
pH Alkaline
Application Culture Media